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Serving leading biopharmaceutical companies globally:

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Generated: February 22, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,642,012

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Summary for Patent: 8,642,012
Title:Methods of treatment using ammonia-scavenging drugs
Abstract: The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.
Inventor(s): Scharschmidt; Bruce (South San Francisco, CA)
Assignee: Hyperion Therapeutics, Inc. (South San Francisco, CA)
Application Number:12/350,111
Patent Claim Types:
see list of patent claims
Use;

Drugs Protected by US Patent 8,642,012

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Horizon Theraps Inc RAVICTI glycerol phenylbutyrate LIQUID;ORAL 203284-001 Feb 1, 2013 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial DOSAGE ADJUSTMENT OF A NITROGEN SCAVENGING DRUG IN THE TREATMENT OF A UREA CYCLE DISORDER ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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International Patents Family Members for US Patent 8,642,012

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Lithuania 2330892 ➤ Try a Free Trial
Japan 2014102255 ➤ Try a Free Trial
Japan 2012501451 ➤ Try a Free Trial
Japan 5577341 ➤ Try a Free Trial
Japan 2012501329 ➤ Try a Free Trial
Hungary S1600057 ➤ Try a Free Trial
Hungary E029912 ➤ Try a Free Trial
Croatia P20161222 ➤ Try a Free Trial
United Kingdom 2470310 ➤ Try a Free Trial
United Kingdom 2465250 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Daiichi Sankyo
Accenture
Cipla
Farmers Insurance
Merck
UBS
Cerilliant
QuintilesIMS
Queensland Health

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