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Atropine - Generic Drug Details

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What are the generic sources for atropine and what is the scope of atropine freedom to operate?

Atropine is the generic ingredient in twenty-four branded drugs marketed by Meridian Medcl Techn, Abbvie, Rafa Labs Ltd, Us Army, Akorn, Alcon Labs Inc, Hospira, Fresenius Kabi Usa, Sebela Ireland Ltd, Scherer Rp, Medpointe Pharm Hlc, West-ward Pharms Int, Alpharma Us Pharms, Gd Searle Llc, Md Pharm, Able, Ani Pharms Inc, Ascot, Bayshore Pharms Llc, Fosun Pharma, Heather, Hikma Pharms, Inwood Labs, Kv Pharm, Lannett, Lederle, Mylan, Par Pharm, Parke Davis, Pvt Form, R And S Pharma, Roxane, Sun Pharm Industries, Upsher Smith Labs, Usl Pharma, Valeant Pharm Intl, Watson Labs, Vangard, Superpharm, Halsey, Mylan Institutional, Wyeth Ayerst, and Meridian Medcl, and is included in fifty-one NDAs. Additional information is available in the individual branded drug profile pages.

There are twenty-three drug master file entries for atropine. Two suppliers are listed for this compound.

Summary for atropine

US Patents:	0
Tradenames:	24
Applicants:	43
NDAs:	51
Drug Master File Entries:	23
Suppliers / Packagers:	2
Bulk Api Vendors:	45
Clinical Trials:	234
Patent Applications:	6,133
Formulation / Manufacturing:	see details
Drug Prices:	Drug price trends for atropine
DailyMed Link:	atropine at DailyMed

Pharmacology for atropine

Drug Class	Anticholinergic Cholinergic Muscarinic Antagonist
Mechanism of Action	Cholinergic Antagonists Cholinergic Muscarinic Antagonists

Medical Subject Heading (MeSH) Categories for atropine

Adjuvants, Anesthesia

Anti-Arrhythmia Agents

Bronchodilator Agents

Muscarinic Antagonists

Mydriatics

Parasympatholytics

Synonyms for atropine

(+-)-atropine

(+-)-hyoscyamine

(+,-)-Tropyl tropate

(+)-HYOSCYAMINE

(+/-)-Atropine

(+/-)-Hyoscyamine

(1beta,3alpha,5beta)-3-[(3-Hydroxy-1-oxo-2-phenylpropyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane

(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate

(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate

(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate

(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl tropate

[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate

[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate

[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] 3-hydroxy-2-phenyl-propanoate

[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenyl-propanoate

1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester)

1-alpha-H,5-alpha-H-Tropan-3-alpha-ol (+-)-tropate (ester) (8CI)

13269-35-7

1445960-43-9

1alphaH,5alphaH-Tropan-3alpha-ol (+-)-tropate (ester)

2-Phenylhydracrylic acid 3-alpha-tropanyl ester

3-tropoyloxytropane

51-55-8

5908-99-6

78597-12-3

8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate

8-Methyl-8-azabicyclo[3.2.1]oct-3-yl tropate

8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropionate

AB00694549_14

AB00694549-11

AB00694549-12

AC1L5AX3

AC1Q3XL2

ACon1_000046

AI3-60219

AKOS015955538

alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester

alpha-Hydroxymethylphenylacetic acid (1R,5S)-8-methyl-8-azabicyclo[3.2.1]octane-3-yl ester

Anaspaz

Atropair

Atropen

Atropen (TN)

Atropin

Atropin [German]

Atropin-flexiolen

Atropina

Atropina [Italian]

Atropine (USP)

Atropine [BAN]

Atropine [USP:BAN]

Atropine Care

Atropine for peak identification, European Pharmacopoeia (EP) Reference Standard

Atropine sulfate

Atropine Sulfate Ansyr Plastic Syringe

Atropine Sulfate S.O.P.

Atropine, >=95.0% (NT)

Atropine, >=99% (TLC), powder

Atropine, analytical standard

Atropine, European Pharmacopoeia (EP) Reference Standard

Atropine, meets USP testing specifications

Atropinol

Atropinum

Atropt

Atrosulf

b eta-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

BCP15060

BDBM200229

BDBM50403547

Belladenal

Benzeneacetic acid, alpha-(hydroxymethyl)- (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester

Benzeneacetic acid, alpha-(hydroxymethyl)- 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester endo-(+-)-

Benzeneacetic acid, alpha-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester

Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-

Benzeneacetic acid, alpha-(hydroxymethyl)-, 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+/-)-

Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo [3.2.1]oct-3-yl ester, endo-(+/-)-

Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3,2,1)oct-3-yl ester, endo-(+-)-

Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, endo-(+-)-

Benzeneacetic acid, alpha-(hydroxymethyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester endo-(+-)-

beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester

beta-Phenyl-gamma-oxypropionsaeure-tropyl-ester [German]

beta-Phenyl-gamma-oxypropionsaure-tropyl-ester

beta-Phenyl-gamma-oxypropionsaure-tropyl-ester [German]

bmse000649

BRD-A27290375-001-01-8

BRD-A27290375-330-01-1

C01479

C1504

C17H23NO3

CAS-51-55-8

CCRIS 3080

CHEBI:16684

CHEBI:78734

CHEMBL475124

CHEMBL517712

cid_174174

CPD001906768

CS-4834

Cytospaz

D00113

DB00572

dl-Hyoscyamine

DL-Tropanyl 2-hydroxy-1-phenylpropionate

DL-Tropyl tropate

dl-Tropyltropate

Donnagel

DSSTox_CID_113

DSSTox_GSID_20113

DSSTox_RID_75375

DTXSID4020113

EINECS 200-104-8

endo-( inverted exclamation markA)-|A-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester

Eyesules

FT-0602865

FT-0627165

GP2470

GTPL320

HMS2089A16

HMS2231G17

HMS3259M13

HSDB 2199

HY-B1205

hyoscyamine

Hyoscyamine sulfate

I-Tropine

Isopto Atropine

Isopto-atropine

L-Hyoscyamine

LS-7203

MEGxp0_001878

MFCD00022622

Minims

Minims Atropine

MLS000069795

MLS001148094

MLS002695888

MolPort-001-742-593

Mydriasine

NC00493

NCGC00017333-02

NCGC00017333-03

NCGC00017333-04

NCGC00017333-05

NCGC00017333-06

NCGC00142514-01

NCGC00142514-03

NCGC00159345-02

NCGC00258041-01

NCGC00385525-01

Neo-Diophen

Ocu-Tropine

Opera_ID_1088

Protamine & Atropine

rac-(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate

rac-tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate

RKUNBYITZUJHSG-SPUOUPEWSA-N

RL00080

ropine tropate

SAM002554885

SBB005985

SCHEMBL2812

SMR000058248

ST057178

Tox21_110816

Tox21_111590

Tox21_200487

TR-000361

tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate

Tropic acid, 3-alpha-tropanyl ester

Tropic acid, ester with tropine

Tropine (+/-)-tropate

Tropine tropate

Tropine, tropate (ester)

Troyl tropate

Urised

US Patents and Regulatory Information for atropine

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Alpharma Us Pharms	LOMANATE	atropine sulfate; diphenoxylate hydrochloride	SOLUTION;ORAL	085746-001	Approved Prior to Jan 1, 1982		DISCN	No	No
West-ward Pharms Int	DIPHENOXYLATE HYDROCHLORIDE AND ATROPINE SULFATE	atropine sulfate; diphenoxylate hydrochloride	SOLUTION;ORAL	087708-001	May 3, 1982		RX	No	Yes
Meridian Medcl Techn	ATROPEN	atropine	SOLUTION;INTRAMUSCULAR	017106-003	Jun 19, 2003		RX	Yes	Yes