Last Updated: June 27, 2026

Patents Expiring in December 2043

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Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Vertex Pharms Inc ALYFTREK deutivacaftor; tezacaftor; vanzacaftor calcium TABLET;ORAL 218730-002 Dec 20, 2024 RX Yes Yes 12,186,306 ⤷  Start Trial TREATMENT OF CF IN PATIENTS AGED 6 YEARS AND OLDER WHO HAVE AT LEAST ONE F508DEL MUTATION OR ANOTHER RESPONSIVE MUTATION IN THE CFTR GENE WITH 21.4 MG OF VNZ CALCIUM SALT HYDRATE FORM D, 100 MG OF TEZ, AND 250 MG OF D-IVA DAILY
Vertex Pharms Inc ALYFTREK deutivacaftor; tezacaftor; vanzacaftor calcium TABLET;ORAL 218730-002 Dec 20, 2024 RX Yes Yes 12,186,306 ⤷  Start Trial TREATMENT OF CF WITH VNZ CA SALT HYDRATE FORM D/TEZ/D-IVA (21.24/100/250 MG) IN CF PATIENTS AGED ≥6 Y WITH AT LEAST ONE VARIANT IN THE CFTR GENE THAT IS EITHER RESPONSIVE BASED ON CLINICAL AND/OR IN VITRO DATA OR RESULTS IN PRODUCTION OF CFTR PROTEIN
Neurocrine CRENESSITY crinecerfont CAPSULE;ORAL 218808-001 Dec 13, 2024 RX Yes No 12,582,634 ⤷  Start Trial Y
Neurocrine CRENESSITY crinecerfont CAPSULE;ORAL 218808-002 Dec 13, 2024 RX Yes No 12,582,634 ⤷  Start Trial Y
Neurocrine CRENESSITY crinecerfont CAPSULE;ORAL 218808-003 Dec 13, 2024 RX Yes Yes 12,582,634 ⤷  Start Trial Y
Bioxcel IGALMI dexmedetomidine hydrochloride FILM;BUCCAL, SUBLINGUAL 215390-001 Apr 5, 2022 RX Yes Yes 12,364,683 ⤷  Start Trial ACUTE TREATMENT OF AGITATION IN PATIENTS WITH SEVERE HEPATIC IMPAIRMENT
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use

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