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Serving leading biopharmaceutical companies globally:

AstraZeneca
Dow
Harvard Business School
Daiichi Sankyo
Chubb
QuintilesIMS
Cantor Fitzgerald
Farmers Insurance
McKesson
Teva

Generated: October 20, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,642,012

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Which drugs does patent 8,642,012 protect, and when does it expire?


Patent 8,642,012 protects RAVICTI and is included in one NDA. There has been one Paragraph IV challenge on Ravicti.

This patent has twenty-three patent family members in sixteen countries.

Summary for Patent: 8,642,012

Title:Methods of treatment using ammonia-scavenging drugs
Abstract: The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.
Inventor(s): Scharschmidt; Bruce (South San Francisco, CA)
Assignee: Hyperion Therapeutics, Inc. (South San Francisco, CA)
Application Number:12/350,111
Patent Claim Types:
see list of patent claims
Use;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Horizon Theraps Inc
RAVICTI
glycerol phenylbutyrate
LIQUID;ORAL203284-001Feb 1, 2013RXYesYes► Subscribe► Subscribe DOSAGE ADJUSTMENT OF A NITROGEN SCAVENGING DRUG IN THE TREATMENT OF A UREA CYCLE DISORDER
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International Patent Family for Patent: 8,642,012

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Poland2330892► Subscribe
Norway2016023► Subscribe
Netherlands300854► Subscribe
LithuaniaPA2016041► Subscribe
Lithuania2330892► Subscribe
Japan2014102255► Subscribe
Japan2012501451► Subscribe
Japan5577341► Subscribe
Japan2012501329► Subscribe
HungaryS1600057► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Fish and Richardson
Harvard Business School
Cipla
Daiichi Sankyo
Chubb
US Department of Justice
Merck
Boehringer Ingelheim
Express Scripts
Queensland Health

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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