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Last Updated: December 6, 2021

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Patent: 8,039,469

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Summary for Patent: 8,039,469
Title:Triazine compounds as PI3 kinase and mTOR inhibitors
Abstract: Compounds of formula I ##STR00001## wherein: R.sup.1 is ##STR00002## and R.sup.2, R.sup.4, and R.sup.6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
Inventor(s): Venkatesan; Aranapakam Mudumbai (Rego Park, NY), Chen; Zecheng (New City, NY), Dehnhardt; Christoph Martin (New York, NY), Santos; Osvaldo dos (Astoria, NY), Santos; Efren Guillermo Delos (Nanuet, NY), Zask; Arie (New York, NY), Verheijen; Jeroen Cunera (Highland Mills, NY), Kaplan; Joshua Aaron (Nyack, NY), Richard; David James (Warwick, NY), Ayral-Kaloustian; Semiramis (Tarrytown, NY), Mansour; Tarek Suhayl (New City, NY), Gopalsamy; Ariamala (Mahwah, NJ), Curran; Kevin Joseph (Congers, NY), Shi; Mengxiao (Eastchester, NY)
Assignee: Wyeth LLC (Madison, NJ)
Application Number:12/470,521
Patent Claims:see list of patent claims

Details for Patent 8,039,469

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 1978-01-10 ⤷  Free Forever Trial 2039-02-26
Bayer Healthcare Pharmaceuticals Inc. BETASERON interferon beta-1b For Injection 103471 1993-07-23 ⤷  Free Forever Trial 2039-02-26
Biogen Inc. AVONEX interferon beta-1a For Injection 103628 1996-05-17 ⤷  Free Forever Trial 2039-02-26
Biogen Inc. AVONEX interferon beta-1a Injection 103628 2003-05-28 ⤷  Free Forever Trial 2039-02-26
Biogen Inc. AVONEX interferon beta-1a Injection 103628 2012-02-27 ⤷  Free Forever Trial 2039-02-26
Emd Serono, Inc. REBIF interferon beta-1a Injection 103780 2002-03-07 ⤷  Free Forever Trial 2039-02-26
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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