DrugPatentWatch Database Preview

Ivacaftor - Generic Drug Details

« Back to Dashboard

What are the generic sources for ivacaftor and what is the scope of ivacaftor patent protection?

Ivacaftor is the generic ingredient in three branded drugs marketed by Vertex Pharms Inc and Vertex Pharms, and is included in five NDAs. There are thirty patents protecting this compound. Additional information is available in the individual branded drug profile pages.

Ivacaftor has one hundred and thirty-six patent family members in twenty-five countries.

There are three drug master file entries for ivacaftor. One supplier is listed for this compound.

Summary for ivacaftor

International Patents:	136
US Patents:	30
Tradenames:	3
Applicants:	2
NDAs:	5
Drug Master File Entries:	3
Suppliers / Packagers:	1
Bulk Api Vendors:	69
Clinical Trials:	89
Patent Applications:	285
Drug Prices:	Drug price information for ivacaftor
DailyMed Link:	ivacaftor at DailyMed

Pharmacology for ivacaftor

Drug Class	Cystic Fibrosis Transmembrane Conductance Regulator Potentiator
Mechanism of Action	Chloride Channel Activation Potentiators Cytochrome P450 3A4 Inhibitors Cytochrome P450 2C9 Inhibitors P-Glycoprotein Inhibitors Cytochrome P450 3A Inhibitors

Synonyms for ivacaftor

1134822-00-6

1174930-71-2

1413431-05-6

1Y740ILL1Z

3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-

3-Quinolinecarboxamide, N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-

4CA-0661

873054-44-5

A25626

AB0008116

AB01565806_02

AB2000007

ABP000259

AC-28324

AK170457

AKOS015994762

AKOS032950001

AN-16981

AOB31714

BC660099

BCP9000799

BCPP000199

BDBM50032693

CHEBI:66901

CHEMBL2010601

CS-0497

D09916

D0W7WC

DB08820

DTXSID00236281

EX-7211

EX-A441

FT-0696681

GTPL4342

HE066376

HE399755

HMS3654E10

HY-13017

Ivacaftor (USAN/INN)

Ivacaftor (VX-770)

Ivacaftor [USAN:INN]

Ivacaftor-d18

ivacaftorum

Kalydeco

Kalydeco (TN)

Kalydeco|||N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide

KB-81476

KS-0000063W

LE-0002

MFCD17171361

MLS006011119

MolPort-009-194-229

N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide

N-(2,4-ditert-butyl-5-hydroxy-phenyl)-4-oxo-1H-quinoline-3-carboxamide

N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-carboxamide

N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide

N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide

NCGC00242480-01

PURKAOJPTOLRMP-UHFFFAOYSA-N

QCR-155

QUI135

s1144

SC-95534

SCHEMBL351373

SMR004702900

Tube715

UNII-1Y740ILL1Z

VX 770

VX-770

VX-770 - Ivacaftor

VX-770, Ivacaftor, Kalydeco

VX-770/VX770

VX770

VX770, VX 770, Ivacaftor, 873054-44-5

W-5681

X7565

ZINC52509463

US Patents and Regulatory Information for ivacaftor

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Vertex Pharms Inc	SYMDEKO (COPACKAGED)	ivacaftor; ivacaftor, tezacaftor	TABLET, TABLET;ORAL	210491-001	Feb 12, 2018		RX	Yes	Yes			Y	Y
Vertex Pharms Inc	SYMDEKO (COPACKAGED)	ivacaftor; ivacaftor, tezacaftor	TABLET, TABLET;ORAL	210491-001	Feb 12, 2018		RX	Yes	Yes			Y
Vertex Pharms Inc	ORKAMBI	ivacaftor; lumacaftor	TABLET;ORAL	206038-002	Sep 28, 2016		RX	Yes	No			Y	Y

International Patents for ivacaftor

Country	Document Number	Estimated Expiration
Hong Kong	1105970
European Patent Office	3216787
Denmark	1993360

Supplementary Protection Certificates for ivacaftor

Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
/2015	Austria		PRODUCT NAME: N-(5-HYDROXY-2,4DITERT-BUTYL-PHENYL)-4-OXO-1H-QUINOLIN-3-CARBOXAMID ODER EIN PHARMAZEUTISCH ANNEHMBARES SALZ DAVON; REGISTRATION NO/DATE: EU/1/12/782/001, EU/1/12/782/002 (MITTEILUNG) 20120725
2015000050	Germany		PRODUCT NAME: N-(5-HYDROXY-2,4-DI-TERT-BUTYL-PHENYL)-4-OXO-1H-CHINOLIN-3-CARBONSAEUREAMID ODER EIN PHARMAZEUTISCH AKZEPTABLES SALZ DAVON; REGISTRATION NO/DATE: EU/1/12/782/001-002 20120723
7 5014-2015	Slovakia		PRODUCT NAME: N-(5-HYDROXY-2,4-DITERC-BUTYL-FENYL)-4-OXO- -1H-CHINOLIN-3-KARBOXAMID (IVACAFTOR); REGISTRATION NO/DATE: EU/1/12/782/001 - EU/1/12/782/002 20120725