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Details for Patent: 5,112,861

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Summary for Patent: 5,112,861

Title: Method of treating Parkinson's Disease using pentanedione derivatives
Abstract:The invention concerns a method for the treatment of Parkinson's Disease. The method comprises administering a catechol-O-methyl-transferase inhibiting amount of a compound having the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, alkylcarbamoyl of 2 to 5 carbon atoms or alkylcarbonyl of 2 to 5 carbon atoms, X represents nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents cyano; alkylcarbonyl of 2 to 5 carbon atoms; or carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms, or hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable salts or esters thereof; and a sufficient amount of levodopa to treat Parkinson's Disease. A peripheral decarboxylase inhibitor such as carbidopa or benzerazide is also preferably administered.
Inventor(s): Backstrom; Reijo (Helsinki, FI), Heinola; Kalevi E. (Jarvempaa, FI), Honkanen; Erkki J. (Vantaa, FI), Kaakkola; Seppo K. (Helsinki, FI), Kairisalo; Pekka J. (Helsinki, FI), Linden; Inge-Britt Y. (Helsinki, FI), Mannisto; Pekka I. (Helsinki, FI), Nissinen; Erkki A. O. (Espoo, FI), Pohto; Pentti (Helsinki, FI), Pippuri; Aino K. (Espoo, FI), Pystynen; Jarmo (Espoo, FI)
Assignee: Orion-yhtyma Oy (Espoo, FI)
Application Number:07/587,791
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Foreign Priority and PCT Information for Patent: 5,112,861

Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Finland864875Nov 28, 1986
United Kingdom8712437May 27, 1987

International Patent Family for Patent: 5,112,861

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Spain2008359► subscribe
Denmark623087► subscribe
Germany19975025► subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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