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Serving leading biopharmaceutical companies globally:

Moodys
Merck
Chubb
AstraZeneca
US Army
Harvard Business School
Federal Trade Commission
Queensland Health
Medtronic
Citi

Generated: October 23, 2017

DrugPatentWatch Database Preview

Details for Patent: 8,877,938

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Which drugs does patent 8,877,938 protect, and when does it expire?


Patent 8,877,938 protects ENTRESTO and is included in one NDA.

This patent has forty-eight patent family members in thirty countries.

Summary for Patent: 8,877,938

Title:Compounds containing S-N-valeryl-N-{[2'-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and cations
Abstract: A compound of an angiotensin receptor antagonist (ARB), a neutral endopeptidase inhibitor (NEPi) and one or more monovalent cations are useful for the treatment of hypertension and/or heart failure. ARB includes S--N-valeryl-N-{[2'-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl}-v- aline in the anion form, NEPi includes (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester in the anion form and cation includes monovalent cations such as Na.sup.+. The compound includes trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propi- onate-(S)-3'-methyl-2'-(pentanoyl{2''-(tetrazol-5-ylate)biphenyl-4'-ylmeth- yl}amino)butyrate] hemipentahydrate.
Inventor(s): Feng; Lili (Pine Brook, NJ), Godtfredsen; Sven Erik (Chatham, NJ), Hu; Bin (Green Brook, NJ), Liu; Yugang (Bridgewater, NJ), Karpinski; Piotr (Lincoln Park, NJ), Sutton; Paul Allen (Parsippany, NJ), Prashad; Mahavir (Montville, NJ), Girgis; Michael J. (Montville, NJ), Blacklock; Thomas J. (Clark, NJ)
Assignee: Novartis Pharmaceuticals Corporation (East Hanover, NJ)
Application Number:11/722,360
Patent Claim Types:
see list of patent claims
Compound; Composition;

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use
Novartis Pharms Corp
ENTRESTO
sacubitril; valsartan
TABLET;ORAL207620-001Jul 7, 2015RXYesNo► Subscribe► SubscribeYY
Novartis Pharms Corp
ENTRESTO
sacubitril; valsartan
TABLET;ORAL207620-002Jul 7, 2015RXYesNo► Subscribe► SubscribeYY
Novartis Pharms Corp
ENTRESTO
sacubitril; valsartan
TABLET;ORAL207620-003Jul 7, 2015RXYesYes► Subscribe► SubscribeYY
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Foreign Priority and PCT Information for Patent: 8,877,938

PCT Information
PCT FiledNovember 08, 2006PCT Application Number:PCT/US2006/043710
PCT Publication Date:May 18, 2007PCT Publication Number: WO2007/056546

Non-Orange Book Patents for Patent: 8,877,938

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
9,388,134Compounds containing S-N-valeryl-N-{[2'-(1H-tetrazole-5-yl)-biphenyl-4-yl]-methyl)-valine and (2R,4S)-5-biphenyl-4-yl-4-(3-carboxy-propionylamino)-2-methyl-pentanoic acid ethyl ester moieties and cations► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Because of the complexity of determining patent expiration dates it is advisable to have patent counsel verify freedom to operate.

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International Patent Family for Patent: 8,877,938

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina057882► Subscribe
Australia2006311481► Subscribe
BrazilPI0605921► Subscribe
Canada2590511► Subscribe
China101098689► Subscribe
China102702119► Subscribe
Cyprus1115004► Subscribe
Denmark1948158► Subscribe
European Patent Office1948158► Subscribe300810Netherlands► Subscribe
European Patent Office1948158► SubscribePA2016017Lithuania► Subscribe
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The estimated expiration dates shown above are derived by simply adding 20 years to the priority date.
Due to the complexity of determining patent expirations even in a single country, compounded by the diversity of global patent laws, it is advisable to have patent counsel verify freedom to operate.

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Serving leading biopharmaceutical companies globally:

Colorcon
Cerilliant
Fuji
Mallinckrodt
McKinsey
Deloitte
Queensland Health
Medtronic
Dow
Julphar

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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