Patent: 10,265,291
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Summary for Patent: 10,265,291
| Title: | Disulfur bridge linkers for conjugation of a cell-binding molecule |
| Abstract: | The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders. |
| Inventor(s): | Zhao; Robert Yongxin (Lexington, MA) |
| Assignee: | HANGZHOU DAC BIOTECH CO., LTD. (Hangzhou, CN) |
| Application Number: | 15/431,154 |
| Patent Claims: | see list of patent claims |
Details for Patent 10,265,291
| Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
|---|---|---|---|---|---|---|---|
| Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | January 15, 1974 | ⤷ Start Trial | 2037-02-13 |
| Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | December 27, 1984 | ⤷ Start Trial | 2037-02-13 |
| Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | February 15, 1985 | ⤷ Start Trial | 2037-02-13 |
| Ferring Pharmaceuticals Inc. | NOVAREL | chorionic gonadotropin | For Injection | 017016 | February 16, 1990 | ⤷ Start Trial | 2037-02-13 |
| Bel-mar Laboratories, Inc. | CHORIONIC GONADOTROPIN | chorionic gonadotropin | Injection | 017054 | March 26, 1974 | ⤷ Start Trial | 2037-02-13 |
| Fresenius Kabi Usa, Llc | CHORIONIC GONADOTROPIN | chorionic gonadotropin | For Injection | 017067 | March 05, 1973 | ⤷ Start Trial | 2037-02-13 |
| >Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
International Patent Family for US Patent 10,265,291
| Country | Patent Number | Estimated Expiration |
|---|---|---|
| United States of America | 10292961 | ⤷ Start Trial |
| United States of America | 10307391 | ⤷ Start Trial |
| United States of America | 10322104 | ⤷ Start Trial |
| United States of America | 2015314017 | ⤷ Start Trial |
| United States of America | 2017151346 | ⤷ Start Trial |
| United States of America | 2017202975 | ⤷ Start Trial |
| >Country | >Patent Number | >Estimated Expiration |
