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Generated: August 16, 2018

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Ibuprofen - Generic Drug Details

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What are the generic sources for ibuprofen and what is the scope of ibuprofen patent protection?

Ibuprofen is the generic ingredient in forty-four branded drugs marketed by Pfizer, Amneal Pharms, Ascent Pharms Inc, Aurobindo Pharma Ltd, Bionpharma Inc, Contract Pharmacal, Humanwell Puracap, Marksans Pharma, P And L Dev Llc, Sofgen Pharms, Strides Pharma, Bayer, Cumberland Pharms, J And J Consumer Inc, L Perrigo Co, Tris Pharma Inc, Mcneil, Wyeth Cons, Moberg Pharma North, Perrigo, Abbott, Actavis Mid Atlantic, Arise Pharms, Hi-tech Pharmacal, Perrigo R And D, Taro, Mcneil Consumer, Mcneil Ped, Lederle, Basf, Alra, Pliva, Aiping Pharm Inc, Amneal Pharms Ny, Ani Pharms Inc, Aurolife Pharma Llc, Avema Pharma, Dr Reddys La, Dr Reddys Labs Inc, Granules India, Granules India Ltd, Halsey, Ivax Sub Teva Pharms, Leiner, LNK, Merro Pharm, Mylan, Mylan Pharms Inc, Northstar Hlthcare, OHM, Ohm Labs, Par Pharm, Purepac Pharm, Sandoz, Sun Pharm Industries, Superpharm, Teva, Vintage Pharms, Watson Labs, Bristol Myers, Exela Pharma Science, Recordati Rare, Pfizer Cons Hlthcare, Forest Labs, Actavis Elizabeth, Barr Labs Inc, and Dr Reddys Labs Ltd, and is included in two hundred and eleven NDAs. There are fifteen patents protecting this compound. Additional information is available in the individual branded drug profile pages.

Ibuprofen has fifty-five patent family members in seventeen countries.

There are sixty-four drug master file entries for ibuprofen. Two hundred and sixty-six suppliers are listed for this compound.

Pharmacology for ibuprofen
Medical Subject Heading (MeSH) Categories for ibuprofen
Synonyms for ibuprofen
.alpha.-(4-Isobutylphenyl)propionic acid
.alpha.-(p-isobutylphenyl)propionic acid
.alpha.-2-(p-Isobutylphenyl)propionic acid
.alpha.-Methyl-4-(2-methylpropyl)benzeneacetic acid
( inverted exclamation markA)-Ibuprofen
( inverted question mark)-Ibuprofen
(? inverted exclamation markA)-2-(4-Isobutylphenyl)Propanoic Acid
(?)-Ibuprofen
(.+-.)-2-(p-Isobutylphenyl)propionic acid
(.+-.)-p-Isobutylhydratropic acid
(.+/-.)-2-(p-Isobutylphenyl)propionic acid
(.+/-.)-p-Isobutylhydratropic acid
(+-)-2-(p-Isobutylphenyl)propionic acid
(+-)-alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
(+-)-Ibuprofen
(+-)-Ibuprophen
(+-)-p-Isobutylhydratropic acid
(+) ibuprofen
(+/-)-2-(4-Isobutylphenyl)Propanoic Acid
(+/-)-2-(p-isobutylphenyl)propionic acid
(+/-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid
(+/-)-Ibuprofen
(+/-)-p-Isobutylhydratropic acid
(4-Isobutylphenyl)-alpha-methylacetic acid
(A+/-)-Ibuprofen
(r/s)-alpha-methyl-4-isobutylphenylacetic acid
(RS)-2-(4-(2-Methylpropyl)phenyl)propanoic acid
(RS)-Ibuprofen
(S)-4-Isobutyl-alpha-methylphenylacetic acid
(y)-Ibuprofen
[(+/-)-2-(4-Isobutylphenyl)-propionic Acid
139466-08-3
15687-27-1
2-(4-Isobutyl-phenyl)-propionic acid
2-(4-isobutylphenyl) propanoic acid
2-(4-isobutylphenyl) propionic acid
2-(4-isobutylphenyl)-propionic acid
2-(4-isobutylphenyl)-propionoic acid
2-(4-Isobutylphenyl)propanoic acid
2-(4-Isobutylphenyl)propanoicAcid
2-(4-ISOBUTYLPHENYL)PROPIONIC ACID
2-(4'-isobutylphenyl)-propionic acid
2-(4'-isobutylphenyl)propionic acid
2-(p-Isobutylphenyl)propionic acid
2-[4-(2-methylpropyl)phenyl]propanoic acid
2-p-isobutylphenylpropionic acid
31121-93-4 (hydrochloride salt)
4-Isobutyl-.alpha.-methylphenylacetic acid
4-Isobutyl-alpha-methylphenylacetic acid
4-Isobutylhydratropic acid
4-Isobutylphenyl)-.alpha.-methylacetic acid
58560-75-1
687I271
79261-49-7 (potassium salt)
A831926
AB00052020_18
AB00052020_19
AB00052020-16
AB00052020-17
AB1009266
AC-11312
AC1L1GGE
AC1Q1P84
AC1Q1P85
ACHES-N-PAIN
Acide (isobutyl-4 phenyl)-2 propionique
Acide (isobutyl-4-phenyl)-2 propionique
Acide (isobutyl-4-phenyl)-2 propionique [French]
ACMC-209df0
ACMC-209ks2
Act-3
Act-3 (TN)
ACT03248
Actiprofen
Adex 200
Adran
Advil
Advil (TN)
Advil Cold & Sinus (Salt/Mix)
Advil Liqui-Gels
Advil migraine
Advil Migraine Liqui-Gels
Advil, Children's
AK-47272
Ak+C2278tren
AKOS003237488
AKOS016340658
Aktre (TN)
Aktren
Alaxan
Alaxan (TN)
ALBB-025647
Algofen
Algoflex (TN)
Alivium
Alivium (TN)
alpha-(4-isobutylphenyl)-propionic acid
alpha-(4-Isobutylphenyl)propionate
alpha-(4-Isobutylphenyl)propionic acid
alpha-(p-isobutylphenyl)-propionic acid
alpha-(p-isobutylphenyl)propionic acid
alpha-Methyl-4-(2-methylpropyl)benzeneacetic acid
alpha-Methyl-4-(isobutyl)phenylacetic acid
alpha-Methyl-4-[2-methylpropyl] benzeneacetic Acid
alpha-p-Isobutylphenylpropionate
alpha-p-Isobutylphenylpropionic acid
Am-Fam 400
AM20060782
Amelior
Amersol
Amibufen
AN-18584
Anafen
Anco
Andran
Anflagen
Antagil
Antalfene
Antarene
Antiflam
ANW-21658
Apo-Ibuprofen
Apsifen
Apsifen-F
ARONIS23835
Arthrofen (TN)
Artofen
Artril
Artril 300
Balkaprofen
Bayer Select Pain Relief
BB 0258487
BB_SC-1358
BBL010660
BDBM50009859
Benzeneacetic acid, ?-methyl-4-(2-methylpropyl)-
Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl)-
Benzeneacetic acid, .alpha.-methyl-4-(2-methylpropyl), (.+/-.)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+-)-
Benzeneacetic acid, alpha-methyl-4-(2-methylpropyl), (+/-)-
Betaprofen
BIDD:GT0050
Bloom
Bluton
Bonifen (TN)
BR-47272
BRD-A17655518-001-02-0
BRN 2049713
Brofen
Brufanic
Brufen
Brufen (TN)
Brufen 400
Brufen Retard
Bruflam
Brufort
BSPBio_002170
Buburone
Bufeno
Bufigen
Bugesic (TN)
Bukrefen
Bupron
Buracaps
Burana
Burana (TN)
Butacortelone
Butylenin
C01588
C13H18O2
Caldolor
Caldolor (TN)
Calprofen (TN)
Cambridge id 5152402
Cap-Profen
Carol
CAS-15687-27-1
CBMicro_005634
CCG-38947
CCRIS 3223
CDT-ibuprofen
Cesra
CHEBI:5855
CHEMBL521
Children's Advil
CHILDREN'S ADVIL-FLAVORED
Children's Elixsure
Children's Elixsure IB
Children's Elixsure IB (Salt/Mix)
Children's Ibuprofen
Children's Motrin
Citalgan
Cobo
Codral
Codral Period Pain
Combiflam
Combunox (Salt/Mix)
CPD000058184
CS-1931
CTK3J2010
Cunil
D00126
D03SHR
D0R1QE
Daiprophen
Dalsy
Dalsy (TN)
Dansida
DB01050
Deep Relief
Dentigoa
Dibufen
Dignoflex
Dismenol (TN)
Diverin (TN)
DivK1c_000887
Dolgin
Dolgirid
Dolgit
Dolgit (TN)
Dolibu
Dolmaral
DOLO PUREN
Dolo-Dolgit
Dolo-Spedifen (TN)
Dolocyl
Dolofen
Dolofen-F
Dolofin
Dolofort
Dolofort (TN)
Dologel
Dolomax
Doloraz (TN)
Doloren
Dolormin
Dolormin (TN)
Doltibil
Dolven
Donjust B
Dorival
Dorival (TN)
DR000342
Drin
DSSTox_CID_732
DSSTox_GSID_20732
DSSTox_RID_75759
DTXSID5020732
Duafen
Dularbuprofen
Duobrus
Dura-Ibu
duralbuprofen
Dysdolen
Easifon
Ebufac
Ebufac (TN)
EC 239-784-6
EINECS 239-784-6
Emflam
Emflam-200
EmuProfen (TN)
Epitope ID:139973
Epobron
Eputex
Ergix
Espidifen (TN)
Esprenit
EU-0100691
Eve (TN)
Exneural
Faspic
Femadon
Femafen
Femapirin
Femidol
Fenbid
Fenbid (TN)
Fenbid Spansule
Fendol
Fenpaed (TN)
Fenspan
Fibraflex
Finalflex (TN)
FT-0601629
FT-0655194
Galprofen (TN)
Gelufene
Genpril
Gofen
Grefen
GTPL2713
Gynofug
Haltran
Hedex (TN)
HEFNNWSXXWATRW-UHFFFAOYSA-
HEFNNWSXXWATRW-UHFFFAOYSA-N
Hemagene Tailleur
Herron Blue (TN)
HMS1920F15
HMS2089P05
HMS2091N03
HMS2230N04
HMS3259G05
HMS3262K03
HMS3372M09
HMS3649M11
HMS3651A15
HMS502M09
HSDB 3099
HY-78131
Hydratropic acid, p-isobutyl-
I 4883
I-profen (TN)
I01-7039
I0415
IB-100
Ibalgin (TN)
Ibol
Ibren
Ibu
Ibu-Attritin
IBU-Ratiopharm (TN)
Ibu-slo
Ibu-slow
Ibu-Tab
Ibu-Tab 200
Ibu-Vivimed (TN)
Ibubest
Ibubeta
Ibucasen
Ibudol
Ibudolor
Ibufen
IBUFEN (TN)
Ibuflamar
Ibufug
Ibugel
Ibugel (TN)
Ibugen
Ibugesic
Ibuhexal
IbuHEXAL (TN)
Ibulagic
Ibular
Ibulav
Ibuleve
Ibuleve (TN)
Ibulgan
Ibum (TN)
Ibumax (TN)
Ibumed
Ibumerck
Ibumetin
Ibumetin (TN)
Ibup
Ibupirac
Ibupril
Ibuprin
Ibuprocin
Ibuprofen - Adooq Bioscience
Ibuprofen (Advil)
Ibuprofen (Dolgesic)
Ibuprofen (JP17/USP/INN)
Ibuprofen [USAN:BAN:INN:JAN]
Ibuprofen [USAN:USP:INN:BAN:JAN]
Ibuprofen 1.0 mg/ml in Methanol
Ibuprofen for peak identification, European Pharmacopoeia (EP) Reference Standard
Ibuprofen I.V. Solution
ibuprofen lysine salt
IBUPROFEN USP GRADE
Ibuprofen-Zinc
IBUPROFEN, (+-)-
Ibuprofen, >=98% (GC)
Ibuprofen, British Pharmacopoeia (BP) Reference Standard
Ibuprofen, European Pharmacopoeia (EP) Reference Standard
Ibuprofen, meets USP testing specifications
Ibuprofen, pharmaceutical secondary standard; traceable to USP, PhEur, BP
Ibuprofen, United States Pharmacopeia (USP) Reference Standard
Ibuprofen, Vetec(TM) reagent grade, 97%
Ibuprofen, VETRANAL(TM), analytical standard
Ibuprofene
Ibuprofene [INN-French]
Ibuprofeno
Ibuprofeno [INN-Spanish]
Ibuprofenum
Ibuprofenum [INN-Latin]
Ibuprohm
Ibuprom (TN)
Ibuprophen
Ibuprosyn (TN)
Ibuprox
Ibusal
Ibutid
Ibux
Ibux (TN)
Ibuxin (TN)
IDI1_000887
Ifen
Inabrin
InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
Inflam
Inoven
IP 82
IP-82
IP82
Ipren
Ipren (TN)
Irfen
Isobutylpropanoicphenolic acid
Isodol
J-009349
J10135
Jenaprofen
Junifen
Junior Strength Advil
Junior Strength Ibuprofen
Junior Strength Motrin
KB-222912
KBio1_000887
KBio2_001329
KBio2_003897
KBio2_006465
KBio3_001390
KBioGR_000389
KBioSS_001329
Kesan
Kontagripp Mono
Kratalgin
Kratalgin (TN)
KS-00000CJ0
KS-000047NV
KS-5029
KSC492A1B
Lamidon
Lebrufen
Librofem
Lidifen
Liptan
Lopac0_000691
Lopane
LP00691
LS-7454
M-4957
Malafene
Manypren
MCULE-9475454445
Medicol (TN)
Medipren
Melfen
Mensoton
MFCD00010393
Midol
Midol 200
Midol IB Cramp Relief
Midol Liquid Gels
MLS000069733
MLS001146965
MolPort-001-791-802
Moment
Moment (TN)
Motrin
Motrin (TN)
Motrin IB
Motrin IB Gelcaps
Motrin IB Gelcaps (Salt/Mix)
MOTRIN MIGRAINE PAIN
Mynosedin
N4,N4' -Di(naphthalen-1-yl)-N4,N4' -bis(4-vinylphenyl)biphenyl-4,4'-diamine
Nagifen-D
Napacetin
Narfen
Narfen (TN)
NC00458
NCGC00015529-04
NCGC00015529-05
NCGC00015529-06
NCGC00015529-07
NCGC00015529-08
NCGC00015529-09
NCGC00015529-10
NCGC00015529-12
NCGC00015529-13
NCGC00015529-14
NCGC00015529-15
NCGC00015529-18
NCGC00089819-02
NCGC00089819-03
NCGC00089819-04
NCGC00089819-05
NCGC00089819-06
NCGC00089819-07
NCGC00256416-01
NCGC00258935-01
NCGC00261376-01
NCI60_002065
Neo-Helvagit
Neo-Mindol
Neobrufen
Neobrufen (TN)
Neofen (TN)
Nerofen
NINDS_000887
Noalgil
Nobafon
Nobfelon
Nobfen
Nobgen
Noritis
Norton
Norvectan (TN)
Novadol
Novo Dioxadol
Novo-Profen
Novogent
Novogent N
Novoprofen
NSC 256857
NSC-256857
NSC-757073
NSC256857
NSC757073
Nuprilan
Nuprin
Nuprin (TN)
Nureflex (TN)
Nurofen
Nurofen (TN)
Nurofen Meltlets
Opera_ID_554
Optifen
Opturem
OR209164
OR289785
Oralfene
Orbifen (TN)
Ostarin
Ostofen
Ozonol
p-Isobutyl-2-phenylpropionate
p-Isobutyl-2-phenylpropionic acid
p-isobutyl-hydratropic acid
p-Isobutylhydratropate
p-Isobutylhydratropic acid
Paduden
Panafen
Panafen (TN)
Pantrop
Para-Isobutylhydratropic Acid
Paxofen
Pedea
Pedia-Profen
PediaProfen
Pediatric Advil
Perifar (TN)
Perofen
Perrigo ibuprofen
Pharmakon1600-01500347
Proartinal
Profen
Profin (TN)
Proflex
Propanoic acid, 2-(4-isobutylphenyl)
Provon
PubChem16054
Quadrax
R.D. 13621
Racemic ibuprofen
Rafen
Ranofen
Ratiodolor (TN)
RD 13621
Rebugen
Relcofen
Retard (TN)
Rhinadvil
Rimafen (TN)
Rofen
Roidenin
RP26239
RTR-006580
Rufen
Rufin
Rupan
s1638
Sadefen
Salivia
Salprofen
Salvarina (TN)
SAM002264619
SBB064160
SBI-0050669.P004
SC-18867
SCHEMBL3001
Schmerz-Dolgit
Seclodin
Sednafen
Seklodin
Seskafen
Sine-Aid IB Caplets (Salt/Mix)
Siyafen
SMR000058184
Solpaflex
Solpaflex (TN)
Solufen
SPBio_000178
Spectrum_000849
SPECTRUM1500347
Spectrum2_000129
Spectrum3_000465
Spectrum4_000015
Spectrum5_000862
Spedifen (TN)
Speedpain NANO (TN)
Spidifen (TN)
SR-01000000214
SR-01000000214-13
SR-01000000214-2
ST-1482
ST024750
ST24032335
Stelar
STK177358
Sugafen
Suprafen
Suspren
Syntofene
Tab-Profen
Tabalon
Tabalon 400
Tatanal
Tempil
TL8001184
Tofen
Togal N
Tonal
Tox21_110170
Tox21_110170_1
Tox21_201384
Tox21_302829
Tox21_500691
TR-006580
TRA0047278
Trauma-Dolgit Gel
Trendar
U 18573
U-18,573
U-18573
UCB 79171
Unipron
Upfen
Upfen (TN)
Uprofen
Urem
VUFB 9649
WLN: QVY&R DIY
Z1695709473
Zafen
ZAG-1701
Zofen

US Patents and Regulatory Information for ibuprofen

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Dr Reddys Labs Inc IBUPROFEN ibuprofen TABLET;ORAL 076117-001 Nov 20, 2001 OTC No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Ivax Sub Teva Pharms IBUPROFEN ibuprofen TABLET;ORAL 071769-001 May 8, 1987 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Northstar Hlthcare IBUPROFEN ibuprofen TABLET;ORAL 078132-003 Sep 10, 2007 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Forest Labs COMBUNOX ibuprofen; oxycodone hydrochloride TABLET;ORAL 021378-001 Nov 26, 2004 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for ibuprofen

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Mcneil Consumer MOTRIN ibuprofen SUSPENSION;ORAL 019842-001 Sep 19, 1989 ➤ Sign Up ➤ Sign Up
Bionpharma Inc MIDOL LIQUID GELS ibuprofen CAPSULE;ORAL 021472-001 Oct 18, 2002 ➤ Sign Up ➤ Sign Up
J And J Consumer Inc CHILDREN'S MOTRIN ibuprofen TABLET, CHEWABLE;ORAL 020601-001 Nov 15, 1996 ➤ Sign Up ➤ Sign Up
Mcneil Ped MOTRIN ibuprofen TABLET, CHEWABLE;ORAL 020135-002 Nov 16, 1994 ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Cerilliant
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Harvard Business School
Baxter
Chinese Patent Office
Deloitte

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