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Serving leading biopharmaceutical companies globally:

Express Scripts
Medtronic
Covington
Teva
Johnson and Johnson
Chubb
Federal Trade Commission
Boehringer Ingelheim
Dow
Merck

Generated: February 20, 2018

DrugPatentWatch Database Preview

Details for Patent: 8,741,933

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Which drugs does patent 8,741,933 protect, and when does it expire?

Patent 8,741,933 protects ORKAMBI and is included in one NDA.

This patent has forty-eight patent family members in twenty-three countries.
Summary for Patent: 8,741,933
Title:Modulators of ATP-binding cassette transporters
Abstract: Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
Inventor(s): Hadida Ruah; Sara S. (La Jolla, CA), Hamilton; Matthew (Hackettstown, NJ), Miller; Mark (San Diego, CA), Grootenhuis; Peter D. J. (San Diego, CA), Bear; Brian (Carlsbad, CA), McCartney; Jason (Cardiff by the Sea, CA), Zhou; Jinglan (San Diego, CA)
Assignee: Vertex Pharmaceuticals Incorporated (Boston, MA)
Application Number:13/871,356
Patent Claim Types:
see list of patent claims
Use; Composition;

Drugs Protected by US Patent 8,741,933

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted
Vertex Pharms Inc ORKAMBI ivacaftor; lumacaftor TABLET;ORAL 206038-002 Sep 28, 2016 RX Yes No ➤ Try a Free Trial ➤ Try a Free Trial METHOD OF TREATING CYSTIC FIBROSIS IN A PATIENT, THE PATIENT HAVING THE F508DEL MUTATION IN CFTR, USING IVACAFTOR AND LUMACAFTOR ➤ Try a Free Trial
Vertex Pharms Inc ORKAMBI ivacaftor; lumacaftor TABLET;ORAL 206038-001 Jul 2, 2015 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial METHOD OF TREATING CYSTIC FIBROSIS IN A PATIENT, THE PATIENT HAVING THE F508DEL MUTATION IN CFTR, USING IVACAFTOR AND LUMACAFTOR ➤ Try a Free Trial
Vertex Pharms Inc ORKAMBI ivacaftor; lumacaftor TABLET;ORAL 206038-001 Jul 2, 2015 RX Yes Yes ➤ Try a Free Trial ➤ Try a Free Trial METHOD OF TREATING CYSTIC FIBROSIS IN PATIENTS WHO ARE HOMOZYGOUS FOR THE F508DEL MUTATION IN THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR) GENE ➤ Try a Free Trial
Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Patent Submitted

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Non-Orange Book US Patents Family Members for Patent 8,741,933

For Orange Book-listed patents (shown in the main table above) generic applications must certify that the listed patents are expired, invalid, or will not be infringed by generic entry.

The non-Orange Book patents listed below do not require formal certifications, so they do not automatically impede generic entry. Instead, they represent potential opportunities for branded firms to block generic entry through patent infringment challenges.

Patent No. Title Estimated Patent Expiration
7,659,268 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
7,956,052 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
8,461,156 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
7,973,038 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
8,318,733 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
8,993,600 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
8,324,207 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
8,012,999 Modulators of CFTR ➤ Try a Free Trial
7,741,321 Modulators of ATP-binding cassette transporters ➤ Try a Free Trial
7,754,739 Modulators of CFTR ➤ Try a Free Trial
Patent No. Title Estimated Patent Expiration

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International Patents Family Members for US Patent 8,741,933

Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Slovenia 2774925 ➤ Try a Free Trial
Slovenia 2404919 ➤ Try a Free Trial
Slovenia 2395002 ➤ Try a Free Trial
Slovenia 1945632 ➤ Try a Free Trial
Russian Federation 2608610 ➤ Try a Free Trial
Russian Federation 2012123372 ➤ Try a Free Trial
Russian Federation 2463303 ➤ Try a Free Trial
Russian Federation 2008122929 ➤ Try a Free Trial
Portugal 2774925 ➤ Try a Free Trial
Portugal 2404919 ➤ Try a Free Trial
Country Document Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration

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Serving hundreds of leading biopharmaceutical companies globally:

Deloitte
QuintilesIMS
McKesson
Covington
US Army
Chinese Patent Office
Teva
US Department of Justice
Daiichi Sankyo

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verifification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.

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