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ELIQUIS Drug Profile
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Which patents cover Eliquis, and what generic alternatives are available?
This drug has one hundred and thirty-nine patent family members in forty countries.
The generic ingredient in ELIQUIS is apixaban. There are twenty-seven drug master file entries for this compound. Three suppliers are listed for this compound. Additional details are available on the apixaban profile page.
Summary for ELIQUIS
| International Patents: | 139 |
| US Patents: | 3 |
| Applicants: | 1 |
| NDAs: | 1 |
| Suppliers / Packagers: | 3 |
| Bulk Api Vendors: | 91 |
| Clinical Trials: | 40 |
| Patent Applications: | 793 |
| Formulation / Manufacturing: | see details |
| Patent Litigation and PTAB cases: | See patent lawsuits and PTAB cases for ELIQUIS |
| DailyMed Link: | ELIQUIS at DailyMed |
Pharmacology for ELIQUIS
| Drug Class | Factor Xa Inhibitor |
| Mechanism of Action | Factor Xa Inhibitors |
Synonyms for ELIQUIS
| 1-(4-Methoxy-phenyl)-7-oxo-6-[4-(2-oxo-piperidin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide |
| 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide |
| 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo piperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide |
| 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidyl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide |
| 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide |
| 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-car |
| 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydropyrazolo[3,4-c]pyridine-3-carboxamide |
| 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide |
| 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide?BMS-562247; BMS-562247-01 |
| 1H-Pyrazolo(3,4-c)pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxo-1-piperidinyl)phenyl)- |
| 1H-Pyrazolo[3,4-c]pyridine-3-carboxamide, 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]- |
| 2p16 |
| 3Z9Y7UWC1J |
| 4,5,6,7-TETRAHYDRO-1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXO-1-PIPERIDINYL)PHENYL]-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE |
| 503612-47-3 |
| 612A473 |
| AB0007933 |
| AB01565766_02 |
| AB1008435 |
| ABP000333 |
| AC-26301 |
| AJ-59962 |
| AK161862 |
| AKOS005146204 |
| AN-429 |
| AOB87769 |
| Apixaban |
| Apixaban - Adooq Bioscience |
| Apixaban (BMS 562247-01) |
| Apixaban (JAN/USAN/INN) |
| Apixaban [USAN] |
| Apixaban BMS-562247-01 |
| Apixaban,BMS-562247-01 |
| Apixaban;503612-47-3 |
| Apixaban(BMS-562247-01) |
| Apixaban/BMS562247-01/Apixaban |
| apixabanum |
| Apixabin |
| AX8161411 |
| BC654125 |
| BCP9000310 |
| BCPP000396 |
| BDBM19023 |
| BMS 562247 |
| BMS 562247-01 |
| BMS-562247 |
| BMS-562247-01 |
| BMS-562247-01, Apixaban |
| BMS562247-01 |
| CA0186 |
| CCG-229675 |
| CHEBI:72296 |
| CHEMBL231779 |
| CS-0401 |
| D03213 |
| D0I5HF |
| DB06605 |
| DTXSID80436500 |
| Eliquis (TN) |
| EX-A048 |
| FT-0686944 |
| GG2 |
| GTPL6390 |
| HE069298 |
| HE346199 |
| HMS3655O07 |
| HY-50667 |
| I14-11577 |
| J-200194 |
| KB-47429 |
| KS-0000075V |
| ME-0152 |
| MFCD11977295 |
| MLS006010026 |
| MolPort-006-170-153 |
| NCGC00346555-01 |
| PB10976 |
| PYR431 |
| Q-4456 |
| QC-8191 |
| QNZCBYKSOIHPEH-UHFFFAOYSA-N |
| ro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid amide |
| RP18047 |
| s1593 |
| SC-49755 |
| SCHEMBL118023 |
| SMR004676529 |
| ST24045978 |
| UNII-3Z9Y7UWC1J |
| X1060 |
| ZINC11677837 |
US Patents and Regulatory Information for ELIQUIS
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bristol Myers Squibb | ELIQUIS | apixaban | TABLET;ORAL | 202155-001 | Dec 28, 2012 | RX | Yes | No | ➤ Sign Up | ➤ Sign Up | Y | Y | ➤ Sign Up | ||
| Bristol Myers Squibb | ELIQUIS | apixaban | TABLET;ORAL | 202155-002 | Dec 28, 2012 | RX | Yes | Yes | ➤ Sign Up | ➤ Sign Up | Y | Y | ➤ Sign Up | ||
| Bristol Myers Squibb | ELIQUIS | apixaban | TABLET;ORAL | 202155-001 | Dec 28, 2012 | RX | Yes | No | ➤ Sign Up | ➤ Sign Up | Y | ➤ Sign Up | |||
| Bristol Myers Squibb | ELIQUIS | apixaban | TABLET;ORAL | 202155-001 | Dec 28, 2012 | RX | Yes | No | ➤ Sign Up | ➤ Sign Up | Y | Y | ➤ Sign Up | ||
| Applicant | Tradename | Generic Name | Dosage | NDA | Approval Date | TE | Type | RLD | RS | Patent No. | Patent Expiration | Product | Substance | Delist Req. | Exclusivity Expiration |
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Paragraph IV (Patent) Challenges for ELIQUIS
| Drugname | Dosage | Strength | RLD | Submissiondate |
|---|---|---|---|---|
| ➤ Subscribe | Tablets | 2.5 mg and 5 mg | ➤ Subscribe | 2016-12-28 |
Non-Orange Book US Patents for ELIQUIS
For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.
The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.
| Patent No. | Title | Estimated Patent Expiration |
|---|---|---|
| 6,995,172 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | ➤ Sign Up |
| 8,188,120 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | ➤ Sign Up |
| 7,338,963 | Lactam-containing compounds and derivatives thereof as factor Xa inhibitors | ➤ Sign Up |
| 6,673,810 | Imidazo-heterobicycles as factor Xa inhibitors | ➤ Sign Up |
| Patent No. | Title | Estimated Patent Expiration |
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International Patents for ELIQUIS
Supplementary Protection Certificates for ELIQUIS
| Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
|---|---|---|---|
| 1427415/01 | Switzerland | ➤ Sign Up | FORMER OWNER: BRISTOL-MYERS SQUIBB COMPANY, US |
| 5 5011-2011 | Slovakia | ➤ Sign Up | FORMER OWNER: BRISTOL-MYERS SQUIBB COMPANY, US |
| 11/032 | Ireland | ➤ Sign Up | PRODUCT NAME: APIXABAN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF; REGISTRATION NO/DATE: EU/1/11/691/001-005 20110518 |
| C/GB11/042 | United Kingdom | ➤ Sign Up | PRODUCT NAME: APIXABAN AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF; REGISTERED: UK EU/1/11/691/001 20110520; UK EU/1/11/691/002 20110520; UK EU/1/11/691/003 20110520; UK EU/1/11/691/004 20110520; UK EU/1/11/691/005 20110520 |
| Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
