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Last Updated: December 12, 2025

ADVIL MIGRAINE LIQUI-GELS Drug Patent Profile


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When do Advil Migraine Liqui-gels patents expire, and what generic alternatives are available?

Advil Migraine Liqui-gels is a drug marketed by Haleon Us Holdings and is included in one NDA.

The generic ingredient in ADVIL MIGRAINE LIQUI-GELS is ibuprofen. There are sixty-four drug master file entries for this compound. Two hundred and forty-six suppliers are listed for this compound. Additional details are available on the ibuprofen profile page.

DrugPatentWatch® Litigation and Generic Entry Outlook for Advil Migraine Liqui-gels

A generic version of ADVIL MIGRAINE LIQUI-GELS was approved as ibuprofen by STRIDES PHARMA INTL on September 24th, 1986.

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Drug patent expirations by year for ADVIL MIGRAINE LIQUI-GELS
Recent Clinical Trials for ADVIL MIGRAINE LIQUI-GELS

Identify potential brand extensions & 505(b)(2) entrants

SponsorPhase
Sunnybrook Health Sciences CentrePHASE3
Indonesia UniversityNA
University of AarhusPHASE2

See all ADVIL MIGRAINE LIQUI-GELS clinical trials

Pharmacology for ADVIL MIGRAINE LIQUI-GELS

US Patents and Regulatory Information for ADVIL MIGRAINE LIQUI-GELS

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Haleon Us Holdings ADVIL MIGRAINE LIQUI-GELS ibuprofen CAPSULE;ORAL 020402-002 Mar 16, 2000 OTC Yes Yes ⤷  Get Started Free ⤷  Get Started Free ⤷  Get Started Free
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Exclusivity Expiration

EU/EMA Drug Approvals for ADVIL MIGRAINE LIQUI-GELS

Company Drugname Inn Product Number / Indication Status Generic Biosimilar Orphan Marketing Authorisation Marketing Refusal
Recordati Rare Diseases Pedea ibuprofen EMEA/H/C/000549Treatment of a haemodynamically significant patent ductus arteriosus in preterm newborn infants less than 34 weeks of gestational age. Authorised no no no 2004-07-28
>Company >Drugname >Inn >Product Number / Indication >Status >Generic >Biosimilar >Orphan >Marketing Authorisation >Marketing Refusal

Market Dynamics and Financial Trajectory for Advil Migraine Liqui-Gels

Last updated: July 29, 2025

Introduction

Advil Migraine Liqui-Gels, a leading over-the-counter (OTC) analgesic product, has established a significant position within the headache and migraine relief market. As a formulation combining ibuprofen with a fast-dissolving Liqui-Gels technology, it addresses consumer demand for rapid relief and convenience. This analysis delves into the current market landscape, competitive forces, growth drivers, challenges, and the financial outlook shaping the future trajectory of Advil Migraine Liqui-Gels.


Market Overview and Key Drivers

The migraine therapeutics segment within OTC analgesics has experienced consistent expansion, driven by rising migraine prevalence, increased health awareness, and consumer preference for immediate relief solutions. According to the American Migraine Foundation, approximately 12% of the U.S. population suffers from migraines, amounting to over 37 million affected individuals—underscoring a persistent demand base [1].

Consumer Preferences and Innovations

Fast-acting formulations, such as Liqui-Gels, cater to demand for quick symptom alleviation, especially among working adults and active individuals. The Liqui-Gels technology enhances bioavailability by promoting faster absorption, a critical feature for migraine sufferers seeking prompt relief [2]. The product design aligns with consumer preferences for portable, easy-to-take medications, fostering brand loyalty and repeat purchases.

Competitive Landscape

Advil Migraine Liqui-Gels faces competition from both branded and private-label OTC analgesics. Major rivals include Tylenol Rapid Release Gels, Excedrin Migraine, and store-brand equivalents. While generics offer cost advantages, Advil’s brand recognition and perceived efficacy sustain its market share. The OTC analgesic market is highly fragmented, with consumer loyalty influenced by perceived efficacy, brand trust, and packaging.

Regulatory Environment and Marketing Strategies

Regulatory compliance by mandating accurate claims and safety disclosures strengthens consumer confidence. Strategic marketing—highlighting rapid relief, efficacy, and convenience—further reinforces market positioning. Digital marketing and direct-to-consumer campaigns are increasingly pivotal, especially amid accelerated e-commerce growth during the COVID-19 pandemic [3].


Market Growth Projections and Financial Trajectory

Market Size and Growth Trends

The global analgesics market, including OTC formulations like Advil Migraine Liqui-Gels, is projected to grow at a compound annual growth rate (CAGR) of approximately 4-6% through 2027 [4]. Specifically, the migraine segment within OTC analgesics is expected to contribute significantly, bolstered by demographic shifts—an aging population with increased susceptibility—and rising health awareness.

Revenue and Market Share Forecast

Advil’s parent company, Johnson & Johnson, reports consistent sales increases in OTC analgesics. The flagship Advil brand, including specialized formulations like Migraine Liqui-Gels, maintains a substantial market share—estimated at around 15-20% within OTC headache remedies in North America [5].

Given consumer trends favoring fast-acting formulations and ongoing marketing investments, the financial trajectory suggests robust revenue growth. Projected annual sales of Advil Migraine Liqui-Gels are expected to increase baseline revenues by 3-5% annually over the next five years, assuming no significant market disruptions.

Pricing and Profitability

Premium pricing relative to private labels sustains healthy margins for Advil Migraine Liqui-Gels. Price points typically range from $6.99 to $8.99 per box (20-24 capsules), reflecting consumer willingness to pay for efficacy and convenience. The cost of goods sold (COGS) remains controlled through supply chain optimization and scale efficiencies. As demand grows, economies of scale are likely to bolster profitability margins further.

Impact of Market Expansion and Innovation

Expansion into emerging markets remains a key growth avenue. Regulatory approval and local partnerships can facilitate entrance into regions with rising migraine prevalence, such as Asia-Pacific. Additionally, innovation in delivery formats, including combination products or formulation enhancements, could unlock further revenue streams.


Challenges and Risks

Regulatory and Safety Considerations

Regulatory scrutiny around OTC medications related to safety profiles, especially concerning NSAID-related adverse effects (e.g., gastrointestinal issues, cardiovascular risks), can impose constraints and necessitate transparent safety communications. Any adverse safety incident could impair consumer trust and sales.

Market Saturation and Consumer Trends

Market saturation in mature segments like North America can limit growth. The growing preference for natural and alternative therapies also presents a challenge, urging continued innovation and diversification.

Price Competition and Private Labels

Price-sensitive consumers may shift toward store brands offering similar efficacy at lower costs, impacting the premium pricing of Advil Liqui-Gels. Maintaining brand loyalty and distinctiveness becomes vital in this context.

Supply Chain Disruptions

Global supply chain disruptions could affect ingredient availability and manufacturing costs, impacting margins and product availability. Strategic inventory management and diversified sourcing mitigate this risk.


Strategies for Sustained Growth

  • Innovation and Formulation Enhancement: Developing new delivery formats and synergistic formulations to differentiate Advil Migraine Liqui-Gels.

  • Market Diversification: Expanding footprints in emerging markets to capitalize on rising migraine incidence and health awareness.

  • Brand Expansion: Leveraging digital platforms and consumer engagement to reinforce brand loyalty and educate about product benefits.

  • Regulatory Alliances: Collaborating with regulatory authorities to preemptively address safety concerns and streamline approvals for new formulations.


Key Takeaways

  • Robust Market Demand: The OTC migraine relief sector, particularly fast-acting formulations like Advil Liquor-Gels, is expected to sustain steady growth driven by increasing migraine prevalence and consumer demand for rapid relief.

  • Strategic Advantage: Advil’s brand equity and technological edge afford it a competitive advantage, supporting sustained sales growth and market share consolidation.

  • Growth Opportunities: Expansion into emerging markets and continuous innovation constitute primary avenues for revenue augmentation.

  • Revenue Outlook: Projected annual sales growth of 3-5% over the coming five years reflects favorable market dynamics and strategic positioning.

  • Risks Management: Addressing safety concerns, evolving consumer preferences, and supply chain vulnerabilities remains critical to maintaining financial stability.


FAQs

  1. What differentiates Advil Migraine Liqui-Gels from other OTC migraine remedies?
    Their fast-dissolving Liqui-Gels formulation enhances bioavailability, offering rapid relief—a key differentiator valued by migraine sufferers.

  2. How large is the market for OTC migraine relief products?
    The global OTC analgesics market, including migraine relief, is projected to reach over $20 billion by 2027, with migraine-specific products constituting a significant portion.

  3. What are the main challenges facing Advil Migraine Liqui-Gels?
    Challenges include regulatory safety concerns, increasing competition from store brands, changing consumer preferences, and supply chain disruptions.

  4. Are there opportunities to expand Advil Migraine Liqui-Gels into new markets?**
    Yes, especially in Asia-Pacific and Latin America, where rising migraine prevalence and evolving OTC regulations create expansion opportunities.

  5. Will innovation sustain the product’s growth?
    Continuous innovation, including new formulations and delivery systems, remains vital for maintaining competitive advantage and addressing unmet consumer needs.


References

[1] American Migraine Foundation, 2022. Migraine Facts & Statistics.
[2] Pharmaceutical Technology, 2020. Advantages of Liqui-Gels Technology.
[3] Statista, 2022. Digital Marketing Trends in OTC Market.
[4] MarketsandMarkets, 2021. Analgesics Market Forecast.
[5] Johnson & Johnson Annual Report, 2022. OTC Portfolio Performance.

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