Last Updated: November 8, 2026

Patent: 10,322,104

Summary for Patent: 10,322,104

Title:	Disulfur bridge linkers for conjugation of a cell-binding molecule
Abstract:	The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders.
Inventor(s):	Zhao; Robert Yongxin (Lexington, MA)
Assignee:	HANGZHOU DAC BIOTECH CO., LTD. (Hangzhou, CN)
Application Number:	15/479,859
Patent Claims:	see list of patent claims

Details for Patent 10,322,104

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	August 24, 1998	10,322,104	2037-04-05
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	September 25, 1998	10,322,104	2037-04-05
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	February 10, 2017	10,322,104	2037-04-05
Imclone Llc A Wholly-owned Subsidiary Of Eli Lilly And Company	ERBITUX	cetuximab	Injection	125084	February 12, 2004	10,322,104	2037-04-05
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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