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Serving hundreds of leading biopharmaceutical companies globally:

Chinese Patent Office
Farmers Insurance
UBS
Fuji
US Army
Julphar
Harvard Business School
McKinsey
McKesson

Generated: July 19, 2018

DrugPatentWatch Database Preview

BREVIBLOC Drug Profile

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When do Brevibloc patents expire, and when can generic versions of Brevibloc launch?

Brevibloc is a drug marketed by Baxter Hlthcare and is included in one NDA. There are two patents protecting this drug and one Paragraph IV challenge.

This drug has thirty-six patent family members in twenty-four countries.

The generic ingredient in BREVIBLOC is esmolol hydrochloride. There are eight drug master file entries for this compound. Twelve suppliers are listed for this compound. Additional details are available on the esmolol hydrochloride profile page.
Drug patent expirations by year for BREVIBLOC
Pharmacology for BREVIBLOC
Synonyms for BREVIBLOC
(+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate hydrochloride
(+/-)-methyl p-[2-hydroxy-3-(isopropylamino) propoxy]hydrocinnamate hydrochloride
4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoic acid methyl ester HCl
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benxzenepropanoic Acid Methyl Ester Hydrochloride
4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]BENZENEPROPANOIC ACID METHYL ESTER HYDROCHLORIDE
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride
598E034
81147-92-4 (Parent)
81161-17-3
81161-17-3, 81147-92-4(free base)
AB0013228
AB07716
AC-6972
AC1L2XGQ
AC1Q3EA6
AKOS015895316
AN-9460
API0001758
Asl 8052
ASL-8052
Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride
Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester, hydrochloride, (+-)-
Benzenepropanoic acid, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-, methyl ester,hydrochloride
BG0502
Brevibloc (TN)
Brevibloc Double Strength in plastic container
Brevibloc in plastic container
C16H25NO4.HCl
CAS-81161-17-3
CCG-100972
CCG-220890
CHEBI:4857
CHEMBL1201115
CPD000469141
CS-4908
CTK8F9497
D00644
DSSTox_CID_28929
DSSTox_GSID_49003
DSSTox_RID_83195
DTXSID7049003
EBD13377
Esmolol (hydrochloride)
Esmolol HCL
Esmolol hydrochloride
Esmolol hydrochloride (JAN/USAN)
Esmolol hydrochloride [USAN]
Esmolol hydrochloride, >=98% (HPLC), solid
Esmolol hydrochloride, United States Pharmacopeia (USP) Reference Standard
Esmolol(hydrochloride)
Esmololhydrochloride
FT-0082446
FT-0601541
H746
HSDB 6530
HY-B1392
I06-0682
J-003862
KS-00001FBX
KS-1353
LS-31122
methyl 3-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)propanoate hydrochloride
METHYL 3-(4-[2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY]PHENYL)PROPANOATE HYDROCHLORIDE
methyl 3-(4-{2-hydroxy-3-[(methylethyl)amino]propoxy}phenyl)propanoate, chlori de
METHYL 3-[4-(2-HYDROXY-3-PROPAN-2-YLAMINO-PROPOXY)PHENYL]PROPANOATE HYDROCHLORIDE
Methyl 3-[4-(2-hydroxy-3-propan-2-ylamino-propoxy)phenyl]propanoate hydrochloride; Brevibloc
methyl 3-[4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl]propanoate hydrochloride
methyl 3-[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl]propanoate hydrochloride
Methyl 3-{4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl}propanoate hydrochloride (Esmolol HCl)
MLS001401393
MolPort-003-847-093
NC00222
NCGC00185766-01
NCGC00185766-04
OR161498
Q-201070
s4100
SAM001246533
SBB055181
SCHEMBL41086
SMR000469141
TL8005428
Tox21_113496
Tox21_113496_1
W-1240

US Patents and Regulatory Information for BREVIBLOC

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration
Baxter Hlthcare BREVIBLOC esmolol hydrochloride INJECTABLE;INJECTION 019386-003 Aug 15, 1988 DISCN No No ➤ Sign Up ➤ Sign Up ➤ Sign Up
Baxter Hlthcare BREVIBLOC DOUBLE STRENGTH IN PLASTIC CONTAINER esmolol hydrochloride INJECTABLE;INJECTION 019386-005 Jan 27, 2003 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Baxter Hlthcare BREVIBLOC esmolol hydrochloride INJECTABLE;INJECTION 019386-007 May 28, 2003 DISCN No No ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Baxter Hlthcare BREVIBLOC IN PLASTIC CONTAINER esmolol hydrochloride INJECTABLE;INJECTION 019386-004 Feb 16, 2001 RX Yes Yes ➤ Sign Up ➤ Sign Up Y ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Exclusivity Expiration

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Expired US Patents for BREVIBLOC

Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration
Baxter Hlthcare BREVIBLOC esmolol hydrochloride INJECTABLE;INJECTION 019386-007 May 28, 2003 ➤ Sign Up ➤ Sign Up
Baxter Hlthcare BREVIBLOC esmolol hydrochloride INJECTABLE;INJECTION 019386-003 Aug 15, 1988 ➤ Sign Up ➤ Sign Up
Baxter Hlthcare BREVIBLOC esmolol hydrochloride INJECTABLE;INJECTION 019386-003 Aug 15, 1988 ➤ Sign Up ➤ Sign Up
Baxter Hlthcare BREVIBLOC esmolol hydrochloride INJECTABLE;INJECTION 019386-006 Feb 25, 2003 ➤ Sign Up ➤ Sign Up
Applicant Tradename Generic Name Dosage NDA Approval Date Patent No. Patent Expiration

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Paragraph IV (Patent) Challenges for BREVIBLOC
Drugname Dosage Strength RLD Date
➤ Subscribe Injection 10 mg/mL, 250 mL infusion bags and 20 mg/mL, 100 mL infusion bags ➤ Subscribe ➤ Sign Up

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Serving hundreds of leading biopharmaceutical companies globally:

Covington
Farmers Insurance
US Army
Julphar
Fish and Richardson
Daiichi Sankyo
AstraZeneca
McKesson
Dow

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