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Last Updated: August 4, 2021

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Details for Patent: 8,703,780


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Summary for Patent: 8,703,780
Title:Inhibitors of Bruton's tyrosine kinase
Abstract: Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.
Inventor(s): Honigberg; Lee (San Francisco, CA), Verner; Erik (Belmont, CA), Pan; Zhengying (Austin, TX)
Assignee: Pharmacyclics, Inc. (Sunnyvale, CA)
Application Number:13/526,161
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,703,780
Patent Claim Types:
see list of patent claims
Use; Device; Delivery;

Drugs Protected by US Patent 8,703,780

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Pharmacyclics Inc IMBRUVICA ibrutinib CAPSULE;ORAL 205552-002 Dec 20, 2017 AB RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib CAPSULE;ORAL 205552-001 Nov 13, 2013 AB RX Yes Yes ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib TABLET;ORAL 210563-001 Feb 16, 2018 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib TABLET;ORAL 210563-001 Feb 16, 2018 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH 17P DELETION ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib TABLET;ORAL 210563-002 Feb 16, 2018 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH 17P DELETION ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib TABLET;ORAL 210563-002 Feb 16, 2018 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA ⤷  Free Forever Trial
Pharmacyclics Inc IMBRUVICA ibrutinib TABLET;ORAL 210563-003 Feb 16, 2018 RX Yes No ⤷  Free Forever Trial ⤷  Free Forever Trial TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA ⤷  Free Forever Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,703,780

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Austria 531263 ⤷  Free Forever Trial
Australia 2006348662 ⤷  Free Forever Trial
Australia 2008232762 ⤷  Free Forever Trial
Australia 2010201052 ⤷  Free Forever Trial
Australia 2012205166 ⤷  Free Forever Trial
Brazil PI0622054 ⤷  Free Forever Trial
Brazil PI0622277 ⤷  Free Forever Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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