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Last Updated: September 24, 2020

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Patent: 8,846,681

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Summary for Patent: 8,846,681
Title:Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. ##STR00001## Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
Inventor(s): Mitchell; Ian S. (Lafayette, CO), Blake; James F. (Longmont, CO), Xu; Rui (Longmont, CO), Kallan; Nicholas C. (Boulder, CO), Xiao; Dengming (Longmont, CO), Spencer; Keith Lee (Lyons, CO), Bencsik; Josef R. (Longmont, CO), Wallace; Eli M. (Lyons, CO), Schlachter; Stephen T. (Boulder, CO), Banka; Anna L. (Longmont, CO), Liang; Jun (Palo Alto, CA), Safina; Brian (Redwood City, CA), Li; Jun (Foster City, CA), Chabot; Christine (San Mateo, CA)
Assignee: Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA)
Application Number:13/160,351
Patent Claims:see list of patent claims

Details for Patent 8,846,681

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 001 1997-11-26   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX search
Genentech RITUXAN rituximab SOLUTION;INTRAVENOUS 103705 002 1997-11-26   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 001 1998-06-19   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX search
Medimmune SYNAGIS palivizumab VIAL 103770 002 1998-06-19   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX search
Genentech HERCEPTIN trastuzumab VIAL; INTRAVENOUS 103792 001 1998-09-25   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 001 2001-05-07   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX Orphan search
Genzyme CAMPATH alemtuzumab VIAL; INTRAVENOUS 103948 002 2001-05-07   Start Trial Array BioPharma, Inc. (Boulder, CO) Genentech, Inc. (South San Francisco, CA) 2027-07-05 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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