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Generated: August 22, 2019

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Patent: 10,111,968

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Summary for Patent: 10,111,968
Title:Nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
Abstract: The present invention relates to a nucleic add sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic add for increasing the expression of the encoded peptide or protein, particularly for the use in gene therapy. It also discloses its use for the preparation of a pharmaceutical composition, e.g., for use in gene therapy, particularly in the treatment of diseases which are in need of a treatment with a therapeutic peptide or protein, preferably as defined herein. The present invention further describes a method for increasing the expression of a peptide or protein comprising a therapeutic protein or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.
Inventor(s): Thess; Andreas (Kusterdingen, DE), Schlake; Thomas (Gundelfingen, DE), Probst; Jochen (Wolfschlugen, DE)
Assignee: CureVac AG (Tubingen, DE)
Application Number:15/233,933
Patent Claims:see list of patent claims

Details for Patent 10,111,968

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech Inc OCREVUS ocrelizumab INJECTABLE;INJECTION 761053 001 2017-03-28 ➤ Sign Up CureVac AG (Tubingen, DE) 2032-02-15 RX search
Janssen Biotech STELARA ustekinumab INJECTABLE;INJECTION 761044 001 2016-09-23 ➤ Sign Up CureVac AG (Tubingen, DE) 2032-02-15 RX search
Eli Lilly And Co LARTRUVO olaratumab INJECTABLE; INJECTION 761038 001 2016-10-19 ➤ Sign Up CureVac AG (Tubingen, DE) 2032-02-15 RX Orphan search
Bristol Myers Squibb EMPLICITI elotuzumab INJECTABLE;INJECTION 761035 002 2015-11-30 ➤ Sign Up CureVac AG (Tubingen, DE) 2032-02-15 RX Orphan search
Bristol Myers Squibb EMPLICITI elotuzumab INJECTABLE;INJECTION 761035 001 2015-11-30 ➤ Sign Up CureVac AG (Tubingen, DE) 2032-02-15 RX Orphan search
Teva Respiratory Llc CINQAIR reslizumab INJECTABLE;INJECTION 761033 001 2016-03-23 ➤ Sign Up CureVac AG (Tubingen, DE) 2032-02-15 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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International Patent Family for US Patent 10,111,968

Country Patent Number Publication Date
World Intellectual Property Organization (WIPO) 2013120497 Aug 22, 2013
World Intellectual Property Organization (WIPO) 2013120629 Aug 22, 2013
United States of America 2015057340 Feb 26, 2015
United States of America 2017056529 Mar 02, 2017
United States of America 2018177894 Jun 28, 2018
United States of America 2018185517 Jul 05, 2018
>Country >Patent Number >Publication Date

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