Suppliers and packagers for ADVIL MIGRAINE LIQUI-GELS

ADVIL MIGRAINE LIQUI-GELS

Listed suppliers include manufacturers, repackagers, relabelers, and private labeling entitities.

Applicant	Tradename	Generic Name	Dosage	NDA	NDA/ANDA	Supplier	Package Code	Package	Marketing Start
Haleon Us Holdings	ADVIL MIGRAINE LIQUI-GELS	ibuprofen	CAPSULE;ORAL	020402	NDA	Haleon US Holdings LLC	0573-0149-04	2 PACKET in 1 BLISTER PACK (0573-0149-04) / 2 CAPSULE, LIQUID FILLED in 1 PACKET	1995-04-10
Haleon Us Holdings	ADVIL MIGRAINE LIQUI-GELS	ibuprofen	CAPSULE;ORAL	020402	NDA	Haleon US Holdings LLC	0573-0149-13	1 BOTTLE in 1 CARTON (0573-0149-13) / 80 CAPSULE, LIQUID FILLED in 1 BOTTLE	1995-04-10
Haleon Us Holdings	ADVIL MIGRAINE LIQUI-GELS	ibuprofen	CAPSULE;ORAL	020402	NDA	Haleon US Holdings LLC	0573-0149-66	160 CAPSULE, LIQUID FILLED in 1 BOTTLE (0573-0149-66)	1995-04-10

Suppliers for the Pharmaceutical Drug: ADVIL MIGRAINE LIQUI-GELS

Last updated: August 10, 2025

Introduction

Advil Migraine Liqui-Gels represent a specialized over-the-counter (OTC) analgesic product designed for rapid relief from migraine symptoms. Manufactured under the widely recognized Advil brand by Pfizer Inc., these liqui-gels leverage liquid-filled capsule technology to provide faster absorption and onset of pain relief. As a popular OTC medication, Advil Migraine Liqui-Gels are distributed globally, necessitating a reliable and compliant supply chain comprising raw material suppliers, contract manufacturers, and distribution channels.

This analysis dissects the key suppliers involved in the production of Advil Migraine Liqui-Gels, emphasizing raw materials, encapsulation technology, manufacturing services, and logistics. Understanding these suppliers enables stakeholders to assess supply chain robustness, potential risks, and the competitive landscape shaping Advil Migraine Liqui-Gels’ market availability.

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Raw Material Suppliers

1. Active Pharmaceutical Ingredient (API) Suppliers

The core API in Advil Migraine Liqui-Gels is ibuprofen, a non-steroidal anti-inflammatory drug (NSAID). Pfizer sources ibuprofen from established chemical manufacturers adhering to Good Manufacturing Practices (GMP). Key suppliers include:

• BASF: A global chemical corporation supplying pharmaceutical-grade APIs, including ibuprofen, with extensive manufacturing facilities compliant with regulatory standards [1].

• Sabinsa Corporation: Known for producing active ingredients for OTC and prescription drugs, offering high-purity ibuprofen variants. Their supply ensures consistent potency and purity levels.

• Mingtai Chemical Co., Ltd.: An Asian API manufacturer providing bulk ibuprofen, often serving as a cost-effective option for large-volume orders.

2. Excipients and Fillers

Liqui-Gel capsules require specific excipients like:

• Gelatin or HPMC (hydroxypropyl methylcellulose): Sourced from suppliers like Gelatin Suppliers of America or Jungbunzlauer, approved for pharmaceutical use.

• Solvents and Stabilizers: Ethanol, glycerol, or other stabilizers sourced from global chemical companies such as Dow Chemical or Shell Chemicals.

• Colorants and Flavorings: Food-grade dyes and flavorings from suppliers like Sunset Ingredients or BASF Colors.

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Capsule Encapsulation Suppliers and Technologies

1. Capsule Manufacturers

The liqui-gel technology relies on softgel capsules that contain liquid ibuprofen.

• MSD (Matthews Silverspoon Drug) and Capsugel (a Lonza company): Among the leading providers of pharmaceutical softgel capsules globally, with production facilities complying with GMP guidelines.

• ACG (Associated Capsules): Supplies a broad range of softgel capsules with customized formulations, including gelatin-based and HPMC-based options accessible for vegan or vegetarian formulations.

2. Encapsulation Equipment Suppliers

• Fette Compacting and MG2: Equipment providers for softgel encapsulation machinery that Pfizer or its contract manufacturers may utilize.

• Pharma Technology Inc.: Supplies filling and sealing equipment tailored for liquid-filled capsules, ensuring secure encapsulation and stability.

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Contract Manufacturing Organizations (CMOs)

Pfizer predominantly utilizes contract manufacturing to produce Advil Migraine Liqui-Gels, relying on specialized facilities:

• Catalent: A global leader in OTC drug manufacturing, offering softgel production, formulation development, and packaging services. Catalent’s facilities are compliant with FDA cGMP standards, providing high-quality manufacturing capacity.

• Lonza: Through its Capsugel division, Lonza supplies softgel capsules, provides formulation expertise, and supports manufacturing processes.

• Recipharm: An international CMO provider with expertise in OTC softgel formulations and scalable production.

The engagement with these CMOs ensures continuous supply, regulatory compliance, and technological innovation.

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Distribution and Logistics

Key logistics suppliers facilitate the global distribution of Advil Migraine Liqui-Gels:

• DHL Supply Chain: Provides international freight, warehousing, and distribution services, ensuring timely delivery to retail outlets.

• UPS Healthcare: Manages temperature-sensitive pharmaceutical logistics, safeguarding product integrity across transit.

• CFI Logistics: Specializes in healthcare logistics, ensuring compliance with pharmaceutical storage requirements.

Efficient logistics channels are imperative for maintaining product availability amidst varying regulatory landscapes.

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Regulatory and Supply Chain Challenges

The supply chain for Advil Migraine Liqui-Gels faces challenges including:

• Raw Material Scarcity: Global disruptions in chemical supply chains can induce shortages of ibuprofen or excipients, impacting production schedules.

• Regulatory Compliance: Suppliers must adhere to strict GMP standards. Regulatory changes in ingredient approval or labeling can affect supplier eligibility.

• Manufacturing Capacity Limitations: During increased demand or pandemic-related disruptions, manufacturing capacity constraints may lead to shortages.

• Quality Assurance: Ensuring consistency across multiple suppliers requires rigorous quality control protocols to meet health authority standards globally.

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Conclusion

The supply chain for Advil Migraine Liqui-Gels hinges on a network of reputable raw material suppliers, advanced encapsulation technology providers, and experienced CMOs. Major players such as BASF, Sabinsa, Capsugel (Lonza), Catalent, and logistics providers like DHL and UPS underpin the availability of this OTC product. Maintaining diversified sourcing, transparent supplier qualification, and resilient logistics are crucial to mitigating risks and ensuring continuous market supply.

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Key Takeaways

• The core API—ibuprofen—is supplied by global chemical manufacturers like BASF and Sabinsa, emphasizing the importance of diversified sourcing.

• Capsule formulations rely heavily on providers like Capsugel and encapsulation technology firms that adhere to GMP standards.

• Contract manufacturing by firms such as Catalent enables Pfizer to maintain quality and scale without substantial in-house infrastructure.

• Global logistics partners play a critical role in maintaining product availability, especially amid disruptions.

• Vigilance over supply chain risks, including raw material shortages and regulatory changes, is essential for ensuring consistent product supply.

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FAQs

1. Who are the primary raw material suppliers for ibuprofen in Advil Migraine Liqui-Gels?
Major suppliers include BASF, Sabinsa Corporation, and Mingtai Chemical, who provide pharmaceutical-grade ibuprofen underpinning the product’s efficacy.

2. What companies manufacture the softgel capsules used in Advil Migraine Liqui-Gels?
Capsugel (a Lonza division), MSD, and ACG are leading manufacturers specializing in pharmaceutical softgel capsules, ensuring compliance and technological suitability.

3. Which contract manufacturers produce Advil Migraine Liqui-Gels at scale?
Catalent and Lonza are key partners, providing formulation, encapsulation, and packaging services for Pfizer.

4. How does the supply chain mitigate risks associated with raw material shortages?
Pfizer maintains supplier diversity, conducts rigorous quality assessments, and manages inventory buffers to ensure resiliency against disruptions.

5. What logistics providers are involved in distributing Advil Migraine Liqui-Gels globally?
DHL Supply Chain, UPS Healthcare, and CFI Logistics are primary partners managing transportation, warehousing, and distribution.

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Sources

[1] BASF. (2022). Pharmaceutical Active Ingredients. Available at: https://www.basf.com.