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Generated: December 16, 2017

DrugPatentWatch Database Preview

Details for Patent: 5,135,950

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Summary for Patent: 5,135,950

Title: Stable polymorphic form of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide and the process for its preparation
Abstract:Stable and crystallographically essentially pure polymorphic form A of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)acrylamide may be prepared by crystallizing crude synthesis product from lower aliphatic carboxylic acid such as formic or acetic acid with a catalytic amount of hydrochloric or hydrobromic acid added. The product is a potent inhibitor of catechol-O-methyl-transferase enzyme (COMT).
Inventor(s): Pippuri; Aino K. (Espoo, FI), Honkanen; Erkki J. (Vantaa, FI), Haarala; Jorma V. (Helsinki, FI)
Assignee: Orion-yhtyma Oy (Espoo, FI)
Application Number:07/606,717
Patent Claim Types:
see list of patent claims
Compound; Process; Use; Composition;

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Foreign Priority and PCT Information for Patent: 5,135,950

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
United Kingdom8924838.9Nov 03, 1989

International Patent Family for Patent: 5,135,950

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria127447► Subscribe
Brazil1100289► Subscribe
Germany122004000014► Subscribe
Germany69022166► Subscribe
Denmark0426468► Subscribe
European Patent Office0426468► Subscribe91071Luxembourg► Subscribe
European Patent Office0426468► SubscribeCA 2004 00007Denmark► Subscribe
European Patent Office0426468► SubscribeC00426468/01Switzerland► Subscribe
European Patent Office0426468► Subscribe0490007-2Sweden► Subscribe
Spain2075885► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Farmers Insurance
Federal Trade Commission
Daiichi Sankyo
Chinese Patent Office

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