Claims for Patent: 7,208,162
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Summary for Patent: 7,208,162
Title: | Combination therapy of respiratory diseases using antibodies and anti-inflammatory agents |
Abstract: | Therapeutically effective anti-viral compositions, useful especially against respiratory diseases caused or mediated by respiratory syncytial virus (RSV) are disclosed, wherein said compositions comprise at least one anti-RSV antibody, including high affinity antibodies, and an additional anti-inflammatory agent, especially corticosteroids, as well as anti-inflammatory antibodies, especially anti-interleukin-6. Also disclosed are methods of using such compositions to treat and/or prevent respiratory diseases. Such compositions may optionally contain other non-antibody anti-viral agents. |
Inventor(s): | Prince; Gregory (Potomac, MD), Johnson; Leslie S. (Germantown, MD) |
Assignee: | MedImmune, Inc. (Gaithersburg, MD) Virion Systems, Inc. (Rockville, MD) |
Application Number: | 09/848,377 |
Patent Claims: | 1. A method of treating respiratory syncytial virus infection (RSV) in a patient afflicted therewith comprising administering to said patient a therapeutically effective
regimen of an anti-RSV antibody and a steroid wherein said regimen is administered systemically.
2. The method of claim 1 wherein the steroid is a corticosteroid. 3. The method of claim 2 wherein said corticosteroid is selected from the group consisting of cortisone, hydrocortisone, prednisone, prednisolone, methylprednisolone, triamcinolone, betamethasone, beclamethasone and dexamethasone. 4. The method of claim 1 wherein the anti-viral antibody is administered in a dosage of 5 to 20 mg/kg body weight. 5. The method of claim 1 wherein the anti-viral antibody is MEDI-493 (palivizumab). 6. The method of claim 1 wherein said steroid is administered in the dosage range is 0.5 mg to 50 mg per kg body weight. 7. The method of claim 1 wherein said steroid is administered in a dosage of 10 .mu.g to 1 gram per kg body weight. 8. The method of claim 1 wherein said antibody and said steroid are administered contemporaneously. 9. The method of claim 1 wherein the antibody is administered prior to administering the steroid. 10. The method of claim 1 wherein the steroid is administered prior to administering the antibody. |
Details for Patent 7,208,162
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Swedish Orphan Biovitrum Ab (publ) | SYNAGIS | palivizumab | For Injection | 103770 | 06/19/1998 | ⤷ Try a Trial | 2020-05-03 |
Swedish Orphan Biovitrum Ab (publ) | SYNAGIS | palivizumab | Injection | 103770 | 07/23/2004 | ⤷ Try a Trial | 2020-05-03 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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