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CAYSTON Drug Profile

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Which patents cover Cayston, and when can generic versions of Cayston launch?

Cayston is a drug marketed by Gilead and is included in one NDA. There are four patents protecting this drug.

This drug has forty-nine patent family members in eighteen countries.

The generic ingredient in CAYSTON is aztreonam. There are eight drug master file entries for this compound. Three suppliers are listed for this compound. Additional details are available on the aztreonam profile page.

Summary for CAYSTON

International Patents:	49
US Patents:	4
Applicants:	1
NDAs:	1
Suppliers / Packagers:	1
Bulk Api Vendors:	46
Clinical Trials:	4
Patent Applications:	4,661
Formulation / Manufacturing:	see details
DailyMed Link:	CAYSTON at DailyMed

Medical Subject Heading (MeSH) Categories for CAYSTON

Anti-Bacterial Agents

Synonyms for CAYSTON

(2S,3S)-3-((Z)-2-(2-ammoniothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-2-methyl-4-oxoazetidine-1-sulfonate

(2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate

(2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate(aztreonam)

(2S,3S)-3-[(2Z)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-2-methyl-4-oxoazetidine-1-sulfonate

(2S,3S)-3-[[(2Z)-2-(2-ammonio-4-thiazolyl)-2-(2-carboxypropan-2-yloxyimino)-1-oxoethyl]amino]-2-methyl-4-oxo-1-azetidinesulfonate

(2S,3S)-3-[[(2Z)-2-(2-azaniumyl-1,3-thiazol-4-yl)-2-(2-methyl-1-oxidanyl-1-oxidanylidene-propan-2-yl)oxyimino-ethanoyl]amino]-2-methyl-4-oxidanylidene-azetidine-1-sulfonate

(Z)-2-((((2-Amino-4-thiazolyl)(((2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid

(Z)-2-[[[(2-Amino-4-thiazolyl)[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3- azetidinyl]carbamoyl]methylene]amino]oxy]-2-methylpropionic acid

[2S-[2alpha,3beta(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid

110A380

2-((((E)-1-(2-aminothiazol-4-yl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid

2-((((Z)-1-(2-aminothiazol-4-yl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid

2-(((Z)-(1-(2-Aminothiazol-4-yl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl)amino)-2-oxoethylidene)amino)oxy)-2-methylpropanoic acid

2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl) -2- {[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino} -2- oxoethylidene]amino}oxy)-2-methylpropanoic acid

2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-{[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino}-2-oxoethylidene]amino}oxy)-2-methylpropanoic acid

2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid

2-[(Z)-[1-(2-aminothiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-azetidin-3-yl]amino]-2-oxo-ethylidene]amino]oxy-2-methyl-propanoic acid

2-[[(Z)-[1-(2-Amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methylpropionic Acid

2-[1-(2-Amino-thiazol-4-yl)-1-((2S,3S)-2-methyl-4-oxo-1-sulfo-azetidin-3-ylcarbamoyl)-meth-(Z)-ylideneaminooxy]-2-methyl-propionic acid

78110-38-0

A839338

AB2000129

AC-4330

AC1NX3U2

AK-41883

AKOS015840157

AKOS015961777

AKOS026750006

Ambap78110-38-0

AN-12074

Antibiotic squibb 26,776

AS-13760

Az-threonam

Azactam

Azactam (TN)

AZACTAM IN PLASTIC CONTAINER

Azetreonam

Azonam

Azthreonam

Aztreon

aztreonam

Aztreonam (Azactam, Cayston)

Aztreonam (JP17/USP/INN)

Aztreonam [USAN:INN:BAN:JAN]

Aztreonam [USAN:USP:INN:BAN:JAN]

Aztreonam lysine

Aztreonam, analytical standard

Aztreonam, pharmaceutical secondary standard; traceable to USP

Aztreonam, United States Pharmacopeia (USP) Reference Standard

Aztreonamum

Aztreonamum [Latin]

BC208259

BCP9000372

BCPP000356

BDBM50240480

BIDD:GT0765

BPBio1_000121

BRD-K62607865-001-03-0

BRN 3577211

BSPBio_000109

C06840

C13H17N5O8S2

CC-24234

CCG-220185

CHEBI:161680

CHEMBL158

Corus 1020

CS-1902

D00240

D0F2XV

DB00355

Dynabiotic

E-Aztreonam

EINECS 278-839-9

G2B4VE5GH8

HMS1568F11

HMS2090K09

HMS2095F11

HY-B0129

J10266

LS-121219

MFCD00072145

MLS003915628

MLS006011974

MolPort-003-886-345

Monobactam

Monobactam, SQ 26776, Squibb 26776, Aztreonam

Monobactam;SQ 26776;Squibb 26776;Azactam;Cayston

NCGC00179656-01

Nebactam

NSC 646279

NSC-646279

NSC646279

Prestwick_914

Prestwick2_000185

Prestwick3_000185

Primbactam

Propanoic acid, 2-(((1-(2-amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-2-methyl-, (2S-(2-alpha,3-beta(Z)))-

Propanoic acid, 2-(((1-(2-amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-2-methyl-, (2S-(2alpha,3beta(Z)))-

Propanoic acid, 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl]amino]-2-oxoethylidene]amino]oxy]-2-methyl-

PubChem13620

RP18114

S1505

SCHEMBL37511

SMR002204030

SMR004703537

SO-26776

SQ 26,776

SQ 26776

SQ-26,776

SQ-26776

Squibb 26,776

Squibb 26776

SR-01000841814

SR-01000841814-2

UNII-G2B4VE5GH8

Urobactam

WZPBZJONDBGPKJ-VEHQQRBSSA-N

ZINC12503091

US Patents and Regulatory Information for CAYSTON

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Exclusivity Expiration
Gilead	CAYSTON	aztreonam	FOR SOLUTION;INHALATION	050814-001	Feb 22, 2010		RX	Yes	Yes			Y
Gilead	CAYSTON	aztreonam	FOR SOLUTION;INHALATION	050814-001	Feb 22, 2010		RX	Yes	Yes			Y
Gilead	CAYSTON	aztreonam	FOR SOLUTION;INHALATION	050814-001	Feb 22, 2010		RX	Yes	Yes			Y
Gilead	CAYSTON	aztreonam	FOR SOLUTION;INHALATION	050814-001	Feb 22, 2010		RX	Yes	Yes			Y

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Non-Orange Book US Patents for CAYSTON

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No.	Title	Estimated Patent Expiration
9,533,000	Inhalable aztreonam for treatment and prevention of pulmonary bacterial infections
6,660,249	Inhalable dry powder aztreonam for treatment and prevention of pulmonary bacterial infections
8,841,286	Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections
9,345,663	Inhalable aztreonam lysinate formulation for treatment and prevention of pulmonary bacterial infections

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International Patents for CAYSTON

Country	Document Number	Estimated Expiration
Canada	2708703
Japan	2004516302
Norway	20032946
Denmark	2158901

Supplementary Protection Certificates for CAYSTON

Supplementary Protection Certificate	SPC Country	SPC Expiration	SPC Description
0492	Netherlands		PRODUCT NAME: AZTREONAMLYSINE; REGISTRATION NO/DATE: EU/1/09/543/001 20090923
2011 00021	Denmark
851	Luxembourg		91851, EXPIRES: 20240921
5	Finland