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Last Updated: October 20, 2019

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COMETRIQ Drug Profile

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Which patents cover Cometriq, and when can generic versions of Cometriq launch?

Cometriq is a drug marketed by Exelixis and is included in one NDA. There are three patents protecting this drug.

This drug has one hundred and forty-three patent family members in twenty-nine countries.

The generic ingredient in COMETRIQ is cabozantinib s-malate. There are three drug master file entries for this compound. One supplier is listed for this compound. Additional details are available on the cabozantinib s-malate profile page.

Summary for COMETRIQ
Drug patent expirations by year for COMETRIQ
Drug Prices for COMETRIQ

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Recent Clinical Trials for COMETRIQ

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SponsorPhase
Emory UniversityPhase 2
Liza Villaruz, MDPhase 2
University of Alabama at BirminghamPhase 2

See all COMETRIQ clinical trials

Pharmacology for COMETRIQ
Drug ClassKinase Inhibitor
Mechanism of ActionProtein Kinase Inhibitors
Synonyms for COMETRIQ
1,1-Cyclopropanedicarboxamide, N'-(4-((6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4- fluorophenyl)-
1,1-Cyclopropanedicarboxamide, N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-
1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-
1C39JW444G
849217-68-1
AB0033751
AB01565831_02
ABP000796
AC-25082
AKOS025142112
AOB87755
AS-16277
BC267213
BCP02591
BCP9000470
BCPP000308
BDBM50021574
BMS 907351
BMS-907351
BMS907351
BRD-K51544265-001-01-8
C28H24FN3O5
Cabometyx (TN)
Cabozantinib
Cabozantinib (USAN)
Cabozantinib (XL-184)
Cabozantinib (XL184, BMS-907351)
Cabozantinib [USAN:INN]
Cabozantinib XL-184
Cabozantinib/XL184
cc-10
CHEBI:72317
CHEMBL2105717
Cometriq (TN)
CS-0278
cyclopropane-1,1-dicarboxylic acid [4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide(4-fluoro-phenyl)-amide
cyclopropane-1,1-dicarboxylic acid[4-(6,7-dimethoxy-quinoline-4-yloxy)-phenyl]-amide (4-fluoro-phenyl)-amide
D10062
DB-023624
DB08875
DTXSID10233968
EX-A075
FT-0664184
GTPL5887
HMS3654G06
HY-13016
J-523016
KB-62285
MolPort-021-804-939
n-(4-((6,7-dimethoxy-4-quinolinyl)oxy)phenyl)-n'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
N-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-N-(4-f
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4 fluorophenyl)cyclopropane-1,1-dicarboxamide
N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide
N-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
N'-[4-[(6,7-DIMETHOXY-4-QUINOLINYL)OXY]PHENYL]-N-(4-FLUOROPHENYL)-1,1-CYCLOPROPANEDICARBOXAMIDE
NCGC00263164-01
NCGC00263164-14
ONIQOQHATWINJY-UHFFFAOYSA-N
PubChem22994
Q-3907
QCR-122
RL05229
s1119
SB20062
SC-85393
SCHEMBL360795
SR-01000941569
SR-01000941569-1
SW218093-3
SYN1138
UNII-1C39JW444G
X7477
XL 184
XL 184, XL-184, 1021950-26-4
XL-184
XL-184 (Cabozantinib BMS907351)
XL-184 free base (Cabozantinib)
XL-184,Cabozantinib, BMS-907351
XL184
XL184 free base
XL184 free base - Cabozantinib
ZINC70466416

US Patents and Regulatory Information for COMETRIQ

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Exelixis COMETRIQ cabozantinib s-malate CAPSULE;ORAL 203756-001 Nov 29, 2012 RX Yes Yes   Start Trial   Start Trial Y Y   Start Trial
Exelixis COMETRIQ cabozantinib s-malate CAPSULE;ORAL 203756-002 Nov 29, 2012 RX Yes No   Start Trial   Start Trial Y   Start Trial
Exelixis COMETRIQ cabozantinib s-malate CAPSULE;ORAL 203756-001 Nov 29, 2012 RX Yes Yes   Start Trial   Start Trial   Start Trial
Exelixis COMETRIQ cabozantinib s-malate CAPSULE;ORAL 203756-002 Nov 29, 2012 RX Yes No   Start Trial   Start Trial   Start Trial
Exelixis COMETRIQ cabozantinib s-malate CAPSULE;ORAL 203756-001 Nov 29, 2012 RX Yes Yes   Start Trial   Start Trial Y   Start Trial
Exelixis COMETRIQ cabozantinib s-malate CAPSULE;ORAL 203756-001 Nov 29, 2012 RX Yes Yes   Start Trial   Start Trial Y Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Supplementary Protection Certificates for COMETRIQ

Patent Number Supplementary Protection Certificate SPC Country SPC Expiration SPC Description
2213661 583 Finland   Start Trial
2213661 122014000091 Germany   Start Trial PRODUCT NAME: CABOZANTINIB UND JEDES THERAPEUTISCHE AEQUIVALENT HIERVON WIE DURCH DAS GRUNDPATENT GESCHUETZT, EINSCHLIESSLICH PHARMAZEUTISCH ANNEHMBARER SALZE; REGISTRATION NO/DATE: EU/1/13/890/001-003 20140321
2213661 92508 Luxembourg   Start Trial PRODUCT NAME: CABOZANTINIB ET TOUTES LES FORMES THERAPEUTIQUEMENT EQUIVALENTES QUI EN DERIVENT TELLES QUE PROTEGEES PAR LE BREVET DE BASE, Y COMPRIS LES SELS PHARMACEUTIQUEMENT ACCEPTABLES. FIRST REGISTRATION: 20140326
2213661 PA2014033,C2213661 Lithuania   Start Trial PRODUCT NAME: KABOZANTINIBAS IR JO FARMACINIU POZIURIU PRIIMTINOS DRUSKOS; REGISTRATION NO/DATE: EU/1/13/890/001 - EU/1/13/890/003 20140321
2213661 C300678 Netherlands   Start Trial PRODUCT NAME: CABOZANTINIB EN ELKE THERAPEUTISCH EQUIVALENTE VORM DAARVAN ZOALS BESCHERMD DOOR HET BASISOCTROOI, WAARONDER FARMACEUTISCH AANVAARDBARE ZOUTEN; REGISTRATION NO/DATE: EU/1/13/890/001-003 20140326
2213661 C20140029 00117 Estonia   Start Trial PRODUCT NAME: KABOSANTINIIB;REG NO/DATE: K(2014)2043 (LOPLIK) 26.03.2014
>Patent Number >Supplementary Protection Certificate >SPC Country >SPC Expiration >SPC Description

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