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Serving 500+ biopharmaceutical companies globally:

Queensland Health
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Generated: July 25, 2017

DrugPatentWatch Database Preview

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Which drugs does patent 8,877,776 protect, and when does it expire?


Patent ► Subscribe protects COMETRIQ and CABOMETYX and is included in two NDAs.

This patent has thirty-nine patent family members in twenty-four countries.

Summary for Patent: ► Subscribe

Title:(L)-malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxami- de
Abstract: Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cy- clopropane -1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and crystalline and amorphous forms of the malate salts. Also disclosed are pharmaceutical compositions comprising at least one malate salts of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)-cy- clopropane-1,1-dicarboxamide; and methods of treating cancer comprising administering at least one malate salt of N-(4-{[6,7-bis(methyloxy)quinolin-4-yl]oxy}phenyl)-N'-(4-ffuorophenyl)cyc- lopropane-1,1-dicarboxamide.
Inventor(s): Brown; Adrian St. Clair (Ely, GB), Lamb; Peter (Oakland, CA), Gallagher; William P. (Princeton, NJ)
Assignee: Exelixis, Inc. (South San Francisco, CA)
Application Number:13/145,054
Patent Claim Types:
see list of patent claims
Compound; Composition; Use;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Exelixis
COMETRIQ
cabozantinib s-malate
CAPSULE;ORAL203756-001Nov 29, 2012RXYesNo► Subscribe► SubscribeYY METHOD OF TREATING MEDULLARY THYROID CANCER
Exelixis
COMETRIQ
cabozantinib s-malate
CAPSULE;ORAL203756-002Nov 29, 2012RXYesYes► Subscribe► SubscribeYY METHOD OF TREATING MEDULLARY THYROID CANCER
Exelixis Inc
CABOMETYX
cabozantinib s-malate
TABLET;ORAL208692-001Apr 25, 2016RXYesNo► Subscribe► SubscribeYY
Exelixis Inc
CABOMETYX
cabozantinib s-malate
TABLET;ORAL208692-002Apr 25, 2016RXYesNo► Subscribe► SubscribeYY
Exelixis Inc
CABOMETYX
cabozantinib s-malate
TABLET;ORAL208692-003Apr 25, 2016RXYesYes► Subscribe► SubscribeYY
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Foreign Priority and PCT Information for Patent: ► Subscribe

PCT Information
PCT FiledJanuary 15, 2010PCT Application Number:PCT/US2010/021194
PCT Publication Date:July 22, 2010PCT Publication Number: WO2010/083414

International Patent Family for Patent: ► Subscribe

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina075025► Subscribe
Australia2010204619► Subscribe
Australia2013203780► Subscribe
Australia2016262732► Subscribe
Canada2758030► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving 500+ biopharmaceutical companies globally:

Fuji
Citi
Medtronic
Accenture
Mallinckrodt
Colorcon
QuintilesIMS
Johnson and Johnson
Daiichi Sankyo
Chubb

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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