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Single-Source Off-Patent Drugs

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Recent Paragraph IV (Patent) Challenges

Tradename	Submission date
ACTIQ	October 29, 2004
INVOKAMET	March 29, 2017
LUVOX CR	April 13, 2009

All Paragraph IV Challenges >>

Authorized Generic Drugs

Tradename	Ingredient	Marketing Start
CARDIZEM	diltiazem hydrochloride	Apr 03, 2018
QUARTETTE	ethinyl estradiol; levonorgestrel	Mar 26, 2018
ALOXI	palonosetron hydrochloride	Mar 23, 2018

All Authorized Generics >>

Pharmaceutical Class, Formulation, and Dosage 

Pharmacology

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Ingredient

Adenosine Deaminase Adrenocorticotropic Hormone Allergens Allylamine Amides Amino Acids Amino Acids, Aromatic Aminoglycosides Aminosalicylic Acids Amphenicols Amphetamines Analogs/Derivatives Androstanes Anthracyclines Aptamers, Nucleotide Ascorbic Acid Azoles Barbiturates Benzodiazepines Benzothiazoles Benzylamines Biguanides Bile Acids and Salts Bismuth Boron Compounds Calcitonin Calcium Cannabinoids Carbapenems Cardiac Glycosides Carnitine Catecholamines Cations, Divalent Cephalosporins Cholecalciferol Cholecystokinin Copper Deoxyuridine Diarylquinolines Dihydropyridines Diphosphonates Ergocalciferols Ergolines Ergotamines Esters Estradiol Estradiol Congeners Estrogens, Conjugated (USP) Fatty Acids, Omega-3 Fluoroquinolones

Drug Class

4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor 5-alpha Reductase Inhibitor 5-Lipoxygenase Inhibitor Acetylcholine Releasing Agent Actinomycin Adenosine Receptor Agonist Adrenal Steroid Synthesis Inhibitor Adrenergic Receptor Agonist Adrenocorticotropic Hormone Aldehyde Dehydrogenase Inhibitor Aldosterone Antagonist Alkylating Drug Allylamine Antifungal alpha-1 Adrenergic Agonist alpha-Adrenergic Agonist alpha-Adrenergic Blocker alpha-Glucosidase Inhibitor Aluminum Complex Amide Local Anesthetic Amino Acid Aminoglycoside Antibacterial Aminoketone Aminosalicylate Amphenicol-class Antibacterial Amphetamine Anorectic Amylin Analog Androgen Androgen Receptor Inhibitor Angiotensin 2 Receptor Blocker Angiotensin Converting Enzyme Inhibitor Anthracycline Topoisomerase Inhibitor Anti-anginal Anti-coagulant Anti-epileptic Agent Antiarrhythmic Anticholinergic Antidiarrheal Antidote Antidote for Acetaminophen Overdose Antiemetic Antifibrinolytic Agent Antihelminthic Antihistamine Antihypoglycemic Agent Antileishmanial Antimalarial Antimetabolite Antimetabolite Immunosuppressant Antimycobacterial Antiparasitic

Mechanism of Action

5-alpha Reductase Inhibitors 5-Lipoxygenase Inhibitors Acetyl Aldehyde Dehydrogenase Inhibitors Acidifying Activity Adenosine Receptor Agonists Adrenal Steroid Synthesis Inhibitors Adrenergic Agonists Adrenergic alpha-Agonists Adrenergic alpha-Antagonists Adrenergic alpha1-Agonists Adrenergic alpha2-Agonists Adrenergic beta-Agonists Adrenergic beta-Antagonists Adrenergic beta1-Antagonists Adrenergic beta2-Agonists Adrenergic beta2-Antagonists Adrenergic beta3-Agonists Aldosterone Antagonists Alkylating Activity alpha Glucosidase Inhibitors alpha-Particle Emitting Activity Ammonium Ion Binding Activity AMPA Receptor Antagonists Amylin Agonists Androgen Receptor Agonists Androgen Receptor Antagonists Angiotensin 2 Receptor Antagonists Angiotensin 2 Type 1 Receptor Antagonists Angiotensin-converting Enzyme Inhibitors Aromatase Inhibitors beta Lactamase Inhibitors Bile-acid Binding Activity Bradykinin B2 Receptor Antagonists Breast Cancer Resistance Protein Inhibitors Calcineurin Inhibitors Calcium Channel Antagonists Calcium Chelating Activity Carbamoyl Phosphate Synthetase 1 Activators Carbonic Anhydrase Inhibitors Catechol O-Methyltransferase Inhibitors Catecholamine Synthesis Inhibitors Chelating Activity Chemokine Co-receptor 5 Antagonists Chloride Channel Activation Potentiators Chloride Channel Activators Cholinergic Agonists Cholinergic Antagonists Cholinergic Muscarinic Agonists Cholinergic Muscarinic Antagonists Cholinesterase Inhibitors

Physiological Effect

Alveolar Surface Tension Reduction Appetite Suppression Arteriolar Vasodilation Cardiac Rhythm Alteration Cell-mediated Immunity Central Nervous System Depression Central Nervous System Stimulation Centrally-mediated Muscle Relaxation Decreased Autonomic Ganglionic Activity Decreased Blood Pressure Decreased Cell Membrane Integrity Decreased Cell Wall Integrity Decreased Cell Wall Synthesis & Repair Decreased Central Nervous System Disorganized Electrical Activity Decreased Central Nervous System Organized Electrical Activity Decreased Cholesterol Absorption Decreased Coagulation Factor Activity Decreased Copper Ion Absorption Decreased DNA Replication Decreased Embryonic Implantation Decreased Fibrinolysis Decreased GI Motility Decreased GI Smooth Muscle Tone Decreased Glycolysis Decreased GnRH Secretion Decreased Histamine Release Decreased Immunologic Activity Decreased Immunologically Active Molecule Activity Decreased Leukotriene Production Decreased Mitosis Decreased Parasympathetic Acetylcholine Activity Decreased Platelet Aggregation Decreased Platelet Production Decreased Prostaglandin Production Decreased Protein Synthesis Decreased Renal K+ Excretion Decreased Respiratory Secretion Viscosity Decreased RNA Replication Decreased Sebaceous Gland Activity Decreased Sperm Motility Decreased Striated Muscle Contraction Decreased Striated Muscle Tone Decreased Tracheobronchial Stretch Receptor Activity Depigmenting Activity Digestive/GI System Activity Alteration Emesis Suppression General Anesthesia Genitourinary Arterial Vasodilation GI Motility Alteration Hematologic Activity Alteration

Medical Subject Heading (MeSH) Category

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Whether you need access for yourself or for your whole team, DrugPatentWatch offers subscription plans tailored to your needs. Attractive pricing is available for small groups or for enterprise-wide access.

For more information see the Plans and Pricing and Discount Schedule. Please contact us with any questions.