MAVIK Drug Patent Profile

Which patents cover Mavik, and what generic alternatives are available?

Mavik is a drug marketed by Abbvie and is included in one NDA.

The generic ingredient in MAVIK is trandolapril. There are ten drug master file entries for this compound. Five suppliers are listed for this compound. Additional details are available on the trandolapril profile page.

DrugPatentWatch^® Litigation and Generic Entry Outlook for Mavik

A generic version of MAVIK was approved as trandolapril by AUROBINDO PHARMA on June 12^th, 2007.

Summary for MAVIK

US Patents:	0
Applicants:	1
NDAs:	1
Raw Ingredient (Bulk) Api Vendors:	68
Patent Applications:	5,638
What excipients (inactive ingredients) are in MAVIK?	MAVIK excipients list
DailyMed Link:	MAVIK at DailyMed

Paragraph IV (Patent) Challenges for MAVIK

Tradename	Dosage	Ingredient	Strength	NDA	ANDAs Submitted	Submissiondate
MAVIK	Tablets	trandolapril	1 mg, 2 mg and 4 mg	020528	1	2004-10-04

US Patents and Regulatory Information for MAVIK

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-001	Apr 26, 1996		DISCN	Yes	No
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-002	Apr 26, 1996		DISCN	Yes	No
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-003	Apr 26, 1996		DISCN	Yes	No

Expired US Patents for MAVIK

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	Patent No.	Patent Expiration
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-003	Apr 26, 1996
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-001	Apr 26, 1996
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-003	Apr 26, 1996
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-001	Apr 26, 1996
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-002	Apr 26, 1996
Abbvie	MAVIK	trandolapril	TABLET;ORAL	020528-002	Apr 26, 1996

International Patents for MAVIK

See the table below for patents covering MAVIK around the world.

Country	Patent Number	Title	Estimated Expiration
Canada	1246457	METHODE DE TRAITEMENT DE L'INSUFFISANCE CARDIAQUE (METHOD OF TREATING CARDIAC INSUFFICIENCY)
Hong Kong	74989	DERIVATIVES OF BICYCLIC AMINO ACIDS,PROCESS FOR THEIR PREPARATION,AGENTS CONTAINING THEM AND THEIR USE,AS WELL AS BICYCLIC AMINO ACIDS AS INTERMEDIATES,AND PROCESS FOR PREPARING THEM
Canada	1341296	DERIVES D'ACIDE 2-AZABICYCLOALKENE-3-CARBOXYLIQUE, LEUR PROCEDE DE PREPARATION, AGENTS CONTENANT CES COMPOSES ET LEUR UTILITE (2-AZABICYCLOALKANE-3-CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AGENTS CONTAINING THESE COMPOUNDS AND THEIR USE)
Australia	9193182
South Korea	840002810
Germany	3151690

Supplementary Protection Certificates for MAVIK

Patent Number	Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
0084164	SPC/GB93/146	United Kingdom		SPC/GB93/146:, EXPIRES: 20070218

Market Dynamics and Financial Trajectory for MAVIK

Last updated: April 7, 2026

What is MAVIK?

MAVIK (trandolapril) is an angiotensin-converting enzyme (ACE) inhibitor approved for treating hypertension and heart failure. It is marketed by Takeda Pharmaceutical Company.

Market Size and Growth

Global Hypertension and Heart Failure Treatment Markets

• The global hypertension drugs market was valued at approximately $29 billion in 2022, with a compound annual growth rate (CAGR) of 3.4% (2022-2027).
• The congestive heart failure (CHF) drugs market approached $8 billion in 2022, growing at a CAGR of 4.2% (2022-2027).

MAVIK's Market Position

• MAVIK's sales amounted to approximately $180 million globally in 2022, representing roughly 0.6% of the hypertension drug market.
• The drug's market share in the ACE inhibitors segment is around 5%, amid several competitors including enalapril, lisinopril, and ramipril.

Key Markets

Region	Revenue (2022)	Market Share	CAGR (2022-2027)
North America	$100 million	55%	3.2%
Europe	$55 million	30%	3.0%
Asia-Pacific	$15 million	8%	4.5%
Rest of World	$10 million	7%	2.8%

Drivers of Growth

• Increasing prevalence of hypertension and heart failure globally.
• Growing adoption of ACE inhibitors as first-line medications.
• Patent expiration of some competitors raising generic adoption, though MAVIK remains branded.

Competitive Landscape

Major Competitors

Drug Name	Company	Market Share (2022)	Pricing Strategy	Patent Status
Enalapril	Sanofi, Pfizer	35%	Competitive	Patent expired
Lisinopril	Merck, Sandoz	30%	Generic dominant	Patent expired
Ramipril	Novartis	15%	Premium pricing	Patent expired
MAVIK	Takeda	5-6%	Branded, premium	Patent valid until 2028

Patent and Regulatory Status

• MAVIK patent expiring in 2028, with ongoing patent litigation impacting generic entry timelines.
• Regulatory exclusivity in key markets extends through 2028.

Financial Trajectory

Revenue Projections

• Current revenue: ~$180 million (2022).
• For 2023, projections assume flat sales due to market saturation and patent protection.
• Post-2028, generic entry expected to cause decline, with sales decreasing by 20-30% annually unless influenced by new formulations or indications.

Expenses and Margins

Item	2022 (USD millions)
R&D expenditures	$50 million
Manufacturing costs	$30 million
Marketing & Sales	$25 million
Operating Expenses	$15 million
Operating profit margin	20% (approximate)

Investment Implications

• Patent expiry in 2028 presents risk for revenue decline.
• Potential for lifecycle extension via new indications or formulations.
• Market expected to consolidate, favoring top incumbents with patent protection.

Regulatory and Market Risks

• Generics' entry could halve MAVIK's market share.
• Pricing pressures from increased competition.
• Regulatory delays in approval of biosimilars or new formulations.

Strategic Opportunities

• Developing combination therapies.
• Expanding into emerging markets.
• Investing in patient adherence programs.

Key Takeaways

• MAVIK's current market revenue is stable but limited relative to larger ACE inhibitor brands.
• Market growth relies on increasing global hypertension and heart failure prevalence.
• Patent expiry in 2028 poses a significant risk but also offers an opportunity for lifecycle extensions.
• Competition from generics will intensify post-patent, pressuring pricing and market share.
• Strategic initiatives could include new formulations or indications to sustain revenue.

FAQs

1. When does MAVIK's patent expire?
In 2028.

2. What is MAVIK's main competitive advantage?
Its existing patent protection and positioning as a branded ACE inhibitor.

3. How will patent expiration impact MAVIK's revenue?
Sales are expected to decline 20-30% annually post-2028 due to generic competition.

4. Which regions represent growth opportunities for MAVIK?
Asia-Pacific and emerging markets with rising hypertension prevalence.

5. What strategies could extend MAVIK's market life?
Developing new formulations, exploring additional indications, and expanding geographic reach.

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References

[1] MarketsandMarkets. (2023). Hypertension drugs market report.

[2] GlobalData. (2022). Heart failure drugs market analysis.

[3] Takeda Pharmaceutical. (2023). Annual report.

[4] IQVIA. (2022). Medicine use and spending in the U.S.: A review of 2022.