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Spironolactone - Generic Drug Details
What are the generic sources for spironolactone and what is the scope of spironolactone freedom to operate?
Spironolactone
is the generic ingredient in three branded drugs marketed by Cmp Dev Llc, Gd Searle Llc, Accord Hlthcare, Actavis Elizabeth, Amneal Pharms, Ascot, Aurobindo Pharma Ltd, Casi Pharms Inc, Ivax Pharms, Jubilant Generics, Lederle, Mutual Pharm, Mylan, Oxford Pharms, Purepac Pharm, Sun Pharm Industries, Superpharm, Upsher Smith, Vangard, Warner Chilcott, Watson Labs, and Zydus Pharms Usa Inc, and is included in twenty-five NDAs. There is one patent protecting this compound. Additional information is available in the individual branded drug profile pages.Spironolactone has one patent family member in one country.
There are sixteen drug master file entries for spironolactone. Fifty-one suppliers are listed for this compound.
Summary for spironolactone
| International Patents: | 1 |
| US Patents: | 1 |
| Tradenames: | 3 |
| Applicants: | 22 |
| NDAs: | 25 |
| Drug Master File Entries: | 16 |
| Suppliers / Packagers: | 51 |
| Bulk Api Vendors: | 69 |
| Clinical Trials: | 185 |
| Patent Applications: | 6,264 |
| Formulation / Manufacturing: | see details |
| Drug Prices: | Drug price information for spironolactone |
| Drug Sales Revenues: | Drug sales revenues for spironolactone |
| DailyMed Link: | spironolactone at DailyMed |
Pharmacology for spironolactone
| Drug Class | Aldosterone Antagonist |
| Mechanism of Action | Aldosterone Antagonists |
Medical Subject Heading (MeSH) Categories for spironolactone
Synonyms for spironolactone
| (1'S,2R,2'R,9'R,10'R,11'S,15'S)-9'-(acetylsulfanyl)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan]-6'-ene-5,5'-dione |
| (1'S,2R,2'R,9'R,10'R,11'S,15'S)-9'-(acetylsulfanyl)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadecan]-6'-ene-5,5'-dione |
| (7?,17?)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid ?-lactone |
| 082S250 |
| 1050678-93-7 |
| 1436392-20-9 |
| 17-alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7-alpha-mercapto-3-oxo-, gamma-lactone acetate |
| 17-HYDROXY-7ALPHA-MERCAPTO-3-OXO-17ALPHA-PREGN-4-ENE-21- CARBOXYLIC ACID |
| 17-HYDROXY-7ALPHA-MERCAPTO-3-OXO-17ALPHA-PREGN-4-ENE-21- CARBOXYLIC ACID, GAMMA-LACTONE ACETATE |
| 17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid, gamma-lactone acetate |
| 17.alpha.-Pregn-4-ene-21-carboxylic acid, .gamma.-lactone acetate |
| 17.alpha.-Pregn-4-ene-21-carboxylic acid, .gamma.-lactone, acetate |
| 17alpha-Pregn-4-ene-21-carboxylic acid, 17-hydroxy-7alpha-mercapto-3-oxo-, gamma-lactone, acetate |
| 2'',15''-dimethyl-5,5''-dioxo-(9''R)-spiro[tetrahydrofuran-2,14''-tetracyclo[8.7.0.02,7.011,15]heptadec-6''-ene]-9-yl ethanethioate |
| 2'',15''-dimethyl-5,5''-dioxospiro[tetrahydrofuran-2,14''-tetracyclo[8.7.0.02,7.011,15]heptadec-6''-ene]-9-yl ethanethioate |
| 2'',15''-dimethyl-5,5''-dioxospiro[tetrahydrofuran-2,14''-tetracyclo[8.7.0.02,7.011,15]heptadec-6''-ene]-9-yl ethanethioate(Spiranolactone) |
| 27O7W4T232 |
| 2oax |
| 3-(3-Keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propionic acid lactone |
| 3-(3-Keto-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alpha.-yl)propionic acid lactone |
| 3'-(3-Oxo-7-alpha-acetylthio-17-beta-hydroxyandrost-4-en-17-beta-yl)propionic acid lactone |
| 3vhu |
| 4-18-00-01601 (Beilstein Handbook Reference) |
| 4-Pregnen-21-oic acid-17|A-ol-3-one-7|A-thiol |A-lactone 7-acetate; 7|A-(Acetylthio)-17|A-hydroxy-3-oxopregn-4-ene-21-carboxylic acid |A-lactone |
| 4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate |
| 496916-40-6 |
| 52-01-7 |
| 7-.alpha.-(acetylthio)-17-.alpha.-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, .gamma.-lactone |
| 7-alpha-(acetylthio)-17-alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, gamma-lactone |
| 7-alpha-(acetylthio)-17-alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid, gamma-lactone (9CI) |
| 7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone |
| 7080-EP2269989A1 |
| 7080-EP2270011A1 |
| 7080-EP2272841A1 |
| 7080-EP2295406A1 |
| 7080-EP2298772A1 |
| 7080-EP2298776A1 |
| 7080-EP2301936A1 |
| 7080-EP2308562A2 |
| 7080-EP2308839A1 |
| 7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone |
| 7alpha-(Acetylthio)-17alpha-hydroxy-3-oxopregn-4-ene-21-carboxylic acid gamma-lactone |
| AB00513806 |
| AB01275520_02 |
| AB01275520-01 |
| AB1009415 |
| Abbolactone |
| AC-4214 |
| AC1L1L8Q |
| Acelat |
| ACT02596 |
| AK546740 |
| AKOS015896401 |
| Aldace |
| Aldactide |
| Aldactone |
| Aldactone (TN) |
| Aldactone A |
| Alderon |
| Aldopur |
| Almatol |
| Altex |
| Aquareduct |
| BC204094 |
| BDBM50228080 |
| Berlactone |
| BIDD:PXR0071 |
| BPBio1_000194 |
| BRD-K90027355-001-03-4 |
| BRD-K90027355-001-19-0 |
| BRN 0057767 |
| BSPBio_000176 |
| C07310 |
| C24H32O4S |
| Carospir |
| CAS-52-01-7 |
| CCG-220128 |
| CHEBI:9241 |
| CHEMBL1393 |
| CPD000471892 |
| CS-2670 |
| D00443 |
| DB00421 |
| Deverol |
| Diatense |
| Diatensec |
| Dira |
| DSSTox_CID_14186 |
| DSSTox_GSID_34186 |
| DSSTox_RID_79120 |
| DTXSID6034186 |
| Duraspiron |
| EINECS 200-133-6 |
| EN300-123035 |
| Espironolactona |
| Espironolactona [INN-Spanish] |
| Euteberol |
| GAMMA-LACTONE ACETATE |
| GTPL2875 |
| H490 |
| HMS1568I18 |
| HMS2090N21 |
| HMS2095I18 |
| HMS2236E06 |
| HMS3259G11 |
| HMS3712I18 |
| HSDB 3184 |
| HY-B0561 |
| I06-1970 |
| KS-00000FA6 |
| KS-5234 |
| Lacalmin |
| Lacdene |
| Laractone |
| LS-118614 |
| LXMSZDCAJNLERA-ZHYRCANASA-N |
| MCULE-4394091100 |
| Melarcon |
| MFCD00082250 |
| MLS001074672 |
| MLS001333253 |
| MLS001333254 |
| MLS002153245 |
| MLS002207058 |
| MLS002548846 |
| MolPort-033-355-721 |
| NC00482 |
| NCGC00015948-02 |
| NCGC00164397-01 |
| NCGC00164397-02 |
| NCGC00164397-03 |
| NCGC00164397-05 |
| NCGC00255229-01 |
| Nefurofan |
| NSC 150399 |
| NSC-150399 |
| NSC150399 |
| Osyrol |
| Pregn-4-ene-21-carboxylic acid, .gamma.-lactone, (7.alpha.,17.alpha.)- |
| Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, gamma-lactone, (7alpha,17alpha)- |
| Prestwick0_000128 |
| Prestwick1_000128 |
| Prestwick2_000128 |
| Prestwick3_000128 |
| Q-201737 |
| S-((7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl) ethanethioate |
| S-(2''R,7R,8R,9S,10R,13S,14S)-10,13-dimethyl-3,5''-dioxo-1,2,3,4'',5'',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3''H-spiro[cyclopenta[a]phenanthrene-17,2''-furan]-7-yl ethanethioate |
| S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-yl] ethanethioate |
| S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate |
| S0260 |
| s4054 |
| Sagisal |
| SC 15983 |
| SC 9420 |
| SC-15112 |
| SC-9420 |
| SCHEMBL20939 |
| Sincomen |
| SMR000471892 |
| SNL |
| SPBio_002115 |
| Spiractin |
| Spiranolactone |
| Spiresis |
| Spiretic |
| Spiridon |
| Spiro-Tablinen |
| Spiro(17H-cyclopenta(a)phenanthrene-17,2'(5'H)-furan), pregn-4-ene-21-carboxylic acid deriv |
| Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan) |
| Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan] |
| Spiroctan |
| Spiroctanie |
| Spiroderm |
| Spirolactone |
| Spirolakton |
| Spirolang |
| Spirolone |
| Spirone |
| Spironocompren |
| Spironolactone (JP17/USP/INN) |
| Spironolactone [BAN:INN:JAN] |
| Spironolactone [INN:BAN:JAN] |
| Spironolactone [USP:INN:BAN:JAN] |
| Spironolactone 1.0 mg/ml in Acetonitrile |
| Spironolactone A |
| Spironolactone for system suitability, European Pharmacopoeia (EP) Reference Standard |
| Spironolactone, 97.0-103.0% |
| Spironolactone, 99% |
| Spironolactone, European Pharmacopoeia (EP) Reference Standard |
| Spironolactone, United States Pharmacopeia (USP) Reference Standard |
| Spironolactonum |
| Spironolactonum [INN-Latin] |
| spironolattone |
| Spironolattone [DCIT] |
| spirotone |
| Sprioderm |
| SR-01000765419 |
| SR-01000765419-2 |
| SR-05000000452 |
| SR-05000000452-2 |
| Supra-puren |
| Suracton |
| Tox21_113047 |
| Tox21_302154 |
| UNII-27O7W4T232 |
| Uractone |
| Urusonin |
| Veroshpiron |
| Verospiron |
| Verospirone |
| Verospirone Opianin |
| WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ |
| Xenalon |
| Z1551900341 |
| ZINC3861599 |
US Patents and Regulatory Information for spironolactone
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Warner Chilcott | SPIRONOLACTONE | spironolactone | TABLET;ORAL | 087952-001 | Nov 18, 1982 | DISCN | No | No | ➤ Try a Free Trial | ➤ Try a Free Trial | ➤ Try a Free Trial | ||||
| Mylan | SPIRONOLACTONE | spironolactone | TABLET;ORAL | 040424-003 | Aug 20, 2001 | AB | RX | No | No | ➤ Try a Free Trial | ➤ Try a Free Trial | ➤ Try a Free Trial | |||
| Actavis Elizabeth | SPIRONOLACTONE | spironolactone | TABLET;ORAL | 040353-002 | Jul 29, 1999 | AB | RX | No | No | ➤ Try a Free Trial | ➤ Try a Free Trial | ➤ Try a Free Trial | |||
| Actavis Elizabeth | SPIRONOLACTONE | spironolactone | TABLET;ORAL | 040353-001 | Jul 29, 1999 | AB | RX | No | No | ➤ Try a Free Trial | ➤ Try a Free Trial | ➤ Try a Free Trial | |||
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
International Patents for spironolactone
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| World Intellectual Property Organization (WIPO) | 2017075463 | ➤ Try a Free Trial |
| Country | Patent Number | Estimated Expiration |
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ISSN: 2162-2639
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Preferred Citation:
Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2019, www.DrugPatentWatch.com.
Friedman, Yali. "DrugPatentWatch" DrugPatentWatch, thinkBiotech, 2019, www.DrugPatentWatch.com.
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