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Enalapril maleate - Generic Drug Details
What are the generic drug sources for enalapril maleate and what is the scope of enalapril maleate freedom to operate?
Enalapril maleate
is the generic ingredient in seven branded drugs marketed by Silvergate Pharms, Apotex, Apothecon, Ivax Sub Teva Pharms, Krka Dd Novo Mesto, Mylan, Sandoz, Sandoz Inc, Sun Pharm Inds Ltd, Taro, Teva, Watson Labs, Wockhardt Ltd, Valeant Pharms North, Astrazeneca, Apotex Inc, Dr Reddys Labs Ltd, G And W Labs Inc, Taro Pharm Inds, Upsher Smith Labs, and Valeant Intl, and is included in twenty-eight NDAs. There are seven patents protecting this compound and two Paragraph IV challenges. Additional information is available in the individual branded drug profile pages.Enalapril maleate has five patent family members in four countries.
There are twenty-seven drug master file entries for enalapril maleate. Forty suppliers are listed for this compound.
Summary for enalapril maleate
| International Patents: | 5 |
| US Patents: | 7 |
| Tradenames: | 7 |
| Applicants: | 21 |
| NDAs: | 28 |
| Drug Master File Entries: | 27 |
| Suppliers / Packagers: | 40 |
| Bulk Api Vendors: | 55 |
| Clinical Trials: | 14 |
| Patent Applications: | 3,500 |
| Formulation / Manufacturing: | see details |
| Drug Prices: | Drug price information for enalapril maleate |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for enalapril maleate |
| DailyMed Link: | enalapril maleate at DailyMed |
Pharmacology for enalapril maleate
| Drug Class | Angiotensin Converting Enzyme Inhibitor |
| Mechanism of Action | Angiotensin-converting Enzyme Inhibitors |
| Physiological Effect | Decreased Blood Pressure |
Medical Subject Heading (MeSH) Categories for enalapril maleate
Synonyms for enalapril maleate
| ((S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl)-L-alanyl-L-proline |
| (2S)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-carboxylic aci |
| (2S)-1-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid; maleic acid |
| (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid |
| (2S)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]pyrrolidine-2-carboxylic acid |
| (S,S,S)-1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid |
| (S,S,S)-Enalapril Maleate |
| (S)-(-)-1-[N-(1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-Lproline |
| (S)-1-((S)-2-(((S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl)amino)propanoyl)pyrrolidine-2-carboxylic acid |
| (S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-ylamino)propanoyl)pyrrolidine-2-carboxylic acid |
| (S)-1-((S)-2-((S)-1-ETHOXY-1-OXO-4-PHENYLBUTAN-2-YLAMINO)PROPANOYL)PYRROLIDINE-2-CARBOXYLIC ACID MALEATE |
| (S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline |
| (S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline maleate |
| (S)-1-(N-(1-(Ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-L-proline maleate (1:1) |
| (S)-1-[(R)-2-((R)-1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid |
| (S)-1-[N-[1-(ETHOXYCARBONXYL)-3-PHENYLPROPYL]-L-AL |
| (S)-1-[N-[1-(ETHOXYCARBONXYL)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE |
| (S)-1-[N-[1-(ETHOXYCARBONYL)-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE MALEATE |
| (S)-1-{(S)-2-[1-((S)-Ethoxycarbonyl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid |
| (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt |
| (SSS)1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid |
| (Z)-but-2-enedioic acid; (2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid |
| (Z)-but-2-enedioic acid;(2S)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]pyrrolidine-2-carboxylic acid |
| 095E164 |
| 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester |
| 1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline 1'-ethyl ester, maleate (1:1) |
| 1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid |
| 1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid (Enalapril) |
| 1-[2-(1-Ethoxycarbonyl-3-phenyl-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid(enalapril) |
| 1-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-L-proline Maleate |
| 172964-46-4 |
| 2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid(enalapril) |
| 69PN84IO1A |
| 75847-73-3 |
| 75847-73-3 (Parent) |
| 76095-16-4 |
| 76095-16-4 (maleate) |
| 76420-75-2 |
| 77549-58-7 |
| 77549-59-8 |
| 847E733 |
| 9O25354EPJ |
| A-Rin |
| AB00053615_19 |
| AB00053615_20 |
| AB00053615-17 |
| AB00053615-18 |
| AB0013100 |
| AB03713 |
| AB2000386 |
| AC1NTUS2 |
| AC1NTUS5 |
| Acetensil |
| AK325516 |
| AK486954 |
| AKOS016340376 |
| AKOS025310615 |
| Alphrin |
| Amprace |
| AN-15422 |
| analapril |
| Analept |
| AOB5651 |
| API0002541 |
| Atens |
| Baripril |
| BDBM50017129 |
| Benalapril |
| Benalipril |
| BIDD:GT0751 |
| Biocronil |
| BPBio1_000340 |
| BQL |
| BSPBio_000308 |
| BSPBio_003035 |
| C-21264 |
| C06977 |
| C20H28N2O5 |
| C20H28N2O5.C4H4O4 |
| CAS-75847-73-3 |
| CAS-76095-16-4 |
| CC-27456 |
| CCG-39221 |
| CHEBI:4784 |
| CHEBI:4785 |
| CHEMBL1200659 |
| CHEMBL578 |
| Controlvas |
| Converten |
| Convertin |
| Coprilor |
| Coroldil |
| CPD001906771 |
| Crinoren |
| CS-2373 |
| CS-2918 |
| CTK8F9436 |
| D00621 |
| D00SEB |
| D07892 |
| Dabonal |
| DB00584 |
| Defluin |
| Denapril |
| Ditensor |
| DivK1c_000408 |
| DR002110 |
| DSSTox_CID_2982 |
| DSSTox_GSID_22982 |
| DSSTox_RID_76817 |
| DTXSID5022982 |
| Ecapril |
| Ednit |
| Ednyt |
| EINECS 278-375-7 |
| EINECS 278-460-9 |
| Elfonal |
| Enacard |
| Enalabene |
| Enaladex |
| Enaladil |
| enalapril |
| Enalapril (INN) |
| Enalapril (maleate) |
| Enalapril (TN) |
| Enalapril [INN:BAN] |
| ENALAPRIL 2-BUTENEDIOATE |
| enalapril hydrogen maleate |
| Enalapril maleate (JP17/USP) |
| Enalapril maleate (Vasotec) |
| Enalapril maleate [USAN:JAN] |
| Enalapril maleate [USAN:USP:JAN] |
| Enalapril maleate salt |
| Enalapril Maleate Usp Xxi |
| Enalapril Richet |
| Enalapril, AldrichCPR |
| Enalaprila |
| Enalaprila [INN-Spanish] |
| Enalaprilmaleate |
| Enalaprilum |
| Enalaprilum [INN-Latin] |
| Enalasyn |
| Enaloc |
| Enalped |
| Enap |
| Enapren |
| Enapres |
| Enapril |
| Enaprin |
| Enarenal |
| Enaril |
| Envas |
| Epaned |
| Epaned Kit |
| Eupressin |
| Feliberal |
| GBXSMTUPTTWBMN-XIRDDKMYSA-N |
| Glioten |
| Glioten;Renitec;Vasotec |
| GTPL6322 |
| H531 |
| HE386417 |
| Herten |
| Hipoartel |
| Hipten |
| HMS1921B10 |
| HMS2090E08 |
| HMS2092L17 |
| HMS2095P10 |
| HMS2231D22 |
| HMS2232I24 |
| HMS501E10 |
| HSDB 6529 |
| HY-B0331 |
| HY-B0331A |
| Hytrol |
| I04-153 |
| IDI1_000408 |
| Innovace |
| Innovace Melt |
| Innovade |
| Inoprilat |
| Insup |
| Invoril |
| J10412 |
| K298 |
| KBio1_000408 |
| KBio2_001787 |
| KBio2_004355 |
| KBio2_006923 |
| KBio3_002535 |
| KBioGR_000355 |
| KBioSS_001787 |
| Kenopril |
| KM1738 |
| Konveril |
| KS-1137 |
| L-Proline, 1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-, (S)- |
| L-Proline, 1-(N-(1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl)-, (S)-, (Z)-2-butenedioate (1:1) |
| L-Proline, N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl- |
| L-Proline, N-((1S)-1-(ethoxycarbonyl)-3-phenylpropyl)-L-alanyl-, (2Z)-2-butenedioate (1:1) |
| L-Proline, N-[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl- |
| Lapril |
| Lipraken |
| Lotrial |
| LS-118938 |
| LS-190651 |
| Mapryl |
| Mepril |
| MFCD00133304 |
| MFCD00865774 |
| Minipril |
| MK 421 |
| MK 421 maleate |
| MK-421 |
| MLS000028657 |
| MLS001077272 |
| MLS006010047 |
| MolPort-002-885-877 |
| MolPort-003-666-389 |
| N-((S)-1-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline maleate (1:1) |
| N-(1 (S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline maleate |
| N-(1(S)-Ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline |
| N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline maleate |
| N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline |
| N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl-L-proline (2Z)-but-2-enedioate |
| N-[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]-L-ALANYL]-L-PROLINE MALEATE(1: 1) |
| N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline |
| N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline maleic acid salt |
| N-{(1S)-1-[(ethyloxy)carbonyl]-3-phenylpropyl}-L-alanyl-L-proline |
| N-{N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl}-L-proline hydrogen maleate |
| Nalpha -[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl-L-proline |
| Naprilene |
| Naritec |
| NCGC00016932-01 |
| NCGC00021569-04 |
| NCGC00021569-05 |
| NCGC00021569-06 |
| NCGC00021569-09 |
| Neotensin |
| NINDS_000408 |
| Norpril |
| NSC-758143 |
| NSC758143 |
| Nuril |
| Opera_ID_1793 |
| OYFJQPXVCSSHAI-QFPUQLAESA-N |
| Palane |
| Pharmakon1600-01501214 |
| Pres |
| Presil |
| Pressotec |
| Prestwick_197 |
| Prestwick3_000314 |
| Pril |
| Prilenap |
| PRO106 |
| Pulsol |
| Reca |
| Regomed |
| Renavace |
| Renitec |
| Reniten |
| Renivace |
| Renivace (TN) |
| Repantril |
| Ristalen |
| s1941 |
| SAM002564252 |
| SBI-0051691.P002 |
| SC-17520 |
| SC-76440 |
| SCHEMBL18 |
| SCHEMBL9 |
| Sintec |
| SMR000058883 |
| SMR000653477 |
| SPBio_001349 |
| Spectrum_001307 |
| SPECTRUM1501214 |
| Spectrum2_001455 |
| Spectrum3_001478 |
| Spectrum4_000008 |
| Spectrum5_001107 |
| SR-01000000234 |
| SR-01000000234-4 |
| ST51052621 |
| Tenace |
| Tensazol |
| Tox21_110872 |
| Tox21_110872_1 |
| Unaril |
| UNII-69PN84IO1A |
| UNII-9O25354EPJ |
| Vapresan |
| Vasopril |
| Vasotec |
| Xanef |
| ZINC3791297 |
US Patents and Regulatory Information for enalapril maleate
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wockhardt Ltd | ENALAPRIL MALEATE | enalapril maleate | TABLET;ORAL | 075483-002 | Aug 22, 2000 | AB | RX | No | No | ➤ Sign Up | ➤ Sign Up | ➤ Sign Up | |||
| Krka Dd Novo Mesto | ENALAPRIL MALEATE | enalapril maleate | TABLET;ORAL | 075369-001 | Aug 22, 2000 | DISCN | No | No | ➤ Sign Up | ➤ Sign Up | ➤ Sign Up | ||||
| Apothecon | ENALAPRIL MALEATE | enalapril maleate | TABLET;ORAL | 075583-004 | Aug 22, 2000 | DISCN | No | No | ➤ Sign Up | ➤ Sign Up | ➤ Sign Up | ||||
| Wockhardt Ltd | ENALAPRIL MALEATE | enalapril maleate | TABLET;ORAL | 075483-004 | Aug 22, 2000 | AB | RX | No | No | ➤ Sign Up | ➤ Sign Up | ➤ Sign Up | |||
| Wockhardt Ltd | ENALAPRIL MALEATE | enalapril maleate | TABLET;ORAL | 075483-001 | Aug 22, 2000 | AB | RX | No | No | ➤ Sign Up | ➤ Sign Up | ➤ Sign Up | |||
| Mylan | ENALAPRIL MALEATE | enalapril maleate | TABLET;ORAL | 075480-004 | Aug 22, 2000 | AB | RX | No | No | ➤ Sign Up | ➤ Sign Up | ➤ Sign Up | |||
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
Expired US Patents for enalapril maleate
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | Patent No. | Patent Expiration |
|---|---|---|---|---|---|---|---|
| Valeant Pharms North | VASOTEC | enalapril maleate | TABLET;ORAL | 018998-005 | Jul 26, 1988 | ➤ Sign Up | ➤ Sign Up |
| Valeant Pharms North | VASOTEC | enalapril maleate | TABLET;ORAL | 018998-001 | Dec 24, 1985 | ➤ Sign Up | ➤ Sign Up |
| Valeant Pharms North | VASOTEC | enalapril maleate | TABLET;ORAL | 018998-003 | Dec 24, 1985 | ➤ Sign Up | ➤ Sign Up |
| Valeant Pharms North | VASOTEC | enalapril maleate | TABLET;ORAL | 018998-002 | Dec 24, 1985 | ➤ Sign Up | ➤ Sign Up |
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | Patent No. | Patent Expiration |
International Patents for enalapril maleate
| Country | Document Number | Estimated Expiration |
|---|---|---|
| European Patent Office | 2903690 | ➤ Sign Up |
| World Intellectual Property Organization (WIPO) | 2017161339 | ➤ Sign Up |
| Brazil | 112015007592 | ➤ Sign Up |
| Canada | 2887379 | ➤ Sign Up |
| World Intellectual Property Organization (WIPO) | 2014055667 | ➤ Sign Up |
| Country | Document Number | Estimated Expiration |
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Preferred Citation:
Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2019, www.DrugPatentWatch.com.
Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2019, www.DrugPatentWatch.com.
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