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Doxycycline hyclate - Generic Drug Details
What are the generic drug sources for doxycycline hyclate and what is the scope of doxycycline hyclate freedom to operate?
Doxycycline hyclate
is the generic ingredient in fifteen branded drugs marketed by Pliva, Mayne Pharma Intl, Warner Chilcott, Medicis, Almirall, Teva, Actavis Labs Fl Inc, Ajanta Pharma Ltd, Alembic Pharms Ltd, Amneal Pharms, Chartwell Life Sci, Halsey, Heather, Hikma Intl Pharms, Interpharm, Mutual Pharm, Mylan, Par Pharm, Pvt Form, Ranbaxy, Sun Pharm Industries, Superpharm, Watson Labs, Zydus Pharms Usa Inc, Collagenex, Pfizer, Fresenius Kabi Usa, Rachelle, Mylan Labs Ltd, West-ward Pharms Int, Tolmar, Mayne Pharma, Actavis Elizabeth, Heritage Pharms Inc, Impax Labs Inc, Mylan Pharms Inc, Prinston Inc, Amneal Pharms Co, Cadila, Caribe Holdings, Emcure Pharms Ltd, Epic Pharma Llc, Ivax Sub Teva Pharms, Lannett Co Inc, Larken Labs, Lupin Ltd, Mayne Pharma Inc, Novel Labs Inc, Vintage Pharms, Chartwell Pharma, and Galderma Labs Lp, and is included in seventy-six NDAs. There are five patents protecting this compound and seven Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.Doxycycline hyclate has two patent family members in two countries.
There are twenty-eight drug master file entries for doxycycline hyclate. Ninety-five suppliers are listed for this compound.
Summary for doxycycline hyclate
| International Patents: | 2 |
| US Patents: | 5 |
| Tradenames: | 15 |
| Applicants: | 51 |
| NDAs: | 76 |
| Drug Master File Entries: | 28 |
| Suppliers / Packagers: | 95 |
| Bulk Api Vendors: | 126 |
| Clinical Trials: | 8 |
| Patent Applications: | 3,319 |
| Formulation / Manufacturing: | see details |
| Drug Prices: | Drug price trends for doxycycline hyclate |
| Drug Sales Revenues: | Drug sales revenues for doxycycline hyclate |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for doxycycline hyclate |
| DailyMed Link: | doxycycline hyclate at DailyMed |
Pharmacology for doxycycline hyclate
| Ingredient-type | Tetracyclines |
| Drug Class | Tetracycline-class Drug |
Synonyms for doxycycline hyclate
| (1S,4aS,11R,11aR,12S,12aR)-3-carbamoyl-2,4a,5,7,12-pentahydroxy-N,N,11-trimethyl-4,6-dioxo-1,4,4a,6,11,11a,12,12a-octahydrotetracen-1-aminium chloride--ethanol--water (2/1/1) |
| (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione |
| (2E,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; ethanol; hydrate; dihydrochloride |
| (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; ethanol; hydrate; dihydrochloride |
| (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione |
| (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrochloride |
| (2Z,4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; ethanol; hydrate; dihydrochloride |
| (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide |
| (4S,4aR,5S,5aR,6R,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione |
| (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)- 3,5,10,12,12a-pentahydroxy- 6-methyl- 1,11-dioxo- 1,4,4a,5,5a,6,11,12a-octahydrotetracene- 2-carboxamide hydrochloride hemiethanolate hemihydrate |
| (4s,4ar,5s,5ar,6r,12as)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide |
| (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide |
| (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide - ethanol (2:1) dihydrochloride hydrate |
| (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide compound with ethanol (2:1) dihydrochloride hydrate |
| (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide |
| (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride |
| 100929-47-3 |
| 10592-13-9 |
| 10592-13-9 (. HCl) |
| 10597-92-9 |
| 1368-EP2269978A2 |
| 1368-EP2269985A2 |
| 1368-EP2269991A2 |
| 1368-EP2284150A2 |
| 1368-EP2284151A2 |
| 1368-EP2284152A2 |
| 1368-EP2284153A2 |
| 1368-EP2284155A2 |
| 1368-EP2284156A2 |
| 1368-EP2284164A2 |
| 1368-EP2287140A2 |
| 1368-EP2287148A2 |
| 1368-EP2287150A2 |
| 1368-EP2289871A1 |
| 1368-EP2295402A2 |
| 1368-EP2295419A2 |
| 1368-EP2298732A1 |
| 1368-EP2301534A1 |
| 1368-EP2301912A2 |
| 1368-EP2301913A1 |
| 1368-EP2301914A1 |
| 1368-EP2301916A2 |
| 1368-EP2305637A2 |
| 1368-EP2305640A2 |
| 1368-EP2308863A1 |
| 1368-EP2311451A1 |
| 1368-EP2311796A1 |
| 1368-EP2311797A1 |
| 1368-EP2311798A1 |
| 1368-EP2311799A1 |
| 1368-EP2316450A1 |
| 17086-28-1 (mono-hydrate) |
| 19XTS3T51U |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS) |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aR,5S,5aR,6R,12aS)- |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol, hydrate (2:2:1:1) |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S-(4alpha,4aalpha,5alpha,5aalpha,6alpha,12aalpha))- |
| 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)- |
| 2-Naphthacenecarboxamide, 4-alpha-S-(dimethylamino)-1,4,4a-alpha-5,5a-alpha,6,11,12a-octahydro-3,5-alpha,10,12,12a-alpha-pentahydroxy-6-alpha-methyl-1,11-dioxo- |
| 2-Naphthacenecarboxamide, 4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride |
| 2-Naphthacenecarboxamide, 4beta-(dimeethylamino)-1,4,4abeta,5,5abeta,6,11,12a-octahydro-3,5beta,10,12,12abeta-pentahydroxy-6beta-methyl-1,11-dioxo-, monohydrochloride, compd. with ethyl alcohol (2:1), monohydrate |
| 2-Naphthacenecarboxamide,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrochloride, (4S,4aR,5S,5aR,6R,12aS)-, compd. with ethanol (2:1), monohydrate (9CI) (CA INDEX NAME) |
| 2387AH |
| 24390-14-5 |
| 2C22H24N2O8.C2H6O.2ClH.H2O |
| 2C22H24N2O8.C2H6O.H2O |
| 334895S862 |
| 390D145 |
| 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride, compound with ethyl alcohol (2:1), monohydrate |
| 4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide - ethanol (2:1) dihydrochloride hydrate |
| 4-Epioxytetracycline, 6-deoxy- |
| 41411-66-9 (6-epimer, mono-hydrochloride) |
| 4182Z6T2ET |
| 5-Hydroxy-alpha-6-deoxytetracycline |
| 5-Hydroxy-alpha-6-deoxytetracycline monohydrate |
| 53108-42-2 |
| 564-25-0 |
| 564D250 |
| 6-alpha-Deoxy-5-oxytetracycline |
| 6-Deoxy-5-hydroxytetracycline hydrochloride hemihydrate |
| 6-Deoxyoxytetracycline |
| 6-Deoxytetracycline |
| 6-Desoxy-5-hydroxytetracycline hydrochloride hemihydrate hemiethanolate |
| 61281-03-6 |
| 62149-53-5 |
| 69935-17-7 (mono-hydrochloride, di-hydrate) |
| 6alpha-Deoxy-5-oxytetracycline |
| 7164-70-7 |
| 7264-10-0 |
| 94088-85-4 (calcium salt (1:2)) |
| AB00053465_04 |
| AB00053465_05 |
| AB00053465-03 |
| AB08 (*Fosfatex) |
| AC-12044 |
| AC-6017 |
| AC1L1WYQ |
| AC1NQXW7 |
| AC1NQZPV |
| AC1NTTH2 |
| AC1NUYS5 |
| AC1NUYS8 |
| Acticlate |
| Acticlate CAP |
| AK175707 |
| AK321970 |
| AKOS015900372 |
| AKOS015924649 |
| AKOS025310153 |
| AKOS025402170 |
| alpha-6-Deoxy-5-hydroxytetracycline |
| alpha-6-Deoxyoxytetracycline |
| alpha-6-Deoxyoxytetracycline monohydrate |
| alpha-6-Tetracycline monohydrate |
| alpha-Doxycycline |
| Alti-Doxycycline |
| AN-18097 |
| Anhydrous doxycycline |
| API0002491 |
| API0002492 |
| Apo-Doxy |
| AS-13499 |
| Atridox |
| Azudoxat |
| BCBcMAP01_000024 |
| Biocamycin |
| bis((4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide) ethanol hydrate dihydrochloride |
| BMY 28689 |
| BMY-28689 |
| BMY28689 |
| BSPBio_001936 |
| BU 3839T |
| BU-3839T |
| C-0055 |
| C06973 |
| C22H24N2O8.HCl.0.5H2O.0.5C2H6O |
| C22H25ClN2O8 |
| CAS-10592-13-9 |
| CCG-204498 |
| CCG-38949 |
| CHEBI:34730 |
| CHEBI:50845 |
| CHEBI:652992 |
| CHEMBL1200567 |
| CHEMBL1256723 |
| CHEMBL1433 |
| CHEMBL3989740 |
| CHEMBL436921 |
| controlled-release doxycycline hy-clate |
| CS-2632 |
| D 9891 |
| D02129 |
| D07876 |
| D07877 |
| D4116 |
| DB00254 |
| Dentista |
| Deoxy-5-hydroxytetracycline hydrochloride |
| Deoxymykoin |
| Deoxyoxytetracycline hydrochloride |
| DivK1c_000345 |
| DMSC (*Fosfatex) |
| Doryx |
| Doryx (TN) |
| Doryx Mpc |
| Dossiciclina |
| Dossiciclina [DCIT] |
| DOXCYCLINE ANHYDROUS |
| Doxiciclina |
| Doxiciclina [INN-Spanish] |
| Doxiciclina [Italian] |
| Doxigalumicina |
| Doxitard |
| Doxivetin |
| Doxteric |
| DOXY |
| Doxy 100 |
| DOXY 200 |
| Doxy-Caps |
| Doxy-II |
| Doxy-Lemmon |
| Doxy-Puren |
| Doxy-tablinen |
| Doxy-Tabs |
| Doxycen |
| Doxychel |
| Doxychel (TN) |
| Doxychel Hyclate |
| Doxycin |
| Doxycyclin |
| doxycycline |
| Doxycycline (200mg/day) or Placebo |
| Doxycycline (anhydrous) |
| Doxycycline (hyclate) |
| Doxycycline (hydrochloride) |
| Doxycycline (INN) |
| Doxycycline (internal use) |
| Doxycycline (TN) |
| Doxycycline [USAN:INN:BAN] |
| DOXYCYCLINE CALCIUM |
| Doxycycline HCl |
| Doxycycline Hyclate (100 mg) |
| Doxycycline hyclate (internal use) |
| Doxycycline hyclate (USP) |
| Doxycycline hyclate [USAN:USP] |
| doxycycline hyclate 20 mg twice daily |
| Doxycycline hydrochloride |
| Doxycycline Hydrochloride [JAN] |
| Doxycycline hydrochloride hemiethanolate hemihydrate |
| Doxycycline hydrochloride hydrate (JP17) |
| DOXYCYCLINE HYLATE |
| Doxycycline-Chinoin |
| Doxycycline, Antibiotic for Culture Media Use Only |
| Doxycycline, HCl |
| Doxycycline, Hyclate |
| Doxycyclinum |
| Doxycyclinum [INN-Latin] |
| Doxylin |
| Doxyprex |
| Doxysol |
| Doxytec |
| Doxytetracycline |
| DS-9077 |
| DSSTox_CID_25405 |
| DSSTox_GSID_45405 |
| DSSTox_RID_80856 |
| DTXSID0037653 |
| DTXSID1045405 |
| DTXSID4041020 |
| Ecodox |
| EINECS 209-271-1 |
| EINECS 234-198-7 |
| Ethanol, compd. with (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (1:2), monohydrate |
| EU-0100405 |
| FT-0603476 |
| GS-3065 |
| GS-3065 (*monohydrate) |
| GTPL6464 |
| HMS1920I20 |
| HMS2090E06 |
| HSDB 3071 |
| HY-N0565A |
| Hydramycin |
| I015 |
| I455 |
| IDI1_000345 |
| Idocyklin |
| Investin |
| J-000264 |
| J10246 |
| JBIWCJUYHHGXTC-AKNGSSGZSA-N |
| Jenacyclin |
| JRNIHERUNQWMMW-WBYAVNBMSA-N |
| KBio1_000345 |
| KBio2_001287 |
| KBio2_003855 |
| KBio2_006423 |
| KBio3_001156 |
| KBioGR_001133 |
| KBioSS_001287 |
| KS-5254 |
| Liomycin |
| Liviatin |
| LMPK07000001 |
| Lopac0_000405 |
| LP00405 |
| LS-174052 |
| LS-187766 |
| LS-93868 |
| MCULE-4368118692 |
| MCULE-8555113623 |
| Mespafin |
| MFCD07357237 |
| Midoxin |
| MMV000011 |
| MolPort-002-507-423 |
| MolPort-003-666-171 |
| MolPort-005-932-536 |
| MolPort-023-220-303 |
| MolPort-039-338-208 |
| Monodoks |
| Monodox |
| Monodox (*monohydrate) |
| NCGC00016693-01 |
| NCGC00161602-01 |
| NCGC00161602-03 |
| NCGC00161602-04 |
| NCGC00161602-05 |
| NCGC00161602-06 |
| NCGC00188979-01 |
| NCGC00261090-01 |
| NINDS_000345 |
| Nivocilin |
| Novadox |
| Novo-Doxylin |
| NPV78C39GQ |
| NSC-633557 |
| NSC-741421 |
| NSC-756751 |
| NSC633557 |
| NSC741421 |
| NSC756751 |
| Nu-Doxycycline |
| Oracea |
| Oxytetracycline, 6-deoxy- |
| Periostat |
| Periostat (TN) |
| Pharmakon1600-01500266 |
| RETENS |
| Ronaxan |
| Roximycin |
| RPRXAHFLWOCXQL-AKNGSSGZSA-N |
| RUYHIJHUVHIMIR-CVHRZJFOSA-N |
| Samecin |
| SBI-0050391.P004 |
| SC-15766 |
| SCHEMBL1176275 |
| SCHEMBL17826665 |
| SCHEMBL19270298 |
| SCHEMBL40834 |
| SCHEMBL40930 |
| SCHEMBL66828 |
| SGKRLCUYIXIAHR-AKNGSSGZSA-N |
| SMP1_000107 |
| Spanor |
| SPBio_000246 |
| Spectrum_000807 |
| SPECTRUM1500266 |
| Spectrum2_000143 |
| Spectrum3_000408 |
| Spectrum4_000527 |
| Spectrum5_000947 |
| SR-01000075844 |
| SR-01000075844-1 |
| SR-01000075844-7 |
| SR-01000075844-8 |
| Supracyclin |
| SW219440-1 |
| SW219440-2 |
| Tanamicin |
| Tecacin |
| Tetraclean |
| Tetradox |
| Tox21_110566 |
| Tox21_110566_1 |
| Tox21_500405 |
| UNII-19XTS3T51U |
| UNII-334895S862 |
| UNII-4182Z6T2ET |
| UNII-NPV78C39GQ |
| UPCMLD-DP021 |
| UPCMLD-DP021:001 |
| Vibra-tabs |
| Vibra-tabs (TN) |
| Vibradox |
| Vibramycin |
| Vibramycin (*monohydrate) |
| Vibramycin (TN) |
| Vibramycin hyclate |
| Vibramycin hydrochloride |
| Vibramycin Novum |
| Vibramycin, Hyclate |
| Vibramycine |
| Vibravenos |
| Vivox |
| Vivox (*Hyclate) |
| W-105517 |
| WC 2031 |
| Z2791720087 |
| Zenavod |
| ZINC100056779 |
| ZINC100302137 |
| ZINC100611210 |
| ZINC109562088 |
| ZINC16052277 |
US Patents and Regulatory Information for doxycycline hyclate
International Patents for doxycycline hyclate
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2006045152 | ➤ Try a Free Trial |
| Australia | 2005299253 | ➤ Try a Free Trial |
| Country | Patent Number | Estimated Expiration |
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Major Patent Expirations 2019 - 2020
NCE-1 Generic Application Dates 2019 - 2020
ISSN: 2162-2639
Privacy and Cookies
Terms & Conditions
Site Map
Major Patent Expirations 2019 - 2020
NCE-1 Generic Application Dates 2019 - 2020
Preferred Citation:
Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2019, www.DrugPatentWatch.com.
Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2019, www.DrugPatentWatch.com.
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