Claims for Patent: 8,685,381

Summary for Patent: 8,685,381

Title:	Topical base and active agent-containing compositions, and methods for improving and treating skin
Abstract:	The invention provides skin protecting and penetrating, easy-to-administer base and active agent-containing compositions, such as those including hydrocortisone, for treating the skin of mammals for different dermatologic disorders. This is effected by topically administering effective amounts of the compositions thereto in forms that address the skin and mucosa of the mouth and lips, and the rest of the body. Additionally, an optional flavoring addition to these products affords significantly better tasting, and less bitter, compositions, allowing a more pleasant experience and better compliance by patients. The compositions include a unique formulation of FANCOL VB, Natunola Castor 1023, Finsolv TN, bees wax and, optionally, one or a plurality of plant or plant seed oils, fatty alcohols, fats and flavorings, in desirable weight percents thereof, in various forms, and preferably in a form of a solid roll-on stick in a variety of sizes and of a jar or pot.
Inventor(s):	Schlessinger; Joel (Omaha, NE), Schlessinger; Daniel Isaac (Omaha, NE)
Assignee:
Application Number:	13/233,012
Patent Claims:	1. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of (i) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (ii) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iii) C.sub.12-15 Alkyl Benzoate, and (iv) bees wax, each in amounts that are effective for collectively forming a base composition having an ability to function effectively as a topically-applied carrier vehicle for the active agents, wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 2. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of (i) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (ii) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iii) C.sub.12-15 Alkyl Benzoate, and (iv) bees wax, and one or a plurality of plant oils, plant seed oils, fatty alcohols or fats, or any combination thereof, each in combined amounts that are effective for collectively forming a base composition having an ability to function effectively as a topically-applied carrier vehicle for the active agents, wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 3. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of (i) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (ii) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iii) C.sub.12-15 Alkyl Benzoate, and (iv) bees wax, and one or a plurality of flavorings, and one or a plurality of plant oils, plant seed oils, fatty alcohols or fats, or any combination thereof, each in combined amounts that are effective for collectively forming a base composition having an ability to function effectively as a topically-applied carrier vehicle for the active agents, wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition, and wherein the base composition does not have a bitter taste or odor, has no distinctive taste or odor or has a pleasant taste or odor. 4. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, comprising (i) 11.00 weight percent Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (ii) 10.00 weight percent Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iii) 15.00 weight percent C.sub.12-15 Alkyl Benzoate, (iv) 11.00weight percent Bees Wax, (v) 26.00 weight percent Castor Oil, (vi) 20.00 weight percent Stearyl Alcohol, (vii) 7.00 weight percent Cocoa Butter, and (viii) 0.00 weight percent Flavoring (Vanilla), wherein the base composition has an ability to function effectively as a topically-applied carrier vehicle for the active agents, and wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 5. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of: (a) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the base composition in an amount ranging from about 6 to about 25 weight percent; (b) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the base composition in an amount ranging from about 5 to about 39 weight percent; (c) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the base composition in an amount ranging from about 9 to about 25 weight percent; (d) bees wax, wherein the bees wax is present in the base composition in an amount ranging from about 6 to about 43 weight percent; (e) optionally, one or a plurality of plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the base composition in a combined amount ranging from about 0 to about 38.5 weight percent; (f) optionally, one or a plurality of fatty alcohols, wherein the fatty alcohols are present in the base composition in a combined amount ranging from about 0 to about 25 weight percent; (g) optionally, one or a plurality of fats, wherein the fats are present in the base composition in a combined amount ranging from about 0 to about 12 weight percent; and (h) optionally, one or a plurality of flavorings, wherein the flavorings are present in the base composition in a combined amount ranging from about 0 to about 3.5 weight percent; wherein the base composition has an ability to function effectively as a topically-applied carrier vehicle for the active agents, and wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 6. A base composition of claim 5, wherein the base composition includes one or more flavorings. 7. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of: (a) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the base composition in an amount ranging from about 6 to about 25 weight percent; (b) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the base composition in an amount ranging from about 5 to about 39 weight percent; (c) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the base composition in an amount ranging from about 9 to about 25 weight percent; (d) bees wax, wherein the bees wax is present in the base composition in an amount ranging from about 6 to about 43 weight percent; (e) one or more plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the base composition in a combined amount ranging from about 0.1 to about 38.5 weight percent; (f) one or more fatty alcohols, wherein the fatty alcohols are present in the base composition in a combined amount ranging from about 0.1 to about 25 weight percent; (g) one or more fats, wherein the fats are present in the base composition in a combined amount ranging from about 0.1 to about 12 weight percent; and (h) optionally, one or more flavorings, wherein the flavorings are present in the base composition in an amount ranging from about 0 to about 3.5 weight percent; wherein the base composition has an ability to function effectively as a topically-applied carrier vehicle for the active agents, and wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 8. A base composition of claim 7, wherein the base composition includes one or more flavorings. 9. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of: (a) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the base composition in an amount ranging from about 6 to about 16 weight percent; (b) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the base composition in an amount ranging from about 5 to about 15 weight percent; (c) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the base composition in an amount ranging from about 10 to about 20 weight percent; (d) bees wax, wherein the bees wax is present in the base composition in an amount ranging from about 6 to about 16 weight percent; (e) one or more plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the base composition in a combined amount ranging from about 13 to about 38.5 weight percent; (f) one or more fatty alcohols, wherein the fatty alcohols are present in the base composition in a combined amount ranging from about 15 to about 25 weight percent; (g) one or more fats, wherein the fats are present in the base composition in a combined amount ranging from about 2 to about 12 weight percent; and (h) optionally, one or more flavorings, wherein the flavorings are present in the base composition in an amount ranging from about 0 to about 3.5 weight percent; wherein the base composition has an ability to function effectively as a topically-applied carrier vehicle for the active agents, and wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 10. A base composition of claim 9, wherein the base composition includes one or more flavorings. 11. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, consisting of: (a) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the base composition in an amount ranging from about 10 to about 12 weight percent; (b) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the base composition in an amount ranging from about 9 to about 11 weight percent; (c) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the base composition in an amount ranging from about 14 to about 16 weight percent; (d) bees wax, wherein the bees wax is present in the base composition in an amount ranging from about 10 to about 12 weight percent; (e) one or more plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the base composition in a combined amount ranging from about 24.5 to about 27 weight percent; (f) one or more fatty alcohols, wherein the fatty alcohols are present in the base composition in a combined amount ranging from about 19 to about 21 weight percent; (g) one or more fats, wherein the fats are present in the base composition in a combined amount ranging from about 6 to about 8 weight percent; and (h) optionally, one or more flavorings, wherein the flavorings are present in the base composition in an amount ranging from about 0 to about 3.5 weight percent; wherein the base composition has an ability to function effectively as a topically-applied carrier vehicle for the active agents, and wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 12. A base composition of claim 11, wherein the base composition includes one or more flavorings. 13. A base composition of claim 5, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 14. A base composition of claim 6, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 15. A base composition of claim 7, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 16. A base composition of claim 8, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 17. A base composition of claim 9, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 18. A base composition of claim 10, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 19. A base composition of claim 11, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 20. A base composition of claim 12, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 21. A composition in a solid or semi-solid form for topical application to the skin of a mammal for repairing, improving or fully healing a skin disorder, disease, adverse condition, or other condition that requires, or could benefit from, improvement, or for causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, comprising (i) 1.0 weight percent Hydrocortisone, (ii) 11.00 weight percent Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (iii) 10.00 weight percent Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iv) 15.00 weight percent C.sub.12-15 Alkyl Benzoate, (v) 11.00 weight percent Bees Wax; (vi) 24.50 weight percent Castor Oil, (vii) 20.00 weight percent Stearyl Alcohol, (viii) 7.00 weight percent Cocoa Butter, and (ix) 0.50 weight percent Flavoring (Vanilla), wherein the composition is effective in repairing, improving or fully healing skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement, or in causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, and wherein the composition has an ability to act within one or more layers, tissues, or layers and tissues, of the skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement. 22. A composition in a solid or semi-solid form for topical application to the skin of a mammal for repairing, improving or fully healing a skin disorder, disease, adverse condition, or other condition that requires, or could benefit from, improvement, or for causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, consisting of: (a) one or a plurality of active agents, wherein the active agents are present in the composition in a combined amount ranging from about 0.1 to about 5 weight percent; (b) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the composition in an amount ranging from about 6 to about 25 weight percent; (c) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the composition in an amount ranging from about 5 to about 39 weight percent; (d) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the composition in an amount ranging from about 9 to about 25 weight percent; (e) bees wax, wherein the bees wax is present in the composition in an amount ranging from about 6 to about 43 weight percent; (f) optionally, one or a plurality of plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the composition in a combined amount ranging from about 0 to about 37.5 weight percent; (g) optionally, one or a plurality of fatty alcohols, wherein the fatty alcohols are present in the composition in a combined amount ranging from about 0 to about 25 weight percent; (h) optionally, one or a plurality of fats, wherein the fats are present in the composition in a combined amount ranging from about 0 to about 12 weight percent; and (i) optionally, one or a plurality of flavorings, wherein the flavorings are present in the composition in a combined amount ranging from about 0 to about 3.5 weight percent, wherein the composition is effective in repairing, improving or fully healing skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement, or in causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, and wherein the composition has an ability to act within one or more layers, tissues, or layers and tissues, of the skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement. 23. A composition of claim 22, wherein the composition includes one or more flavorings. 24. A composition of claim 22, wherein the active agent is hydrocortisone. 25. A composition of claim 23, wherein the active agent is hydrocortisone. 26. A composition in a solid or semi-solid form for topical application to the skin of a mammal for repairing, improving or fully healing a skin disorder, disease, adverse condition, or other condition that requires, or could benefit from, improvement, or for causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, consisting of: (a) one or a plurality of active agents, wherein the active agents are present in the composition in a combined amount ranging from about 0.1 to about 5 weight percent; (b) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the composition in an amount ranging from about 6 to about 25 weight percent; (c) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the composition in an amount ranging from about 5 to about 39 weight percent; (d) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the composition in an amount ranging from about 9 to about 25 weight percent; (e) bees wax, wherein the bees wax is present in the composition in an amount ranging from about 6 to about 43 weight percent; (f) one or a plurality of plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the composition in a combined amount ranging from about 0.1 to about 37.5 weight percent; (g) one or a plurality of fatty alcohols, wherein the fatty alcohols are present in the composition in a combined amount ranging from about 0.1 to about 25 weight percent; (h) one or a plurality of fats, wherein the fats are present in the composition in a combined amount ranging from about 0.1 to about 12 weight percent; and (i) optionally, one or a plurality of flavorings, wherein the flavorings are present in the composition in a combined amount ranging from about 0 to about 3.5 weight percent, wherein the composition is effective in repairing, improving or fully healing skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement, or in causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, and wherein the composition has an ability to act within one or more layers, tissues, or layers and tissues, of the skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement. 27. A composition of claim 26, wherein the composition includes one or more flavorings. 28. A composition of claim 26, wherein the active agent is hydrocortisone. 29. A composition of claim 27, wherein the active agent is hydrocortisone. 30. A composition in a solid or semi-solid form for topical application to the skin of a mammal for repairing, improving or fully healing a skin disorder, disease, adverse condition, or other condition that requires, or could benefit from, improvement, or for causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, consisting of: (a) one or a plurality of active agents, wherein the active agents are present in the composition in a combined amount ranging from about 0.5 to about 3 weight percent; (b) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the composition in an amount ranging from about 6 to about 16 weight percent; (c) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the composition in an amount ranging from about 5 to about 15 weight percent; (d) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the composition in an amount ranging from about 10 to about 20 weight percent; (e) bees wax, wherein the bees wax is present in the composition in an amount ranging from about 6 to about 16 weight percent; (f) one or a plurality of plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the composition in a combined amount ranging from about 12 to about 37.5 weight percent; (g) one or a plurality of fatty alcohols, wherein the fatty alcohols are present in the composition in a combined amount ranging from about 15 to about 25 weight percent; (h) one or a plurality of fats, wherein the fats are present in the composition in a combined amount ranging from about 2 to about 12 weight percent; and (i) optionally, one or a plurality of flavorings, wherein the flavorings are present in the composition in a combined amount ranging from about 0 to about 2.5 weight percent, wherein the composition is effective in repairing, improving or fully healing skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement, or in causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, and wherein the composition has an ability to act within one or more layers, tissues, or layers and tissues, of the skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement. 31. A composition of claim 30, wherein the composition includes one or more flavorings. 32. A composition of claim 30, wherein the active agent is hydrocortisone. 33. A composition of claim 31, wherein the active agent is hydrocortisone. 34. A composition in a solid or semi-solid form for topical application to the skin of a mammal for repairing, improving or fully healing a skin disorder, disease, adverse condition, or other condition that requires, or could benefit from, improvement, or for causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, consisting of: (a) one or a plurality of active agents, wherein the active agents are present in the composition in a combined amount ranging from about 0.8 to about 2 weight percent; (b) Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, wherein the Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract is present in the composition in an amount ranging from about 10 to about 12 weight percent; (c) Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, wherein the Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica is present in the composition in an amount ranging from about 9 to about 11 weight percent; (d) C.sub.12-15 Alkyl Benzoate, wherein the C.sub.12-15 Alkyl Benzoate is present in the composition in an amount ranging from about 14 to about 16 weight percent; (e) bees wax, wherein the bees wax is present in the composition in an amount ranging from about 10 to about 12 weight percent; (f) one or a plurality of plant oils or plant seed oils, wherein the plant oils or plant seed oils are present in the composition in a combined amount ranging from about 23.5 to about 26 weight percent; (g) one or a plurality of fatty alcohols, wherein the fatty alcohols are present in the composition in a combined amount ranging from about 19 to about 21 weight percent; (h) one or a plurality of fats, wherein the fats are present in the composition in a combined amount ranging from about 6 to about 8 weight percent; and (i) optionally, one or a plurality of flavorings, wherein the flavorings are present in the composition in a combined amount ranging from about 0.3 to about 1.5 weight percent, wherein the composition is effective in repairing, improving or fully healing skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement, or in causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, and wherein the composition has an ability to act within one or more layers, tissues, or layers and tissues, of the skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement. 35. A composition of claim 34, wherein the composition includes one or more flavorings. 36. A composition of claim 34, wherein the active agent is hydrocortisone. 37. A composition of claim 36, wherein the active agent is hydrocortisone. 38. A composition of claim 26, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 39. A composition of claim 27, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 40. A composition of claim 28, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 41. A composition of claim 29, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 42. A composition of claim 30, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 43. A composition of claim 31, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 44. A composition of claim 32, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 45. A composition of claim 33, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 46. A composition of claim 34, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 47. A composition of claim 35, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 48. A composition of claim 36, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 49. A composition of claim 37, wherein the plant oil or plant seed oil is castor oil, the fatty alcohol is stearyl alcohol or the fat is cocoa butter, or any combination thereof. 50. A topical base composition in a solid or semi-solid form for use as a carrier vehicle for one or a plurality of active agents, comprising (i) 11.00 weight percent Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (ii) 10.00 weight percent Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iii) 15.00 weight percent C.sub.12-15 Alkyl Benzoate, (iv) 11.00 weight percent Bees Wax, (v) 25.50 weight percent Castor Oil, (vi) 20.00 weight percent Stearyl Alcohol, (vii) 7.00 weight percent Cocoa Butter, and (viii) 0.50 weight percent Flavoring (Vanilla), wherein the base composition has an ability to function effectively as a topically-applied carrier vehicle for the active agents, and wherein the base composition is effective in promoting or causing a penetration of the active agents within one or more layers, tissues, or layers and tissues, of skin of a mammal that is damaged, injured, diseased or has an inflammatory reaction or condition. 51. A composition in a solid or semi-solid form for topical application to the skin of a mammal for repairing, improving or fully healing a skin disorder, disease, adverse condition, or other condition that requires, or could benefit from, improvement, or for causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, comprising (i) 1.0 weight percent Hydrocortisone, (ii) 11.00 weight percent Limnanthes Alba (Meadowfoam) Seed Oil, Butyrospermum Parkii (Shea Butter) Extract, (iii) 10.00 weight percent Ricinus Communis (Castor) Seed Oil (and) Glycine Soja (Soybean) Germ Extract (and) Zea Mays (Corn) Starch (and) Silica, (iv) 15.00 weight percent C.sub.12-15 Alkyl Benzoate, (v) 11.00 weight percent Bees Wax, (vi) 25.00 weight percent Castor Oil, (vii) 20.00 weight percent Stearyl Alcohol, (viii) 7.00 weight percent Cocoa Butter, and (ix) 0.00 weight percent Flavoring (Vanilla), wherein the composition is effective in repairing, improving or fully healing skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement, or in causing the mammal's skin to experience a reduction in pain, soreness or itchiness, or a combination thereof, and wherein the composition has an ability to act within one or more layers, tissues, or layers and tissues, of the skin of the mammal that is damaged, injured, diseased, has an inflammatory reaction or condition, or requires, or could benefit from, improvement. 52. A composition of claim 21, claim 22, claim 23, claim 26, claim 27, claim 30, claim 31, claim 34, claim 35, claim 38, claim 39, claim 42, claim 43, claim 46, claim 47 or claim 51, wherein one of the active agents is selected from the group consisting of: clobetasol propionate 0.05%; betamethasone dipropionate 0.25%; halobetasol proprionate 0.05%; diflorasone diacetate 0.05%; fluocinonide 0.05%; halcinonide 0.05%; amcinonide 0.05%; desoximetasone 0.25%; triamcinolone acetonide; 0.5%; mometasone furoate 0.1%; fluticasone propionate 0.005%; betamethasone dipropionate 0.05%; fluocinolone acetonide 0.01-0.2%; hydrocortisone valerate 0.2%; hydrocortisone butyrate 0.1%; flurandrenolide 0.05%; triamcinolone acetonide 0.1%; triamcinolone acetonide 0.1%; fluticasone propionate 0.05%; desonide 0.05%; fluocinolone acetonide 0.025%; hydrocortisone valerate 0.2%; prednicarbate 0.05%; triamcinolone acetonide 0.025%; fluocinolone acetonide 0.01%; desonide 0.05%; hydrocortisone 2.5%; hydrocortisone 1%; topical erythromycin; topical mupirocin; topical retapamulin; topical bacitracin/polymyxin B; topical bacitracin/neomycin/polymyxin B; topical sulfacetamide sodium/urea; natamycin; rimocidin; filipin; nystatin; amphotericin B; candicin; hamycin; miconazole; miconazole nitrate; ketoconazole; clotrimazole; econazole; bifonazole; butoconazole; fenticonazole; isoconazole; oxiconazole; sertaconazole; sulconazole; tioconazole; fluconazole; itraconazole; isavuconazole; ravuconazole; posaconazole; voriconazole; terconazole; abafungin; terbinafine; naftifine; butenafine; anidulafungin; caspofungin; micafungin; polygodial; ciclopirox; ciclopirox olamine; tolnaftate; undecylenic acid; flucytosine; 5-fluorocytosine; griseofulvin; haloprogin; sodium bicarbonate; pimecrolimus 1% Cream; tacrolimus 0.1% ointment; clemastine; diphenhydramine; doxylamine; loratadine; desloratadine; fexofenadine; pheniramine; cetirizine; ebastine; promethazine; chlorpheniramine; levocetirizine; olopatadine; quetiapine; meclizine; dimenhydrinate; embramine; dimethindene; dexchlorpheniramine; vitamin C; cimetidine; famotidine; ranitidine; nizatidine; roxatidine; lafutidine; ciproxifan; clobenpropit; thioperamide; cromoglicate; nedocromil; a 132 adrenergic agonist; acetaminophen; diclofenac; diflunisal; etodolac; fenoprofen; flurbiprofen; ibuprofen; indomethacin; ketoprofen; ketorolac; meclofenamate; mefenamic acid; meloxicam; nabumetone; naproxen; oxaprozin; phenylbutazone; piroxicam; sulindac; tolmetin; celecoxib; buprenorphine; butorphanol; codeine; hydrocodone; hydromorphone; levorphanol; meperidine; methadone; morphine; nalbuphine; oxycodone; oxymorphone; pentazocine; propoxyphene; tramadol; tramadol and acetaminophen; butalbital, acetaminophen, and caffeine; butalbital, aspirin, and caffeine; butalbital, acetaminophen, caffeine, and codeine; hydrocodone and ibuprofen; pentazocine/naloxone; acetaminophen and codeine; dihydrocodeine, acetaminophen, and caffeine; hydrocodone and acetaminophen; oxycodone and acetaminophen; pentazocine and acetaminophen; propoxyphene and acetaminophen; aspirin, caffeine and dihydrocodeine; aspirin and codeine; hydrocodone and aspirin; oxycodone and aspirin; pentazocine and aspirin; propoxyphene, aspirin, and caffeine; capsaicin; benzocaine; benzocaine/menthol; dibucaine; lidocaine; lidocaine/prilocaine; onabotulinumtoxinA; abobotulinumtoxinA; incobotulinumtoxinA; botulinum toxin type A; DEET (N,N-diethyl-m-toluamide); essential oil; icaridin; nepetalactone; citronella oil; permethrin; neem oil; bog myrtle; 3-[N-Butyl-N-acetyl]-aminopropionic acid, ethyl ester; p-aminobenzoic acid; padimate O; phenylbenzimidazole sulfonic acid; cinoxate; dioxybenzone; oxybenzone; homosalate; menthyl anthranilate; octocrylene; octyl methoxycinnamate; octyl salicylate; sulisobenzone; trolamine salicylate; avobenzone; ecamsule; titanium dioxide; zinc oxide; 4-methylbenzylidene camphor; bisoctrizole; bis-ethylhexyloxyphenol methoxyphenyl triazine; disodium phenyl dibenzimidazole tetrasulfonate; drometrizole trisiloxane; benzophenone-9; ethylhexyl triazone; diethylamino hydroxybenzoyl hexyl benzoate; iscotrizinol; polysilicone-15; and isopentenyl-4-methoxycinnamate.

Details for Patent 8,685,381

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Allergan, Inc.	BOTOX COSMETIC	onabotulinumtoxina	For Injection	103000	12/09/1991		2030-10-23
Allergan, Inc.	BOTOX	onabotulinumtoxina	For Injection	103000	12/09/1991		2030-10-23
Ipsen Biopharm Limited	DYSPORT	abobotulinumtoxina	For Injection	125274	04/29/2009		2030-10-23
Merz Pharmaceuticals Gmbh C/o Merz Pharmaceuticals Llc	XEOMIN	incobotulinumtoxina	For Injection	125360	07/30/2010		2030-10-23
Merz Pharmaceuticals Gmbh C/o Merz Pharmaceuticals Llc	XEOMIN	incobotulinumtoxina	For Injection	125360	11/20/2015		2030-10-23