Claims for Patent: 10,358,453

Summary for Patent: 10,358,453

Title:	Antiviral compounds
Abstract:	Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).
Inventor(s):	Wang; Guangyi (Carlsbad, CA), Beigelman; Leonid (San Mateo, CA), Truong; Anh (Burlingame, CA), Stein; Karin Ann (Mountain View, CA)
Assignee:	Alios BioPharma, Inc. (South San Francisco, CA)
Application Number:	15/052,631
Patent Claims:	1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure: ##STR00333## wherein: L.sup.1 is selected from the group consisting of ##STR00334## L.sup.2 is selected from the group consisting of ##STR00335## A is selected from the group consisting of an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; Y is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; R.sup.1a is hydrogen or an unsubstituted C.sub.1-4 alkyl; R.sup.2a and R.sup.2a1 are each independently hydrogen or an unsubstituted C.sub.1-4 alkyl; R.sup.3a and R.sup.3a1 are each independently hydroxy, CHF.sub.2, CF.sub.3 or NH.sub.2; R.sup.4a, R.sup.4a1 and R.sup.4a2 are each independently selected from the group consisting of hydrogen, halogen, hydroxy, an optionally substituted C.sub.1-8 alkyl, an optionally substituted C.sub.1-8 alkoxy and haloalkyl; R.sup.5a1 and R.sup.5a3 are each independently an unsubstituted C.sub.1-6 alkyl, an unsubstituted C.sub.3-6 cycloalkyl, or --(CH.sub.2).sub.1-4OH; R.sup.5a2 and R.sup.5a4 are each independently hydrogen, hydroxy, an unsubstituted C.sub.1-6 alkyl, an optionally substituted monocyclic heterocyclyl, --C(.dbd.O)R.sup.5a5, an unsubstituted --C-amido, --C(.dbd.NH)-an unsubstituted C.sub.1-6 alkyl; or R.sup.5a1 and R.sup.5a2 are taken together with the atoms to which they are attached to form an optionally substituted 4 to 6 membered ring; or R.sup.5a3 and R.sup.5a4 are taken together with the atoms to which they are attached to form an optionally substituted 4 to 6 membered ring; R.sup.5a5 is an unsubstituted C.sub.1-4 alkyl; each R.sup.6a1, each R.sup.6a2, each R.sup.6a3 and each R.sup.6a4 are independently selected from the group consisting of hydrogen, halogen, an unsubstituted C.sub.1-6 alkyl and hydroxy; R.sup.6a5 is selected from the group consisting of halogen, an unsubstituted C.sub.1-6 alkyl and hydroxy; R.sup.7a and R.sup.8a are each independently an unsubstituted C.sub.1-6 alkyl; R.sup.9a1, R.sup.9a2, R.sup.10a and R.sup.11a are each independently hydrogen or an unsubstituted C.sub.1-6 alkyl; Z.sup.1 is O or S; Z.sup.2 is O, NR.sup.Z or CR.sup.Z1R.sup.Z2; Z.sup.3 is O, NR.sup.Z3 or CR.sup.Z4R.sup.Z5; Z.sup.4 is O, NR.sup.Z6 or CR.sup.Z7R.sup.Z8; R.sup.Z, R.sup.Z1, R.sup.Z2, R.sup.Z3, R.sup.Z4, R.sup.Z5, R.sup.Z6, R.sup.Z7 and R.sup.Z8 are each independently hydrogen or an unsubstituted C.sub.1-4 alkyl; p and q are each independently 1 or 2; and provided that when L.sup.1 is ##STR00336## and L.sup.2 is ##STR00337## then one of R.sup.3a and R.sup.3a1 is NH.sub.2, and the other of R.sup.3a and R.sup.3a1 is OH; provided that when L.sup.1 is ##STR00338## L.sup.2 is ##STR00339## one of R.sup.3a and R.sup.3a1 is CF.sub.3, and other of R.sup.3a and R.sup.3a1 is OH, then Y is ##STR00340## and A is a disubstituted phenyl wherein one substituent is ##STR00341## and the other substituent is --O--(CH.sub.2).sub.2-4OH or ##STR00342## and provided that the compound of Formula (I) is not any one of the group consisting of: ##STR00343## ##STR00344## ##STR00345## ##STR00346## ##STR00347## ##STR00348## ##STR00349## ##STR00350## ##STR00351## ##STR00352## ##STR00353## ##STR00354## or a pharmaceutically acceptable salt of any of the foregoing. 2. The compound of claim 1, or a pharmaceutically acceptable salt thereof, wherein R.sup.1a can be hydrogen. 3. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein R.sup.2a and R.sup.2a1 are both hydrogen. 4. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein R.sup.3a is hydroxy, and R.sup.3a1 is CF.sub.3. 5. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein R.sup.3a is CF.sub.3, and R.sup.3a1 is NH.sub.2. 6. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00355## 7. The compound of claim 6, or a pharmaceutically acceptable salt thereof, wherein R.sup.5a1 is an unsubstituted C.sub.1-6 alkyl. 8. The compound of any one of claim 6, or a pharmaceutically acceptable salt thereof, wherein R.sup.5a2 is hydrogen. 9. The compound of any one of claim 6, or a pharmaceutically acceptable salt thereof, wherein p is 1. 10. The compound of any one of claim 6, or a pharmaceutically acceptable salt thereof, wherein p is 2. 11. The compound of any one of claim 6, or a pharmaceutically acceptable salt thereof, wherein Z.sup.2 is O. 12. The compound of any one of claim 6, or a pharmaceutically acceptable salt thereof, wherein Z.sup.2 is NR.sup.Z. 13. The compound of any one of claim 6, or a pharmaceutically acceptable salt thereof, wherein Z.sup.2 is CR.sup.Z1R.sup.Z2. 14. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00356## 15. The compound of any one of claim 14, or pharmaceutically acceptable salt thereof, wherein Z.sup.3 is O or NR.sup.Z3. 16. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00357## 17. The compound of any one of claim 1, or pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00358## 18. The compound of claim 17, or a pharmaceutically acceptable salt thereof, wherein L.sup.2 is ##STR00359## 19. The compound of claim 17, or a pharmaceutically acceptable salt thereof, wherein L.sup.2 is ##STR00360## 20. The compound of claim 17, or a pharmaceutically acceptable salt thereof, wherein L.sup.2 is ##STR00361## 21. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00362## 22. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is an optionally substituted phenyl. 23. The compound of claim 22, or a pharmaceutically acceptable salt thereof, wherein A is a phenyl substituted with one or more substituents selected from the group consisting of: an unsubstituted C.sub.1-4 alkyl, an optionally substituted C.sub.1-4 alkyl, cycloalkyl, hydroxy, an optionally substituted C.sub.1-4 alkoxy, C.sub.1-4 alkoxy, halogen, haloalkyl, an optionally substituted haloalkoxy, nitro, amino, mono-substituted amino, di-substituted amine, --O-amido, sulfenyl, alkyoxyalkyl, an optionally substituted aryl, an optionally substituted mono-cyclic heteroaryl, an optionally substituted mono-cyclic heterocyclyl, an optionally substituted aryl(C.sub.1-4 alkyl), an optionally substituted monocyclic heteroaryl(C.sub.1-4 alkyl), an optionally substituted monocyclic heterocyclyl(C.sub.1-4 alkyl), hydroxyalkyl and aminoalkyl. 24. The compound of claim 22, or a pharmaceutically acceptable salt thereof, wherein A is a phenyl substituted with one or more substituents selected from the group consisting of: methyl, ethyl, propyl, butyl, hydroxy, methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, t-butoxy, phenoxy, bromo, chloro, fluoro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, cyano, N,N-di-methyl-amine, N,N-di-ethyl-amine, N-methyl-N-ethyl-amine, N-methyl-amino, N-ethyl-amino, amino, N-amido, N-sulfonamido, alkylthio, an optionally substituted phenyl, an optionally substituted imidazole, an optionally substituted morpholinyl, an optionally substituted pyrazole, an optionally substituted pyrrolidinyl, an optionally substituted pyridinyl, an optionally substituted piperidinyl, an optionally substituted piperidinone, an optionally substituted pyrrolidinone, an optionally substituted pyrimidine, an optionally substituted pyrazine, an optionally substituted 1,2,4-oxadiazole, --(CH.sub.2).sub.1-4--OH, --(CH.sub.2).sub.1-2--NH(CH.sub.3), an optionally substituted --(CH.sub.2).sub.1-2-imidazole, an optionally substituted --(CH.sub.2).sub.1-2-pyrrolidinone, an optionally substituted --(CH.sub.2).sub.1-2-imidazolidinone, --O(CH.sub.2).sub.2--NH.sub.2, --O(CH.sub.2).sub.2--NH(CH.sub.3), --O(CH.sub.2).sub.2--N(CH.sub.3).sub.2, --O--(CH.sub.2).sub.2-4OH, --O(CH.sub.2).sub.2OCH.sub.3, an optionally substituted --O(CH.sub.2).sub.0-2-cyclopentanone, an optionally substituted --O(CH.sub.2).sub.0-2pyrrolidinone, an optionally substituted --O(CH.sub.2).sub.0-2-morpholinyl, an optionally substituted --O(CH.sub.2).sub.0-2-triazole, an optionally substituted --O(CH.sub.2).sub.0-2-imidazole, an optionally substituted --O(CH.sub.2).sub.0-2-pyrazole, an optionally substituted --O(CH.sub.2).sub.0-2-tetrahydrofuran, an optionally substituted --O(CH.sub.2).sub.0-2-pyrrolidinone, an optionally substituted --O(CH.sub.2).sub.0-2-tetrazole, an optionally substituted --O(CH.sub.2).sub.0-2-tetrazolone, --NH(CH.sub.2).sub.1-2OH, ##STR00363## ##STR00364## 25. The compound of any one of claim 22, or a pharmaceutically acceptable salt thereof, wherein A is a di-substituted phenyl. 26. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein A is an optionally substituted heteroaryl or an optionally substituted heterocyclyl. 27. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein Y is an optionally substituted aryl. 28. The compound of any one of claim 27, or a pharmaceutically acceptable salt thereof, wherein Y is substituted with one or more R.sup.B, wherein each R.sup.B is independently selected from the group consisting of: cyano, halogen, an optionally substituted C.sub.1-4 alkyl, an unsubstituted C.sub.2-4 alkenyl, an unsubstituted C.sub.2-4 alkynyl, an optionally substituted aryl, an optionally substituted 5 or 6 membered heteroaryl, an optionally substituted 5 or 6 membered heterocyclyl, hydroxy, C.sub.1-4 alkoxy, alkoxyalkyl, C.sub.1-4 haloalkyl, haloalkoxy, an unsubstituted acyl, an optionally substituted --C-carboxy, an optionally substituted --C-amido, sulfonyl, carbonyl, amino, mono-substituted amine, di-substituted amine and ##STR00365## 29. The compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, wherein Y is an optionally substituted heteroaryl or an optionally substituted heterocyclyl. 30. The compound of claim 1, wherein the compound of Formula (I) is selected from the group consisting of: ##STR00366## ##STR00367## ##STR00368## ##STR00369## ##STR00370## ##STR00371## ##STR00372## ##STR00373## ##STR00374## ##STR00375## ##STR00376## ##STR00377## ##STR00378## ##STR00379## ##STR00380## ##STR00381## ##STR00382## or a pharmaceutically acceptable salt of any of the foregoing. 31. The compound of claim 1, wherein the compound of Formula (I) is selected from the group consisting of: ##STR00383## ##STR00384## ##STR00385## ##STR00386## or a pharmaceutically acceptable salt of any of the foregoing. 32. The compound of claim 1, wherein the compound of Formula (I) is selected from the group consisting of: ##STR00387## ##STR00388## or a pharmaceutically acceptable salt of any of the foregoing. 33. A pharmaceutical composition comprising an effective amount of a compound of any one of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, excipient, or combination thereof. 34. A method for ameliorating or treating a paramyxovirus infection comprising administering to a subject identified as suffering from the paramyxovirus infection an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 35. The use of claim 34, wherein the paramyxovirus infection is a human respiratory syncytial virus infection, further comprising administering one or more additional anti-viral agents, wherein the one or more additional anti-viral agents is an anti-RSV agent selected from the group consisting of an anti-RSV antibody, a fusion protein inhibitor, an N-protein inhibitor, a RSV polymerase inhibitor, an IMPDH inhibitor, an interferon and another compound that inhibits the RSV virus, or a pharmaceutically acceptable salt of any of the foregoing. 36. The use of claim 35, wherein the one or more additional anti-viral agents is selected from the group consisting of RSV-IGIV, palivizumab, motavizumab, 1-cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-- c]pyridin-2-one (BMS-433771), 4,4''-bis-{4,6-bis-[3-(bis-carbamoylmethyl-sulfamoyl)-phenylamino]-(1,3,5- )triazin-2-ylamino}-biphenyl-2,2''-disulfonic-acid (RFI-641), 4,4'-Bis[4,6-di[3-aminophenyl-N,N-bis(2-carbamoylethyl)-sulfonilimino]-1,- 3,5-triazine-2-ylamino]-biphenyl-2,2'-disulfonic acid, disodium salt (CL387626), 2-[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-4-methyl-1H-benzimidazol-1-- yl]-6-methyl-3-pyridinol (JNJ-2408068), 2-[[6-[[[2-(3-Hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(morpholi- n-4-yl)propyl]amino]benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol (TMC-353121), 5,5'-bis[1-(((5-amino-1H-tetrazolyl)imino)methyl)]2,2',4''-methylidynetri- sphenol (VP-14637, MDT-637), N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl-[1,2,4]triazolo[3,4-a]p- hthalazin-3-yl)benzenesulfonamide (P13), 2-((2-((1-(2-aminoethyl)piperidin-4-yl)amino)-4-methyl-1H-benzo[d]imidazo- l-1-yl)methyl)-6-methylpyridin-3-ol (R170591), 1,4-bis(3-methylpyridin-4-yl)-1,4-diazepane (C15), (R)-9b-(4-chlorophenyl)-1-(4-fluorobenzoyl)-2,3-dihydro-1H-imidazo[1',2':- 1,2]pyrrolo[3,4-c]pyridin-5(9bH)-one (BTA9981), [2,2-bis(docosyloxy-oxymethyl)propyl-5-acetaoamido-3,5-dideoxy-4,7,8,9-te- tra-O-(sodium-oxysulfonyl)-D-glycero-D-galacto-2-nonulopyranosid]onate (MBX-300), BTA-C286, N-(2-((S)-2-(5-((S)-3-aminopyrrolidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimi- din-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide (GS-5806), an anti-RSV nanobody, a peptide fusion inhibitor (such as a peptide having the sequence DEFDASISQVNEKINQSLAFIRKSDELL (T-67), a peptide having the sequence FDASISQVNEKINQSLAFIRKSDELLHNVNAGKST (T-118), (S)-1-(2-fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diaz- epin-3-yl)urea (RSV-604), STP-92, iKT-041, 6-{4-[(biphenyl-2-ylcarbonyl) amino]benzoyl}-N-cyclopropyl-5,6-dihydro-4H-thieno[3,2-d][1]benzazepine-2- -carboxamide (YM-53403). N-cyclopropyl-5-(4-(2-(pyrrolidin-1-yl)benzamido)benzoyl)-5,6,7,10-tetrah- ydrobenzo[b]cyclopenta[d]azepine-9-carboxamide, 6-(4-(2-(2-oxa-7-azaspiro[3.5]nonan-7-yl)nicotinamido)benzoyl)-N-cyclopro- pyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide, 4-amino-8-(3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl)-6,6-dimethyl-2-- (4-methyl-3-nitrophenyl)-1H-imidazo[4,5-h]-isoquinoline-7,9(6H,8H)-dione, AZ27, ribavirin, 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR), 4-hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide (pyrazofurin), 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl)tetrahydrofuran-2-yl)-1H-1- ,2,4-triazole-3-carboximidamide (Taribavirin, viramidine), (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-fluo- ro-2-((isobutyryloxy)methyl)tetrahydrofuran-3-yl isobutyrate, (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-fluo- ro-2-(hydroxymethyl)tetrahydrofuran-3-yl isobutyrate, ((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-flu- oro-3-hydroxytetrahydrofuran-2-yl)methyl triphosphate, 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxyme- thyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one, 1,3,4-thiadiazol-2-ylcyanamide (LY253963), tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylc- arbamate (VX-497), (4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)- -4-methylhex-4-enoic acid (Mycophenolic acid), 2-morpholin-4-ylethyl-(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benz- ofuran-5-yl)-4-methylhex-4-enoate (Mycophenolate Mofetil), a Type 1 interferon, a Type 2 interferon, a Type 3 interferon, a double stranded RNA oligonucleotide, 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide (leflumomide), N-(2-chloro-4-methylphenyl)-2-((1-(4-methoxyphenyl)-1H-benzo[d]imidazol-2- -yl)thio)propanamide (JMN3-003), an intratracheal formulation of recombinant human CC10 (CG-100), high titer, human immunoglobulin (RI-001), a non-neutralizing mAb against the G protein (mAb 131-2G), ALN-RSV01, ALN-RSV02, Medi-559, Medi-534 and Medi-557, or a pharmaceutically acceptable salt of any of the foregoing. 37. A method for inhibiting replication of a paramyxovirus comprising contacting a cell infected with the paramyxovirus with an effective amount of a compound of claim 1, or a pharmaceutically acceptable salt thereof. 38. The use of any one of claim 37, wherein the paramyxovirus infection is a human respiratory syncytial virus infection. 39. A compound, or a pharmaceutically acceptable salt thereof, wherein the compound has the structure of: ##STR00389## wherein: L.sup.1 is ##STR00390## L.sup.2 is selected from the group consisting of ##STR00391## and ##STR00392## A is selected from the group consisting of an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; Y is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl and an optionally substituted heterocyclyl; R.sup.1a is hydrogen or an unsubstituted C.sub.1-4 alkyl; R.sup.2a and R.sup.2a1 are each independently hydrogen or an unsubstituted C.sub.1-4 alkyl; R.sup.3a and R.sup.3a1 are each independently hydroxy, CHF.sub.2 or CF.sub.3; R.sup.4a is selected from the group consisting of hydrogen, halogen, hydroxy, an optionally substituted C.sub.1-8 alkyl, an optionally substituted C.sub.1-8 alkoxy and haloalkyl; R.sup.5a is an unsubstituted C.sub.1-6 alkyl or --(CH.sub.2).sub.1-4OH; R.sup.6a1 and R.sup.6a2 are each independently selected from the group consisting of hydrogen, halogen, an unsubstituted C.sub.1-6 alkyl and hydroxy; and R.sup.7a and R.sup.8a are each independently an unsubstituted C.sub.1-6 alkyl; provided that the compound is not any one of the group consisting of: ##STR00393## ##STR00394## ##STR00395## ##STR00396## ##STR00397## ##STR00398## ##STR00399## ##STR00400## or a pharmaceutically acceptable salt of any of the foregoing. 40. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.1a is hydrogen. 41. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.2a and R.sup.2a1 are both hydrogen. 42. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.3a is hydroxy; and R.sup.3a1 is CF.sub.3. 43. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00401## 44. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.5a is an unsubstituted C.sub.1-6 alkyl. 45. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.5a is --(CH.sub.2).sub.1-4OH. 46. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.6a1 and R.sup.6a2 are each hydrogen. 47. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein R.sup.4a is hydrogen. 48. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein L.sup.1 is ##STR00402## 49. The compound of claim 48, or a pharmaceutically acceptable salt thereof, wherein L.sup.2 is selected from the group consisting of ##STR00403## and ##STR00404## 50. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein A is a di-substituted phenyl; or wherein A is a phenyl substituted with one or more substituents selected from the group consisting of: an unsubstituted C.sub.1-4 alkyl, a substituted C.sub.1-4 alkyl, cycloalkyl, hydroxy, a substituted C.sub.1-4 alkoxy, an unsubstituted C.sub.1-4 alkoxy, halogen, haloalkyl, an optionally substituted haloalkoxy, nitro, amino, mono-substituted amine, di-substituted amine, -O-amido, sulfenyl, alkyoxyalkyl, an optionally substituted aryl, an optionally substituted mono-cyclic heteroaryl, an optionally substituted mono-cyclic heterocyclyl, an optionally substituted aryl(C.sub.1-4 alkyl), an optionally substituted monocyclic heteroaryl(C.sub.1-4 alkyl), an optionally substituted monocyclic heterocyclyl(C.sub.1-4 alkyl), hydroxyalkyl and aminoalkyl. 51. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein A is a phenyl substituted with one or more substituents selected from the group consisting of: methyl, ethyl, propyl, butyl, hydroxy, methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, t-butoxy, bromo, chloro, fluoro, trifluoromethyl, difluoromethoxy, trifluoromethoxy, N,N-di-methyl-amine, N,N-di-ethyl-amine, N-methyl-N-ethyl-amine, N-methyl-amine, N-ethyl-amine, amino, an optionally substituted phenyl, an optionally substituted imidazole, an optionally substituted morpholinyl, an optionally substituted pyrazole, an optionally substituted pyrrolidinyl, an optionally substituted pyridinyl, an optionally substituted piperidinyl, an optionally substituted piperidinone, an optionally substituted pyrrolidinone, an optionally substituted pyrimidine, an optionally substituted pyrazine, an optionally substituted 1,2,4-oxadiazole, --(CH.sub.2).sub.1-4--OH, --(CH.sub.2).sub.1-2--NH(CH.sub.3), an optionally substituted --(CH.sub.2).sub.1-2-imidazole, an optionally substituted --(CH.sub.2).sub.1-2-pyrrolidinone, an optionally substituted --(CH.sub.2).sub.1-2-imidazolidinone, --O(CH.sub.2).sub.2--NH.sub.2, --O(CH.sub.2).sub.2--NH(CH.sub.3), --O(CH.sub.2).sub.2--N(CH.sub.3).sub.2, --O--(CH.sub.2).sub.2-4OH, --O(CH.sub.2).sub.2OCH.sub.3, --NH(CH.sub.2).sub.1-2OH, ##STR00405## ##STR00406## and ##STR00407## 52. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein A is an optionally substituted heteroaryl; or wherein A is a heteroaryl selected from the group consisting of: an optionally substituted imidazole, an optionally substituted indole, an optionally substituted thiazole, an optionally substituted furan, an optionally substituted thiophene, an optionally substituted pyrrole, an optionally substituted pyridine, an optionally substituted pyrimidine, an optionally substituted pyrazine, an optionally substituted pyrazole, an optionally substituted quinolone, an optionally substituted imidazole, an optionally substituted oxazole, an optionally substituted isoxazole, an optionally substituted benzoimidazole, an optionally substituted benzooxazole, an optionally substituted benzothiazole and an optionally substituted imidazo[1,2-a]pyrimidine. 53. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein A is an optionally substituted heterocyclyl; or wherein A is an optionally substituted heterocyclyl selected from the group consisting of: an optionally substituted ##STR00408## an optionally substituted ##STR00409## an optionally substituted ##STR00410## an optionally substituted ##STR00411## an optionally substituted ##STR00412## an optionally substituted ##STR00413## an optionally substituted ##STR00414## an optionally substituted ##STR00415## an optionally substituted ##STR00416## an optionally substituted ##STR00417## an optionally substituted ##STR00418## 54. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein Y is an optionally substituted aryl; or wherein Y is a mono-substituted phenyl. 55. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein Y is an optionally substituted heteroaryl or heterocyclyl. 56. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of: ##STR00419## ##STR00420## ##STR00421## and ##STR00422## or a pharmaceutically acceptable salt of any of the foregoing. 57. The compound of claim 39, or a pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of: ##STR00423## and ##STR00424## or a pharmaceutically acceptable salt of any of the foregoing. 58. A pharmaceutical composition comprising an effective amount of a compound of claim 39, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent, excipient, or combination thereof. 59. A method for ameliorating or treating a paramyxovirus infection comprising administering to a subject identified as suffering from the paramyxovirus infection an effective amount of a compound of claim 39, or a pharmaceutically acceptable salt thereof. 60. A method for inhibiting replication of a paramyxovirus comprising contacting a cell infected with the paramyxovirus with an effective amount of a compound of claim 39, or a pharmaceutically acceptable salt thereof. 61. The method of claim 60, wherein the paramyxovirus infection is a human respiratory syncytial virus infection. 62. The method of claim 59, wherein the paramyxovirus infection is a human respiratory syncytial virus infection, further comprising administering one or more additional anti-viral agents, wherein the one or more additional anti-viral agents is an anti-RSV agent selected from the group consisting of an anti-RSV antibody, a fusion protein inhibitor, an N-protein inhibitor, a RSV polymerase inhibitor, an IMPDH inhibitor, an interferon and another compound that inhibits the RSV virus, or a pharmaceutically acceptable salt of any of the foregoing. 63. The method of Claim 62, wherein the one or more additional anti-viral agents is selected from the group consisting of RSV-IGIV, palivizumab, motavizumab, 1-cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-- c]pyridin-2-one (BMS-433771), 4,4''-bis-{4,6-bis-[3-(bis-carbamoylmethyl-sulfamoyl)-phenylamino]-(1,3,5- )triazin-2-ylamino}-biphenyl-2,2'-disulfonic-acid (RFI-641), 4,4'-Bis[4,6-di[3-aminophenyl -N,N-bis(2-carbamoylethyl)-sulfonilimino]-1,3,5-triazine-2-ylamino]-biphe- nyl-2,2'-disulfonic acid, disodium salt (CL387626), 2-[[2-[[1-(2-aminoethyl)-4-piperidinyl]amino]-4-methyl-1H-benzimidazol-1-- yl]-6-methyl-3-pyridinol (JNJ-2408068), 2-[[6-[[[2-(3-Hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(morpholi- n-4-yl)propyl]amino]benzimidazol-1-yl]methyl]-6-methylpyridin-3-ol (TMC-353121), 5,5'-bis[1-(((5-amino-1H-tetrazolyl)imino)methyl)]2,2',4''-methylidynetri- sphenol (VP-14637, MDT-637), N-(2-hydroxyethyl)-4-methoxy-N-methyl-3-(6-methyl-[1,2,4]triazolo[3,4-a]p- hthalazin-3 -yl)benzenesulfonamide (P13), 2-((2-((1-(2-aminoethyl)piperidin-4-yl)amino)-4-methyl-1H -benzo[d]imidazol-1-yl)methyl)-6-methylpyridin-3-ol (R170591), 1,4-bis(3-methylpyridin-4-yl)-1,4-diazepane (C15), (R)-9b-(4-chlorophenyl)-1-(4-fluorobenzoyl)-2,3-dihydro-1H -imidazo[1',2':1,2]pyrrolo[3,4-c]pyridin-5(9bH)-one (BTA9981), [2,2-bis(docosyloxy -oxymethyl)propyl-5-acetaoamido-3,5-dideoxy-4,7,8,9-tetra-O-(sodium-oxysu- lfonyl)-D-glycero-D-galacto-2-nonulopyranosid]onate (MBX-300), BTA-C286, N-(2-((S)-2-(5-((S)-3-aminopyrrolidin-1-yl)-6-methylpyrazolo[1,5-a]pyrimi- din-2-yl)piperidine-1-carbonyl)-4-chlorophenyl)methanesulfonamide (GS-5806), an anti-RSV nanobody, a peptide fusion inhibitor (such as a peptide having the sequence DEFDASISQVNEKINQSLAFIRKSDELL (T-67), a peptide having the sequence FDASISQVNEKINQSLAFIRKSDELLHNVNAGKST (T-118), (S)-1-(2-fluoropheny1)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diaz- epin-3-yl)urea (RSV-604), STP-92, iKT-041, 6-{4-[(biphenyl-2-ylcarbonyl) amino]benzoyl }-N-cyclopropyl-5,6-dihydro-4H-thieno[3,2-d][1]benzazepine-2-carboxamide (YM-53403). N-cyclopropyl-5-(4-(2-(pyrrolidin-1-yl)benzamido)benzoyl)-5,6,7,10-tetrah- ydrobenzo[b]cyclopenta[d]azepine-9-carboxamide, 6-(4-(2-(2-oxa-7-azaspiro[3,5]nonan-7-yl)nicotinamido)benzoyl)-N-cyclopro- pyl-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide, 4-amino-8-(3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}propyl)-6,6-dimethyl-2-- (4-methyl-3-nitrophenyl)-1H-imidazo[4,5-h]-isoquinoline-7,9(6H,8H)-dione, AZ27, ribavirin, 5-ethynyl-1-beta-D -ribofuranosylimidazole-4-carboxamide (EICAR), 4-hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide (pyrazofurin), 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran -2-yl)-1H-1,2,4-triazole-3-carboximidamide (taribavirin, viramidine), (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin -1(2H)-yl)-2-(chloromethyl)-4-fluoro-2-((isobutyryloxy)methyl)tetrahydrof- uran-3-yl isobutyrate, (2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin -1(2H)-yl)-2-(chloromethyl)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-3-y- l isobutyrate, ((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-flu- oro-3-hydroxytetrahydrofuran-2-yl)methyl triphosphate, 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxyme- thyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one, 1,3,4-thiadiazol-2-ylcyanamide (LY253963), tetrahydrofuran-3-yl-3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylc- arbamate (VX-497), (4E)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)- -4-methylhex-4-enoic acid (Mycophenolic acid), 2-morpholin-4-ylethyl -(E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1H-2-benzofuran-5-yl)-4-methyl- hex-4-enoate (Mycophenolate Mofetil), a Type 1 interferon, a Type 2 interferon, a Type 3 interferon, a double stranded RNA oligonucleotide, 5-methyl-N-[4-(trifluoromethyl) phenyl]-isoxazole-4-carboxamide (leflumomide), N-(2-chloro-4-methylphenyl)-2-((1-(4-methoxyphenyl)-1H -benzo[d]imidazol-2-yl)thio)propanamide (JMN3-003), an intratracheal formulation of recombinant human CC0O (CG-100), high titer, human immunoglobulin (RI-001), a non-neutralizing mAb against the G protein (mAb 131-2G), ALN-RSV01, ALN-RSV02, Medi-559, Medi-534 and Medi-557, or a pharmaceutically acceptable salt of any of the foregoing.

Details for Patent 10,358,453

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Swedish Orphan Biovitrum Ab (publ)	SYNAGIS	palivizumab	For Injection	103770	06/19/1998		2039-08-19
Swedish Orphan Biovitrum Ab (publ)	SYNAGIS	palivizumab	Injection	103770	07/23/2004		2039-08-19