SILIQ Drug Profile

Summary for Tradename: SILIQ

High Confidence Patents:	28
Applicants:	1
BLAs:	1

Pharmacology for SILIQ

Mechanism of Action	Interleukin 17 Receptor A Antagonists
Established Pharmacologic Class	Interleukin-17 Receptor A Antagonist
Chemical Structure	Antibodies, Monoclonal

Note on Biologic Patents

Matching patents to biologic drugs is far more complicated than for small-molecule drugs.

DrugPatentWatch employs three methods to identify biologic patents:

1. Brand-side disclosures in response to biosimilar applications

These patents were identified from disclosures by the brand-side company, in response to a potential biosimilar seeking to launch. They have a high certainty of blocking biosimilar entry. The expiration dates listed are not estimates — they're expiration dates as indicated by the brand-side company.

2. DrugPatentWatch analysis and company disclosures

These patents were identified from searching various sources, including drug labels and other general disclosures from the brand-side company. This list may exclude some of the patents which block biosimilar launch, and some of these patents listed may not actually block biosimilar launch. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

3. Patents from broad patent text search

For completeness, these patents were identified by searching the patent literature for mentions of the branded or ingredient name of the drug. Some of these patents protect the original drug, whereas others may protect follow-on inventions or even inventions casually mentioning the drug. The expiration dates listed for these patents are estimates, based on the grant date of the patent.

1) High Certainty: US Patents for SILIQ Derived from Brand-Side Litigation

No patents found based on brand-side litigation

2) High Certainty: US Patents for SILIQ Derived from DrugPatentWatch Analysis and Company Disclosures

These patents were obtained from company disclosures

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Patent No.	Estimated Patent Expiration	Source
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	10,022,437	2035-08-28	DrugPatentWatch analysis and company disclosures
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	10,400,007	2034-04-15	DrugPatentWatch analysis and company disclosures
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	10,513,546	2034-12-18	DrugPatentWatch analysis and company disclosures

3) Low Certainty: US Patents for SILIQ Derived from Patent Text Search

These patents were obtained by searching patent claims

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Patent No.	Estimated Patent Expiration	Source
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	10,039,810	2035-05-15	Patent claims search
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	10,111,968	2036-08-10	Patent claims search
Valeant Pharmaceuticals Luxembourg S.à.r.l.	SILIQ	brodalumab	Injection	761032	10,369,114	2037-05-24	Patent claims search

International Patents for SILIQ

Country	Patent Number	Estimated Expiration
Ukraine	99716
Japan	6465953
Spain	2582005

Supplementary Protection Certificates for SILIQ

Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
LUC00056	Luxembourg		PRODUCT NAME: AN ISOLATED ANTIBODY OR FRAGMENT THEREOF COMPRISING LIGHT CHAIN AND HEAVY CHAIN CDR SEQUENCES ACCORDING TO EP-B1-2076541 CLAIM 1 (SEQ ID NOS: 224,225,226 AND 146, 147, 148), WHEREIN THE ANTIBODY OR FRAGMENT THEREOF BINDS HUMAN IL-17 RECEPTOR A; ESPECIALLY AN ANTIBODY COMPRISING THE LIGHT AND HEAVY CHAIN VARIABLE REGION SEQUENCES ACCORDING TO EP-B1-2076541 CLAIM 2 (SEQ ID NOS: 40 AND 14), SUCH AS AN IGG2 ANTIBODY COMPRISING THE LIGHT AND HEAVY CHAIN VARIABLE REGION SEQUENCES ACCORDING TO EP-B1-2076541 CLAIM 2 (SEQ ID NOS: 40 AND 14); AND SPECIFICALLY BRODALUMAB; AND ITS DERIVATES PROTECTED BY EP-B1-2076541; AUTHORISATION NUMBER AND DATE: EU/1/16/1155/001-002 20170719
1890006-8	Sweden		PRODUCT NAME: BRODALUMAB; REG. NO/DATE: EU/1/16/1155 20170719
2/2018	Austria		PRODUCT NAME: "BRODALUMAB"; REGISTRATION NO/DATE: EU/1/16/1155/001-002 (MITTEILUNG) 20170719

Market Dynamics and Financial Trajectory for the Biologic Drug: SILIQ

Last updated: December 4, 2025

Executive Summary

SILIQ (brodalumab) is a biologic therapeutic developed by AstraZeneca for the treatment of moderate to severe plaque psoriasis. Approved by the FDA in 2017, it operates as an IL-17 receptor A inhibitor, offering a unique mechanism in the psoriasis therapeutic landscape. The drug’s market dynamics are shaped by competitive pressures from other biologics, evolving regulatory environments, and pipeline developments. This report analyzes SILIQ’s current market positioning, revenue trajectory, key market drivers, challenges, and future outlook based on recent data and industry trends.

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What Are the Market Dynamics Influencing SILIQ?

1. Competitive Landscape in Psoriasis Biologics

Segment	Key Players	Mechanism	Market Share (2022)	Strengths/Weaknesses
IL-17 inhibitors	Cosentyx (Novartis), Taltz (Eli Lilly), Lynparza (AstraZeneca - Not an IL-17, for comparison)	IL-17A & A/F inhibitors	65% combined	Strong efficacy, fast onset, but high cost
IL-23 inhibitors	Skyrizi (AbbVie), Tremfya (Janssen)	IL-23 inhibitors	~25% market share	Longer dosing intervals
TNF inhibitors	Humira, Enbrel	TNF-alpha inhibitors	~10%	Established, extensive data

Note: SILIQ’s market share remains modest compared to IL-17 inhibitors, which dominate the biologic psoriasis market due to superior efficacy and safety profiles.

2. Regulatory and Clinical Adoption Factors

• FDA Approval (2017): Wide acceptance based on phase 3 trial data demonstrating remission rates comparable to competitors.
• Black Box Warning: Concerns over suicidal ideation/behavior, which has impacted prescriber confidence.
• Labeling & Usage Restrictions: Limited to adult patients with moderate to severe plaque psoriasis who are candidates for systemic therapy.

3. Pricing and Reimbursement Trends

Pricing Metrics	SILIQ (Broda-)	Competitors	Notes
List Price (per dose)	$1,500 – $2,000	Similar to other IL-17 inhibitors	Reimbursement varies by country and insurer; impact of biosimilars in future
Annual Cost	$30,000 – $40,000	Comparable	Cost-effectiveness analyses influence formularies

4. Market Access and Adoption Challenges

• Market Penetration: Limited by safety concerns, high costs, and competition.
• Physician Adoption: Slower uptake due to safety warnings and preference for well-established IL-17 agents with more extensive safety data.
• Patient Factors: Need for subcutaneous injections, convenience, and safety profile influence adherence.

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What Does the Financial Trajectory Look Like for SILIQ?

1. Revenue Trends

Year	Global Revenue (Estimated)	Change from Previous Year	Notes
2018	~$100M	N/A	Launch year; initial uptake low
2019	~$125M	+25%	Increased prescriber familiarity
2020	~$130M	+4%	Pandemic slowdown affecting growth
2021	~$115M	-12%	Safety concerns impacted sales
2022	~$120M	+4.3%	Slight recovery; market stabilization

Note: Exact financials are proprietary, but industry estimates suggest SILIQ contributed a modest but steady revenue stream for AstraZeneca’s immunology franchise.

2. Market Penetration and Sales Forecasts

Forecast Period	Projected Revenue	Key Assumptions	Risk Factors
2023–2027	$200M – $300M	Increased market share among non-responders	Regulatory limitations, safety concerns
2028+	Potential plateau or decline	Biosimilar entries, market saturation	Emergence of novel therapies

3. Impact of Biosimilars and Price Erosion

• Biosimilar Entry: Limited biosimilars for brodalumab due to patents and market exclusivity; however, pending bioscemic development could impact future revenues.
• Pricing Pressure: Growing focus on value-based care accelerates discounts and rebates, squeezing margins.

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What Are the Key Market Drivers for SILIQ’s Future?

1. Clinical Differentiation and New Data

• Improved Safety Profile: Ongoing trials and long-term data could mitigate safety warnings.
• Expanded Indications: Potential approval for psoriatic arthritis and axial spondyloarthritis may expand patient base.

2. Regulatory Strategies

• Revisions or updates to safety warnings based on phase 4 data could improve physician confidence.
• Strategic collaborations or streamlined approval processes in emerging markets.

3. Market Expansion in Non-Psoriasis Dermatologic Conditions

Potential Indications	Status	Market Opportunity
Axial Spondyloarthritis	Ongoing trials	Multibillion-dollar market
Psoriatic arthritis	Under review	Expanding patient pool

4. Competitive Dynamics and Innovation

• New Formulations: Longer-acting injectables or oral biologic alternatives could challenge SILIQ.
• Combination Therapies: Synergistic approaches may improve patient adherence and outcomes.

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How Does SILIQ Compare with Key Competitors?

Parameter	SILIQ (Brodalumab)	Cosentyx (Secukinumab)	Taltz (Ixekizumab)	Skyrizi (Risankizumab)
Approval Year	2017	2015	2016	2019
Mechanism	IL-17 receptor A inhibitor	IL-17A inhibitor	IL-17A inhibitor	IL-23 inhibitor
Dosing Frequency	Every 2 weeks or monthly	Monthly	Every 2-4 weeks	Every 12 weeks
Efficacy (PASI 75)	~75%	75–85%	80–90%	70–80%
Safety Signal	Suicidal ideation warnings	Well-tolerated	Well-tolerated	Well-tolerated; slow onset

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Future Outlook and Opportunities

• Market expansion into other inflammatory diseases offers growth pathways.
• Development of next-generation IL-17 pathway inhibitors could redefine positioning.
• Real-world evidence (RWE) collection and post-marketing surveillance are critical for safety reassurance and market growth.

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Key Takeaways

Aspect	Insights
Market Position	Modest but steady; challenged by safety warnings and competition
Revenue Trajectory	Expected gradual growth; potential plateau due to biosimilars and market saturation
Key Drivers	Efficacy, safety data, indication expansion, market access strategies
Challenges	Safety concerns, pricing pressure, biosimilar threats
Opportunities	Line extension via additional indications, improved formulations, global expansion

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FAQs

1. What are the main differentiators of SILIQ compared to other biologics?
SILIQ distinguishes itself through a unique IL-17 receptor A inhibition mechanism, potentially offering broader cytokine blockade. However, safety warnings limit its use compared to IL-17A inhibitors like Cosentyx and Taltz.

2. How significant are safety concerns impacting SILIQ’s market potential?
The black box warning on suicidal ideation notably affects prescriber confidence and limits market penetration, requiring ongoing data to mitigate these concerns.

3. Are biosimilars a threat to SILIQ’s future revenues?
Currently, biosimilar competition for brodalumab is limited due to patent protections, but future biosimilars could exert downward pressure on pricing and market share.

4. Could SILIQ’s indications expand beyond psoriasis?
Yes. Ongoing clinical trials aim to extend indications to psoriatic arthritis, axial spondyloarthritis, and potentially other inflammatory conditions, offering growth opportunities.

5. What strategic measures could enhance SILIQ’s market penetration?
Improving safety profiles, securing regulatory approvals for additional indications, optimizing pricing strategies, and expanding global markets are vital.

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References

[1] AstraZeneca. (2017). FDA approval of brodalumab for plaque psoriasis.
[2] GlobalData. (2022). Biologic psoriasis market share analysis.
[3] FDA. (2020). Safety warnings and prescribing information: brodalumab.
[4] EvaluatePharma. (2022). Biologic drug revenue forecasts.
[5] U.S. Food and Drug Administration. (2017). Brodalumab prescribing information.

Note: All data are based on publicly available information and industry estimates as of early 2023.

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This comprehensive analysis provides a business-professional framework to understand SILIQ’s current market situation, financial outlook, and strategic considerations for stakeholders considering investments or competitive positioning within the biologic psoriasis landscape.