Last Updated: August 9, 2026

Details for Patent: 8,754,224


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 8,754,224
Title:Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
Abstract:The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
Inventor(s):Patricia Hurter, William Rowe, Christopher R. Young, Adriana Costache, Patrick R. Connelly, Mariusz Krawlec, Yuchuan Gong, Yushi Feng, Martin Trudeau
Assignee: Vertex Pharmaceuticals Inc
Application Number:US13/785,692
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,754,224
Patent Claim Types:
see list of patent claims
Composition; Compound;

Drugs Protected by US Patent 8,754,224

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Vertex Pharms Inc TRIKAFTA (COPACKAGED) elexacaftor, ivacaftor, tezacaftor; ivacaftor GRANULE;ORAL 217660-001 Apr 26, 2023 RX Yes No 8,754,224 ⤷  Start Trial Y Y ⤷  Start Trial
Vertex Pharms Inc TRIKAFTA (COPACKAGED) elexacaftor, ivacaftor, tezacaftor; ivacaftor GRANULE;ORAL 217660-002 Apr 26, 2023 RX Yes Yes 8,754,224 ⤷  Start Trial Y Y ⤷  Start Trial
Vertex Pharms Inc ALYFTREK deutivacaftor; tezacaftor; vanzacaftor calcium TABLET;ORAL 218730-001 Dec 20, 2024 RX Yes No 8,754,224 ⤷  Start Trial Y Y ⤷  Start Trial
Vertex Pharms Inc ALYFTREK deutivacaftor; tezacaftor; vanzacaftor calcium TABLET;ORAL 218730-002 Dec 20, 2024 RX Yes Yes 8,754,224 ⤷  Start Trial Y Y ⤷  Start Trial
Vertex Pharms Inc SYMDEKO (COPACKAGED) ivacaftor; ivacaftor, tezacaftor TABLET;ORAL 210491-002 Jun 21, 2019 RX Yes No 8,754,224 ⤷  Start Trial Y Y ⤷  Start Trial
Vertex Pharms Inc SYMDEKO (COPACKAGED) ivacaftor; ivacaftor, tezacaftor TABLET;ORAL 210491-001 Feb 12, 2018 RX Yes Yes 8,754,224 ⤷  Start Trial Y Y ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,754,224

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Australia 2006332726 ⤷  Start Trial
Brazil PI0620960 ⤷  Start Trial
Canada 2635581 ⤷  Start Trial
China 101384172 ⤷  Start Trial
Cyprus 1118980 ⤷  Start Trial
Cyprus 1122861 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.