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Generated: April 29, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,642,012

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Which drugs does patent 8,642,012 protect, and when does it expire?

Patent 8,642,012 protects RAVICTI and is included in one NDA. There has been one Paragraph IV challenge on Ravicti.

This patent has nineteen patent family members in eleven countries.

Summary for Patent: 8,642,012

Title:Methods of treatment using ammonia-scavenging drugs
Abstract: The invention provides a method for determining a dose and schedule and making dose adjustments of PBA prodrugs used to treat nitrogen retention states, or ammonia accumulation disorders, by measuring urinary excretion of phenylacetylglutamine and/or total urinary nitrogen. The invention provides methods to select an appropriate dosage of a PBA prodrug based on the patient's dietary protein intake, or based on previous treatments administered to the patient. The methods are applicable to selecting or modifying a dosing regimen for a subject receiving an orally administered ammonia scavenging drug.
Inventor(s): Scharschmidt; Bruce (South San Francisco, CA)
Assignee: Hyperion Therapeutics, Inc. (South San Francisco, CA)
Application Number:12/350,111
Patent Claim Types:
see list of patent claims

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Horizon Theraps Inc
glycerol phenylbutyrate
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International Patent Family for Patent: 8,642,012

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Japan2012501451► Subscribe
Japan5577341► Subscribe
Japan2012501329► Subscribe
HungaryS1600057► Subscribe
CroatiaP20161222► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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