Claims for Patent: 8,039,469

Summary for Patent: 8,039,469

Title:	Triazine compounds as PI3 kinase and mTOR inhibitors
Abstract:	Compounds of formula I ##STR00001## wherein: R.sup.1 is ##STR00002## and R.sup.2, R.sup.4, and R.sup.6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
Inventor(s):	Venkatesan; Aranapakam Mudumbai (Rego Park, NY), Chen; Zecheng (New City, NY), Dehnhardt; Christoph Martin (New York, NY), Santos; Osvaldo dos (Astoria, NY), Santos; Efren Guillermo Delos (Nanuet, NY), Zask; Arie (New York, NY), Verheijen; Jeroen Cunera (Highland Mills, NY), Kaplan; Joshua Aaron (Nyack, NY), Richard; David James (Warwick, NY), Ayral-Kaloustian; Semiramis (Tarrytown, NY), Mansour; Tarek Suhayl (New City, NY), Gopalsamy; Ariamala (Mahwah, NJ), Curran; Kevin Joseph (Congers, NY), Shi; Mengxiao (Eastchester, NY)
Assignee:	Wyeth LLC (Madison, NJ)
Application Number:	12/470,521
Patent Claims:	1. A compound of the Formula I: ##STR00036## wherein: R.sup.1 is ##STR00037## wherein: R.sup.6, R.sup.7, R.sup.8, R.sup.9 are each independently selected from the group consisting of a hydrogen atom, and a C.sub.1-C.sub.6alkyl optionally substituted with C.sub.2-C.sub.6alkenyl, C.sub.4-C.sub.6alkadienyl, C.sub.2-C.sub.6alkynyl or C.sub.4-C.sub.6alkadiynyl; or one of R.sup.6 and R.sup.7 or R.sup.8 and R.sup.9, together with the carbon atoms to which they are attached form an optionally substituted 5-8 membered saturated or unsaturated ring containing 0, 1 or 2 atoms independently selected from O, NH and S; the dashed line - - - - - represents an optional second bond; R.sup.2 is optionally substituted C.sub.6-C.sub.14aryl-NH--COR.sup.3, optionally substituted C.sub.1-C.sub.9heteroaryl-NH--COR.sup.3, --CH.dbd.CH--C.sub.6-C.sub.10aryl-NH--COR.sup.3 or --CH.dbd.CH--C.sub.1-C.sub.9heteroaryl-NH--COR.sup.3; R.sup.3 is OR.sup.5, NR.sup.5R.sup.5 or NHR.sup.5; R.sup.5 is independently selected from the group consisting of C.sub.1-C.sub.6alkyl, C.sub.3-C.sub.6alkenyl, C.sub.3-C.sub.6alkynyl, optionally substituted C.sub.6-C.sub.10aryl, C.sub.1-C.sub.6haloalkyl, optionally substituted C.sub.1-C.sup.9heteroaryl, C.sub.1-C.sub.6hydroxylalkyl-, C.sub.3-C.sub.10saturated or unsaturated mono or bicyclic C.sub.3-C.sub.10cycloalkyl optionally substituted with OH, NR.sup.11R.sup.11 or 3-7 membered C.sub.1-C.sub.6heterocyclyl, and 3-10 membered saturated or unsaturated mono or bicyclic C.sub.1-C.sub.9heterocyclyl, with the proviso that three-membered cycloalkyl and heterocyclyl rings are saturated; or two R.sup.5 groups taken together with the nitrogen atom to which they are attached form a 3 to 8 membered ring system optionally substituted with C.sub.1-C.sub.6alkyl, which ring system is saturated or unsaturated and has, in addition to said nitrogen atom, 0 to 2 heteroatom ring members selected from O, S, S(O), S(O).sub.2 and NR.sup.10; R.sup.10 is selected from the group consisting of H, C.sub.1-C.sub.6alkyl, --SO.sub.2(C.sub.1-C.sub.6alkyl), --COO(C.sub.1-C.sub.6alkyl), --CONH(C.sub.1-C.sub.6alkyl), --CON(C.sub.1-C.sub.6alkyl).sub.2, --CO(C.sub.1-C.sub.6alkyl), and --SO.sub.2NHR.sup.11; R.sup.11 is selected from the group consisting of H, C.sub.1-C.sub.6alkyl optionally substituted with OH, NR.sup.11R.sup.11 or a 3-7 membered C.sub.1-C.sub.6heterocyclyl, --CO(C.sub.1-C.sub.6alkyl), optionally substituted C.sub.6-C.sub.10aryl, and optionally substituted C.sub.1-C.sub.9heteroaryl; R.sup.4 is selected from the group consisting of: a) C.sub.1-C.sub.6alkyl optionally substituted with: i) 3-10 membered C.sub.1-C.sub.9heterocyclyl optionally substituted with C.sub.1-C.sub.6alkyl-, ii) H.sub.2N--, iii) (C.sub.1-C.sub.6alkyl)NH--, iv) (C.sub.1-C.sub.6alkyl).sub.2N--, v) NH(CH.sub.2).sub.aN(C.sub.1-C.sub.6alkyl).sub.2 wherein a is 2, 3 or 4, and vi) CHO, b) C.sub.3-C.sub.6alkenyl, c) C.sub.3-C.sub.6alkynyl, d) --O--C.sub.1-C.sub.8alkyl optionally substituted with --O--C.sub.1-C.sub.8alkyl, e) --O--C.sub.3-C.sub.8alkenyl, f) --O--C.sub.3-C.sub.8alkynyl, g) saturated or unsaturated mono or bicyclic C.sub.3-C.sub.8cycloalkyl, and h) saturated or unsaturated mono or bicyclic --O--C.sub.3-C.sub.12cycloalkyl, all the above optionally substituted with OH, NR.sup.11R.sup.11 or a 3-7 membered C.sub.1-C.sub.6heterocyclyl optionally substituted with C.sub.1-C.sub.6alkyl-, provided that an OH or NR.sup.11R.sup.11 is not directly bonded to a carbon atom that is double- or triple-bonded to another carbon atom; i) --CH.dbd.CH--C.sub.6-C.sub.10aryl; j) --CH.dbd.CH--C.sub.1-C.sub.9heteroaryl; k) optionally substituted C.sub.6-C.sub.10aryl; l) optionally substituted 5-10 membered C.sub.1-C.sub.9heteroaryl attached to the triazine moiety via a carbon atom; m) 3-10 membered saturated or unsaturated monocyclic C.sub.1-C.sub.9heterocyclyl attached to the triazine moiety through a carbon or nitrogen atom and optionally substituted with from 1 to 3 substituents independently selected from: OH, NR.sup.11R.sup.11, C.sub.1-C.sub.6alkyl, (C.sub.1-C.sub.6alkyl)amido-, (C.sub.1-C.sub.6alkyl)C(O)--, (C.sub.1-C.sub.6alkoxy)carbonyl-, adamantyl, C.sub.1-C.sub.6hydroxylalkyl-, (C.sub.1-C.sub.6alkyl)amido-; or a3-7 membered C.sub.1-C.sub.6heterocyclyl, with the proviso that 3 membered heterocyclyl is saturated and attached to the triazine moiety through a nitrogen atom, and 5 membered bicyclic heterocyclyl is saturated; n) optionally substituted --O--C.sub.6-C.sub.10aryl; o) optionally substituted --O--C.sub.1-C.sub.9heteroaryl; p) --O-(3-12 membered saturated or unsaturated mono or bicyclic)C.sub.1-C.sub.9heterocyclyl optionally substituted with (C.sub.1-C.sub.6alkoxy)carbonyl-, H.sub.2NS(O).sub.2--, or C.sub.1-C.sub.6alkyl further optionally substituted with OH, NR.sup.11R.sup.11 or a 3-7 membered C.sub.1-C.sub.6heterocyclyl, with the proviso that three membered heterocyclyl is saturated; q) --NHC.sub.6-C.sub.10aryl, r) --NHC.sub.1-C.sub.9heteroaryl, s) --NHNH.sub.2, t) --NHNHC.sub.1-C.sub.6alkyl, u) --NHN(C.sub.1-C.sub.6alkyl).sub.2, v) --NHOH, w) --COOH, x) --COO--C.sub.1 ##STR00038## -C.sub.6alkyl, y) --CONR.sup.12R.sup.13, z) --NR.sup.12R.sup.13, wherein Z is CH.sub.2, O, S(O).sub.n or NR.sup.10 and n is 0, 1 or 2; ee) halogen, ff) C.sub.6-C.sub.14aryl-S(O).sub.2--NH--, gg) R.sup.11NHC(O)NH--O--, and hh) optionally substituted 5-membered monocyclic C.sub.1-C.sub.4heteroaryl attached to the triazine moiety via a nitrogen atom; R.sup.12 and R.sup.13 are each independently selected from H, optionally mono or disubstituted C.sub.1-C.sub.8alkyl, optionally substituted C.sub.3-C.sub.8alkenyl, and optionally substituted C.sub.3-C.sub.8alkynyl, the optional substituents being selected from C.sub.1-C.sub.6alkoxy, OH, NR.sup.11R.sup.11, and 3-7 membered C.sub.1-C.sub.6heterocyclyl, provided that an OH or NR.sup.11R.sup.11 is not directly bonded to a carbon atom that is double- or triple-bonded to another carbon atom; or R.sup.12 and R.sup.13 taken together with the nitrogen atom to which they are attached form a 3 to 8 membered monocyclic ring system optionally substituted with C.sub.1-C.sub.6alkyl, which ring system is saturated or unsaturated and has, in addition to said nitrogen atom, 0 to 2 heteroatom ring members selected from O, S(O).sub.n and NR.sup.10; ##STR00039## or R.sup.12 and R.sup.13 taken together with the nitrogen atom to which they are attached form wherein a and b are each independently --CH.sub.2--, O, S, or NR.sup.10, and x is 1-3; C.sub.1-C.sub.9heteroaryl refers to a 5-10 membered aromatic ring system having one or more rings and 1, 2, 3 or 4 ring members independently selected from O, NR.sup.10, and S(O).sub.n; C.sub.1-C.sub.9heterocyclyl refers to a 3-10 membered ring system having one or more rings and 1, 2, 3 or 4 ring members independently selected from O, NR.sup.10, and S(O).sub.n; and optionally substituted aryl and heteroaryl groups are unsubstituted or are substituted with 1 or 2 moieties selected from the group consisting of: a) C.sub.1-C.sub.6alkyl optionally substituted with OH, NH.sub.2, NH(C.sub.1-C.sub.6alkyl), N(C.sub.1-C.sub.6alkyl).sub.2, --NH(CH.sub.2).sub.wN(C.sub.1-C.sub.6alkyl).sub.2 wherein w is 2, 3 or 4, or 3-10 membered C.sub.1-C.sub.9heterocyclyl optionally substituted with from 1 to 3 independently selected C.sub.1-C.sub.6alkyl- substituents; b) halogen; c) hydroxy; d) NH.sub.2; e) NO.sub.2; f) SO.sub.2NH.sub.2; g) COOH; h) COO(C.sub.1-C.sub.6alkyl); i) NHCOO(C.sub.1-C.sub.6alkyl); j) NH(C.sub.1-C.sub.6alkyl); k) N(C.sub.1-C.sub.6alkyl).sub.2; l) C(O)NR.sup.aR.sup.b, wherein R.sup.a is H or C.sub.1-C.sub.6alkyl, and R.sup.b is H, C.sub.1-C.sub.6alkyl, (C.sub.6-C.sub.14aryl)alkyl-, or (C.sub.1-C.sub.9heteroaryl)alkyl-; m) -Y-Q, wherein Y is: i) O, ii) NH, iii) N(C.sub.1-C.sub.6alkyl), iv) NHSO.sub.2, v) SO.sub.2NH, vi) NHCONH, vii) NHCON(C.sub.1-C.sub.6alkyl), viii) S(O).sub.q, q is 0, 1 or 2, ix) --C(O)NH--, x) --NHC(O)-- xi) --C(O)N(CH.sub.3)--, xii) C(O), or xiii) absent, and Q is selected from: i) C.sub.6-C.sub.10aryl, optionally substituted with from 1 to 3 substituents independently selected from: A) C.sub.1-C.sub.6alkoxy- optionally substituted with 1) H.sub.2N--, 2) (C.sub.1-C.sub.6alkyl)amino-, 3) di(C.sub.1-C.sub.6alkyl)amino-, 4) C.sub.1-C.sub.9heterocyclyl- optionally substituted by C.sub.1-C.sub.6alkyl-, or 5) hydroxyl, B) (C.sub.1-C.sub.6alkoxy)carbonyl-, C) (C.sub.1-C.sub.6alkoxy)C(O)NH--, D) C.sub.1-C.sub.6alkyl- optionally substituted with 1) H.sub.2N--, 2) (C.sub.1-C.sub.6alkyl)amino-, or 3) di(C.sub.1-C.sub.6alkyl)amino-, E) (C.sub.1-C.sub.6alkyl)amino-, F) di(C.sub.1-C.sub.6alkyl)amino-, G) (C.sub.1-C.sub.6alkyl)amido- optionally substituted with 1) H.sub.2N--, 2) (C.sub.1-C.sub.6alkyl)amino-, or 3) di(C.sub.1-C.sub.6alkyl)amino-, H) (C.sub.1-C.sub.6alkyl)carboxyamido-, I) C.sub.1-C.sub.9heterocyclyl- optionally substituted by C.sub.1-C.sub.6alkyl- or C.sub.1-C.sub.6hydroxylalkyl-, J) heterocyclyl(C.sub.1-C.sub.6alkyl)- optionally substituted by C.sub.1-C.sub.6alkyl-, K) halogen, L) hydroxyl, M) C.sub.1-C.sub.6hydroxylalkyl-, N) perfluoro(C.sub.1-C.sub.6)alkyl-, O) H.sub.2N--, P) O.sub.2N--, Q) H.sub.2NSO.sub.2--, R) HO.sub.2C--, and S) NC--, ii) 5-10 membered C.sub.1-C.sub.9heteroaryl, optionally substituted with from 1 to 3 substituents independently selected from: A) C.sub.1-C.sub.6alkoxy- optionally substituted with 1) H.sub.2N--, 2) (C.sub.1-C.sub.6alkyl)amino-, 3) di(C.sub.1-C.sub.6alkyl)amino-, 4) C.sub.1-C.sub.9heterocyclyl- optionally substituted by C.sub.1-C.sub.6alkyl-, or 5) hydroxyl, B) (C.sub.1-C.sub.6alkoxy)carbonyl-, C) (C.sub.1-C.sub.6alkoxy)C(O)NH--, D) C.sub.1-C.sub.6alkyl- optionally substituted with 1) H.sub.2N--, 2) (C.sub.1-C.sub.6alkyl)amino-, or 3) di(C.sub.1-C.sub.6alkyl)amino-, E) (C.sub.1-C.sub.6alkyl)amino-, F) di(C.sub.1-C.sub.6alkyl)amino-, G) (C.sub.1-C.sub.6alkyl)amido- optionally substituted with 1) H.sub.2N--, 2) (C.sub.1-C.sub.6alkyl)amino-, or 3) di(C.sub.1-C.sub.6alkyl)amino-, H) (C.sub.1-C.sub.6alkyl)carboxyamido-, I) C.sub.1-C.sub.9heterocyclyl- optionally substituted by C.sub.1-C.sub.6alkyl- or C.sub.1-C.sub.6hydroxylalkyl-, J) heterocyclyl(C.sub.1-C.sub.6alkyl)- optionally substituted by C.sub.1-C.sub.6alkyl-, K) halogen, L)hydroxyl, M) C.sub.1-C.sub.6hydroxylalkyl-, N) perfluoro(C.sub.1-C.sub.6)alkyl-, O) H.sub.2N--, P) O.sub.2N--, Q) H.sub.2NSO.sub.2--, R) HO.sub.2C--, and S) NC--, iii) 3-10 membered C.sub.1-C.sub.9heterocyclyl, optionally substituted with from 1 to 3 substituents independently selected from: A) C.sub.1-C.sub.6alkyl-, B) heterocyclyl(C.sub.1-C.sub.6alkyl)-, C) (C.sub.6-C.sub.14aryl)alkyl-, D) C.sub.1-C.sub.8acyl-, E) (C.sub.1-C.sub.6alkoxy)carbonyl-, F) (C.sub.1-C.sub.6alkyl)carboxyl-, G) halogen, H) C.sub.1-C.sub.6haloalkyl-, I) hydroxyl, J) C.sub.1-C.sub.6hydroxyalkyl-, K) H.sub.2N--, L) (C.sub.1-C.sub.6alkyl)amino-, M) di(C.sub.1-C.sub.6alkyl)amino-, N) HO.sub.2C--, O) (C.sub.1-C.sub.6alkoxy)carbonyl-, P) (C.sub.1C.sub.6alkyl)carboxyl-, Q) (C.sub.1-C.sub.6alkyl)amido-, R) H.sub.2NC(O)--, S) (C.sub.1-C.sub.6alkyl)carboxyamido-, T) 5-10 membered C.sub.1-C.sub.9heteroaryl, U) C.sub.6-C.sub.14ary, V) C.sub.3-C.sub.8cycloalkyl W) 3-10 membered C.sub.1-C.sub.9heterocyclyl, X) NC--; and Y) --NO.sub.2; iv) C.sub.3-C.sub.10cycloalkyl, v) C.sub.1-C.sub.6alkyl, vi) C.sub.2-C.sub.6alkenyl, vii) C.sub.2-C.sub.6alkynyl, viii) C.sub.1-C.sub.6hydroxyalkyl-, ix) (CH.sub.2).sub.vO(C.sub.1-C.sub.6alkyl), x) (CH.sub.2).sub.vNH.sub.2, xi) (CH.sub.2).sub.vNH(C.sub.1-C.sub.6alkyl), xii) (CH.sub.2).sub.vN(C.sub.1-C.sub.6alkyl).sub.2, xiii) O(CH.sub.2).sub.vN(C.sub.1-C.sub.6alkyl).sub.2, xiv) (CH.sub.2).sub.vC.sub.6-C.sub.10aryl, xv) --CN, xvi) (CH.sub.2).sub.v 5-10 membered C.sub.1-C.sub.9heteroaryl, xvii) (CH.sub.2).sub.v 3-10 membered C.sub.1-C.sub.9heterocyclyl, optionally substituted by C.sub.1-C.sub.6alkyl-, wherein v is 1, 2, 3 or 4, and xviii) C.sub.1-C.sub.6 perfluoroalkyl-; and n) C(O)R.sup.c wherein R.sup.c is: i) H, ii) C.sub.1-C.sub.6alkyl, or iii) C.sub.3-C.sub.6cycloalkyl, and pharmaceutically acceptable salts thereof. 2. The compound of claim 1 wherein R.sup.1 is ##STR00040## 3. The compound of claim 2 wherein R.sup.2 is optionally substituted C.sub.6-C.sub.14aryl-NH--COR.sup.3. 4. The compound of claim 3 wherein R.sup.2 is optionally substituted phenyl-NH--COR.sup.3. 5. The compound of claim 4 wherein R.sup.3 is NHR.sup.5. 6. The compound of claim 5 wherein R.sup.5 is optionally substituted phenyl or C.sub.1-C.sub.9heteroaryl. 7. The compound of claim 6 wherein R.sup.5 is phenyl substituted with --Y-Q. 8. The compound of claim 7 wherein --Y-- is C(O). 9. The compound of claim 8 wherein Q is 3-10 membered C.sub.1-C.sub.9heterocyclyl, substituted with di(C.sub.1-C.sub.6alkyl)amino-. 10. The compound of any of claims 1-9 wherein R.sup.4 is ##STR00041## and pharmaceutically acceptable salts thereof. 11. The compound of claim 10 wherein R.sup.4 is ##STR00042## and pharmaceutically acceptable salts thereof. 12. The compound selected from the group consisting of: 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-4-ylurea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-3-ylurea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-phenylurea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-thiophen-2-ylurea- ; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-methylphenyl)- urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-fluorophe- nyl)urea; 1-(2,4-dimethoxyphenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin- -2-yl)phenyl]-urea; 1-(4-chlorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]u- rea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-methoxyphe- nyl)urea; (4-chlorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)p- henyl]urea; (2,4-difluorophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl- ]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-ethylurea; tert-butyl 3-{[4-(4-{[(4-fluorophenyl)carbamoyl]amino}phenyl)-6-morpholin-4-yl-1,3,5- -triazin-2-yl]amino}azetidine-1-carboxylate; tert-butyl 3-[(4-morpholin-4-yl-6-{4-[(phenylcarbamoyl)amino]phenyl}1-1,3,5-triazin-- 2-yl)amino]azetidine-1-carboxylate; tert-butyl 3-[(4-morpholin-4-yl-6-{4-[(pyridine-3-ylcarbamoyl)amino]phenyl}1-1,3,5-t- riazin-2-yl)amino]azetidine-1-carboxylate; tert-butyl 3-{[4-(4-{[(4-methylphenyl)carbamoyl]amino}phenyl)-6-morpholin-4-yl-1,3,5- -triazin-2-yl]amino}azetidine-1-carboxylate; 1-{4-[4-(azetidin-3-ylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}1- -3-phenylurea; 1-{4-[4-(azetidin-3-ylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}1- -3-pyridin-3-ylurea; 1-{4-[4-(azetidin-3-ylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}1- -3-(4-fluorophenyl)urea; 1-{4-[4-(azetidin-3-ylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}1- -3-(4-methylphenyl)urea; tert-butyl 3-[(4-morpholin-4-yl-6-{4-[(pyridine-4-ylcarbamoyl)amino]phenyl}1-1,3,5-t- riazin-2-yl)amino]azetidine-1-carboxylate; 1-{4-[4-(azetidin-3-ylamino)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-- 3-pyridin-4-ylurea 1-[2-(dimethylamino)ethyl]-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-- morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(2-methylpyridin-- 4-yl)urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(2-h- ydroxyethyl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(hydroxymethyl- )phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-hydroxyphenyl]- urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydrox- yethyl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(trifluorometh- yl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-hydroxyphenyl)- urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[5-(trifluor- omethyl)pyridin-2-yl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[2,2,2-trifluo- ro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[3-(1-hydroxyethy- l)phenyl]urea; methyl 4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)be- nzoate; 1-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)-1,3,5-triaz- in-2-yl]phenyl}-3-pyridin-4-ylurea; 1-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)-1,3,5-triazin-2-yl- ]phenyl}-3-phenylurea; 1-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)-1,3,5-triazin-2-yl- ]phenyl}-3-pyridin-3-ylurea; 1-[4-(hydroxymethyl)phenyl]-3-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran- -4-yloxy)-1,3,5-triazin-2-yl]phenyl}urea; 1-(2-methylpyridin-4-yl)-3-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-- yloxy)-1,3,5-triazin-2-yl]phenyl}urea; 1-[2-(methylamino)ethyl]-3-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-- yloxy)-1,3,5-triazin-2-yl]phenyl}urea; 1-(3-acetylphenyl)-3-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yloxy)- -1,3,5-triazin-2-yl]phenyl}urea; 1-[4-(dimethylamino)phenyl]-3-{4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran- -4-yloxy)-1,3,5-triazin-2-yl]phenyl}urea; 4-[3-{4-(4,6-dimorpholino-1,3,5-triazin-2yl )phenyl}ureido]benzoic acid; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)p- henyl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)p- henyl)ureido)benzamide HCI salt; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazin- e-1-carbonyl)phenyl)urea; 4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-methylbenza- mide; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2- -yl)phenyl)ureido)-N-methylbenzamide; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-morpholinopiper- idine-1-carbonyl)phenyl)urea; 4-(3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)ureido)-N-(quinuclidi- n-3-yl)benzamide; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-(pyrrolidin-1-y- l)piperidine-1-carbonyl)phenyl)urea; 1-(4-(1,4'-bipiperidine-1'-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-- triazin-2-yl)phenyl)urea; 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholi- no-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(piperazine-1-carb- onyl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-(pyridin-2-yl)a- cetyl)phenyl)urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(1-hydroxyethy- l)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(2-methylpyridin-- 4-yl)urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(hyd- roxymethyl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(trifluorometh- yl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[2,2,2-trifluo- ro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl}urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[5-(trifluorometh- yl)pyridin-2-yl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[3-(1-hydroxyethy- l)phenyl]urea; 1-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl- }phenyl)-3-pyridin-4-ylurea; 1-[4-(2-hydroxyethyl)phenyl]-3-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morp- holin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 1-[4-(2-hydroxymethyl)phenyl]-3-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-mor- pholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 1-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl- }phenyl)-3-(2-methylpyridin-4-yl)urea; 1-[4-(1-hydroxyethyl)phenyl]-3-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morp- holin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 1-[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-- 4-ylurea; methyl 4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl- }-amino)benzoate; 1-[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-m- ethylpiperazin-1-yl)carbonyl]phenyl}urea; 4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl- }amino)-N-(1-methylpiperidin-4-yl)benzamide; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(1-methylpiperidi- n-4-yl)urea; 1-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl- }phenyl)-3-(1-methylpiperidin-4-yl)urea; 1-{4-[4-(3,6-Dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-[1,3,5]triazin-2-yl]- -phenyl}-3-pyridin-4-yl-urea; 1-{4-[4-Morpholin-4-yl-6-(tetrahydro-pyran-4-yl)-[1,3,5]triazin-2-yl]-phe- nyl}-3-pyridin-4-yl-urea; 3-({4-Morpholin-4-yl-6-[4-(3-pyridin-4-yl-ureido)-phenyl]-[1,3,5]triazin-- 2-ylamino}-methyl)-azetidine-1-carboxylic acid tert-butyl ester; 1-(4-{4-[(azetidin-3-ylmethyl)amino]-6-morpholin-4-yl-[1,3,5]triazin-2-yl- }-phenyl)-3-pyridin-4-yl-urea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-pyridin-4-ylurea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-pyridin-3-ylurea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-phenylurea; 1-[4-(dimethylamino)phenyl]-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6- -morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-cyanophenyl)-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin- -4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-(2-methylpyridin-4-yl)urea; 1-[2-(dimethylamino)ethyl]-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-- morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-[4-(4-morpholin-4-yl-6-quinolin-3-yl-1,3,5-triazin-2-yl)phenyl]-3-pyrid- in-4-ylurea; 1-[4-(4-azetidin-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyrid- in-4-ylurea; methyl 4-({[4-(4-azetidin-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbam- oyl}amino)benzoate; 1-[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-m- ethylpiperazin-1-yl)carbonyl]phenyl}urea; 4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl- }amino)-N-(1-methylpiperidin-4-yl)benzamide; 4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)-N- -(2-piperidin-1-ylethyl)benzamide; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(morpholin-4-y- lcarbonyl)phenyl]urea; 1-[4-(4-methyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-4-yl- urea; 4-({[4-(4-methyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoy- l}amino)benzoate; 1-{4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]p- henyl}1-3-{4-[(4-methylpiperazin-1-yl)carbonyl] phenyl}urea; 4-({[4-(4-methyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}ami- no)-N-(1-methylpiperidin-4-yl)benzamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-({[4-(4-methyl-6-morpholin-4-yl-1,3- ,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; 1-[4-(4-methyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-methy- lpiperazin-1-yl)carbonyl]phenyl}urea; 1-(4-{[3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorp- holin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-({4-[2-(dimethylamino)ethyl]piperazin-1-yl}carbonyl)phenyl]-3-[4-(4,- 6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-pyrrolidin- -1-ylpiperidin-1-yl)carbonyl]phenyl}urea; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)benzoic acid; N-[2-(dimethylamino)ethyl]-4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,5-tr- iazin-2-yl)phenyl]carbamoyl}amino)-N-methylbenzamide; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-4-ylu- rea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-isopropoxy-6-morpholin-4-yl-1,3,- 5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)benzoate; 4-({[4-(4-azetidin-1-yl-6-morpholin-4-yl-1,3,5-triazin-2y1)phenyl] carbamoyl} amino) benzoic acid; mp 204 .degree. C.; 1-[4-(4-azetidin-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(- 4-methylpiperazin-1-yl)carbonyl]phenyl}urea; mp 170 .degree. C.; 4-({[4-(4-azetidin-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbam- oyl}amino)-N-[2-(dimethylamino)ethyl]-N-methylbenzamide; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-[2-(dimethylamino)ethyl]-N-methylbenzamide; 1-{4-[4-(1-ethoxyvinyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-pyr- idin-4-ylurea; 1-{4-[4-(2-methoxyethoxy)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-p- yridin-4-ylurea; 1-[4-(4-acetyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-4-yl- urea; methyl 4-[({4-[4-(2-methoxyethoxy)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}ca- rbamoyl)amino]benzoate; 1-{4-[4-(1-hydroxyethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-py- ridin-4-ylurea; methyl 4-[({4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl- ]phenyl}carbamoyl)amino]benzoate; 4-[({4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl- ]phenyl}carbamoyl)amino]benzoic acid; 1-(4-{4-morpholin-4-yl-6-[2-(pyridin-4-ylamino)ethyl]-1,3,5-triazin-2-yl}- phenyl)-3-pyridin-4-ylurea; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-[2-(dimethylamino)ethyl]benzamide; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-methyl- piperazin-1-yl)carbonyl]phenyl}urea; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-methyl- piperazin-1-yl)carbonyl]phenyl}urea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin- -2-yl)phenyl]carbamoyl}amino)benzamide; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4-ethyl-6-m- orpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(hydroxyme- thyl)phenyl]urea; 4-[({4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl- ]phenyl}carbamoyl)amino]-N-[2-(dimethylamino)ethyl]-N-methylbenzamide; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-{[4-(dimet- hylamino)piperidin-1-yl]carbonyl}phenyl)urea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin- -2-yl)phenyl]carbamoyl}amino)-N-methylbenzamide; N-[2-(dimethylamino)ethyl]-4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)-N-methylbenzamide; N-[2-(dimethylamino)ethyl]-4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)benzamide; 4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}am- ino)-N-methyl-N-[2-(methylamino)ethyl]benzamide; 1-[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3{4-[(4-methy- lpiperazin-1-yl)carbonyl]phenyl}urea; 1-{4-[(3,3-dimethylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-methoxy-6-morp- holin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}am- ino)-N-(2-piperidin-1-ylethyl)benzamide; 4-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-({[2-(dime- thylamino)ethyl]amino}methyl)phenyl]urea; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-[4-(4-methylpiperazin-1-yl)phenyl]benzamide; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-methyl- piperazin-1-yl)methyl]phenyl}urea; 1-[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-formylphen- yl)urea; 4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}- amino)-N-(pyridin-2-ylmethyl)benzamide; 1-(4-{4-[2-(1,3-dioxan-2-yl)ethyl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}ph- enyl)-3-pyridin-4-ylurea; 1-(4-{4-[2,5-bis(hydroxymethyl)pyrrolidin-1-yl]-6-morpholin-4-yl-1,3,5-tr- iazin-2-yl}phenyl)-3-pyridin-4-ylurea; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-{4-[2-(dimethylamino)ethoxy]phenyl}benzamide; 1-{4-[(4-benzylpiperidin-1-yl)carbonyl]phenyl}-3-[4-(4-butyl-6-morpholin-- 4-yl-1,3,5-triazin-2-yl)phenyl]urea; 4-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-(1-methylpiperidin-4-yl)benzamide; 4-({[4-(4-butyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-(1-methylpiperidin-4-yl)benzamide; 1-(4-{4-[3-(dimethylamino)propyl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phe- nyl)-3-pyridin-4-ylurea; 1-[4-(4-{3-[(1-methylethyl)amino]propyl}-6-morpholin-4-yl-1,3,5-triazin-2- -yl)phenyl]-3-pyridin-4-ylurea; 1-{4-[4-morpholin-4-yl-6-(3-pyrrolidin-1-ylpropyl)-1,3,5-triazin-2-yl]phe- nyl}-3-pyridin-4-ylurea; 1-(4-{4-[3-(4-methylpiperazin-1-yl)propyl]-6-morpholin-4-yl-1,3,5-triazin- -2-yl}phenyl)-3-pyridin-4-ylurea; 1-{4-[4-(3-{[2-(dimethylamino)ethyl]amino}propyl)-6-morpholin-4-yl-1,3,5-- triazin-2-yl]phenyl}-3-pyridin-4-ylurea; 1-{4-[4-(3-hydroxypropyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-p- yridin-4-ylurea; 1-{4-[4-morpholin-4-yl-6-(3-oxopropyl)-1,3,5-triazin-2-yl]phenyl}-3-pyrid- in-4-ylurea; 1-{4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]p- henyl}-3-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)urea; 4-[({4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl- ]phenyl}carbamoyl)amino]-N-[2-(dimethylamino)ethyl]benzamide; 1-[4-(4-methylpiperazin-1-yl)phenyl]-3-[4-(4-morpholin-4-yl-6-propyl-1,3,- 5-triazin-2-yl)phenyl]urea; 1-{4-[2-(dimethylamino)ethoxy]phenyl}-3-[4-(4-ethyl-6-morpholin-4-yl-1,3,- 5-triazin-2-yl)phenyl]urea; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-(4-methylp- iperazin-1-yl)phenyl]urea; 1-[4-(4-methylpiperazin-1-yl)phenyl]-3-{4-[4-(2-methylpropyl)-6-morpholin- -4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[(3,3-dimethylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-ethyl-6-morpho- lin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 4-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-(1-methylazetidin-3-yl)benzamide; methyl 4-[({4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}carb- amoyl)amino]benzoate N-[2-(dimethylamino)ethyl]-4-[({4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3- ,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-(1-methylethyl)-6-morpholin- -4-yl-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; N-(1-methylazetidin-3-yl)-4-[({4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,- 5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-(1-methyl- ethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 4-[({4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}carb- amoyl)amino]-N-pyridin-4-ylbenzamide; 4-[({4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}carb- amoyl)amino]-N-pyridin-3-ylbenzamide; N-cyclobutyl-4-[({4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-y- l]phenyl}carbamoyl)amino]benzamide; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-phenyl- piperidin-1-yl)carbonyl]phenyl}urea; 4-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)-N-(pyridin-4-ylmethyl)benzamide; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-(2-methylpropyl)-6- -morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-(2-methyl- propyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-(2-methylpropyl)-6-morpholi- n-4-yl-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-{4- -[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-(4-methylphenyl)-6-morpholi- n-4-yl-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}-3-{4-[4-(4-methylphenyl)-6-- morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-py- ridin-4-ylurea; 1-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}-3-[4-(4-ethyl-6-morpholin-4- -yl-1,3,5-triazin-2-yl)phenyl]urea; 4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoic acid; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-[4- -(4-methylpiperazin-1-yl)phenyl]urea; methyl 4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoate; 1-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}-3-[4-(4-morpholin-4-yl-6-ph- enyl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-4-yl- urea; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-morp- holin-4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(pyrid- in-4-yl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(pyrid- in-3-yl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- methylpiperazin-1-yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(6-(4-- methylpiperazin-1-yl)pyridin-3-yl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-((d- imethylamino)methyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- (dimethylamino)ethoxy)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- (pyrrolidin-1-yl)ethoxy)phenyl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(pyridin-3-yl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(4-(piperazin-1-yl)phenyl)urea; 1-(4-(4-((R)-3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(4-((S)-3-methylpiperazin-1-yl)phenyl)urea; 1-(4-(4-((R)-3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(4-((R)-3-methylpiperazin-1-yl)phenyl)urea; 1-(4-((3R,5S)-3,5-dimethylpiperazin-1-yl)phenyl)-3-(4-(4-((R)-3-methylmor- pholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(2-(dimethylamino)ethoxy)phenyl)-3-(4-(4-(3-methylmorpholino)-6-- (tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-ethylpiperazin-1-yl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(t- etrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-isopropylpiperazin-1-yl)phenyl)-3-(4-(4-(3-methylmorpholino)-- 6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-3-(4-(4-(3-methylmorpho- lino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; (R)-1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmorph- olino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- ethylpiperazin-1-yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- isopropylpiperazin-1-yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- (dimethylamino)piperidin-1-yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- isopropylpiperazine-1-carbonyl)phenyl)urea; 4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)ureido- )-N,N-dimethylbenzamide; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(py- rrolidin-1-ylmethyl)phenyl)urea; 4-({[4-(4-{4-[(methylcarbamoyl)amino]phenyl}-6-morpholin-4-yl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)benzamide; 1-{4-[4-(3,5-dimethylmorpholin-4-yl)-6-{4-[(methylcarbamoyl)amino]phenyl}- -1,3,5-triazin-2-yl]phenyl}-3-pyridin-3-ylurea; 3-({[4-(4-{4-[(methylcarbamoyl)amino]phenyl}-6-morpholin-4-yl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)benzamide; 1-methyl-3-[4-(4-morpholin-4-yl-6-{4-[(pyridin-3-ylcarbamoyl)amino]phenyl- }-1,3,5-triazin-2-yl)phenyl]urea; 1-methyl-3-[4-(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl- }-1,3,5-triazin-2-yl)phenyl]urea; 3-[({4-[4-(3,5-dimethylmorpholin-4-yl)-6-{4-[(methylcarbamoyl)amino]pheny- l}-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 4-[({4-[4-(3,5-dimethylmorpholin-4-yl)-6-{4-[(methylcarbamoyl)amino]pheny- l}-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[4-(3,5-dimethylmorpholin-4-yl)-6-{4-[(methylcarbamoyl)amino]phenyl}- -1,3,5-triazin-2-yl]phenyl}-3-pyridin-4-ylurea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-methylurea; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-morpholin- -4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-morpholin-4-yl-6-[- (3S)-tetrahydrofuran-3-yloxy]-1,3,5-triazin-2-yl}phenyl)urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-pyridazin-4-ylure- a; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-morpholin-4-yl-6- -(oxetan-3-yloxy)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-d- imorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-d- imorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-(4-isopropyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-me- thylpiperazin-1-yl)carbonyl]phenyl}urea; 1-{4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-(4-- pyrimidin-5-ylphenyl)urea; 1-(4-{4-[(2,2-dimethoxyethyl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl}p- henyl)-3-pyridin-3-ylurea; 1-{4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-(4-- pyridin-4-ylphenyl)urea; 1-(4-iodophenyl)-3-{4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2- -yl]phenyl}urea; 1-{4-[4-(1-methylethyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-(4-- {[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)urea; 1-[4-(4-azetidin-1-yl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-{[- 4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)urea; 1-{4-[2-(dimethylamino)pyrimidin-5-yl]phenyl}-3-{4-[4-(1-methylethyl)-6-m- orpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; tert-butyl 3-[(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}-1,3,5-tri- azin-2-yl)oxy]azetidine-1-carboxylate; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorph- olin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-nitrophenyl)ur- ea; 1-(4-aminophenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl- ]urea; N-[4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl- }amino)phenyl]-4-methylpiperazine-1-carboxamide; 4-(dimethylamino)-N-[4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phen- yl]carbamoyl}amino)phenyl]piperidine-1-carboxamide; 1-[2-(dimethylamino)ethyl]-3-[4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-- 2-yl)phenyl]carbamoyl}amino)phenyl]-1-methylurea; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-{[(2-piperidin- -1-ylethyl)carbamoyl]amino}phenyl)urea; N-[4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino- )phenyl]-4-methyl-1,4-diazepane-1-carboxamide; N-[4-({[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino- )phenyl]-4-ethylpiperazine-1-carboxamide; 1-{4-[(dimethylcarbamoyl)amino]phenyl}-3-[4-(4,6-dimorpholin-4-yl-1,3,5-t- riazin-2-yl)phenyl]urea; 1-{4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]p- henyl}-3-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)urea; 4-[({4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl- ]phenyl}carbamoyl)amino]-N-[2-(dimethylamino)ethyl]-N-methylbenzamide; 1-{4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]p- henyl}-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; 4-[({4-[4-(3,6-dihydro-2H-pyran-4-yl)-6-morpholin-4-yl-1,3,5-triazin-2-yl- ]phenyl}carbamoyl)amino]-N-[2-(dimethylamino)ethyl]benzamide; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-morpholin- -4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; N-[2-(dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyra- n-4-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 4-[({4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]- phenyl}carbamoyl)amino]-N-(2-pyrrolidin-1-ylethyl)benzamide; 4-[({4-[4-morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]- phenyl}carbamoyl)amino]-N-(2-piperidin-1-ylethyl)benzamide; 1-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-(4-{[4-(1-methyle- thyl)piperazin-1-yl]carbonyl}phenyl)urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-{[(4-{4-morpholin-4-yl-6-[(3S)-tetr- ahydrofuran-3-yloxy]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; 4-{[(4-{4-morpholin-4-yl-6-[(3S)-tetrahydrofuran-3-yloxy]-1,3,5-triazin-2- -yl}phenyl)carbamoyl]amino}-N-(2-piperidin-1-ylethyl)benzamide; 4-{[(4-{4-morpholin-4-yl-6-[(3S)-tetrahydrofuran-3-yloxy]-1,3,5-triazin-2- -yl}phenyl)carbamoyl]amino}-N-(2-pyrrolidin-1-ylethyl)benzamide; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-(4-{4-morpholin- -4-yl-6-[(3S)-tetrahydrofuran-3-yloxy]-1,3,5-triazin-2-yl}phenyl)urea; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-{4-[4-morpholin- -4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-6-(tetrahydr- o-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 4-[({4-[4-(2-methylpropyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoic acid; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-[4- -(4-methylpiperazin-1-yl)phenyl]urea; 4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoic acid; methyl 4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoate; 1-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}-3-[4-(4-ethyl-6-morpholin-4- -yl-1,3,5-triazin-2-yl)phenyl]urea; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-py- ridin-4-ylurea; 1-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}-3-{4-[4-(4-methylphenyl)-6-- morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-(4-methylphenyl)-6-morpholi- n-4-yl-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-{4- -[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-pyridi- n-2-ylpiperazin-1-yl)carbonyl]phenyl}urea; 1-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}1-3-[4-(4-morpholin-4-yl-6-p- henyl-1,3,5-triazin-2-yl)phenyl]urea; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-methyl- piperazin-1-yl)carbonyl]phenyl}urea; 1-[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]-3-pyridin-4-yl- urea; methyl 4-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]carbamoyl}ami- no)benzoate; N-[2-(dimethylamino)ethyl]-N-methyl-4-({[4-(4-morpholin-4-yl-6-phenyl-1,3- ,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; methyl 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)ca- rbamoyl]amino}benzoate; 4-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]carbamoyl}ami- no)benzoic acid; N-[2-(dimethylamino)ethyl]-4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,- 3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-morpholin-4-yl-6-p- henyl-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4-morpholin- -4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]urea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazi- n-2-yl)phenyl]carbamoyl}amino)benzamide; 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)ca- rbamoyl]amino}-N-[2-(dimethylamino)ethyl]benzamide; 1-{4-[(4-isopropylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-(4-methylphenyl- )-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]-N-(2-pyrrolid in-1-ylethyl)benzamide; 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)ca- rbamoyl]amino}benzoic acid; N-(2-methoxyethyl)-4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-tria- zin-2-yl]phenyl}carbamoyl)amino]benzamide; N-(2-methoxyethyl)-4-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)p- henyl]carbamoyl}amino)benzamide; 4-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]carbamoyl}ami- no)-N-(2-pyrrolidin-1-ylethyl)benzamide; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-[4- -(pyrrolidin-1-ylcarbonyl)phenyl]urea; N-[3-(dimethylamino)propyl]-4-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1- ,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-[4- -(piperidin-1-ylcarbonyl)phenyl]urea; N-[3-(dimethylamino)propyl]-4-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)benzamide; 1-{4-[4-morpholin-4-yl-6-(2-thienyl)-1,3,5-triazin-2-yl]phenyl}-3-pyridin- -4-ylurea; 4-[({4-[4-morpholin-4-yl-6-(2-thienyl)-1,3,5-triazin-2-yl]pheny- l}carbamoyl)amino]benzoic acid; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-morpholin-4-yl-6-(- 2-thienyl)-1,3,5-triazin-2-yl]phenyl}urea; methyl 4-[({4-[4-morpholin-4-yl-6-(2-thienyl)-1,3,5-triazin-2-yl]phenyl}carbamoy- l)amino]benzoate; N-(2-methoxyethyl)-4-[({4-[4-morpholin-4-yl-6-(2-thienyl)-1,3,5-triazin-2- -yl]phenyl}carbamoyl)amino]benzamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-6-(2-thienyl- )-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; N-[2-(dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-6-(2-thienyl)-1,3,5-t- riazin-2-yl]phenyl}carbamoyl)amino]benzamide; 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)ca- rbamoyl]amino}-N-[2-(dimethylamino)ethyl]-N-methylbenzamide; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-{- 4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; 1-{4-[4-morpholin-4-yl-6-(1,4-oxazepan-4-yl)-1,3,5-triazin-2-yl]phenyl}-3- -pyridin-4-ylurea; methyl 4-[({4-[4-morpholin-4-yl-6-(1,4-oxazepan-4-yl)-1,3,5-triazin-2-yl]phenyl}- carbamoyl)amino]benzoate; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-morpholin- -4-yl-6-(2-thienyl)-1,3,5-triazin-2-yl]phenyl}urea; 4-[({4-[4-morpholin-4-yl-6-(1,4-oxazepan-4-yl)-1,3,5-triazin-2-yl]phenyl}- carbamoyl)amino]benzoic acid; N-[3-(dimethylamino)propyl]-4-[({4-[4-morpholin-4-yl-6-(2-thienyl)-1,3,5-- triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-[- 4-(pyrrolidin-1-ylcarbonyl)phenyl]urea; N-[2-(dimethylamino)ethyl]-4-[({4-[4-morpholin-4-yl-6-(1,4-oxazepan-4-yl)- -1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-morpholin-4-yl-6-(- 1,4-oxazepan-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; N-(2-methoxyethyl)-4-[({4-[4-morpholin-4-yl-6-(1,4-oxazepan-4-yl)-1,3,5-t- riazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-morpholin-4-yl-6-(2- -thienyl)-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-{3- -[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; 3-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoic acid; methyl 3-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}car- bamoyl)amino]benzoate; 1-(3-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-{4-[4-(4-methyl- phenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; N-[2-(dimethylamino)ethyl]-N-methyl-3-[({4-[4-(4-methylphenyl)-6-morpholi- n-4-yl-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; methyl 3-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)benzoate; methyl 3-({[4-(4-morpholin-4-yl-6-thiophen-2-yl-1,3,5-triazin-2-yl)phenyl]carbam- oyl}amino)benzoate; N-[2-(dimethylamino)ethyl]-3-[({4-[4-(4-methylphenyl)-6-morpholin-4-yl-1,- 3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-6-(1,4-oxaze- pan-4-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 3-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amin- o)benzoic acid; methyl 3-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]carbamoyl}ami- no)benzoate; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{3-[(4-pyridi- n-2-ylpiperazin-1-yl)carbonyl]phenyl}urea; N-[2-(dimethylamino)ethyl]-3-({[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin- -2-yl)phenyl]carbamoyl}amino)-N-methylbenzamide; 1-[4-(4-ethyl-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{3-[(4-methyl- piperazin-1-yl)carbonyl]phenyl}urea; 3-({[4-(4-morpholin-4-yl-6-phenyl-1,3,5-triazin-2-yl)phenyl]carbamoyl}ami- no)benzoic acid; methyl 4-({[4-(4-morpholin-4-yl-6-piperid in-1-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzoate; 1-[4-(4-morpholin-4-yl-6-piperidin-1-yl-1,3,5-triazin-2-yl)phenyl]-3-pyri- din-4-ylurea; 4-({[4-(4-morpholin-4-yl-6-piperidin-1-yl-1,3,5-triazin-2-yl)phenyl]carba- moyl}amino)benzoic acid; methyl 4-({[4-(4-morpholin-4-yl-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]carb- amoyl}amino)benzoate; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-[4-(4-morpholin- -4-yl-6-piperidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}1-3-[4-(4-morpholin-4-yl-6-p- iperidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-morpholin-4-yl-6-p- iperidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4-morpholin- -4-yl-6-piperid in-1-yl-1,3,5-triazin-2-yl)phenyl]urea; 4-({[4-(4-morpholin-4-yl-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]carb- amoyl}amino)benzoic acid; 1-[4-(4-morpholin-4-yl-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]-3-pyr- idin-4-ylurea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-morpholin-4-yl-6-piperidin-1-yl-1,3,- 5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4-morpholin- -4-yl-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-[4-(4-morpholin- -4-yl-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-({[4-(4-morpholin-4-yl-6-pyrrolidin- -1-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-({[4-(4-morpholin-4-yl-6-piperidin-- 1-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-morpholin-4-yl-6-py- rrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-morpholin-4-yl-6-p- yrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]urea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-morpholin-4-yl-6-pyrrolidin-1-yl-1,3- ,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-p- yridin-4-ylurea; N-[3-(dimethylamino)propyl]-4-({[4-(4-morpholin-4-yl-6-piperidin-1-yl-1,3- ,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; N-(2-methoxyethyl)-4-({[4-(4-morpholin-4-yl-6-piperid in-1-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}amino)benzamide; 1-[4-(4-morpholin-4-yl-6-pyrrolidin-1-yl-1,3,5-triazin-2-yl)phenyl]-3-[4-- (pyrrolidin-1-ylcarbonyl)phenyl]urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-{- 4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-(- 4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)urea; methyl 4-{[(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-- yl}phenyl)carbamoyl]amino}benzoate; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-(- 4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)urea; 1-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl- }phenyl)-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-(4-{4-[(3S)-3-m- ethylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 4-{[(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-- yl}phenyl)carbamoyl]amino}benzoic acid; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[(3S)-3-methylmorph- olin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; N-[3-(dimethylamino)propyl]-4-{[(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-mor- pholin-4-yl-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; 4-{[(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-morpholin-4-yl-1,3,5-triazin-2-- yl}phenyl)carbamoyl]amino}-N-(2-pyrrolidin-1-ylethyl)benzamide; 1-(4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1,3- ,5-triazin-2-yl}phenyl)-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea- ; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-- (4-{[4-(dipropylamino)piperidin-1-yl]carbonyl}phenyl)urea; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[(3R)-3-methylmorph- olin-4-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)urea; 4-{[(4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1- ,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzoic acid; 1-{4-[(4-butylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[(3R)-3-methylmorph- olin-4-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)urea; methyl 4-{[(4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[(3S)-3-methylmorpholin-- 4-yl]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzoate; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-{- 4-[(4-butylpiperazin-1-yl)carbonyl]phenyl}urea; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-(4-{4-[(3R)-3-m- ethylmorpholin-4-yl]-6-[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}ph- enyl)urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}p- henyl)-3-(4-{[4-(2-methylpropyl)piperazin-1-yl]carbonyl}phenyl)urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-(- 4-{[4-(1-methylpropyl)piperazin-1-yl]carbonyl}phenyl)urea; 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)ca- rbamoyl]amino}-N-[2-(4-methylpiperazin-1-yl)ethyl]benzamide; N-[2-(dimethylamino)ethyl]-4-{[(4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[(3S- )-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzam- ide; 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}pheny- l)carbamoyl]amino}-N-(2-pyrrolidin-1-ylethyl)benzamide; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-{- 4-[(4-propylpiperidin-1-yl)carbonyl]phenyl}urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-[- 4-(piperidin-1-ylcarbonyl)phenyl]urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-{- 4-[(4-propylpiperazin-1-yl)carbonyl]phenyl}urea; 4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)ca- rbamoyl]amino}-N-(2-methoxyethyl)benzamide; 1-{4-[4-morpholin-4-yl-6-(4-tricyclo[3.3.1.13,7]dec-1-ylpiperazin-1-yl)-1- ,3,5-triazin-2-yl]phenyl}1-3-pyridin-4-ylurea; methyl 4-{[(4-{4-[4-(dimethylcarbamoyl)piperazin-1-yl]-6-morpholin-4-yl-1,3,5-tr- iazin-2-yl}phenyl)carbamoyl]amino}benzoate; N,N-dimethyl-4-(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]pheny- l}1-1,3,5-triazin-2-yl)piperazine-1-carboxamide; N,N-dimethyl-4-(4-{4-[({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}carbam- oyl)amino]phenyl}-6-morpholin-4-yl-1,3,5-triazin-2-yl)piperazine-1-carboxa- mide; N, N-dimethyl-4-{4-morpholin-4-yl-6-[4-({[4-(pyridazin-4-ylcarbamoyl- )phenyl]carbamoyl}amino)phenyl]-1,3,5-triazin-2-yl}piperazine-1-carboxamid- e; N,N-dimethyl-4-(4-morpholin-4-yl-6-{4-[({4-[(4-propylpiperidin-1-yl)car- bonyl]phenyl}carbamoyl)amino]phenyl}1,3,5-triazin-2-yl)piperazine-1-carbox- amide; 4-{[(4-{4-[4-(dimethylcarbamoyl)piperazin-1-yl]-6-morpholin-4-yl-1,- 3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzoic acid; 4-(4-{4-[({4-[(2-methoxyethyl)carbamoyl]phenyl}carbamoyl)amino]phenyl}-6-- morpholin-4-yl-1,3,5-triazin-2-yl)-N,N-dimethylpiperazine-1-carboxamide; 4-[4-(4-{[(4-{[2-(dimethylamino)ethyl](methyl)carbamoyl}phenyl)carbamoyl]- amino}phenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]-N,N-dimethylpiperazine-- 1-carboxamide; 4-(4-{4-[({4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}carbamoyl)amino]phen- yl}-6-morpholin-4-yl-1,3,5-triazin-2-yl)-N,N-dimethylpiperazine-1-carboxam- ide; 1-(4-{4-[4-(ethylsulfonyl)piperazin-1-yl]-6-morpholin-4-yl-1,3,5-tria- zin-2-yl}phenyl)-3-pyridin-4-ylurea; methyl 4-{[(4-{4-[4-(ethylsulfonyl)piperazin-1-yl]-6-morpholin-4-yl-1,3,5-triazi- n-2-yl}phenyl)carbamoyl]amino}benzoate; 4-{[(4-{4-[4-(ethylsulfonyl)piperazin-1-yl]-6-morpholin-4-yl-1,3,5-triazi- n-2-yl}phenyl)carbamoyl]amino}benzoic acid; N-[3-(dimethylamino)propyl]-4-{[(4-{4-[4-(ethylsulfonyl)piperazin-1-yl]-6- -morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; N-[2-(dimethylamino)ethyl]-4-{[(4-{4-[4-(ethylsulfonyl)piperazin-1-yl]-6-- morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; 4-{[(4-{4-[4-(1-methylethyl)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-tr- iazin-2-yl}phenyl)carbamoyl]amino}benzoic acid; methyl 4-{[(4-{4-[4-(acetylamino)piperidin-1-yl]-6-morpholin-4-yl-1,3,5-triazin-- 2-yl}phenyl)carbamoyl]amino}benzoate; 1-(4-{4-[4-(1-methylethyl)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-tria- zin-2-yl}phenyl)-3-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}urea; N-[1-(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}-1,3,5-t- riazin-2-yl)piperidin-4-yl]acetamide; 4-{[(4-{4-[4-(acetylamino)piperidin-1-yl]-6-morpholin-4-yl-1,3,5-triazin-- 2-yl}phenyl)carbamoyl]amino}benzoic acid; N-[2-(dimethylamino)ethyl]-4-{[(4-{4-[4-(1-methylethyl)-1,4-diazepan-1-yl- ]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; N-{1-[(4-{[(4-{4-[4-(1-methylethyl)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1- ,3,5-triazin-2-yl}phenyl)carbamoyl]amino}phenyl)carbonyl]piperidin-4-yl}ac- etamide; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[4-(1-methy- lethyl)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea- ; 1-(4-{4-[4-(1-methylethyl)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-tri- azin-2-yl}phenyl)-3-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)u- rea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)- -3-(4-{[(3S)-3-methylmorpholin-4-yl]carbonyl}phenyl)urea; 1-{4-[(4-butylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[4-(1-methylethyl)-- 1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 1-(4-{4-[(4-methylpiperazin-1-yl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-- yl}phenyl)-3-phenylurea; 1-(4-{4-[(1-methylpiperidin-4-yl)oxy]-6-morpholin-4-yl-1,3,5-triazin-2-yl- }phenyl)-3-pyridin-4-ylurea; 1-{4-[4-morpholin-4-yl-6-(piperidin-4-yloxy)-1,3,5-triazin-2-yl]phenyl}-3- -pyridin-4-ylurea; ethyl 4-[(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}1-1,3,5-tr- iazin-2-yl)oxy]piperidine-1-carboxylate; N-ethyl-4-[(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}-1- ,3,5-triazin-2-yl)oxy]piperidine-1-carboxamide; tert-butyl 4-[(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}-1,3,5-tri- azin-2-yl)oxy]piperidine-1-carboxylate; 4-[(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}-1,3,5-tri- azin-2-yl)oxy]piperidine-1-sulfonamide; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-pyridin-4-ylurea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-pyridin-3-ylurea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}-3-phenylurea; 1-[4-(dimethylamino)phenyl]-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6- -morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-cyanophenyl)-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin- -4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-morpholin-4-yl-1,3,5-triazi- n-2-yl]phenyl}1-3-(2-methylpyridin-4-yl)urea; 1-[2-(dimethylamino)ethyl]-3-{4-[4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-- morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}urea; 1-[4-(4-morpholin-4-yl-6-quinolin-3-yl-1,3,5-triazin-2-yl)phenyl]-3-pyrid- in-4-ylurea; 1-{4-[4-(2-methoxyethoxy)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-p- yridin-4-ylurea; methyl 4-[({4-[4-(2-methoxyethoxy)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}ca- rbamoyl)amino]benzoate; 1-(4-{4-morpholin-4-yl-6-[2-(pyridin-4-ylamino)ethyl]-1,3,5-triazin-2-yl}- phenyl)-3-pyridin-4-ylurea; N-[2-(dimethylamino)ethyl]-4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)-N-methylbenzamide; N-[2-(dimethylamino)ethyl]-4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triaz- in-2-yl)phenyl]carbamoyl}amino)benzamide; 4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}am- ino)-N-methyl-N-[2-(methylamino)ethyl]benzamide; 1-[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]-3-{4-[(4-meth- ylpiperazin-1-yl)carbonyl]phenyl}urea; 1-{4-[(3,3-dimethylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(4-methoxy-6-morp- holin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 4-({[4-(4-methoxy-6-morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]carbamoyl}am- ino)-N-(2-piperidin-1-ylethyl)benzamide; 1-(4-{4-[2,5-bis(hydroxymethyl)pyrrolidin-1-yl]-6-morpholin-4-yl-1,3,5-tr- iazin-2-yl}phenyl)-3-pyridin-4-ylurea; 1-(4-{4-[2-(1 ,3-dioxan-2-yl)ethyl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)-3-pyrid- in-4-ylurea; 1-(4-{4-[3-(dimethylamino)propyl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phe- nyl)-3-pyridin-4-ylurea; 1-[4-(4-{3-[(1-methylethyl)amino]propyl}-6-morpholin-4-yl-1,3,5-triazin-2- -yl)phenyl]-3-pyridin-4-ylurea; 1-{4-[4-morpholin-4-yl-6-(3-pyrrolidin-1-ylpropyl)-1,3,5-triazin-2-yl]phe- nyl}-3-pyridin-4-ylurea; 1-(4-{4-[3-(4-methylpiperazin-1-yl)propyl]-6-morpholin-4-yl-1,3,5-triazin- -2-yl}phenyl)-3-pyridin-4-ylurea; 1-{4-[4-(3-{[2-(dimethylamino)ethyl]amino}propyl)-6-morpholin-4-yl-1,3,5-- triazin-2-yl]phenyl}-3-pyridin-4-ylurea; 1-{4-[4-(3-hydroxypropyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-p- yridin-4-ylurea; 1-{4-[4-morpholin-4-yl-6-(3-oxopropyl)-1,3,5-triazin-2-yl]phenyl}-3-pyrid- in-4-ylurea; N-(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino]phenyl}-1,3,5-tria- zin-2-yl)benzenesulfonamide; N-{4-[4-({[4-(4-methylpiperazin-1-yl)phenyl]carbamoyl}amino)phenyl]-6-mor- pholin-4-yl-1,3,5-triazin-2-yl}benzenesulfonamide; N-(4-{4-[({4-[2-(dimethylamino)ethoxy]phenyl}carbamoyl)amino]phenyl}-6-mo- rpholin-4-yl-1,3,5-triazin-2-yl)benzenesulfonamide; N-(4-{4-[({4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}carbamoyl)amino]phe- nyl}-6-morpholin-4-yl-1,3,5-triazin-2-yl)benzenesulfonamide; N-{4-morpholin-4-yl-6-[4-({[4-(piperazin-1-ylcarbonyl)phenyl]carbamoyl}am- ino)phenyl]-1,3,5-triazin-2-yl}benzenesulfonamide; N-[4-(4-{[(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)carbamoyl]- amino}phenyl)-6-morpholin-4-yl-1,3,5-triazin-2-yl]benzenesulfonamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-{[(4-{4-morpholin-4-yl-6-[(phenylsu- lfonyl)amino]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; N-[2-(dimethylamino)ethyl]-4-{[(4-{4-morpholin-4-yl-6-[(phenylsulfonyl)am- ino]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; methyl 4-{[(4-{4-morpholin-4-yl-6-[(phenylsulfonyl)amino]-1,3,5-triazin-2-yl}phe- nyl)carbamoyl]amino}benzoate; 4-{[(4-{4-morpholin-4-yl-6-[(phenylsulfonyl)amino]-1,3,5-triazin-2-yl}phe- nyl)carbamoyl]amino}benzoic acid; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-[4-(6-morpholin-4-yl-4-o- xo-4,5-dihydro-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-(2,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,- 3,5-triazin-2-yl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropyl-2-met- hylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-cyclobutyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4,6-dimorp- holino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropyl-3-met- hylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,- 3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4,6-dimorp- holino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutylpiperazine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,- 3,5-triazin-2-yl)phenyl)urea; 1-(4-(2,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tet- rahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholin- o-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholi- no-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholin- o-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tet- rahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholi- no-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tet- rahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahy- dro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahy- dro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(3-methylpiperazin- e-1-carbonyl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-methylpiperazin- e-1-carbonyl)phenyl)urea; 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,- 3,5-triazin-2-yl)phenyl)urea; 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tet- rahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-morpholino-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl- )-3-(4-(3,3,4-trimethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-(3,3,4-trimethylpi- perazine-1-carbonyl)phenyl)urea; 1-(4-(2,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tet- rahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2- -yl)phenyl)-3-(4-(2-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-isopropyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methyl- morpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methy- lmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methyl- morpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmorpholi- no)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methy- lmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmorpholi- no)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2- -yl)phenyl)-3-(4-(3,3,4-trimethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmorpholi- no)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-(3-methylmorpholino)-6-(te- trahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-- 2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmor- pholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(2,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmorpholi- no)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(2,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmorpholi- no)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methyl- morpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-2-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methy- lmorpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-(2-methylmorpholino)-6-mor- pholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-(4-isopropyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methyl- morpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(2-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4- -(3-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3,4-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmorpholi- no)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-cyclobutyl-3-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methy- lmorpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3,3-dimethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmorpholi- no)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(2-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4- -(3,3,4-trimethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-cyclobutylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmorpholi- no)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-(2-methylmorpholino)-6-morpholino-1- ,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmor- pholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(2-methylmo- rpholino)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-morpholino-- 6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(3-methylmo- rpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-- 1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)urea; 1-(4-(4-(dimethylamino)piperidin-1-yl)phenyl)-3-(4-(4-((2R,5S)-2,5-dimeth- ylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)ur- ea; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholin- o)-1,3,5-triazin-2-yl)phenyl)-3-(4-(quinuclidin-4-yl)phenyl)urea; 1-(4-(4-cyclopropylpiperazin-1-yl)phenyl)-3-(4-(4-((2R,5S)-2,5-dimethylpy- rrolidin-1-yl)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(cyclopropylmethyl)piperazin-1-yl)phenyl)-3-(4-(4-((2R,5S)-2,5-di- methylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)pheny- l)urea; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorph- olino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-ethylpiperazin-1-yl)phenyl)urea; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-- 1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropylpiperazin-1-yl)phenyl)urea; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-- 1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea- ; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)- -1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)- urea; 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-((2R,5S- )-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-- yl)phenyl)urea; 1-(4-(4-((2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-- 1,3,5-triazin-2-yl)phenyl)-3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-cyclopropylpiperazine-1-carbonyl)phenyl)-3-(4-(4-((2R,5S)-2,5-dim- ethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl- )urea; 1-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)-3-(4-(4-((- 2R,5S)-2,5-dimethylpyrrolidin-1-yl)-6-((R)-3-methylmorpholino)-1,3,5-triaz- in-2-yl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)u- rea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-meth- ylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-(dimethylamino)piperidin-- 1-yl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(quinuclidin-4-yl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-cyclopropylpiperazin-1-yl)phe- nyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3- -methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-(cyclopropylmethyl)p- iperazin-1-yl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-ethylpiperazin-1-yl)phenyl)ur- ea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methy- lmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropylpiperazin-1-yl)ph- enyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-- 3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-- carbonyl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-isopropylpiperazine-1-carbony- l)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-(dimethylamino)piperidine-1-c- arbonyl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-ethylpiperazine-1-carbonyl)ph- enyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-- 3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-cyclopropylpiperazi- ne-1-carbonyl)phenyl)urea; 1-(4-(4-((2S,5R)-2,5-bis(hydroxymethyl)pyrrolidin-1-yl)-6-((R)-3-methylmo- rpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-(cyclopropylmethyl)piperazine- -1-carbonyl)phenyl)urea; 1-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)- -3-(pyridin-4-yl)urea; 1-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)- -3-(pyridin-3-yl)urea; 1-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)- -3-(pyridazin-4-yl)urea; 1-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)- -3-(pyrimidin-5-yl)urea; 4-(3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phen- yl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-morpholino-6-(tetrahydrofuran-3-ylo- xy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-morpholino-6-(tetrahydrofu- ran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-(2-(methylamino)ethyl)-4-(3-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy- )-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-methyl-N-(2-(methylamino)ethyl)-4-(3-(4-(4-morpholino-6-(tetrahydrofura- n-3-yloxy)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-((R)-3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-morphol- ino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-morpholino-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)- -3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahy- drofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-ethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetrahyd- rofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)-3-(4-(4-morpholino-6-(tetr- ahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazi- n-2-yl)phenyl)-3-(pyridin-4-yl)urea; 1-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazi- n-2-yl)phenyl)-3-(pyridin-3-yl)urea ; 1-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazi- n-2-yl)phenyl)-3-(pyridazin-4-yl)urea; 1-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazi- n-2-yl)phenyl)-3-(pyrimidin-5-yl)urea; 4-(3-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-tri- azin-2-yl)phenyl)ureido)benzamide; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-((S)-3-meth- ylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazi- n-2-yl)phenyl)-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-((S)-3-methylmorpholino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazi- n-2-yl)phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-ethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-((S)-3-methylmorpholin- o)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)-3-(4-(4-((S)-3-methylmorph- olino)-6-(tetrahydrofuran-3-yloxy)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- ridin-3-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- ridazin-4-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- rimidin-5-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- ridin-4-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-phe- nylurea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-chlorophenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- fluorophenyl)urea; methyl4-(3-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2y1)pheny- l)ureido) benzoate; 4-(3-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ure- ido)benzoic acid; 4-(3-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ure- ido)-N-(2-(dimethylamino)ethyl)benzamide; 4-(3-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ure- ido)-N-(2-(dimethylamino)ethyl)-N-methylbenzamide; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- (3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)urea; 4-(3-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ure- ido)benzamide; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- (piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- (4-ethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- (4-isopropylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- (4-(dimethylamino)piperidine-1-carbonyl)phenyl)urea; 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-(4-methyl-1,- 4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-n-propylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(4-methyl-1- ,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morp- holino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-(4-methyl-1,4-diazepan-1-y- l)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-phenylurea; 1-(4-chlorophenyl)-3-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,- 5-triazin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,- 5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridin-3-yl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridin-4-yl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridazin-4-yl)urea; 1-(4-(4-(4-methyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyrimidin-5-yl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-(4-n-propylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(4-ethyl-1,- 4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morph- olino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-(4-ethyl-1,4-diazepan-1-yl- )-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-phenylurea; 1-(4-chlorophenyl)-3-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5- -triazin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5- -triazin-2-yl)phenyl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyridin-3-yl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyridin-4-yl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyridazin-4-yl)urea; 1-(4-(4-(4-ethyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyrimidin-5-yl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-n-propylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(4-propyl-1- ,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; N-(2-(dimethylamino)ethyl)-4-(3-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morp- holino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; N-(2-(dimethylamino)ethyl)-N-methyl-4-(3-(4-(4-(4-propyl-1,4-diazepan-1-y- l)-6-morpholino-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-phenylurea; 1-(4-chlorophenyl)-3-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,- 5-triazin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,- 5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridin-3-yl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridin-4-yl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridazin-4-yl)urea; 1-(4-(4-(4-propyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyrimidin-5-yl)urea; 1-(4-(4-(4-isopropyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)-3-(pyridin-3-yl)urea; 1-(4-(4-(4-isopropyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)-3-(pyridin-4-yl)urea; 1-(4-(4-(4-isopropyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)-3-(pyridazin-4-yl)urea; 1-(4-(4-(4-isopropyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)-3-(pyrimidin-5-yl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridin-3-yl)urea; ; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridin-4-yl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyridazin-4-yl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(pyrimidin-5-yl)urea ; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-phenylurea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-chlorophenyl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-fluorophenyl)urea; Methyl-4-(3-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin- -2-yl)phenyl)ureido)benzoate; 4-(3-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)ureido)benzoic acid; 4-(3-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)ureido)-N-(2-(dimethylamino)ethyl)benzamide; 4-(3-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)ureido)-N-(2-(dimethylamino)ethyl)-N-methylbenzamide; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)urea; 4-(3-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)p- henyl)ureido)benzamide; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-n-propylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-acetyl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl)-3-(4-(4-(dimethylamino)piperidin-1-carbonyl)phenyl)urea; 1-(4-(4-(dimethylamino)piperidin-1-carbonyl)phenyl)-3-(4-(4-(4-isobutyryl- -1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-ethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(4-isobutyryl-1,4-diaz- epan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(4-isobutyr- yl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-phenylurea; 1-(4-chlorophenyl)-3-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-- 1,3,5-triazin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-- 1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(pyridin-4-yl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(pyridazin-4-yl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(pyridin-3-yl)urea; 1-(4-(4-(4-isobutyryl-1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)- phenyl)-3-(pyrimidin-5-yl)urea; tert-butyl 4-(4-(4-(3-(4-(methoxycarbonyl)phenyl)ureido)phenyl)-6-morpholino-1,3,5-t- riazin-2-yl)-1,4-diazepane-1-carboxylate; methyl4-(3-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phen- yl) ureido)benzoate; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-phe- nylurea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(4-chlorophenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(4-- fluorophenyl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- ridin-3-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- ridin-4-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- ridazin-4-yl)urea; 1-(4-(4-(1,4-diazepan-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)-3-(py- rimidin-5-yl)urea; N-methyl-4-(4-morpholino-6-(4-(3-phenylureido)phenyl)-1,3,5-triazin-2-yl)- -1,4-diazepane-1-carboxamide (M+H) 532.2; 4-(4-(4-(3-(4-chlorophenyl)ureido)phenyl)-6-morpholino-1,3,5-triazin-2-yl- )-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-fluorophenyl)ureido)phenyl)-6-morpholino-1,3,5-triazin-2-yl- )-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(2-(dimethylamino)ethylcarbamoyl)phenyl)ureido)phenyl)-6-mo- rpholino-1,3,5-triazin-2-yl)-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-((2-(dimethylamino)ethyl)(methyl)carbamoyl)phenyl)ureido)ph- enyl)-6-morpholino-1,3,5-triazin-2-yl)-N-methyl-1,4-diazepane-1-carboxamid- e; 4-(4-(4-(3-(4-carbamoylphenyl)ureido)phenyl)-6-morpholino-1,3,5-triazin- -2-yl)-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)ureido)phen- yl)-6-morpholino-1,3,5-triazin-2-yl)-N-methyl-1,4-diazepane-1-carboxamide; N-methyl-4-(4-morpholino-6-(4-(3-(4-(piperazine-1-carbonyl)phenyl)ureido)- phenyl)-1,3,5-triazin-2-yl)-1,4-diazepane-1-carboxamide; N-methyl-4-(4-(4-(3-(4-(4-methylpiperazine-1-carbonyl)phenyl)ureido)pheny- l)-6-morpholino-1,3,5-triazin-2-yl)-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)ureido)phenyl)-6-morph- olino-1,3,5-triazin-2-yl)-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)ureido)phenyl)-6-m- orpholino-1,3,5-triazin-2-yl)-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)ureido)pheny- l)-6-morpholino-1,3,5-triazin-2-yl)-N-methyl-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)ureido)pheny- l)-6-morpholino-1,3,5-triazin-2-yl)-N-isopropyl-1,4-diazepane-1-carboxamid- e; N-isopropyl-4-(4-(4-(3-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)urei- do)phenyl)-6-morpholino-1,3,5-triazin-2-yl)-1,4-diazepane-1-carboxamide; 4-(4-(4-(3-(4-(4-ethylpiperazine-1-carbonyl)phenyl)ureido)phenyl)-6-morph- olino-1,3,5-triazin-2-yl)-N-isopropyl-1,4-diazepane-1-carboxamide; N-isopropyl-4-(4-(4-(3-(4-(4-methylpiperazine-1-carbonyl)phenyl)ureido)ph- enyl)-6-morpholino-1,3,5-triazin-2-yl)-1,4-diazepane-1-carboxamide; N-isopropyl-4-(4-morpholino-6-(4-(3-(4-(piperazine-1-carbonyl)phenyl)urei- do)phenyl)-1,3,5-triazin-2-yl)-1,4-diazepane-1-carboxamide; N-isopropyl-4-(4-morpholino-6-(4-(3-pyridin-4-ylureido)phenyl)-1,3,5-tria- zin-2-yl)-1,4-diazepane-1-carboxamide; N-isopropyl-4-(4-morpholino-6-(4-(3-pyridazin-4-ylureido)phenyl)-1,3,5-tr- iazin-2-yl)-1,4-diazepane-1-carboxamide; N-isopropyl-4-(4-morpholino-6-(4-(3-pyrimidin-5-ylureido)phenyl)-1,3,5-tr- iazin-2-yl)-1,4-diazepane-1-carboxamide; N-isopropyl-4-(4-morpholino-6-(4-(3-pyridin-3-ylureido)phenyl)-1,3,5-tria- zin-2-yl)-1,4-diazepane-1-carboxamide; 1-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyri- din-3-yl)urea; 1-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyri- din-4-yl)urea; 1-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyri- dazin-4-yl)urea; 1-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyri- midin-5-yl)urea; 1-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-pheny- lurea; 1-(4-chlorophenyl)-3-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-tri- azin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-morpholino-6-(1H-pyrazol-1-yl)-1,3,5-triazin-2- -yl)phenyl)urea; 1-(4-(4-(2-methyl-1H-imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-phenylurea; 1-(4-chlorophenyl)-3-(4-(4-(2-methyl-1H-imidazol-1-yl)-6-morpholino-1,3,5- -triazin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-(2-methyl-1H-imidazol-1-yl)-6-morpholino-1,3,5- -triazin-2-yl)phenyl)urea; 1-(4-(4-(2-methyl-1H-imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyridin-4-yl)urea; 1-(4-(4-(2-methyl-1H-imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyridazin-4-yl)urea; 1-(4-(4-(2-methyl-1H-imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)pheny- l)-3-(pyrimidin-5-yl)urea; 1-(4-acetylphenyl)-3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-- yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(pi- perazin-1-yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- (dimethylamino)acetyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- morpholinoacetyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- hydroxyacetyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(me- thoxymethyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- methoxyethyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(1-- hydroxyethyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- hydroxypropan-2-yl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- hydroxypropyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(2-- hydroxy-2-methylpropyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-(4-- (dimethylamino)piperidine-1-carbonyl)phenyl)urea; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(4-cya- nophenyl)urea; 4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)ureido- )-N-methylbenzamide; 4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)ureido- )-N,N-dimethylbenzamide; 4-(3-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)ureido- )benzamide; 1-(4-(4,6-bis((R)-3-methylmorpholino)-1,3,5-triazin-2-yl)phenyl)-3-(6-(4-- methylpiperazine-1-carbonyl)pyridin-3-yl)urea; (R)-1-(4-((dimethylamino)methyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(t- etrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(pyridin-4-yl)urea; (R)-1-(4-acetylphenyl)-3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyra- n-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(2-(dimethylamino)acetyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-- (tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(4-(2-morpholinoacetyl)phenyl)urea; (R)-1-(4-(2-hydroxyacetyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(tetrahy- dro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(methoxymethyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(tetrahydr- o-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(2-methoxyethyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(tetrahyd- ro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(1-hydroxyethyl)phenyl)-3-(4-(4-((R)-3-methylmorpholino)-6-(tetrahyd- ro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(2-hydroxypropan-2-yl)phenyl)-3-(4-(4-(3-methylmorpholino)-6-(te- trahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(2-hydroxypropyl)phenyl)-3-(4-(4-((R)-3-methylmorpholino)-6-(tetrahy- dro-2H-pyran-4-y1)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(2-hydroxy-2-methylpropyl)phenyl)-3-(4-(4-(3-methylmorpholino)-6- -(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-(3-methy- lmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-1-(4-cyanophenyl)-3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran- -4-yl)-1,3,5-triazin-2-yl)phenyl)urea; (R)-N-methyl-4-(3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)- -1,3,5-triazin-2-yl)phenyl)ureido)benzamide; (R)-N,N-dimethyl-4-(3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4- -yl)-1,3,5-triazin-2-yl)phenyl)ureido)benzamide; (R)-4-(3-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-tr- iazin-2-yl)phenyl)ureido)benzamide; (R)-1-(4-(4-(3-methylmorpholino)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triaz- in-2-yl)phenyl)-3-(6-(4-methylpiperazine-1-carbonyl)pyridin-3-yl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-(pyrimidin-5-yl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-(pyridin-3-yl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-(pyridin-4-yl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-(pyridazin-4-yl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-phenylurea; 1-(4-chlorophenyl)-3-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-- triazin-2-yl)phenyl)urea; 1-(4-fluorophenyl)-3-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-- triazin-2-yl)phenyl)urea; methyl 4-(3-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phe- nyl)ureido)benzoate; 4-(3-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phe- nyl)ureido)benzoic acid; 4-(3-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phe- nyl)ureido)benzamide; 1-(4-(3-(dimethylamino)pyrrolidine-1-carbonyl)phenyl)-3-(4-(4-(3-methyl-1- H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-(4-(piperazine-1-carbonyl)phenyl)urea; 1-(4-(4-(3-methyl-1H-pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl- )-3-(4-(4-methylpiperazine-1-carbonyl)phenyl)urea; 1-(4-(4-ethylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methyl-1H-pyrazol-1- -yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-isopropylpiperazine-1-carbonyl)phenyl)-3-(4-(4-(3-methyl-1H-pyraz- ol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-(4-(4-(dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4-(3-methyl-1H- -pyrazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)phenyl)urea; 1-{4-[(4-butylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[4-(1-methylethyl)-- 1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 1-(4-{4-[4-(1-methylethyl)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-tria- zin-2-yl}phenyl)-3-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)ur- ea; 1-{4-[(4-ethylpiperazin-1-yl)carbonyl]phenyl}-3-(4-{4-[4-(1-methylethy- l)-1,4-diazepan-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl}phenyl)urea; 1-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-3-{4-[4-morpholin-4-yl-6-(- tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-di- morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-{[3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-di- morpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea; 1-(4-{[4-(1-methylethyl)piperazin-1-yl]carbonyl}phenyl)-3-{4-[4-morpholin- -4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-6-(tetrahydr- o-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}carbamoyl)amino]benzamide; 1-{4-[4-(azetidin-3-yloxy)-6-morpholin-4-yl-1,3,5-triazin-2-yl]phenyl}-3-- pyridin-4-ylurea; N-(1-methylethyl)-3-[(4-morpholin-4-yl-6-{4-[(pyridin-4-ylcarbamoyl)amino- ]phenyl}-1,3,5-triazin-2-yl)oxy]azetidine-1-carboxamide; N-{1-[(4-{[(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}ph- enyl)carbamoyl]amino}phenyl)carbonyl]piperidin-4-yl}acetamide; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-(- 4-{[4-(1-methylethyl)-1,4-diazepan-1-yl]carbonyl}phenyl)urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-[- 4-(3-oxa-8-azabicyclo[3.2.1]oct-8-ylcarbonyl)phenyl]urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-{- 4-[(4-cyanopiperidin-1-yl)carbonyl]phenyl}urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-(- 4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)urea; 1-(4-{4,6-bis[(3S)-3-methylmorpholin-4-yl]-1,3,5-triazin-2-yl}phenyl)-3-(- 4-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)urea; 1-(4-{[3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-(4-{4-(mor- pholin-4-yl)-6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phen- yl)urea; 1-(4-{[3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-(4- -{4-(morpholin-4-yl) -6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phenyl)urea; 1-{4-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}1-3-{4-[(2-methylp- iperazin-1-yl)carbonyl]phenyl}urea; 1-(4-{4-(morpholin-4-yl)-6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-tria- zin-2-yl}phenyl)-3-[4-(piperazin-1-ylcarbonyl)phenyl]urea; 1-(4-{[3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-(4-{4-(mor- pholin-4-yl)-6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phen- yl)urea; 1-{4-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}-3-{4-[(3,- 3,4-trimethylpiperazin-1-yl)carbonyl]phenyl}urea; 1-{4-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}-3-(4-{[(3R)-3-met- hylpiperazin-1-yl]carbonyl}phenyl)urea; 1-(4-{[(3R)-3,4-dimethylpiperazin-1-yl]carbonyl}phenyl)-3-{4-[4,6-di(morp- holin-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[(3R)-4-cyclobutyl-3-methylpiperazin-1-yl]carbonyl}phenyl)-3-{4-[4,- 6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}-3-(4-{[3R)-3-meth- yl-4-(propan-2-yl)piperazin-1-yl]carbonyl}phenyl)urea; 1-{4-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}-3-(4-{[(3S)-3-met- hylpiperazin-1-yl]carbonyl}phenyl)urea; N-[2-(dimethylamino)ethyl]-N-methyl-4-{[(4-{4-[(3S)-3-methylmorpholin-4-y- l]-6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phenyl)carbamo- yl]amino}benzamide; 1-(4-{4-[(3S)-3-methylmorpholin-4-yl]-6-[4-(propan-2-yl)-1,4-diazepan-1-y- l]-1,3,5-triazin-2-yl}phenyl)-3-{4-[(4-methylpiperazin-1-yl)carbonyl]pheny- l}urea; 1-(4-{[3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-(4-- {4-[(3S)-3-methylmorpholin-4-yl]-6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3- ,5-triazin-2-yl}phenyl)urea; N-[3-(dimethylamino)propyl]-4-{[(4-{4-(morpholin-4-yl)-6-[4-(propan-2-yl)- -1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; N-[2-(dimethylamino)ethyl]-N-methyl-4-{[(4-{4-(morpholin-4-yl)-6-[4-(prop- an-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benz- amide; 1-[4-(morpholin-4-ylcarbonyl)phenyl]-3-(4-{4-(morpholin-4-yl)-6-[4-- (propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phenyl)urea; N-(2-methoxyethyl)-4-{[(4-{4-(morpholin-4-yl)-6-[4-(propan-2-yl)-1,4-diaz- epan-1-yl]-1,3,5-triazin-2-yl}phenyl)carbamoyl]amino}benzamide; 1-[4-(1,4-diazepan-1-ylcarbonyl)phenyl]-3-(4-{4-(morpholin-4-yl)-6-[4-(pr- opan-2-yl)-1,4-diazepan-1-yl]-1,3,5-triazin-2-yl}phenyl)urea; 1-(4-{4-(morpholin-4-yl)-6-[4-(propan-2-yl)-1,4-diazepan-1-yl]-1,3,5-tria- zin-2-yl}phenyl)-3-(4-{[4-(propan-2-yl)-1,4-diazepan-1-yl]carbonyl}phenyl)- urea; 1-(4-{[(3S)-4-cyclobutyl-3-methylpiperazin-1-yl]carbonyl}phenyl)-3-{- 4-[4,6-di(morpholin-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[(3S)-3,4-dimethylpiperazin-1-yl]carbonyl}phenyl)-3-{4-[4,6-di(morp- holin-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-{4-[4-(morpholin-4-yl)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]- phenyl}-3-{4-[(3,3,4-trimethylpiperazin-1-yl)carbonyl]phenyl}urea; 1-(4-{[(3S)-3,4-dimethylpiperazin-1-yl]carbonyl}phenyl)-3-{4-[4-(morpholi- n-4-yl)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[(3S)-3-methylpiperazin-1-yl]carbonyl}phenyl)-3-{4-[4-(morpholin-4-- yl)-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; 1-(4-{[(3R)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-{4-[4-mor- pholin-4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}urea; and 1-(4-{[(3S)-3-(dimethylamino)pyrrolidin-1-yl]carbonyl}phenyl)-3-{4-[4- -morpholin-4-yl-6-(tetrahydro-2H-pyran-4-yl)-1,3,5-triazin-2-yl]phenyl}ure- a, and pharmaceutically acceptable salts thereof. 13. The compound which is 1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorph- olin-4-yl-1,3,5-triazin-2-yl)phenyl]urea, and pharmaceutically acceptable salts thereof. 14. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier. 15. The composition of claim 14, wherein the pharmaceutically acceptable carrier is suitable for oral administration and the composition comprises an oral dosage form. 16. A composition comprising a compound of claim 1; a second compound selected from the group consisting of a topoisomerase I inhibitor, a MEK 1/2 inhibitor, a HSP90 inhibitor, procarbazine, dacarbazine, gemcitabine, capecitabine, methotrexate, taxol, taxotere, mercaptopurine, thioguanine, hydroxyurea, cytarabine, cyclophosphamide, ifosfamide, nitrosoureas, cisplatin, carboplatin, mitomycin, dacarbazine, procarbizine, etoposide, teniposide, campathecins, bleomycin, doxorubicin, idarubicin, daunorubicin, dactinomycin, plicamycin, mitoxantrone, L-asparaginase, doxorubicin, epirubicin, 5-fluorouracil, docetaxel, paclitaxel, leucovorin, levamisole, irinotecan, estramustine, etoposide, nitrogen mustards, BCNU, carmustine, lomustine, vinblastine, vincristine, vinorelbine, oxaliplatin, imatinib mesylate, bevacizumab, hexamethylmelamine, topotecan, tyrosine kinase inhibitors, tyrphostins, herbimycin A, genistein, erbstatin, hydroxyzine, glatiramer acetate, interferon beta-1a, interferon beta-1b, natalizumab and lavendustin A; and a pharmaceutically acceptable carrier. 17. The composition of claim 16, wherein the second compound is bevacizumab.

Details for Patent 8,039,469

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2039-02-26
Bayer Healthcare Pharmaceuticals Inc.	BETASERON	interferon beta-1b	For Injection	103471	07/23/1993		2039-02-26
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