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Generated: April 21, 2018

DrugPatentWatch Database Preview

CARDIZEM Drug Profile

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Which patents cover Cardizem, and what generic alternatives are available?

Cardizem is a drug marketed by Biovail, Biovail Labs Intl, and Valeant Intl. and is included in six NDAs. There are two patents protecting this drug and two Paragraph IV challenges.

The generic ingredient in CARDIZEM is diltiazem hydrochloride. There are twenty-six drug master file entries for this compound. Forty-four suppliers are listed for this compound. Additional details are available on the diltiazem hydrochloride profile page.
Drug patent expirations by year for CARDIZEM
Pharmacology for CARDIZEM
Synonyms for CARDIZEM
(+)-cis-5-[2-(dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester
(+)-cis-diltiazem
(+)-diltiazem
(2S-cis)-3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-[4-(methyloxy)phenyl]-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
[(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-
42399-41-7
5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester(Diltiazem)Acetic acid
75472-92-3
8-Chloro-1-methyl-6-phenyl-4H-2,3,5,10b-tetraaza-benzo[e]azulene
AC-936
AC1L2181
AC1Q6LHX
Acalix
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Acetic acid (S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester (Diltiazem)
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester; hydrochloride
Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester(cis-(+)-Diltiazem)
Adizem
Adizem (TN)
AKOS015897257
Aldizem
Altiazem (TN)
AN-15434
Angiozem (TN)
Angizem (TN)
Angizem CD (TN)
Anoheal
API0005791
Apo-Diltiaz
BC204117
BDBM50004704
BIDD:GT0548
Bio1_000371
Bio1_000860
Bio1_001349
BPBio1_000230
BRD-K24023109-001-02-5
BRD-K24023109-003-03-9
BRN 3573079
BSPBio_000208
BSPBio_001311
C-21975
C06958
C22H26N2O4S
Cardil
Cardizem (Hydrochloride)
Cardizem (TN)
Cardizen LA
Cartia XT (TN)
CAS-42399-41-7
CCG-204422
CD0163
CHEBI:101278
CHEMBL23
cis-Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Citizem
CTK8F9218
D-(cis)-diltiazem
d-cis-Diltiazem
d-diltiazem
D07845
D0OB1J
DB00343
Dilacor
Dilacor-XR
Dilatam (TN)
Dilatem (TN)
Dilcardia (TN)
Dilcontin
Dilcontin SR (TN)
Dilren
Dilt-cd
Dilta-Hexal
Diltelan (TN)
Diltia
diltiazem
Diltiazem (INN)
Diltiazem [INN:BAN]
Diltiazem HCI
Diltiazem HCl
Diltiazem malate
diltiazem;Acetic acid 5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester
Diltiazemum
Diltiazemum [INN-Latin]
Dilticard
Diltime (TN)
Diltzac
Dilzem
Dilzem (TN)
Dilzen
DR002508
DSSTox_CID_2940
DSSTox_GSID_22940
DSSTox_RID_76797
DTXSID9022940
Dyalec (TN)
EE92BBP03H
EINECS 255-796-4
Endrydil
Filazem (TN)
FT-0081415
FT-0625016
GTPL2298
HE342782
Herben (TN)
HMS1791B13
HMS1989B13
HMS2089H09
HSDB 6528
HSUGRBWQSSZJOP-RTWAWAEBSA-N
Incoril AP
l-Diltiazem
Lopac0_000327
LS-40510
MCULE-9931403933
MK-793 (Malate)
MolPort-002-509-369
NCGC00024309-02
NCGC00024309-04
NCGC00024309-05
NCGC00024309-06
NCGC00024309-07
NCGC00024309-08
NCGC00024309-09
NCGC00024309-10
NCGC00024309-11
NCGC00024309-17
Nu-Diltiaz
Prestwick0_000134
Prestwick1_000134
Prestwick2_000134
Prestwick3_000134
Progor (TN)
RG 83606 (Hydrochloride)
RG-83606
SC-16185
SCHEMBL17776
SPBio_002147
STOCK1N-03672
Surazem (TN)
Tiamate
Tiamate (TN)
Tiazac
Tiazac (TN)
Tiazac Tildiem
Tiazac XC
Tiazac XC (TN)
Tildiem (TN)
Tocris-0685
Tox21_110898
Tox21_110898_1
UNII-EE92BBP03H
VA10739
Vasmulax (TN)
Viazem
Viazem (TN)
W-106274
Zandil (TN)
Zemtrial (TN)
ZINC621893

US Patents and Regulatory Information for CARDIZEM

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Biovail CARDIZEM SR diltiazem hydrochloride CAPSULE, EXTENDED RELEASE;ORAL 019471-004 Jan 23, 1989 DISCN Yes No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Biovail CARDIZEM diltiazem hydrochloride INJECTABLE;INJECTION 020792-001 Sep 5, 1997 DISCN No No ➤ Try a Free Trial ➤ Try a Free Trial ➤ Try a Free Trial
Valeant Intl CARDIZEM LA diltiazem hydrochloride TABLET, EXTENDED RELEASE;ORAL 021392-003 Feb 6, 2003 AB RX Yes No ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Valeant Intl CARDIZEM LA diltiazem hydrochloride TABLET, EXTENDED RELEASE;ORAL 021392-006 Feb 6, 2003 AB RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for CARDIZEM

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Valeant Intl CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-003 Dec 8, 1986 ➤ Try a Free Trial ➤ Try a Free Trial
Valeant Intl CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-004 Dec 8, 1986 ➤ Try a Free Trial ➤ Try a Free Trial
Valeant Intl CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-004 Dec 8, 1986 ➤ Try a Free Trial ➤ Try a Free Trial
Valeant Intl CARDIZEM diltiazem hydrochloride TABLET;ORAL 018602-001 Nov 5, 1982 ➤ Try a Free Trial ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Paragraph IV (Patent) Challenges for CARDIZEM
Drugname Dosage Strength RLD Submissiondate
➤ Subscribe Extended-release Tablets 120 mg, 180 mg, 240 mg, 300 mg and 360 mg ➤ Subscribe 2005-08-30
➤ Subscribe Extended-release Tablets 420 mg ➤ Subscribe 2005-04-25

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Healthtrust
Cerilliant
Queensland Health
Colorcon
Chubb
Accenture
US Department of Justice
Cipla

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