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Last Updated: November 17, 2019

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OLEPTRO Drug Profile

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When do Oleptro patents expire, and when can generic versions of Oleptro launch?

Oleptro is a drug marketed by Angelini Pharma and is included in one NDA. There are three patents protecting this drug and one Paragraph IV challenge.

This drug has one hundred and seven patent family members in thirty-three countries.

The generic ingredient in OLEPTRO is trazodone hydrochloride. There are fourteen drug master file entries for this compound. Thirty-eight suppliers are listed for this compound. Additional details are available on the trazodone hydrochloride profile page.

Drug patent expirations by year for OLEPTRO
Drug Sales Revenue Trends for OLEPTRO

See drug sales revenues for OLEPTRO

Recent Clinical Trials for OLEPTRO

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Louis Stokes VA Medical CenterPhase 1
VA Connecticut Healthcare SystemPhase 4
Algorithme Pharma IncPhase 1

See all OLEPTRO clinical trials

Recent Litigation for OLEPTRO

Identify potential future generic entrants

District Court Litigation
Case NameDate
Aziende Chimiche Riunite Angelini Francesco ACRAFSpA v. Intellipharmaceutics International Inc.2014-09-26

See all OLEPTRO litigation

Synonyms for OLEPTRO
1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-
1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, monohydrochloride
1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-,hydrochloride (1:1)
1,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-, monohydrochloride
19666-36-5
19794-93-5
2-(3-(4-(3-Chlorophenyl)-1-piperazinyl)propyl)-s-triazolo(4,3-a)pyridin-3(2H)-one HCl
2-(3-(4-(3-Chlorophenyl)piperazin-1-y)propyl)-1,2,4-triazolo(4,3-a)pyridine-3(2H)-one hydrochloride
2-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
2-(3-(4-(3-Chlorophenyl)piperazin-1-yl)propyl)-1,2,4-triazolo(4,3-a)pyridin-3(2H)-one hydrochloride
2-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-s-triazolo(4,3-a)pyridin-3(2H)-one monohydrochloride
2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one #
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-
2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one hydrochloride
2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one hydrochloride
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one;hydrochloride
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,5-a]pyridin-3-one
2-[3-[4-(m-Chlorophenyl)-1-piperazinyl]propyl]-s-triazolo[4,3-a]pyridin-3(2H)-one monohydrochloride
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-2H,3H-[1,2,4]triazolo[4,3-a]pyridin-3-one hydrochloride
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one hydrochloride
2-{3-[4-(3-chlorophenyl)piperazinyl]propyl}-4-hydro-1,2,4-triazolino[4,3-a]pyr idin-3-one, chloride
25332-39-2
332T392
4CA-1276
6E8ZO8LRNM
794T935
8-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-1,7,8-triazabicyclo[4.3.0]nona-2,4,6-trien-9-one hydrochloride
8-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-6,8,9-triazabicyclo[4.3.0]nona-2,4,9-trien-7-one
A813950
A817789
AB00053648_15
AB00053648_16
AB00053648-14
AB2000676
AC-6778
AC-6779
AC1L1KK2
AC1L1Y2P
AC1Q3BFE
AF 1161
AF-1161
AJ-23398
AKOS015896423
AKOS015897762
AN-9679
AN-9680
API0000873
Apo-Trazodone
AX8215176
Azona
BC209162
BC215367
BCP04922
BCP07176
BDBM50073444
Beneficat
BG0346
Bimaran
BPBio1_000248
BRD-K70778732-003-05-1
BRD-K70778732-003-15-0
BRN 0628010
BSPBio_000224
BSPBio_003040
C07156
C19H22ClN5O
C19H22ClN5O.HCl
C19H23Cl2N5O
CAS-25332-39-2
CCG-205233
CCG-40299
CHEBI:9654
CHEBI:9655
CHEMBL1200798
CHEMBL621
CPD000058520
CS-2592
CT0209
CTK4E2359
CTK4F5497
D00820
D08626
DB00656
Desirel
Desyrel
Desyrel (TN)
Desyrel Dividose
Devidon
DivK1c_000196
DSSTox_CID_24626
DSSTox_GSID_44626
DSSTox_RID_80361
DTXSID5045043
DTXSID8044626
EC 243-317-1
EINECS 243-216-2
EINECS 243-317-1
EINECS 246-855-5
EU-0101159
FT-0658382
FT-0659024
GTPL213
HMS1568L06
HMS1922G09
HSDB 7048
HY-B0478
I06-1977
I13-027
I14-31859
IDI1_000196
J-015941
J10153
Jsp005028
K-6661
KB-831
KBio1_000196
KBio2_001904
KBio2_004472
KBio2_007040
KBio3_002540
KBioGR_001110
KBioSS_001904
KS-00000ZWU
KS-5100
L000771
Lopac-T-6154
Lopac0_001159
LP01159
LS-156735
LS-156736
M979
MCULE-3098459714
MCULE-8110542411
MFCD00079603
MLS000069698
MLS000758230
MLS001148260
MLS001424009
Molipaxin
MolPort-001-684-664
MolPort-003-850-601
NC00046
NCGC00016035-01
NCGC00016035-02
NCGC00016035-03
NCGC00016035-04
NCGC00016035-05
NCGC00016035-06
NCGC00016035-07
NCGC00016035-08
NCGC00016035-09
NCGC00016035-10
NCGC00016035-12
NCGC00016035-13
NCGC00024405-03
NCGC00094420-01
NCGC00094420-02
NCGC00094420-03
NCGC00094420-04
NCGC00256807-01
NCGC00261844-01
NINDS_000196
NSC 292811
NSC-292811
NSC-758393
NSC292811
NSC758393
Opera_ID_850
Oprea1_185901
Pharmakon1600-01503121
PHLBKPHSAVXXEF-UHFFFAOYSA-N
Pragmazone
Prestwick_478
Prestwick0_000292
Prestwick1_000292
Prestwick2_000292
Prestwick3_000292
PubChem15888
s-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-
s-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-, monohydrochloride
s-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-,monohydrochloride
S-Triazolo[4, 2-[3-[4-(m-chlorophenyl)-1-piperazinyl]propyl]-, monohydrochloride
S-Trizolo[4, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-, hydrochloride
S2582
SAM001247045
SBI-0051126.P003
SC-16187
SC-77266
SCHEMBL28167
SCHEMBL61754
Sideril
SMR000058520
SPBio_000867
SPBio_002443
Spectrum_001424
SPECTRUM1503121
Spectrum2_000854
Spectrum3_001560
Spectrum4_000755
Spectrum5_000974
SR-01000000190
SR-01000000190-2
SR-01000000190-8
ST2407780
ST51015149
T 6154
Thombran
Tombran
Tox21_110286
Tox21_110286_1
Tox21_302685
Tox21_501159
Tradozone
Trazalon
Trazodil
Trazodon
Trazodona
Trazodona [INN-Spanish]
Trazodona [Spanish]
trazodone
trazodone (Desyrel)
Trazodone (hydrochloride)
Trazodone (INN)
Trazodone [INN:BAN]
Trazodone Hcl
Trazodone hydrochloride
Trazodone hydrochloride (Desyrel)
Trazodone hydrochloride (JAN/USP)
Trazodone hydrochloride [USAN:JAN]
Trazodone hydrochloride [USAN:USP:JAN]
Trazodone Hydrochloride 1.0 mg/ml in Methanol (as free base)
Trazodone hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material
Trazodone hydrochloride, >=99% (HPLC), powder
Trazodone hydrochloride, United States Pharmacopeia (USP) Reference Standard
Trazodone, HCl
Trazodonum
Trazodonum [INN-Latin]
Trazodonum [Latin]
Trazolan
Trazonil
Trialodine
Tritico
Triticum
Trittico
Trittico (TN)
UNII-6E8ZO8LRNM
UNII-YBK48BXK30
VA11904
WLN: T56 ANVNNJ C3- AT6N DNTJ DR CG &GH
YBK48BXK30
Z1550675462
ZINC538483
Paragraph IV (Patent) Challenges for OLEPTRO
Tradename Dosage Ingredient NDA Submissiondate
OLEPTRO TABLET, EXTENDED RELEASE;ORAL trazodone hydrochloride 022411 2010-10-18

US Patents and Regulatory Information for OLEPTRO

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-001 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y Y   Start Trial
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-002 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y   Start Trial
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-001 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y   Start Trial
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-001 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y   Start Trial
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-002 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y   Start Trial
Angelini Pharma OLEPTRO trazodone hydrochloride TABLET, EXTENDED RELEASE;ORAL 022411-002 Feb 2, 2010 DISCN Yes No   Start Trial   Start Trial Y Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

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