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COREG CR Drug Profile

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Which patents cover Coreg Cr, and what generic alternatives are available?

Coreg Cr is a drug marketed by Smithkline Beecham and is included in one NDA. There are two patents protecting this drug and three Paragraph IV challenges.

The generic ingredient in COREG CR is carvedilol phosphate. There are thirty-six drug master file entries for this compound. Five suppliers are listed for this compound. Additional details are available on the carvedilol phosphate profile page.

Summary for COREG CR

US Patents:	2
Applicants:	1
NDAs:	1
Suppliers / Packagers:	3
Bulk Api Vendors:	119
Patent Applications:	4,186
Formulation / Manufacturing:	see details
Drug Prices:	Drug price information for COREG CR
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for COREG CR
DailyMed Link:	COREG CR at DailyMed

Pharmacology for COREG CR

Drug Class	alpha-Adrenergic Blocker beta-Adrenergic Blocker
Mechanism of Action	Adrenergic alpha-Antagonists Adrenergic beta1-Antagonists Adrenergic beta2-Antagonists

Synonyms for COREG CR

(+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol

(+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol

(+/-)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol

(2RS)-1-(9H-Carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol phosphate salt (1:1)

(2RS)-1-(9H-Carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol phosphate salt (1:1) hemihydrate

(2RS)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]propan-2-ol phosphate salt (1:1) hemihydrate

[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine

1-((9H-Carbazol-4-yl)oxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol

1-(9H-carbazol-4-yloxy)-3-[(2-{[2-(methyloxy)phenyl]oxy}ethyl)amino]propan-2-ol

1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol

1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol

1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol

1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; phosphoric acid; hydrate

1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol

1-9H-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol phosphate hemihydrate

102641-EP2270011A1

102641-EP2272841A1

102641-EP2275420A1

102641-EP2298764A1

102641-EP2298765A1

102641-EP2301936A1

107741-96-8

1196658-85-1

2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, (+-)-

2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, phosphate (1:1)

2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, phosphate (salt), hydrate (2:2:1)

2-Propanol, 1-(9H-carbazol-4-yloxy)-3-((2-(2-methoxyphenoxy)ethyl)amino)-, phosphate, hydrate (1:1:1)

309C892

374779-45-0

610309-89-2

72956-09-3

956C093

AB0008431

AB00639903_10

AB00639903_11

AB00639903_12

AB00639903-07

AB00639903-09

AB1004830

AC-1641

AC1L1E0B

AK163147

AKOS005554967

AKOS026749869

AN-14749

AN-27765

API0001873

Artist

Artist (TN)

Atlana Pharma brand of carvedilol

AX8120145

BBL029064

BC204100

BCP0726000253

BCP9000493

BDBM25759

BG0129

Bio-0014

BIS(1-(9H-CARBAZOL-4-YLOXY)-3-{[2-(2-METHOXYPHENOXY)ETHYL]AMINO}PROPAN-2-OL) BIS(PHOSPHORIC ACID) HYDRATE

BM 14,190

BM 14.190

BM 14190

BM-14-190

BM-14.190

BM-14190

BRD-A10977446-001-04-8

BRD-A10977446-045-01-1

C-21835

C06875

C24H26N2O4

C24H31N2O9P

Carloc

Carloc (TN)

carvedilol

Carvedilol (JAN/USAN/INN)

Carvedilol (phosphate hemihydrate)

Carvedilol [USAN:INN:BAN:JAN]

Carvedilol [USAN:USP:INN:BAN:JAN]

Carvedilol 1.0 mg/ml in Methanol

Carvedilol dihydrogen phosphate hemihydrate

Carvedilol for system suitability, European Pharmacopoeia (EP) Reference Standard

carvedilol HCl

Carvedilol hydrochloride

Carvedilol phosphate

Carvedilol phosphate (USAN)

Carvedilol phosphate [USAN]

Carvedilol phosphate anhydrous

Carvedilol phosphate hemihydrate

Carvedilol phosphate hydrate (JAN)

Carvedilol phosphate monohydrate

carvedilol, (+-)-isomer

carvedilol, (R)-isomer

carvedilol, (S)-isomer

Carvedilol, >=98% (HPLC), solid

carvedilol, 14C-labeled

Carvedilol, European Pharmacopoeia (EP) Reference Standard

Carvedilol, pharmaceutical secondary standard; traceable to USP and PhEur

Carvedilol, United States Pharmacopeia (USP) Reference Standard

Carvedilolum

Carvedilolum [Latin]

carvediol

CC-25436

CCG-100917

CCG-207952

CCG-213312

CHEBI:3441

CHEMBL1201167

CHEMBL723

Coreg

Coreg (TN)

Coreg CR (TN)

Coropres

Coropress

CPD000449280

CS-1194

CTK3J2232

D00255

D03415

D0W9LX

DB01136

Dibloc

Dilatrend

Dilatrend (TN)

DQ 2466

DQ-2466

DTXSID8022747

EG-P042

Eucardic

Eucardic (TN)

FT-0603059

FT-0652640

GlaxoSmithKline brand of carvedilol

GTPL551

HMS2051N03

HMS2089B09

HMS2093E12

HMS3261E15

HMS3269N11

HMS3393N03

HMS3655O14

HSDB 7044

HY-B0006

I06-0064

I06-1477

J10039

JAYBFQXVKDGMFT-UHFFFAOYSA-N

KB-75594

KBio2_002145

KBio2_004713

KBio2_007281

KBio3_002323

KBioGR_001252

KBioSS_002145

Kredex

KS-00000XRT

KS-1037

KSC492E3F

L001243

Lakeside brand of carvedilol

LHNYXTULDSJZRB-UHFFFAOYSA-N

LP00347

LS-121875

LS-186601

MCULE-7944987271

MFCD00864692

MLS000758299

MLS000759508

MLS001424092

MLS006011886

MolPort-003-666-814

NC00167

NCGC00167832-01

NCGC00167832-02

NCGC00167832-03

NCGC00167832-04

NCGC00261032-01

NSC-751177

NSC-758694

NSC751177

NSC758694

OGHNVEJMJSYVRP-UHFFFAOYSA-N

Pharmakon1600-01504257

PL008198

PL039781

PL061817

PL068260

PubChem18218

Q-200801

Querto

Roche brand of carvedilol

RTR-037608

s1831

SAM001246736

SAM001247021

SBI-0206771.P001

SC-13445

SCHEMBL10082334

SCHEMBL13287211

SCHEMBL194220

SCHEMBL22293

SCHEMBL599530

SK&F-105517

SK&F-105517-D

SKF 105517

SKF 105517D

SMR000449280

SPBio_001885

Spectrum_001665

Spectrum2_001673

Spectrum3_001182

Spectrum4_000636

Spectrum5_001436

SR-01000759289

SR-01000759289-9

ST24036957

STK621453

TL8005080

Tox21_500347

TR-037608

W-5131

W0023

Z2786051695

US Patents and Regulatory Information for COREG CR

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-001	Oct 20, 2006	AB	RX	Yes	No					Y
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-004	Oct 20, 2006	AB	RX	Yes	No					Y
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-002	Oct 20, 2006	AB	RX	Yes	No					Y
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-004	Oct 20, 2006	AB	RX	Yes	No					Y
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-001	Oct 20, 2006	AB	RX	Yes	No					Y

Expired US Patents for COREG CR

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-002	Oct 20, 2006
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-002	Oct 20, 2006
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-004	Oct 20, 2006
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-001	Oct 20, 2006
Smithkline Beecham	COREG CR	carvedilol phosphate	CAPSULE, EXTENDED RELEASE;ORAL	022012-001	Oct 20, 2006

Paragraph IV (Patent) Challenges for COREG CR

Drugname	Dosage	Strength	RLD	Date
	Extended-release Capsules	10 mg and 20 mg
	Extended-release Capsules	40 mg
	Extended-release Capsules	80 mg

International Patents for COREG CR

Country	Document Number	Estimated Expiration
South Korea	20140006111
China	101898995
Australia	2002362712
South Korea	101468827
Japan	2005533823