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Generated: February 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 5,112,861

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Summary for Patent: 5,112,861
Title: Method of treating Parkinson's Disease using pentanedione derivatives
Abstract:The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.
Inventor(s): Backstrom; Reijo (Helsinki, FI), Heinola; Kalevi E. (Jarvempaa, FI), Honkanen; Erkki J. (Vantaa, FI), Kaakkola; Seppo K. (Helsinki, FI), Kairisalo; Pekka J. (Helsinki, FI), Linden; Inge-Britt Y. (Helsinki, FI), Mannisto; Pekka I. (Helsinki, FI), Nissinen; Erkki A. O. (Espoo, FI), Pohto; Pentti (Helsinki, FI), Pippuri; Aino K. (Espoo, FI), Pystynen; Jarmo (Espoo, FI)
Assignee: Orion-yhtyma Oy (Espoo, FI)
Application Number:07/587,791
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 5,112,861

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Foreign Priority and PCT Information for Patent: 5,112,861

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Finland864875Nov 28, 1986
United Kingdom8712437May 27, 1987

International Patents Family Members for US Patent 5,112,861

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 243491 ➤ Try a Free Trial
Austria 148626 ➤ Try a Free Trial
Austria 401053 ➤ Try a Free Trial
Austria A312987 ➤ Try a Free Trial
Australia 621036 ➤ Try a Free Trial
Australia 8187987 ➤ Try a Free Trial
Belgium 1003279 ➤ Try a Free Trial
Bulgaria 60407 ➤ Try a Free Trial
Canada 1289078 ➤ Try a Free Trial
Canada 1334967 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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