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Last Updated: September 26, 2020

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Patent: 8,039,469

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Summary for Patent: 8,039,469
Title:Triazine compounds as PI3 kinase and mTOR inhibitors
Abstract: Compounds of formula I ##STR00001## wherein: R.sup.1 is ##STR00002## and R.sup.2, R.sup.4, and R.sup.6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
Inventor(s): Venkatesan; Aranapakam Mudumbai (Rego Park, NY), Chen; Zecheng (New City, NY), Dehnhardt; Christoph Martin (New York, NY), Santos; Osvaldo dos (Astoria, NY), Santos; Efren Guillermo Delos (Nanuet, NY), Zask; Arie (New York, NY), Verheijen; Jeroen Cunera (Highland Mills, NY), Kaplan; Joshua Aaron (Nyack, NY), Richard; David James (Warwick, NY), Ayral-Kaloustian; Semiramis (Tarrytown, NY), Mansour; Tarek Suhayl (New City, NY), Gopalsamy; Ariamala (Mahwah, NJ), Curran; Kevin Joseph (Congers, NY), Shi; Mengxiao (Eastchester, NY)
Assignee: Wyeth LLC (Madison, NJ)
Application Number:12/470,521
Patent Claims:see list of patent claims

Details for Patent 8,039,469

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Merck ELSPAR asparaginase VIAL 101063 001 1978-01-10   Start Trial Wyeth LLC (Madison, NJ) 2039-02-26 RX search
Bayer Healthcare Pharms BETASERON interferon beta-1b VIAL; SUBCUTANEOUS 103471 001 1993-07-23   Start Trial Wyeth LLC (Madison, NJ) 2039-02-26 RX Orphan search
Biogen AVONEX interferon beta-1a VIAL 103628 001 1996-05-17   Start Trial Wyeth LLC (Madison, NJ) 2039-02-26 RX search
Serono Inc REBIF interferon beta-1a SYRINGE 103780 001 2002-03-07   Start Trial Wyeth LLC (Madison, NJ) 2039-02-26 RX search
Serono Inc REBIF interferon beta-1a SYRINGE 103780 002 2002-03-07   Start Trial Wyeth LLC (Madison, NJ) 2039-02-26 RX search
Genentech AVASTIN bevacizumab VIAL; INTRAVENOUS 125085 001 2004-02-26   Start Trial Wyeth LLC (Madison, NJ) 2039-02-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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