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Last Updated: December 9, 2019

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CARDIZEM Drug Profile

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Which patents cover Cardizem, and what generic alternatives are available?

Cardizem is a drug marketed by Biovail, Biovail Labs Intl, and Bausch. and is included in six NDAs. There are two patents protecting this drug and two Paragraph IV challenges.

The generic ingredient in CARDIZEM is diltiazem hydrochloride. There are twenty-six drug master file entries for this compound. Forty-three suppliers are listed for this compound. Additional details are available on the diltiazem hydrochloride profile page.

Drug patent expirations by year for CARDIZEM
Drug Prices for CARDIZEM

See drug prices for CARDIZEM

Recent Clinical Trials for CARDIZEM

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
CAMC Health SystemPhase 4
University of South FloridaN/A
Kowa Research Institute, Inc.Phase 4

See all CARDIZEM clinical trials

Pharmacology for CARDIZEM
Synonyms for CARDIZEM
(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
(+)-cis-diltiazem
(+)-diltiazem
(2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-
(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
[b][1,4]thiazepin-3-yl acetate
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-
42399-41-7
5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester(Diltiazem)Acetic acid
8-Chloro-1-methyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene
AC-936
AC1L2181
AC1Q6LHX
Acalix
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Acetic acid (S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester (Diltiazem)
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; hydrochloride
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester(cis-(+)-Diltiazem)
Adizem
AKOS015897257
Aldizem
AN-15434
Anoheal
API0005791
Apo-Diltiaz
BC204117
BDBM50004704
BIDD:GT0548
Bio1_000371
Bio1_000860
Bio1_001349
BPBio1_000230
BRD-K24023109-001-02-5
BRD-K24023109-003-03-9
BRD-K24023109-003-11-2
BRD-K24023109-003-20-3
BRN 3573079
BSPBio_000208
BSPBio_001311
C-21975
C06958
C22H26N2O4S
Cardil
Cardizem (Hydrochloride)
Cardizen LA
CAS-42399-41-7
CCG-204422
CD0163
CHEBI:101278
CHEMBL23
cis-Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Citizem
CTK8F9218
D-(cis)-diltiazem
d-cis-Diltiazem
D07845
DB00343
Dilacor
Dilacor-XR
Dilcontin
Dilren
Dilt-cd
Dilta-Hexal
Diltia
diltiazem
Diltiazem (INN)
Diltiazem [INN:BAN]
Diltiazem HCI
diltiazem;Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Diltiazemum
Diltiazemum [INN-Latin]
Diltiazen
Dilticard
Diltzac
Dilzen
DSSTox_CID_2940
DSSTox_GSID_22940
DSSTox_RID_76797
DTXSID9022940
EE92BBP03H
EINECS 255-796-4
Endrydil
FT-0081415
FT-0625016
GTPL2298
HMS1791B13
HMS1989B13
HMS2089H09
HSDB 6528
HSUGRBWQSSZJOP-RTWAWAEBSA-N
Incoril AP
Lopac0_000327
LS-40510
MCULE-9931403933
methoxyphenyl)-4-oxo-2,3,4,5-
MK-793 (Malate)
NCGC00024309-02
NCGC00024309-04
NCGC00024309-05
NCGC00024309-06
NCGC00024309-07
NCGC00024309-08
NCGC00024309-09
NCGC00024309-10
NCGC00024309-11
NCGC00024309-17
Nu-Diltiaz
Prestwick0_000134
Prestwick1_000134
Prestwick2_000134
Prestwick3_000134
RG 83606 (Hydrochloride)
RG-83606
SC-16185
SCHEMBL17776
SPBio_002147
Surazem (TN)
tetrahydrobenzo
Tiamate
Tiazac
Tiazac Tildiem
Tiazac XC
Tocris-0685
Tox21_110898
Tox21_110898_1
UNII-EE92BBP03H
VA10739
Viazem
W-106274
ZINC621893

US Patents and Regulatory Information for CARDIZEM

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Biovail CARDIZEM SR diltiazem hydrochloride CAPSULE, EXTENDED RELEASE;ORAL 019471-004 Jan 23, 1989 DISCN Yes No   Start Trial   Start Trial   Start Trial
Biovail CARDIZEM diltiazem hydrochloride INJECTABLE;INJECTION 020792-001 Sep 5, 1997 DISCN No No   Start Trial   Start Trial   Start Trial
Bausch CARDIZEM LA diltiazem hydrochloride TABLET, EXTENDED RELEASE;ORAL 021392-003 Feb 6, 2003 AB RX Yes No   Start Trial   Start Trial Y   Start Trial
Bausch CARDIZEM LA diltiazem hydrochloride TABLET, EXTENDED RELEASE;ORAL 021392-006 Feb 6, 2003 AB RX Yes Yes   Start Trial   Start Trial Y   Start Trial
Bausch CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-004 Dec 8, 1986 AB RX Yes Yes   Start Trial   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

Expired US Patents for CARDIZEM

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Bausch CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-001 Nov 5, 1982   Start Trial   Start Trial
Bausch CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-004 Dec 8, 1986   Start Trial   Start Trial
Bausch CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-004 Dec 8, 1986   Start Trial   Start Trial
Bausch CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-004 Dec 8, 1986   Start Trial   Start Trial
Bausch CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-003 Dec 8, 1986   Start Trial   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >Patent No. >Patent Expiration

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