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Serving hundreds of leading biopharmaceutical companies globally:

Merck
Citi
Moodys
Express Scripts
McKinsey
McKesson
Argus Health
Deloitte
Colorcon

Generated: August 19, 2018

DrugPatentWatch Database Preview

Epinephrine - Generic Drug Details

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What are the generic drug sources for epinephrine and what is the scope of epinephrine freedom to operate?

Epinephrine is the generic ingredient in thirty-three branded drugs marketed by Sterling, Armstrong Pharms, Wyeth Cons, Forest Labs, Mylan Speciality Lp, Impax Labs Inc, Teva Pharms Usa, Par Sterile Products, Kaleo Inc, Luitpold, Adamis Pharms Corp, Belcher Pharms Llc, 3M, Astrazeneca, Dentsply Pharm, Deproco, Septodont Inc, Carlisle, Belmora Llc, Eastman Kodak, Hospira, West-ward Pharms Int, Abbott, Bel Mar, Dell Labs, Intl Medication, Watson Labs, Pharmaton, Septodont, Fresenius Kabi Usa, Vyteris, Iomed, and Empi, and is included in fifty-four NDAs. There are thirty-nine patents protecting this compound and three Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.

Epinephrine has one hundred and eighty-nine patent family members in twenty-six countries.

There are nineteen drug master file entries for epinephrine. Seventeen suppliers are listed for this compound.

Synonyms for epinephrine
(-)-(R)-Epinephrine
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-Epinephrine, >=97.0% (NT)
(-)-Epinephrine;L-Adrenaline;(-)-Adrenalin
(-)-R-Epinephrine
(+/-)-3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol
(+/-)-Adrenalin
(R)-(-)-3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(r)-4-(1-hydroxy-2-(methylamino)ethyl)benzene-1,2-diol
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-Adrenaline
(R)-Epinephrine
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
1,2-Benzenediol, 4-((1R)-1-hydroxy-2-(methylamino)ethyl)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (R)-
1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, (theta)-
1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-
1,2-Benzenediol, 4-[1-hydroxy-2-(methylamino)ethyl]-, (R)-
1401-EP2270011A1
1401-EP2298735A1
1401-EP2301934A1
1401-EP2305677A1
1401-EP2308562A2
1401-EP2308861A1
1401-EP2311464A1
1401-EP2311823A1
1401-EP2314571A2
2,3-bis(oxidanyl)butanedioic acid;4-[(1R)-2-(methylamino)-1-oxidanyl-ethyl]benzene-1,2-diol
2,3-dihydroxybutanedioic acid;4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
204017-EP2277867A2
204017-EP2280003A2
3,4-Dihydroxy-.alpha.-((methylamino)methyl)benzyl alcohol
3,4-Dihydroxy-alpha-(methylaminomethyl)benzyl alcohol
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]pyrocatechol;tartaric acid
4-[(1R)-1-hydroxy-2-methylamino-ethyl]benzene-1,2-diol
4-[(1R)-1-hydroxy-2-methylaminoethyl]benzene-1,2-diol
4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol #
4,5-beta-trihydroxy-N-methylphenethylamine
51-43-4
51-43-4 (FREE BASE)
51028-73-0
6367-EP2272841A1
6367-EP2277861A1
6367-EP2301934A1
6367-EP2301936A1
6367-EP2314571A2
91382-EP2284149A1
91382-EP2305636A1
A0173
AB00573227_14
AB00573227_15
AB00573227-11
AB00573227-12
AB00573227-13
AB2000623
AC-13188
AC1L1L7B
Adnephrine
ADR ADRENALINE
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin chloride
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
adrenaline
Adrenaline (JP15)
Adrenaline (JP17)
Adrenaline (L-Adrenaline)
Adrenaline with impurity F, European Pharmacopoeia (EP) Reference Standard
Adrenaline, European Pharmacopoeia (EP) Reference Standard
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
ADROP
AI3-19015
AJ-08814
AKOS024283500
ALE
AN-15872
Ana-Guard
Ana-Kit
Antiasthmatique
AS-13813
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
Auvi-q (TN)
Auvi-Q auto-injector
Balmadren
BC204174
BDBM44818
BDBM50029050
Benzyl alcohol, 3,4-dihydroxy-.alpha.-[(methylamino)methyl]-, (-)-
Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, (-)-
Bernarenin
BIDD:GT0119
Biorenine
bmse000316
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
C9H13NO3
CAS-51-43-4
CCG-204593
CCRIS 4812
CHEBI:28918
Chelafrin
CHEMBL679
cid_6852374
Citanest Forte
Citanest Forte (Salt/Mix)
component of E-Pilo (Salt/Mix)
Corisol
CS-2558
CTK4J3509
d-Adrenaline
D-Epifrin
D-Epinephrine
D00095
D29A657
DB00668
Drenamist
DSSTox_CID_2986
DSSTox_GSID_22986
DSSTox_RID_76819
DTXSID5022986
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
EPINEPHRINE (SEE ALSO: EPINEPHRINE HYDROCHLORIDE (CAS 55-31-2))
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine [USP:INN:BAN:JAN]
Epinephrine HCl
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
EPIPEN E Z PEN
Epipen EZ Pen
EPIPEN JR
Epipen Jr.
Epipen Jr. Auto-Injector
Epirenamine
Epirenan
Epirenin
Epitrate
Epitrate (Salt/Mix)
Eppy
Esphygmogenina
Exadri
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
GTPL479
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
HSCI1_000215
HSDB 4289
HY-B0447B
Hypernephrin
Hyporenin
Intranefrin
Iontocaine
IOP
Isoptoepinal
J10365
Kidoline
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
L-Adrenaline (Epinephrine)
L-Adrenaline Base
l-adrenaline,(-)adrenaline,l-epinephrine,l-3,4-dihydroxy-alpha-(methylaminomethyl)benzyl alcohol,l-1-methyl aminoethanol catechol
L-Epinehphrine
l-Epinephine
L-epinephrine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
L(-)-Epinephrine
L926
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
LS-156
Lyodrin
Lyophrin
MCULE-9462717294
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
MFCD00002204
MFCD00063027
Micronefrin
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NCGC00142615-08
NCGC00142615-09
nchembio747-comp9
NE58416
Nephridine
Nieraline
NSC 62786
NSC62786
OR023601
OR154878
OR276267
OR349940
Paranephrin
PDSP1_001120
PDSP2_001104
Primatene
Primatene Mist
Q-200601
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
s2522
SBB012384
SCHEMBL3814
Scurenaline
Septocaine
Simplene
Sindrenina
SMP1_000227
Soladren
Sphygmogenin
SR-01000075267-8
ST069368
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
SUS-PHRINE SULFITE-FREE
Susphrine
Symjepi
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Tox21_111562
Tox21_111562_1
TR-033467
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UCTWMZQNUQWSLP-VIFPVBQESA-N
UNII-GR0L9S3J0F component UCTWMZQNUQWSLP-VIFPVBQESA-N
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
YKH834O4BH
Z2686405805
ZINC39089

US Patents and Regulatory Information for epinephrine

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Hospira LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 089646-001 Jun 21, 1988 AP RX No No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Dell Labs LIDOCAINE HYDROCHLORIDE W/ EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 083390-001 Approved Prior to Jan 1, 1982 DISCN No No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Hospira LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 089644-001 Jun 21, 1988 AP RX No No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Kaleo Inc AUVI-Q epinephrine SOLUTION;INTRAMUSCULAR, SUBCUTANEOUS 201739-003 Nov 17, 2017 RX Yes No ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Septodont OCTOCAINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 084048-002 Approved Prior to Jan 1, 1982 AP RX No Yes ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Astrazeneca XYLOCAINE W/ EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 010418-008 Approved Prior to Jan 1, 1982 DISCN No No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Hospira LIDOCAINE HYDROCHLORIDE AND EPINEPHRINE epinephrine; lidocaine hydrochloride INJECTABLE;INJECTION 088571-001 Sep 13, 1985 AP RX No No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for epinephrine

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Impax Labs Inc ADRENACLICK epinephrine INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS 020800-003 Nov 25, 2009 ➤ Try a Free Trial ➤ Try a Free Trial
Impax Labs Inc ADRENACLICK epinephrine INJECTABLE;INTRAMUSCULAR, SUBCUTANEOUS 020800-004 Nov 25, 2009 ➤ Try a Free Trial ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Non-Orange Book US Patents for epinephrine

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,927,303 Medicine injection devices and methods ➤ Try a Free Trial
7,931,618 Apparatuses and methods for injecting medicines to a desired depth ➤ Try a Free Trial
8,187,224 Methods performed by medicine injection apparatuses ➤ Try a Free Trial
7,416,540 Devices systems and methods for medicament delivery ➤ Try a Free Trial
7,648,482 Devices, systems, and methods for medicament delivery ➤ Try a Free Trial
7,648,483 Devices, systems and methods for medicament delivery ➤ Try a Free Trial
8,105,281 Devices, systems and methods for medicament delivery ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents for epinephrine

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Serving hundreds of leading biopharmaceutical companies globally:

Argus Health
Colorcon
Julphar
US Army
AstraZeneca
Cantor Fitzgerald
Fish and Richardson
Boehringer Ingelheim
McKesson

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.