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Last Updated: April 7, 2020

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CLINICAL TRIALS PROFILE FOR BREVIBLOC

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All Clinical Trials for BREVIBLOC

Trial ID Title Status Sponsor Phase Start Date Summary
NCT01114971 Labetalol and Esmolol: Vital Signs and Post Operative Pain Management Recruiting Cedars-Sinai Medical Center Phase 4 2009-09-01 This study proposes to investigate the effects of labetalol or esmolol on managing the vital signs (like blood pressure and heart rate) during surgery, on pain management, and on the later recovery after surgery. It will also assess the cost-effectiveness of Labetalol and esmolol for outpatient surgery.
NCT01179113 Esmolol Infusion During Laminectomy: Effect on Quality of Recovery Terminated Cedars-Sinai Medical Center Phase 4 2011-06-01 The purpose of this study is to evaluate the effects of esmolol, a drug which is commonly administered during surgery to help control blood pressure and heart rate, on postoperative pain levels and requirements for pain medication.
NCT01208402 Esmolol for Treatment of Perioperative Tachycardia Terminated Baxter Healthcare Corporation Phase 3 2010-09-01 The purpose of this study is to find out if Esmolol is a safe and effective alternative treatment compared to standard treatment using a long acting beta blocker drug, in controlling abnormal heart rate before, during and immediately after surgery.
NCT01208402 Esmolol for Treatment of Perioperative Tachycardia Terminated Duke University Phase 3 2010-09-01 The purpose of this study is to find out if Esmolol is a safe and effective alternative treatment compared to standard treatment using a long acting beta blocker drug, in controlling abnormal heart rate before, during and immediately after surgery.
NCT01232400 Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage Withdrawn University of Michigan N/A 2014-07-01 The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; to explore the safety of esmolol treatment shortly after subarachnoid hemorrhage (SAH). Patients will be followed for a maximum of 1 month after the index SAH. The primary outcome will be change in systolic function - ejection fraction by Simpson's rule (baseline versus Day 7 +/- 2 after SAH).
NCT01343329 Controlling Hyperadrenergic Activity in Neurologic Injury Unknown status Johns Hopkins University Phase 1/Phase 2 2011-07-01 Traumatic brain injury (TBI) is frequently associated with a hyperadrenergic state accompanied by elevated levels of plasma catecholamines. In its more severe presentation, the hyperadrenergic state presents as dysautonomia, which is characterized by paroxysmal alteration in vital signs, including tachycardia. The investigators hypothesize that intravenous (IV) esmolol is as effective at controlling heart rate in hyperadrenergic states as oral propranolol, which is the standard of care. Our primary endpoint is efficacy of IV esmolol vs a PRN regimen of intermittent B-blockade in controlling heart rate below a pre-specified level (< 100 bpm) after Traumatic Brain Injury (TBI). Heart rates will be recorded continuously as well as hourly.
>Trial ID >Title >Status >Phase >Start Date >Summary

Clinical Trial Conditions for BREVIBLOC

Condition Name

Condition Name for BREVIBLOC
Intervention Trials
Septic Shock 3
Healthy 1
Laparoscopic Surgery 1
Subarachnoid Hemorrhage 1
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Condition MeSH

Condition MeSH for BREVIBLOC
Intervention Trials
Shock, Septic 3
Shock 3
Tachycardia 2
Autonomic Nervous System Diseases 1
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Clinical Trial Locations for BREVIBLOC

Trials by Country

Trials by Country for BREVIBLOC
Location Trials
United States 8
Brazil 6
Turkey 3
China 1
Egypt 1
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Trials by US State

Trials by US State for BREVIBLOC
Location Trials
Utah 2
California 2
Maryland 1
Michigan 1
Ohio 1
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Clinical Trial Progress for BREVIBLOC

Clinical Trial Phase

Clinical Trial Phase for BREVIBLOC
Clinical Trial Phase Trials
Phase 4 7
Phase 3 1
Phase 2 4
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Clinical Trial Status

Clinical Trial Status for BREVIBLOC
Clinical Trial Phase Trials
Recruiting 7
Unknown status 3
Terminated 2
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Clinical Trial Sponsors for BREVIBLOC

Sponsor Name

Sponsor Name for BREVIBLOC
Sponsor Trials
Baxter Healthcare Corporation 2
Cedars-Sinai Medical Center 2
Beth Israel Deaconess Medical Center 2
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Sponsor Type

Sponsor Type for BREVIBLOC
Sponsor Trials
Other 18
Industry 4
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