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Last Updated: October 22, 2019

DrugPatentWatch Database Preview

Ibuprofen - Generic Drug Details

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What are the generic sources for ibuprofen and what is the scope of patent protection?

Ibuprofen is the generic ingredient in forty-four branded drugs marketed by Pfizer, Amneal Pharms, Ascent Pharms Inc, Aurobindo Pharma Ltd, Bionpharma Inc, Contract Pharmacal, Humanwell Puracap, Marksans Pharma, P And L Dev Llc, Sofgen Pharms, Strides Pharma, Bayer, Cumberland Pharms, J And J Consumer Inc, Guardian Drug, L Perrigo Co, Tris Pharma Inc, Mcneil, Wyeth Cons, Moberg Pharma North, Perrigo, Abbott, Actavis Mid Atlantic, Aptapharma Inc, Arise Pharms, Hi Tech, P And L, Taro, Mcneil Consumer, Mcneil Ped, Lederle, Basf, Alra, Pliva, Amneal Pharms Ny, Ani Pharms Inc, Aurolife Pharma Llc, Avema Pharma, Dr Reddys La, Dr Reddys Labs Inc, Granules India, Granules India Ltd, Halsey, Hec Pharm, Ivax Sub Teva Pharms, Leiner, LNK, Merro Pharm, Mylan, Northstar Hlthcare, OHM, Ohm Labs, Par Pharm, Perrigo Pharms Co, Perrigo R And D, Purepac Pharm, Sandoz, Shandong Xinhua, Sun Pharm Industries, Superpharm, Teva, Vintage Pharms, Watson Labs, Bristol Myers, X-gen Pharms Inc, Recordati Rare, Pfizer Cons Hlthcare, Forest Labs, Actavis Elizabeth, Barr Labs Inc, and Dr Reddys Labs Ltd, and is included in two hundred and fifteen NDAs. There are fifteen patents protecting this compound. Additional information is available in the individual branded drug profile pages.

Ibuprofen has sixty-one patent family members in eighteen countries.

There are sixty-four drug master file entries for ibuprofen. Two hundred and fifty-four suppliers are listed for this compound.

Drug Prices for ibuprofen

See drug prices for ibuprofen

Drug Sales Revenue Trends for ibuprofen

See drug sales revenues for ibuprofen

Recent Clinical Trials for ibuprofen

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Northwestern UniversityPhase 4
Praxair Distribution, Inc.Phase 2/Phase 3
Boston Children’s HospitalPhase 2/Phase 3

See all ibuprofen clinical trials

Pharmacology for ibuprofen
Medical Subject Heading (MeSH) Categories for ibuprofen
Synonyms for ibuprofen
.alpha.-(4-Isobutylphenyl)propionic acid
.alpha.-(p-isobutylphenyl)propionic acid
.alpha.-2-(p-Isobutylphenyl)propionic acid
.alpha.-Methyl-4-(2-methylpropyl)benzeneacetic acid
( inverted exclamation markA)-Ibuprofen
( inverted question mark)-Ibuprofen
(? inverted exclamation markA)-2-(4-Isobutylphenyl)Propanoic Acid
(?)-Ibuprofen
(.+-.)-2-(p-Isobutylphenyl)propionic acid
(.+-.)-p-Isobutylhydratropic acid
(.+/-.)-2-(p-Isobutylphenyl)propionic acid
(.+/-.)-p-Isobutylhydratropic acid
(+-)-2-(p-Isobutylphenyl)propionic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(+-)-Ibuprofen
(+-)-Ibuprophen
(+-)-p-Isobutylhydratropic acid
(+) ibuprofen
(+/-)-2-(4-Isobutylphenyl)Propanoic Acid
(+/-)-2-(p-isobutylphenyl)propionic acid
(+/-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid
(+/-)-Ibuprofen
(+/-)-p-Isobutylhydratropic acid
(2s)-2-[4-(2-methylpropyl)phenyl]propionic acid DEXIBUPROFEN (S)-(+)-2-(4-ISOBUTYLPHENYL)PROPIONIC ACID (S)-(+)-4-ISOBUTYL-ALPHA-ME
(4-Isobutylphenyl)-alpha-methylacetic acid
(A+/-)-Ibuprofen
(R)-Ibuprofen
(r/s)-alpha-methyl-4-isobutylphenylacetic acid
(RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
(RS)-Ibuprofen
(S)-4-Isobutyl-alpha-methylphenylacetic acid
(y)-Ibuprofen
[(+/-)-2-(4-Isobutylphenyl)-propionic Acid
139466-08-3
15687-27-1
2-(4-Isobutyl-phenyl)-propionic acid
2-(4-isobutylphenyl) propanoic acid
2-(4-isobutylphenyl) propionic acid
2-(4-isobutylphenyl)-propionic acid
2-(4-Isobutylphenyl)-propionic acid ; alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid ; p-Isobutylhydratropic acid
2-(4-isobutylphenyl)-propionoic acid
2-(4-Isobutylphenyl)propanoic acid
2-(4-Isobutylphenyl)propanoicAcid
2-(4-ISOBUTYLPHENYL)PROPIONIC ACID
2-(4'-isobutylphenyl)-propionic acid
2-(4'-isobutylphenyl)propionic acid
2-(p-Isobutylphenyl)propionic acid
2-[4-(2-methylpropyl)phenyl]propanoic acid
2-p-isobutylphenylpropionic acid
31121-93-4 (hydrochloride salt)
4-Isobutyl-.alpha.-methylphenylacetic acid
4-Isobutyl-alpha-methylphenylacetic acid
4-Isobutylhydratropic acid
4-Isobutylphenyl)-.alpha.-methylacetic acid
58560-75-1
687I271
79261-49-7 (potassium salt)
A831926
AB00052020_18
AB00052020_19
AB00052020-16
AB00052020-17
AB1009266
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
Acide (isobutyl-4 phenyl)-2 propionique
Acide (isobutyl-4-phenyl)-2 propionique
Acide (isobutyl-4-phenyl)-2 propionique [French]
ACMC-209df0
ACMC-209ks2
Act-3
ACT03248
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Cold & Sinus (Salt/Mix)
Advil Liqui-Gels
Advil migraine
Advil Migraine Liqui-Gels
Advil, Children's
AK-47272
Ak+C2278tren
AKOS003237488
AKOS016340658
Aktren
Alaxan
ALBB-025647
Algofen
Alivium
alpha-(4-isobutylphenyl)-propionic acid
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-(p-isobutylphenyl)-propionic acid
alpha-(p-isobutylphenyl)propionic acid
alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
alpha-Methyl-4-(isobutyl)phenylacetic acid
alpha-Methyl-4-[2-methylpropyl] benzeneacetic Acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
Am-Fam 400
AM20060782
Amelior
Amersol
Amibufen
AN-18584
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
ANW-21658
Apo-Ibuprofen
Apsifen
Apsifen-F
ARONIS23835
Artofen
Artril
Artril 300
Balkaprofen
Bayer Select Pain Relief
BB 0258487
BBL010660
BCP10423
BCP20325
BCP25225
BDBM50009859
Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)-
Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl), (.+/-.)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+-)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+/-)-
Betaprofen
BIDD:GT0050
Bloom
Bluton
BR-47272
BRD-A17655518-001-02-0
BRD-A17655518-001-12-9
BRN 2049713
Brofen
Brufanic
Brufen
Brufen 400
Brufen Retard
Bruflam
Brufort
BSPBio_002170
Buburone
Bufeno
Bufigen
Bukrefen
Bupron
Buracaps
Burana
Butacortelone
Butylenin
C01588
C13H18O2
Caldolor
Cambridge id 5152402
Cap-Profen
Carol
CAS-15687-27-1
CBMicro_005634
CCG-38947
CCRIS 3223
CDT-ibuprofen
Cesra
CHEBI:5855
CHEMBL521
Children's Advil
CHILDREN'S ADVIL-FLAVORED
Children's Elixsure
Children's Elixsure IB
Children's Elixsure IB (Salt/Mix)
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Codral Period Pain
Combiflam
Combunox (Salt/Mix)
CPD000058184
CS-1931
CTK3J2010
Cunil
D00126
Daiprophen
Dalsy
Dansida
DB01050
Deep Relief
Dentigoa
Dibufen
Dignoflex
DivK1c_000887
Dolgin
Dolgirid
Dolgit
Dolibu
Dolmaral
DOLO PUREN
Dolo-Dolgit
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dologel
Dolomax
Doloren
Dolormin
Doltibil
Dolven
Donjust B
Dorival
Drin
DSSTox_CID_732
DSSTox_GSID_20732
DSSTox_RID_75759
DTXSID5020732
Duafen
Dularbuprofen
Duobrus
Dura-Ibu
duralbuprofen
Dysdolen
Easifon
Ebufac
EC 239-784-6
EINECS 239-784-6
Emflam
Emflam-200
Epitope ID:139973
Epobron
Eputex
Ergix
Esprenit
EU-0100691
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid Spansule
Fendol
Fenspan
Fibraflex
FT-0601629
FT-0655194
Gelufene
Genpril
Gofen
Grefen
GTPL2713
Gynofug
Haltran
HEFNNWSXXWATRW-UHFFFAOYSA-
HEFNNWSXXWATRW-UHFFFAOYSA-N
Hemagene Tailleur
HMS1920F15
HMS2089P05
HMS2091N03
HMS2230N04
HMS3259G05
HMS3262K03
HMS3372M09
HMS3649M11
HMS3651A15
HMS502M09
HSDB 3099
HY-78131
Hydratropic acid, p-isobutyl-
I 4883
I01-7039
I0415
IB-100
Ibol
Ibren
Ibu
Ibu-Attritin
Ibu-slo
Ibu-slow
Ibu-Tab
Ibu-Tab 200
Ibubest
Ibubeta
Ibucasen
Ibudol
Ibudolor
Ibufen
Ibuflamar
Ibufug
Ibugel
Ibugen
Ibugesic
Ibuhexal
Ibulagic
Ibular
Ibulav
Ibuleve
Ibulgan
Ibumed
Ibumerck
Ibumetin
Ibup
Ibupirac
Ibupril
Ibuprin
Ibuprocin
Ibuprofen - Adooq Bioscience
Ibuprofen (Advil)
Ibuprofen (Dolgesic)
Ibuprofen (JP17/USP/INN)
Ibuprofen [USAN:BAN:INN:JAN]
Ibuprofen [USAN:USP:INN:BAN:JAN]
Ibuprofen 1.0 mg/ml in Methanol
Ibuprofen for peak identification, European Pharmacopoeia (EP) Reference Standard
Ibuprofen I.V. Solution
IBUPROFEN USP GRADE
Ibuprofen-Zinc
Ibuprofen, >=98% (GC)
Ibuprofen, 99%
Ibuprofen, British Pharmacopoeia (BP) Reference Standard
Ibuprofen, European Pharmacopoeia (EP) Reference Standard
Ibuprofen, meets USP testing specifications
Ibuprofen, Pharmaceutical Secondary Standard; Certified Reference Material
Ibuprofen, United States Pharmacopeia (USP) Reference Standard
Ibuprofen, Vetec(TM) reagent grade, 97%
Ibuprofen, VETRANAL(TM), analytical standard
Ibuprofen,(S)
Ibuprofene
Ibuprofene [INN-French]
Ibuprofeno
Ibuprofeno [INN-Spanish]
Ibuprofenum
Ibuprofenum [INN-Latin]
Ibuprohm
Ibuprophen
Ibuprox
Ibusal
Ibutid
Ibux
IDI1_000887
Ifen
Inabrin
InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Inflam
Inoven
IP-82
Ipren
Irfen
Isobutylpropanoicphenolic acid
Isodol
J-009349
J10135
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KB-222912
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
KBioGR_000389
KBioSS_001329
Kesan
Kontagripp Mono
Kratalgin
KS-00000CJ0
KS-000047NV
KS-5029
KSC492A1B
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopac0_000691
Lopane
LP00691
LS-7454
M-4957
Malafene
Manypren
MCULE-9475454445
Medipren
Melfen
Mensoton
MFCD00010393
Midol
Midol 200
Midol IB Cramp Relief
Midol Liquid Gels
MLS000069733
MLS001146965
MolPort-001-791-802
Moment
Motrin
Motrin (TN)
Motrin IB
Motrin IB Gelcaps
Motrin IB Gelcaps (Salt/Mix)
MOTRIN MIGRAINE PAIN
Mynosedin
N4,N4' -Di(naphthalen-1-yl)-N4,N4' -bis(4-vinylphenyl)biphenyl-4,4'-diamine
Nagifen-D
Napacetin
Narfen
NC00458
NCGC00015529-04
NCGC00015529-05
NCGC00015529-06
NCGC00015529-07
NCGC00015529-08
NCGC00015529-09
NCGC00015529-10
NCGC00015529-12
NCGC00015529-13
NCGC00015529-14
NCGC00015529-15
NCGC00015529-18
NCGC00089819-02
NCGC00089819-03
NCGC00089819-04
NCGC00089819-05
NCGC00089819-06
NCGC00089819-07
NCGC00256416-01
NCGC00258935-01
NCGC00261376-01
NCI60_002065
Neo-Helvagit
Neo-Mindol
Neobrufen
Nerofen
NINDS_000887
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Novadol
Novo Dioxadol
Novo-Profen
Novogent
Novogent N
Novoprofen
NSC 256857
NSC-256857
NSC-757073
NSC256857
NSC757073
Nuprilan
Nuprin
Nurofen
Nurofen Meltlets
Opera_ID_554
Optifen
Opturem
Oralfene
Ostarin
Ostofen
Ozonol
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-isobutyl-hydratropic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
Paduden
Panafen
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedea
Pedia-Profen
PediaProfen
Pediatric Advil
Perofen
Perrigo ibuprofen
Pharmakon1600-01500347
Proartinal
Profen
Proflex
Propanoic acid, 2-(4-isobutylphenyl)
Provon
PubChem16054
Quadrax
R.D. 13621
Racemic ibuprofen
Rafen
Ranofen
RD 13621
Rebugen
Relcofen
Rhinadvil
Rofen
Roidenin
RP26239
RTR-006580
Rufen
Rufin
Rupan
s1638
Sadefen
Salivia
Salprofen
SAM002264619
SB19113
SBB064160
SBI-0050669.P004
SC-18867
SCHEMBL3001
Schmerz-Dolgit
Seclodin
Sednafen
Seklodin
Seskafen
Sine-Aid IB Caplets (Salt/Mix)
Siyafen
SMR000058184
Solpaflex
Solufen
SPBio_000178
Spectrum_000849
SPECTRUM1500347
Spectrum2_000129
Spectrum3_000465
Spectrum4_000015
Spectrum5_000862
SR-01000000214
SR-01000000214-13
SR-01000000214-2
SR-01000000214-4
ST-1482
ST024750
ST24032335
Stelar
STK177358
Sugafen
Suprafen
Suspren
SW203738-2
Syntofene
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
TL8001184
Tofen
Togal N
Tonal
Tox21_110170
Tox21_110170_1
Tox21_201384
Tox21_302829
Tox21_500691
TR-006580
TRA0047278
Trauma-Dolgit Gel
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Uprofen
Urem
VUFB 9649
WLN: QVY&R DIY
Z1695709473
Zafen
ZAG-1701
Zofen

US Patents and Regulatory Information for ibuprofen

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Mcneil MOTRIN ibuprofen SUSPENSION/DROPS;ORAL 020476-001 May 25, 1995 DISCN No No   Start Trial   Start Trial   Start Trial
Halsey IBUPROFEN ibuprofen TABLET;ORAL 071030-001 Mar 23, 1987 DISCN No No   Start Trial   Start Trial   Start Trial
Pfizer CHILDREN'S ADVIL COLD ibuprofen; pseudoephedrine hydrochloride SUSPENSION;ORAL 021373-001 Apr 18, 2002 OTC No No   Start Trial   Start Trial   Start Trial
Pfizer Cons Hlthcare ADVIL ibuprofen sodium TABLET;ORAL 201803-001 Jun 12, 2012 OTC Yes Yes   Start Trial   Start Trial   Start Trial
Pfizer ADVIL COLD AND SINUS ibuprofen; pseudoephedrine hydrochloride TABLET;ORAL 019771-001 Sep 19, 1989 OTC Yes Yes   Start Trial   Start Trial   Start Trial
Watson Labs IBUPROFEN ibuprofen TABLET;ORAL 071911-001 Oct 13, 1987 DISCN No No   Start Trial   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for ibuprofen

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Bionpharma Inc MIDOL LIQUID GELS ibuprofen CAPSULE;ORAL 021472-001 Oct 18, 2002   Start Trial   Start Trial
Mcneil Ped MOTRIN ibuprofen TABLET, CHEWABLE;ORAL 020135-001 Nov 16, 1994   Start Trial   Start Trial
J And J Consumer Inc CHILDREN'S MOTRIN ibuprofen TABLET, CHEWABLE;ORAL 020601-001 Nov 15, 1996   Start Trial   Start Trial
Mcneil Ped MOTRIN ibuprofen TABLET, CHEWABLE;ORAL 020135-002 Nov 16, 1994   Start Trial   Start Trial
J And J Consumer Inc CHILDREN'S MOTRIN ibuprofen SUSPENSION;ORAL 020516-001 Jun 16, 1995   Start Trial   Start Trial
Mcneil Ped MOTRIN ibuprofen TABLET, CHEWABLE;ORAL 020135-002 Nov 16, 1994   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >Patent No. >Patent Expiration

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