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Serving hundreds of leading biopharmaceutical companies globally:

UBS
Covington
Cerilliant
Healthtrust
US Army
Fuji
Express Scripts
Queensland Health
Deloitte

Generated: December 17, 2018

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COMTAN Drug Profile

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When do Comtan patents expire, and what generic alternatives are available?

Comtan is a drug marketed by Orion Pharma and is included in one NDA. There is one patent protecting this drug and one Paragraph IV challenge.

This drug has forty-eight patent family members in thirty-seven countries.

The generic ingredient in COMTAN is entacapone. There are nineteen drug master file entries for this compound. Fifteen suppliers are listed for this compound. Additional details are available on the entacapone profile page.

Drug patent expirations by year for COMTAN
Pharmacology for COMTAN
Synonyms for COMTAN
(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
(E)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-N,N-diethyl-prop-2-enamide
(E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide
(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
(E)-2-cyano-N,N-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide
(E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide
(E)-Entacapone
(E)-N, N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
(E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
116314-67-1
130929-57-6
2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-n,n-diethyl-2-propenamide
2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-N,N-diethyl-prop-2-enamide
2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide
2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-
2-Propenamide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-,(2E)-
4975G9NM6T
929E576
A806167
AB01275450_02
AB01275450_03
AB01275450-01
AC-393
AC1NQY02
AKOS015965009
AN-5935
BC219329
BCP9000645
BDBM50108879
BG0523
BIDD:GT0026
BRD-K83636919-001-01-4
C07943
C14H15N3O5
CAS-130929-57-6
CCG-213064
CHEBI:4798
CHEMBL953
COM-998
Comtan (TN)
Comtess
CS-1266
D00781
D0J1VY
DB00494
DR001248
DSSTox_CID_26439
DSSTox_GSID_46439
DSSTox_RID_81615
DTXSID5046439
Entacapona
Entacapona [INN-Spanish]
ENTACAPONE
Entacapone (JAN/USAN/INN)
Entacapone [USAN:INN]
Entacapone [USAN:USP:INN:BAN]
Entacaponum
Entacaponum [INN-Latin]
Entacom
EX-A1130
GP9755
GTPL6647
HMS2089O16
HSDB 8251
HY-14280
J-005902
J-008069
J90011
JRURYQJSLYLRLN-BJMVGYQFSA-N
K-4072
KB-69546
KB475572
LS-123327
LS-172316
MFCD00866580
MolPort-003-847-054
N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide
NCGC00164555-01
NCGC00164555-02
NCGC00164555-03
Novartis brand of entacapone
OR 611
OR-611
OR136308
OR206343
Orion brand of entacapone
RT-012475
s3147
SCHEMBL13596593
SCHEMBL34504
SCHEMBL34505
SR-05000001452
SR-05000001452-3
Stalevo (TN)
Tox21_112184
Tox21_112184_1
UNII-4975G9NM6T
ZINC35342787

US Patents and Regulatory Information for COMTAN

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Orion Pharma COMTAN entacapone TABLET;ORAL 020796-001 Oct 19, 1999 AB RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial Y ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for COMTAN

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Orion Pharma COMTAN entacapone TABLET;ORAL 020796-001 Oct 19, 1999 ➤ Try a Free Trial ➤ Try a Free Trial
Orion Pharma COMTAN entacapone TABLET;ORAL 020796-001 Oct 19, 1999 ➤ Try a Free Trial ➤ Try a Free Trial
Orion Pharma COMTAN entacapone TABLET;ORAL 020796-001 Oct 19, 1999 ➤ Try a Free Trial ➤ Try a Free Trial
Orion Pharma COMTAN entacapone TABLET;ORAL 020796-001 Oct 19, 1999 ➤ Try a Free Trial ➤ Try a Free Trial
Orion Pharma COMTAN entacapone TABLET;ORAL 020796-001 Oct 19, 1999 ➤ Try a Free Trial ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Paragraph IV (Patent) Challenges for COMTAN
Drugname Dosage Strength RLD Date
➤ Subscribe Tablets 200 mg ➤ Subscribe ➤ Try a Free Trial

For more information try a trial or see the plans and pricing

Serving hundreds of leading biopharmaceutical companies globally:

UBS
Covington
Cerilliant
Healthtrust
US Army
Fuji
Express Scripts
Queensland Health
Deloitte

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