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Merck
Queensland Health
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Deloitte
Daiichi Sankyo
Covington
Colorcon
Teva

Generated: May 26, 2018

DrugPatentWatch Database Preview

TOPOTECAN Drug Profile

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Which patents cover Topotecan, and what generic alternatives are available?

Topotecan is a drug marketed by Sandoz Inc, Accord Hlthcare, Actavis Totowa, Cipla Ltd, Dr Reddys Labs Ltd, Fresenius Kabi Oncol, Fresenius Kabi Usa, Hong Kong, Mylan Labs Ltd, Novast Labs Ltd, Sagent Pharms, Sun Pharm Inds Ltd, Hospira Inc, and Teva Pharms Usa. and is included in sixteen NDAs.

The generic ingredient in TOPOTECAN is topotecan hydrochloride. There are ten drug master file entries for this compound. Twelve suppliers are listed for this compound. Additional details are available on the topotecan hydrochloride profile page.
Drug patent expirations by year for TOPOTECAN
Pharmacology for TOPOTECAN
Medical Subject Heading (MeSH) Categories for TOPOTECAN
Synonyms for TOPOTECAN
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0;{2,11}.0;{4,9}.0;{15,20}]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
(19S)-8-[(DIMETHYLAMINO)METHYL]-19-ETHYL-7,19-DIHYDROXY-17-OXA-3,13-DIAZAPENTACYCLO[11.8.0.0(2),(1)(1).0?,?.0(1)?,(2)?]HENICOSA-1(21),2(11),3,5,7,9,15(20)-HEPTAENE-14,18-DIONE
(20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
(4-Ethyl-4,9-dihydroxy-3,13-dioxo-3,4,12,13-tetrahydro-1H-2-oxa-6,12a-diaza-dibenzo[b,h]fluoren-10-ylmethyl)-dimethyl-ammonium
(4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(alphaS)-alpha-Hydroxy-8-oxylato-1(11H)-oxo-alpha-ethyl-2-(hydroxymethyl)-9-(dimethylaminiomethyl)-5,11a-diaza-11aH-benzo[b]fluorene-3-acetic acid 3,2-lactone
(alphaS)-alpha,8-Dihydroxy-1(11H)-oxo-alpha-ethyl-2-(hydroxymethyl)-9-(dimethylaminomethyl)-5,11a-diaza-11aH-benzo[b]fluorene-3-acetic acid 3,2-lactone
(S)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione
(S)-10-((Dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
(S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3'''',4'''':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE
(S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
(S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride
(S)-11-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
(S)-11-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride
(S)-Topotecan
10-dimethylaminomethyl-4-ethyl-4,9-dihydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano[3'''',4'''':6,7]indolizino[1,2-b]quinoline-3,14-dione
10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione
10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione (Topotecan)
10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione; hydrochloride
10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzo[b,h]fluorene-3,13-dione(Topotecan)
123948-87-8
133242-28-1
138121-88-7
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-, (S)-
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (S)-
1H-Pyrano[3',7]indolizino[1,2-b]quinoline- 3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, (4S)-
7M7YKX2N15
9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin
9-Dimethylaminomethyl-10-hydroxycamptothecin
948T878
AB0015476
AB00641837_15
AB00641837_16
AB00641837-09
AB00641837-11
AB00641837-12
AB00641837-13
AB00641837-14
AC-11592
AC1L1TQZ
AC1Q6APZ
AJ-90579
AK-72818
AKOS015966792
AN-32741
API0004452
AT-2921
AX8224399
B4982
BDBM50008935
BDBM50034026
BRD-K55696337-001-03-2
BSPBio_002348
BT000731
C-22083
C11158
C23H23N3O5
CC-35105
CCG-221171
CCRIS 8163
CHEBI:63632
CHEMBL1607
CHEMBL84
cid_60699
CS-2887
D02PMO
D08618
DB01030
dimethylaminomethyl-ethyl-dihydroxy-[?]dione
DTXSID3042685
EX-A834
FT-0654504
GTPL7101
HMS2090B20
HSCI1_000228
HSDB 8213
HY-13768
Hycamptamine
Hycamptin
Hycamtamine
Hycamtin
Hycamtin (TN)
KB-61805
KS-00000PLT
LS-127395
M965
MFCD00870670
MolPort-003-850-580
NCGC00014925-02
NCGC00014925-03
NCGC00014925-04
NCGC00014925-07
NCGC00178695-01
NCI60_004771
NCIStruc1_001659
NCIStruc2_001796
Nogitecan
nogitecan HCl
NSC-641007
NSC609699
NSC641007
PL002019
potactasol
SCHEMBL3836
SK-S-104864-A
SK&F 104864 A
SK&F-104864-A
SK&F-S-104864A
SKF 104864
SKF-104864-A
SKF-S 104864
SMP2_000312
SMP2_000327
SR-01000763672
SR-01000763672-3
ST24026008
ST24031920
TopoCED
Topophore C
Topotecan (BAN)
Topotecan [INN:BAN]
Topotecan Actavis
Topotecan hydrochloride hydrate, >=98% (HPLC and enzymatic)
Topotecan lactone
Topotecan Monohydrochloride, (S)-Isomer
TOPOTECAN, HYCAMTIN
Topotecane
Topotecane [INN-French]
Topotecanum
Topotecanum [INN-Latin]
UCFGDBYHRUNTLO-QHCPKHFHSA-N
UNII-7M7YKX2N15
W-1887
ZINC1611274

US Patents and Regulatory Information for TOPOTECAN

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Sandoz Inc TOPOTECAN topotecan hydrochloride SOLUTION;INTRAVENOUS 200199-001 Feb 25, 2011 DISCN Yes No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Mylan Labs Ltd TOPOTECAN HYDROCHLORIDE topotecan hydrochloride SOLUTION;INTRAVENOUS 206074-001 Nov 24, 2017 AP RX No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Dr Reddys Labs Ltd TOPOTECAN HYDROCHLORIDE topotecan hydrochloride INJECTABLE;INJECTION 201191-001 Mar 9, 2011 AP RX No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Accord Hlthcare TOPOTECAN HYDROCHLORIDE topotecan hydrochloride INJECTABLE;INJECTION 202351-001 Jun 26, 2013 AP RX No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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US Army
Dow
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