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Last Updated: September 26, 2020

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Patent: 10,058,630

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Summary for Patent: 10,058,630
Title:Methods for inhibiting stenosis, obstruction, or calcification of a stented heart valve or bioprosthesis
Abstract: Methods for inhibiting stenosis, obstruction and/or calcification of a heart valve following implantation in a vessel having a wall are disclosed. In one aspect the method includes providing a bioprosthetic heart valve mounted on an elastical stent; treating the bioprosthetic heart valve with a tissue fixative; coating the stent and the bioprosthetic valve with a coating composition including one or more therapeutic agents; implanting the bioprosthetic valve into the vessel in a diseased natural valve site; eluting the coating composition from the bioprosthetic valve; and inhibiting stenosis, obstruction and/or calcification of the bioprosthetic heart valve by preventing the attachment of stem cells to the bioprosthetic heart valve, the stem cells circulating external and proximate to the bioprosthetic heart valve by activating nitric oxide production (i) in the circulating stem cells, (ii) in an endothelial cell lining covering the bioprosthetic heart valve tissue, (iii) or both.
Inventor(s): Rajamannan; Nalini M. (Chicago, IL)
Assignee: CONCIEVALVE, LLC (Minneapolis, MN)
Application Number:15/601,236
Patent Claims:see list of patent claims

Details for Patent 10,058,630

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Jubilant Hollisterstier Llc POSITIVE SKIN TEST CONTROL - HISTAMINE histamine INJECTION 103891 1 1995-06-15   Start Trial CONCIEVALVE, LLC (Minneapolis, MN) 2032-10-22 search
Amgen PROLIA denosumab INJECTABLE; SUBCUTANEOUS 125320 001 2010-06-01   Start Trial CONCIEVALVE, LLC (Minneapolis, MN) 2032-10-22 RX Orphan search
Amgen XGEVA denosumab INJECTABLE; SUBCUTANEOUS 125320 002 2010-06-01   Start Trial CONCIEVALVE, LLC (Minneapolis, MN) 2032-10-22 RX Orphan search
Amgen Inc REPATHA evolocumab INJECTABLE;INJECTION 125522 001 2016-07-08   Start Trial CONCIEVALVE, LLC (Minneapolis, MN) 2032-10-22 RX Orphan search
Sanofi Aventis PRALUENT alirocumab INJECTABLE;INJECTION 125559 001 2017-04-24   Start Trial CONCIEVALVE, LLC (Minneapolis, MN) 2032-10-22 RX search
Sanofi Aventis PRALUENT alirocumab INJECTABLE;INJECTION 125559 002 2017-04-24   Start Trial CONCIEVALVE, LLC (Minneapolis, MN) 2032-10-22 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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