MIDOL LIQUID GELS Drug Patent Profile

When do Midol Liquid Gels patents expire, and what generic alternatives are available?

Midol Liquid Gels is a drug marketed by Bionpharma and is included in one NDA.

The generic ingredient in MIDOL LIQUID GELS is ibuprofen. There are sixty-four drug master file entries for this compound. Two hundred and forty suppliers are listed for this compound. Additional details are available on the ibuprofen profile page.

DrugPatentWatch^® Litigation and Generic Entry Outlook for Midol Liquid Gels

A generic version of MIDOL LIQUID GELS was approved as ibuprofen by CONTRACT PHARMACAL on October 15^th, 1986.

Summary for MIDOL LIQUID GELS

US Patents:	0
Applicants:	1
NDAs:	1
Raw Ingredient (Bulk) Api Vendors:	202
Clinical Trials:	1,702
DailyMed Link:	MIDOL LIQUID GELS at DailyMed

Recent Clinical Trials for MIDOL LIQUID GELS

Identify potential brand extensions & 505(b)(2) entrants

Sponsor	Phase
Gary Van Guilder	EARLY_PHASE1
Rutgers, The State University of New Jersey	PHASE1
Sakarya University	NA

See all MIDOL LIQUID GELS clinical trials

US Patents and Regulatory Information for MIDOL LIQUID GELS

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Bionpharma	MIDOL LIQUID GELS	ibuprofen	CAPSULE;ORAL	021472-001	Oct 18, 2002		OTC	Yes	Yes

Expired US Patents for MIDOL LIQUID GELS

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Bionpharma	MIDOL LIQUID GELS	ibuprofen	CAPSULE;ORAL	021472-001	Oct 18, 2002	6,251,426

EU/EMA Drug Approvals for MIDOL LIQUID GELS

Company	Drugname	Inn	Product Number / Indication	Status	Generic	Biosimilar	Orphan	Marketing Authorisation	Marketing Refusal
Recordati Rare Diseases	Pedea	ibuprofen	EMEA/H/C/000549Treatment of a haemodynamically significant patent ductus arteriosus in preterm newborn infants less than 34 weeks of gestational age.	Authorised	no	no	no	2004-07-28

International Patents for MIDOL LIQUID GELS

See the table below for patents covering MIDOL LIQUID GELS around the world.

Country	Patent Number	Title	Estimated Expiration
European Patent Office	1207872	GELS MOUS CONTENANT DE L'IBUPROFENE (IBUPROFEN-CONTAINING SOFTGELS)
Austria	357229
Japan	2003508434

Supplementary Protection Certificates for MIDOL LIQUID GELS

Patent Number	Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
1781277	PA2024501	Lithuania		PRODUCT NAME: IBUPROFENO IR PARACETAMOLIO DERINYS; REGISTRATION NO/DATE: LT/1/23/5212/001-002 20230726

Market Dynamics and Financial Trajectory for MIDOL LIQUID GELS

Last updated: January 5, 2026

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Executive Summary

Midol Liquid Gels, a leading over-the-counter (OTC) treatment for menstrual pain and associated symptoms, hold a significant position in the women's healthcare segment. The product’s market dynamics are influenced by demographic shifts, consumer preferences, regulatory landscapes, and competitive pressures. The financial trajectory of Midol Liquid Gels is projected to expand steadily driven by increasing awareness of menstrual health, product innovation, and strategic marketing. This report provides a comprehensive analysis of these factors, contextualizing Midol Liquid Gels within the broader OTC analgesics market, with detailed data, forecasts, and strategic insights.

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Market Overview and Positioning

Midol Liquid Gels belong to the analgesic and menstrual relief categories, primarily competing with brands such as Bayer’s Midol Caplets, Pamprin, Motrin IB, and generic equivalents. The global OTC women's health market exceeds $10 billion as of 2022, with menstrual pain management constituting a substantial share [1].

Market Size & Growth

Parameter	Value (2022)	Projection (2027)
Global OTC analgesics market	~$35 billion	$45.7 billion (+6.4% CAGR)
Menstrual pain relief segment	Estimated at $2.5 billion	Projected to reach ~$3.4 billion
Midol Liquid Gels sales (US)	Estimated at ~$500 million in 2022	Anticipated to reach ~$700 million by 2027

Sources:
[1] Global OTC Drugs Market Report, 2022.
[2] IBISWorld, OTC Pain Relief Industry Report, 2022.

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Key Market Drivers

1. Rising Awareness of Menstrual Health

Increasing societal discourse on women's health issues, coupled with educational campaigns, has bolstered demand for targeted menstrual products, including Midol Liquid Gels.

2. Consumer Preference for Fast-Acting Relief

Liquid gels, known for rapid absorption and quick symptom relief, align with modern consumer expectations, positioning Midol as a preferred brand.

3. Expansion of Product Line and Formulations

Innovation in delivery formats and formulations, such as fast-dissolving capsules and targeted relief options, enhance market appeal.

4. Strategic Marketing and Brand Loyalty

Aggressive advertising, social media engagement, and partnerships with healthcare providers have fortified brand loyalty and expanded market reach.

5. Regulatory Environment Favoring OTC Accessibility

FDA regulations facilitate OTC sales with minimal barriers, enabling broad consumer access [3].

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Competitive Landscape

Company/Brand	Market Share (Estimated, 2022)	Key Differentiators
Johnson & Johnson (Midol)	55%	Brand recognition, wide distribution network
Bayer (Midol Caplets)	20%	Established OTC presence
Other OTC brands	25%	Price competitiveness, specialized formulations

Note:
Midol Liquid Gels hold roughly 30% of the menstrual relief segment, with growth potential driven by targeted advertising and product innovations.

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Financial Trajectory Analysis

Revenue Trends and Forecasts

Year	Estimated Revenue (USD Millions)	Growth Rate
2022	$500	Baseline
2023 (Forecast)	$550	+10%
2024	$605	+10%
2025	$665	+10%
2026	$732	+10%
2027	$805	+10%

Assumptions:

• Steady market expansion + consumer preference for rapid relief.
• Effective marketing campaigns and product line expansion.

Pricing Strategies and Margin Analysis

| Average Retail Price per Unit | $8.00 (per 20 capsules) |
| Cost of Goods Sold (COGS) | $2.50 |
| Gross Margin | 68.75% |

Margins are projected to improve slightly with increased supply chain efficiencies.

Investment in Marketing and R&D

Estimated annual marketing budget: $20 million, focusing on digital campaigns, influencer partnerships, and healthcare provider outreach.
R&D investments: $5 million annually to develop new formulations and delivery methods.

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Regulatory and Policy Impacts

• FDA Regulations: As an OTC drug, Midol Liquid Gels are regulated under the FDA’s OTC Monograph system, requiring compliance with safety, labeling, and marketing standards [3].

• Potential Regulatory Changes: Increased scrutiny around ingredient safety, labeling clarity, and marketing practices could influence product positioning and costs.

• Pricing & Reimbursement: Unlike prescription drugs, OTC products like Midol do not benefit from reimbursement schemes but are sensitive to price competitions and consumer price sensitivity.

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Market Challenges and Risks

Challenge/Risk	Impact	Mitigation Strategies
Regulatory Stringency	Increased compliance costs	Engage proactively with regulators
Competitive Pricing Pressure	Margin compression	Cost management and product differentiation
Consumer Skepticism and Misinformation	Reduced trust and sales	Accurate marketing and education campaigns
Supply Chain Disruptions	Stock shortages	Diversify suppliers, build inventory buffers

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Strategic Opportunities

• Product Line Diversification: Launch new formulations (e.g., chewables, dissolvables) aligned with consumer preferences.
• Digital Marketing Expansion: Leverage social media and e-commerce to reach younger demographics.
• Global Market Penetration: Expand beyond the US into emerging markets with growing demand for OTC menstrual relief products.
• Partnerships with Healthcare Providers: Promote Midol as an effective OTC option for women's health.

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Comparison with Rivals

Feature	Midol Liquid Gels	Bayer Midol Caplets	Pamprin	Motrin IB
Delivery Format	Liquid gel capsules	Caplets	Caplets	Caplets
Absorption Rate	Rapid	Moderate	Moderate	Moderate
Price Point	$8.00 per pack	$7.50 per pack	$7.00	$6.50
Major Differentiator	Fast relief, targeted	Longstanding brand	Multi-symptom	Widely available

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Regulatory and Policy Status

• OTC Monograph Status: Midol Liquid Gels approved under FDA's OTC monograph for menstrual pain and symptoms.
• Labeling & Claims: Must adhere to FDA regulations limiting health claims; cannot make unsubstantiated claims.
• Advertising Regulations: Must comply with FTC guidelines for OTC drug advertising.

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FAQs

1. What factors are driving the growth of Midol Liquid Gels in the OTC market?

The primary drivers include increased awareness of menstrual health, consumer demand for rapid relief, innovative product formulations, and targeted marketing efforts.

2. How does Midol Liquid Gels compare to other menstrual relief products regarding effectiveness?

Liquid gels generally offer faster symptom relief due to quicker absorption. Clinical studies indicate comparable efficacy with caplet formulations, with consumer preference tilting toward liquid formats for quick action.

3. What are the main regulatory hurdles for expanding Midol Liquid Gels globally?

Regulatory differences concerning ingredient approvals, labeling standards, and health claims can pose challenges, requiring localized compliance strategies.

4. What is the projected market share for Midol Liquid Gels by 2027?

Anticipated to hold approximately 30-35% of the US menstrual pain relief OTC segment, driven by ongoing marketing and product innovation.

5. How might emerging bioethical concerns impact future formulations of Midol Liquid Gels?

Growing demand for natural and preservative-free formulations may influence product development, requiring investments in research for safer, sustainable ingredients.

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Key Takeaways

• Market Expansion: The OTC menstrual relief market is poised for steady growth, with Midol Liquid Gels leading due to consumer preference for fast-dissolving, targeted relief products.
• Financial Outlook: Revenue growth is projected at approximately 10% annually through 2027, supported by innovative formulations and strategic marketing.
• Competitive Edge: Midol’s strong brand recognition, rapid relief capability, and expanding product portfolio underpin its market position.
• Regulatory Landscape: Compliance with FDA OTC monograph standards is critical; proactive engagement can mitigate regulatory risks.
• Growth Opportunities: Diversification into new delivery formats, online marketing expansion, and international markets present significant avenues for revenue enhancement.

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References

1. Global OTC Drugs Market Report, 2022.
2. IBISWorld, OTC Pain Relief Industry Report, 2022.
3. FDA, Over-the-Counter Monograph System, 2022.