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Last Updated: September 25, 2020

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Patent: 10,369,114

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Summary for Patent: 10,369,114
Title:Cholestosome vesicles for incorporation of molecules into chylomicrons
Abstract: The present invention is directed to a cargo-loaded cholesteryl ester nanoparticle with a hollow compartment (\"cholestosome\") consisting essentially of at least one non-ionic cholesteryl ester and one or more encapsulated active molecules which cannot appreciably pass through an enterocyte membrane in the absence of said molecule being loaded into said cholestosome, the cholestosome having a neutral surface and having the ability to pass into enterocytes in the manner of orally absorbed nutrient lipids using cell pathways to reach the golgi apparatus. Pursuant to the present invention, the novel cargo loaded cholestosomes according to the present invention are capable of depositing active molecules within cells of a patient or subject and effecting therapy or diagnosis of the patient or subject.
Inventor(s): Schentag; Jerome J. (Amherst, NY), McCourt; Mary P. (Amherst, NY), Mielnicki; Lawrence (Buffalo, NY), Hughes; Julie (Williamsville, NY)
Assignee: THERASYN SENSORS, INC. (Eggertsville, NY)
Application Number:15/603,992
Patent Claims:see list of patent claims

Details for Patent 10,369,114

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Novo Nordisk Inc NOVOLOG insulin aspart recombinant INJECTABLE;SUBCUTANEOUS 020986 001 2001-01-19   Start Trial THERASYN SENSORS, INC. (Eggertsville, NY) 2033-03-14 DISCN search
Novo Nordisk Inc NOVOLOG PENFILL insulin aspart recombinant INJECTABLE;SUBCUTANEOUS 020986 002 2001-01-19   Start Trial THERASYN SENSORS, INC. (Eggertsville, NY) 2033-03-14 DISCN search
Novo Nordisk Inc NOVOLOG FLEXPEN insulin aspart recombinant INJECTABLE;SUBCUTANEOUS 020986 003 2001-01-19   Start Trial THERASYN SENSORS, INC. (Eggertsville, NY) 2033-03-14 DISCN search
Novo Nordisk Inc NOVOLOG INNOLET insulin aspart recombinant INJECTABLE;SUBCUTANEOUS 020986 004 2001-01-19   Start Trial THERASYN SENSORS, INC. (Eggertsville, NY) 2033-03-14 DISCN search
Novo Nordisk Inc NOVOLOG FLEXTOUCH insulin aspart recombinant INJECTABLE;SUBCUTANEOUS 020986 005 2001-01-19   Start Trial THERASYN SENSORS, INC. (Eggertsville, NY) 2033-03-14 DISCN search
Sanofi Aventis Us LANTUS insulin glargine recombinant INJECTABLE;INJECTION 021081 001 2000-11-17   Start Trial THERASYN SENSORS, INC. (Eggertsville, NY) 2033-03-14 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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