Last Updated: August 25, 2026

Details for Patent: 8,198,242


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Which drugs does patent 8,198,242 protect, and when does it expire?

Patent 8,198,242 protects VOXZOGO and is included in one NDA.

This patent has fifty-one patent family members in twenty-eight countries.

Summary for Patent: 8,198,242
Title:Variants of C-type natriuretic peptide
Abstract:The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).
Inventor(s):Daniel J. Wendt, Shinong Long, Sianna CASTILLO, Christopher P. Price, Mika Aoyagi-Scharber, Michel C. Vellard, Augustus O. Okhamafe
Assignee: Biomarin Pharmaceutical Inc
Application Number:US12/784,117
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,198,242
Patent Claim Types:
see list of patent claims
Use; Composition; Formulation;

Drugs Protected by US Patent 8,198,242

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Biomarin Pharm VOXZOGO vosoritide POWDER;SUBCUTANEOUS 214938-001 Nov 19, 2021 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y Y USE TO INCREASE LINEAR GROWTH IN PEDIATRIC PATIENTS WITH ACHONDROPLASIA WITH OPEN EPIPHYSES ⤷  Start Trial
Biomarin Pharm VOXZOGO vosoritide POWDER;SUBCUTANEOUS 214938-002 Nov 19, 2021 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y Y USE TO INCREASE LINEAR GROWTH IN PEDIATRIC PATIENTS WITH ACHONDROPLASIA WITH OPEN EPIPHYSES ⤷  Start Trial
Biomarin Pharm VOXZOGO vosoritide POWDER;SUBCUTANEOUS 214938-003 Nov 19, 2021 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y Y USE TO INCREASE LINEAR GROWTH IN PEDIATRIC PATIENTS WITH ACHONDROPLASIA WITH OPEN EPIPHYSES ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,198,242

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 2432489 ⤷  Start Trial LUC00248 Luxembourg ⤷  Start Trial
European Patent Office 2432489 ⤷  Start Trial 301162 Netherlands ⤷  Start Trial
European Patent Office 2432489 ⤷  Start Trial CA 2022 00004 Denmark ⤷  Start Trial
European Patent Office 2432489 ⤷  Start Trial 2022C/503 Belgium ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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