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Serving leading biopharmaceutical companies globally:

Cantor Fitzgerald
Boehringer Ingelheim
US Department of Justice

Generated: December 10, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,642,012

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Which drugs does patent 8,642,012 protect, and when does it expire?

Patent 8,642,012 protects RAVICTI and is included in one NDA. There has been one Paragraph IV challenge on Ravicti.

This patent has twenty-three patent family members in sixteen countries.

Summary for Patent: 8,642,012

Title:Methods of treatment using ammonia-scavenging drugs
Abstract: The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.
Inventor(s): Scharschmidt; Bruce (South San Francisco, CA)
Assignee: Hyperion Therapeutics, Inc. (South San Francisco, CA)
Application Number:12/350,111
Patent Claim Types:
see list of patent claims

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Patent Submitted Product Substance Delist Req. Patented / Exclusive Use
Horizon Theraps IncRAVICTIglycerol phenylbutyrateLIQUID;ORAL203284-001Feb 1, 2013RXYesYes► Subscribe► Subscribe► SubscribeDOSAGE ADJUSTMENT OF A NITROGEN SCAVENGING DRUG IN THE TREATMENT OF A UREA CYCLE DISORDER
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International Patent Family for Patent: 8,642,012

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office2338050► Subscribe
European Patent Office3133396► Subscribe
Spain2593378► Subscribe
United Kingdom0915545► Subscribe
United Kingdom2465250► Subscribe
United Kingdom201013468► Subscribe
United Kingdom2470310► Subscribe
CroatiaP20161222► Subscribe
HungaryE029912► Subscribe
HungaryS1600057► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Express Scripts
Harvard Business School
Queensland Health

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