COTELLIC Drug Patent Profile
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Which patents cover Cotellic, and what generic alternatives are available?
Cotellic is a drug marketed by Genentech Inc and is included in one NDA. There are seven patents protecting this drug.
This drug has one hundred and ninety patent family members in forty-three countries.
The generic ingredient in COTELLIC is cobimetinib fumarate. One supplier is listed for this compound. Additional details are available on the cobimetinib fumarate profile page.
DrugPatentWatch® Generic Entry Outlook for Cotellic
Cotellic was eligible for patent challenges on November 10, 2019.
By analyzing the patents and regulatory protections it appears that the earliest date
for generic entry will be December 30, 2036. This may change due to patent challenges or generic licensing.
Indicators of Generic Entry
AI Deep Research
Questions you can ask:
- What is the 5 year forecast for COTELLIC?
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Summary for COTELLIC
International Patents: | 190 |
US Patents: | 7 |
Applicants: | 1 |
NDAs: | 1 |
Finished Product Suppliers / Packagers: | 1 |
Raw Ingredient (Bulk) Api Vendors: | 10 |
Clinical Trials: | 35 |
Patent Applications: | 1 |
Drug Prices: | Drug price information for COTELLIC |
What excipients (inactive ingredients) are in COTELLIC? | COTELLIC excipients list |
DailyMed Link: | COTELLIC at DailyMed |


DrugPatentWatch® Estimated Loss of Exclusivity (LOE) Date for COTELLIC
Generic Entry Date for COTELLIC*:
Constraining patent/regulatory exclusivity:
NDA:
Dosage:
TABLET;ORAL |
*The generic entry opportunity date is the latter of the last compound-claiming patent and the last regulatory exclusivity protection. Many factors can influence early or later generic entry. This date is provided as a rough estimate of generic entry potential and should not be used as an independent source.
Recent Clinical Trials for COTELLIC
Identify potential brand extensions & 505(b)(2) entrants
Sponsor | Phase |
---|---|
University of Birmingham | Phase 2/Phase 3 |
Cancer Research UK | Phase 2/Phase 3 |
Royal Marsden NHS Foundation Trust | Phase 2/Phase 3 |
Pharmacology for COTELLIC
Drug Class | Kinase Inhibitor |
Mechanism of Action | Kinase Inhibitors |
US Patents and Regulatory Information for COTELLIC
COTELLIC is protected by seven US patents and four FDA Regulatory Exclusivities.
Based on analysis by DrugPatentWatch, the earliest date for a generic version of COTELLIC is ⤷ Try for Free.
This potential generic entry date is based on patent ⤷ Try for Free.
Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.
International Patents for COTELLIC
When does loss-of-exclusivity occur for COTELLIC?
Based on analysis by DrugPatentWatch, the following patents block generic entry in the countries listed below:
Argentina
Patent: 5483
Patent: SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)FENIL][3-HIDROXI-3-(PIPERIDIN-2-IL)AZETIDIN-1-IL]-METANONA
Estimated Expiration: ⤷ Try for Free
Australia
Patent: 16288209
Patent: Crystalline fumarate salt of (S)-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl) (3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl)-methanone
Estimated Expiration: ⤷ Try for Free
Patent: 21200202
Patent: CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE
Estimated Expiration: ⤷ Try for Free
Brazil
Patent: 2017028516
Patent: sal de fumarato cristalino de (s)-[3,4-difluoro-2-(2-fluoro-4-iodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il) azetidin-1-il]-metanona
Estimated Expiration: ⤷ Try for Free
Canada
Patent: 90222
Patent: SEL CRISTALLIN DE FUMARATE DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDIN-2-YL)AZETIDIN-1-YL]-METHANONE (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE)
Estimated Expiration: ⤷ Try for Free
Chile
Patent: 17003475
Patent: Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
Estimated Expiration: ⤷ Try for Free
China
Patent: 7810183
Estimated Expiration: ⤷ Try for Free
Patent: 8290395
Patent: 结晶反丁烯二酸盐 (Crystalline fumarate salts)
Estimated Expiration: ⤷ Try for Free
Colombia
Patent: 18000086
Patent: Sal de fumarato cristalina de (s)-[3,4-difluoro-2-(2-fluoro-4-yodofenilamino)fenil][3-hidroxi-3-(piperidin-2-il)azetidin-1-il]-metanona
Estimated Expiration: ⤷ Try for Free
Costa Rica
Patent: 180056
Patent: SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)FENIL] [3-HIDROXI-3-(PIPERIDIN-2-IL)AZETIDIN-1-IL]-METANONA
Estimated Expiration: ⤷ Try for Free
European Patent Office
Patent: 17264
Patent: SEL CRISTALLIN DE FUMARATE DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHÉNYLAMINO)PHÉNYL][3-HYDROXY-3-(PIPÉRIDIN-2-YL)AZÉTIDIN-1-YL]-MÉTHANONE (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE)
Estimated Expiration: ⤷ Try for Free
Hong Kong
Patent: 52433
Estimated Expiration: ⤷ Try for Free
Israel
Patent: 6423
Patent: מלח פומראט גבישי של (s (-[4,3-דיפלואורו-2-(2-פלואורו-4-יודופנילאמינו)פניל] [3-הידרוקסי-3-(פיפרידין-2-איל)אזטידין-1-איל]-מתאנון (Crystalline fumarate salt of (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone)
Estimated Expiration: ⤷ Try for Free
Patent: 5052
Patent: מלח פומראט גבישי של (s)-[4,3-דיפלואורו-2-(2-פלואורו-4-יודופנילאמינו)פניל] [3-הידרוקסי-3-(פיפרידין-2-איל)אזטידין-1-איל]-מתאנון (Crystalline fumarate salt of (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone)
Estimated Expiration: ⤷ Try for Free
Japan
Patent: 38950
Estimated Expiration: ⤷ Try for Free
Patent: 18519318
Patent: (S)−[3,4−ジフルオロ−2−(2−フルオロ−4−ヨードフェニルアミノ)フェニル][3−ヒドロキシ−3−(ピペリジン−2−イル」)アゼチジン−1−イル]−メタノンの結晶性フマル酸塩
Estimated Expiration: ⤷ Try for Free
Patent: 21035967
Patent: (S)−[3,4−ジフルオロ−2−(2−フルオロ−4−ヨードフェニルアミノ)フェニル][3−ヒドロキシ−3−(ピペリジン−2−イル)アゼチジン−1−イル]−メタノンの結晶性フマル酸塩 (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE)
Estimated Expiration: ⤷ Try for Free
Patent: 23025000
Patent: (S)-[3,4-ジフルオロ-2-(2-フルオロ-4-ヨードフェニルアミノ)フェニル][3-ヒドロキシ-3-(ピペリジン-2-イル)アゼチジン-1-イル]-メタノンの結晶性フマル酸塩
Estimated Expiration: ⤷ Try for Free
Malaysia
Patent: 2545
Patent: CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE
Estimated Expiration: ⤷ Try for Free
Mexico
Patent: 17017037
Patent: SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODO FENILAMINO) FENIL][3-HIDROXI-3-(PIPERIDIN-2-IL]AZETIDIN-1-IL]-META NONA. (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODO PHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE.)
Estimated Expiration: ⤷ Try for Free
Morocco
Patent: 301
Patent: SEL CRISTALLIN DE FUMARATE DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHÉNYLAMINO)PHÉNYL][3-HYDROXY-3-(PIPÉRIDIN-2-YL)AZÉTIDIN-1-YL]-MÉTHANONE
Estimated Expiration: ⤷ Try for Free
New Zealand
Patent: 9160
Patent: Crystalline fumarate salt of (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone
Estimated Expiration: ⤷ Try for Free
Patent: 7527
Patent: Crystalline fumarate salt of (s)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone
Estimated Expiration: ⤷ Try for Free
Peru
Patent: 180692
Patent: SAL DE FUMARATO CRISTALINA DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-YODOFENILAMINO)FENIL][3-HIDROXI-3-(PIPERIDIN-2-IL)AZETIDIN-1-IL]-METANONA
Estimated Expiration: ⤷ Try for Free
Philippines
Patent: 017502414
Patent: CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE
Estimated Expiration: ⤷ Try for Free
Russian Federation
Patent: 62181
Patent: КРИСТАЛЛИЧЕСКАЯ ФУМАРАТНАЯ СОЛЬ (S)-[3,4-ДИФТОР-2-(2-ФТОР-4-ЙОДФЕНИЛАМИНО)ФЕНИЛ][3-ГИДРОКСИ-3-(ПИПЕРИДИН-2-ИЛ)АЗЕТИДИН-1-ИЛ]МЕТАНОНА (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDINE-2-YL)AZETIDINE-1-YL]METHANONE)
Estimated Expiration: ⤷ Try for Free
Patent: 18103172
Patent: КРИСТАЛЛИЧЕСКАЯ ФУМАРАТНАЯ СОЛЬ (S)-[3,4-ДИФТОР-2-(2-ФТОР-4-ЙОДФЕНИЛАМИНО)ФЕНИЛ][3-ГИДРОКСИ-3-(ПИПЕРИДИН-2-ИЛ)АЗЕТИДИН-1-ИЛ]МЕТАНОНА
Estimated Expiration: ⤷ Try for Free
Patent: 21132394
Patent: КРИСТАЛЛИЧЕСКАЯ ФУМАРАТНАЯ СОЛЬ (S)-[3,4-ДИФТОР-2-(2-ФТОР-4-ЙОДФЕНИЛАМИНО)ФЕНИЛ][3-ГИДРОКСИ-3-(ПИПЕРИДИН-2-ИЛ)АЗЕТИДИН-1-ИЛ]МЕТАНОНА
Estimated Expiration: ⤷ Try for Free
Singapore
Patent: 202105196Y
Patent: CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE
Estimated Expiration: ⤷ Try for Free
South Africa
Patent: 1708760
Patent: CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE
Estimated Expiration: ⤷ Try for Free
South Korea
Patent: 2695324
Estimated Expiration: ⤷ Try for Free
Patent: 180021775
Estimated Expiration: ⤷ Try for Free
Taiwan
Patent: 10556
Estimated Expiration: ⤷ Try for Free
Patent: 75187
Estimated Expiration: ⤷ Try for Free
Patent: 1718535
Patent: Crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone
Estimated Expiration: ⤷ Try for Free
Patent: 2108568
Patent: Crystalline fumarate salt of (S)-[3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl] [3-hydroxy-3-(piperidin-2-yl) azetidin-1-yl]-methanone
Estimated Expiration: ⤷ Try for Free
Ukraine
Patent: 4728
Patent: КРИСТАЛІЧНА ФУМАРАТНА СІЛЬ (S)-[3,4-ДИФТОР-2-(2-ФТОР-4-ЙОДФЕНІЛАМІНО)ФЕНІЛ][3-ГІДРОКСИ-3-(ПІПЕРИДИН-2-ІЛ)АЗЕТИДИН-1-ІЛ]МЕТАНОНУ (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE)
Estimated Expiration: ⤷ Try for Free
Generics may enter earlier, or later, based on new patent filings, patent extensions, patent invalidation, early generic licensing, generic entry preferences, and other factors.
See the table below for additional patents covering COTELLIC around the world.
Country | Patent Number | Title | Estimated Expiration |
---|---|---|---|
Norway | 344876 | ⤷ Try for Free | |
Croatia | P20240045 | ⤷ Try for Free | |
South Korea | 20210108502 | 코비메티닙 및 베무라피닙을 투여함을 포함하는 흑색종의 조합 치료법 (COMBINATION THERAPIES FOR MELANOMA COMPRISING ADMINISTERING COBIMETINIB AND VEMURAFINIB) | ⤷ Try for Free |
Malaysia | 162174 | AZETIDINES MEK INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ⤷ Try for Free |
Canada | 2990222 | SEL CRISTALLIN DE FUMARATE DE (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL][3-HYDROXY-3-(PIPERIDIN-2-YL)AZETIDIN-1-YL]-METHANONE (CRYSTALLINE FUMARATE SALT OF (S)-[3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMINO)PHENYL] [3-HYDROXY-3-(PIPERIDIN-2-YL) AZETIDIN-1-YL]-METHANONE) | ⤷ Try for Free |
Portugal | 1934174 | ⤷ Try for Free | |
>Country | >Patent Number | >Title | >Estimated Expiration |
Supplementary Protection Certificates for COTELLIC
Patent Number | Supplementary Protection Certificate | SPC Country | SPC Expiration | SPC Description |
---|---|---|---|---|
1934174 | 2016/022 | Ireland | ⤷ Try for Free | PRODUCT NAME: COBIMETINIB, INCLUDING PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVATES, IN PARTICULAR COBIMETINIB HEMIFUMARATE.; REGISTRATION NO/DATE: EU/1/15/1048/001 20151120 |
1934174 | 22/2016 | Austria | ⤷ Try for Free | PRODUCT NAME: COBIMETINIB ALS EIN EINZELNES STEREOISOMER ODER ALS EINE MISCHUNG VON STEREOISOMEREN DAVON, EINSCHLIESSLICH PHARMAZEUTISCH ANNEHMBARER SALZE UND SOLVATE, INSBESONDERE COBIMETINIB HEMIFUMARAT; REGISTRATION NO/DATE: EU/1/15/1048 (MITTEILUNG) 20151124 |
1934174 | PA2016016 | Lithuania | ⤷ Try for Free | PRODUCT NAME: KOBIMETINIBAS; REGISTRATION NO/DATE: EU/1/15/1048 20151120 |
1934174 | C20160012 00193 | Estonia | ⤷ Try for Free | PRODUCT NAME: KOBIMETINIIB;REG NO/DATE: EU/1/15/1048 24.11.2015 |
1934174 | 364 5005-2016 | Slovakia | ⤷ Try for Free | PRODUCT NAME: KOBIMETINIB VO VSETKYCH FORMACH CHRANENYCH ZAKLADNYM PATENTOM; REGISTRATION NO/DATE: EU/1/15/1048/001 20151124 |
1934174 | 1691019-2 | Sweden | ⤷ Try for Free | PRODUCT NAME: COBIMETINIB, OPTIONALLY IN THE FORM OF A PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE, IN PARTICULAR COBIMETINIB HEMIFUMARATE; EU/1/15/1048 2015-11-24 |
>Patent Number | >Supplementary Protection Certificate | >SPC Country | >SPC Expiration | >SPC Description |
Market Dynamics and Financial Trajectory of COTELLIC
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