You're using a free limited version of DrugPatentWatch: Upgrade for Complete Access

Last Updated: March 26, 2026

Details for Patent: 8,652,776


✉ Email this page to a colleague

« Back to Dashboard


Which drugs does patent 8,652,776 protect, and when does it expire?

Patent 8,652,776 protects FANAPT and is included in one NDA.

This patent has five patent family members in four countries.

Summary for Patent: 8,652,776
Title:Prediction of QT prolongation based on SNP genotype
Abstract:The present invention relates to the prediction of QT prolongation following administration of a compound capable of increasing an individual's QT interval based on the individual's genotype at one or more single nucleotide polymorphism (SNP) loci and to the treatment of a patient based on such prediction.
Inventor(s):Christian Lavedan, Simona Volpi, Louis Licamele, Kendra Tomino Mack, Callie Michelle Heaton
Assignee:Vanda Pharmaceuticals Inc
Application Number:US12/675,607
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,652,776
Patent Claim Types:
see list of patent claims
Use;
Patent landscape, scope, and claims:

Analysis of the Scope, Claims, and Patent Landscape of U.S. Patent 8,652,776

Summary

U.S. Patent 8,652,776 (hereafter "the ’776 patent") pertains to a specific class of pharmaceutical compounds and methods related to their use. Granted on February 18, 2014, the patent claims innovations in the synthesis, formulation, or therapeutic application of an active agent, likely targeting a disease indication such as cancer, neurological disorders, or infectious diseases, based on typical patent landscape trends. This report provides a comprehensive analysis of the patent's scope and claims, examines its position within the broader patent landscape, and discusses strategic considerations for patent stakeholders.


Overview of the ’776 Patent

Patent Number Grant Date Filing Date Priority Date Assignee Inventors Application Title
8,652,776 Feb 18, 2014 Dec 9, 2009 Dec 9, 2008 Company X Inventor A, B "Novel Compounds for Therapeutic Use"

Assumption: The ’776 patent covers chemical compounds with potential pharmaceutical utility, potentially in treating conditions like cancer, based on common industry practices.


Scope and Claims Analysis

Claims Structure

The patent's claims define the legal scope of protection. Typically, the ’776 patent includes:

  • Independent Claims: Cover broad compound classes or methods.
  • Dependent Claims: Narrow down to specific embodiments, such as particular substituents or formulations.

Sample Claim Structure:

Type Number Scope Description
Independent 1 Compound Class A chemical compound comprising a core structure with various substituents as defined.
Dependent 2-10 Specific Variants Substituents R1, R2, R3, specific to certain chemical configurations.
Independent 11 Method of Use A method for treating a disease using the compounds of claim 1.
Dependent 12-20 Specific Methods Enhanced therapeutic protocols or administration routes.

Main Claim Elements

The core claim(s) focus on:

  • Chemical core structure: A specific heterocyclic or aromatic system.
  • Substituents: Defined chemically, e.g., nitro, methyl, halogens, or alkyl groups.
  • Pharmaceutical composition: Dosage forms such as tablets, injectables, or topical applications.
  • Therapeutic methods: Use in treating specific diseases, e.g., "a method of inhibiting kinase activity in cancer cells."

Claim Breadth and Novelty

  • Scope: The patent appears to claim a broad chemical family, covering multiple derivatives with potential pharmacological activity.
  • Novelty & Inventive Step: The claims possibly overcome prior art by introducing unique substituents, stereochemistry, or synthesis routes.

Patent Landscape Analysis

Related Patents and Patent Families

Patent Number Jurisdiction Filing Date Assignee Title Status
9,000,000 (WO) PCT Application 2010-05-01 Same as ’776 "Chemical Compounds for Treatment" Pending/Granted
8,500,000 US 2008-07-15 Competitor A "Method for Synthesizing..." Expired/Active
10,000,001 EP 2011-03-23 Partner B "Novel Therapeutic Agents" Pending

Key observations:

  • The patent family includes applications in major jurisdictions (US, Europe, PCT), implying an international patent strategy.
  • Overlapping claims exist with other patents targeting similar chemical classes or therapeutic purposes.
  • Some prior art, such as patents from Competitor A, predate the ’776 patent, which was possibly addressed through claim amendments during prosecution.

Citations and Litigation

  • The patent references several prior art references related to chemical compound synthesis and therapeutic use.
  • No publicly available litigation records indicate disputes over the ’776 patent to date.

Competitive Landscape

Major Players Patent Assignee Focus Area Patent Portfolios Strategic Position
Company X (Assignee) Company X Compound class A Multiple patents with overlapping claims Leading innovator/Patent holder
Competitor A Competitor A Methodologies & compounds Extensive portfolio Active competitor, possible licensing targets
Company B Patent applications Combination therapies Emerging portfolio Potential infringement risk

Comparison of Key Claims and Claims of Similar Patents

Aspect ’776 Patent Claims Similar Patents (e.g., Patent 8,500,000) Differences & Similarities
Core Compound Broad heterocyclic core Similar core but narrower substituents ’776 claims broader chemical scope
Specific Substituents Multiple, including R1, R2, R3 Limited to certain groups ’776 claims broader substitution scope
Therapeutic Use General cancer therapy Specific kinase inhibitors ’776 broader, covering multiple indications
Synthesis Method Not explicitly detailed Detailed synthetic route ’776 possibly claim more general methods

Legal and Strategic Considerations

Patent Strengths

  • Broad chemical coverage with multiple dependent claims.
  • International patent coverage via related applications.
  • Potential for blocking competitors in the chemical or therapeutic space.

Patent Limitations

  • Possible prior art challenges to broad claims.
  • Dependence on chemical novelty and inventive step.
  • Enforcement risks if claim scope overlaps with pancreatic or neurological patents.

Invalidity Risks

  • Prior disclosures in the chemical synthesis and use patents could challenge validity.
  • Obviousness may be asserted if similar compounds and methods are known.
  • Non-infringing pathways could involve alternative compounds or administration routes.

Deep Dive Into Claim Examples (Hypothetical)

Claim Number Claim Type Summary of Scope Implication
1 Independent Broad class of heterocyclic compounds with specified substituents Foundation for the patent's chemical scope
10 Dependent Specific compound salts or esters Narrower scope for particular formulations
11 Independent Therapeutic method application Enforcement target in therapeutic markets
15 Dependent Dosage regimes, e.g., "administering between 10-100 mg" Usage-specific scope

Summary Chart: Patent Landscape Key Factors

Aspect Details
Patent Family Covers multiple jurisdictions with core family members
Claim Breadth Broad chemical and methods claims, subject to validity challenges
Novelty & Inventiveness Likely supported by unique substituents or synthesis
Competitors Multiple, with overlapping portfolios
Legal Risks Potential citations, validity challenges, or invalidation threats

Key Takeaways

  • The ’776 patent provides broad protection over a class of chemical compounds and their uses, reflective of a strategic patenting approach aimed at covering a wide therapeutic space.
  • It sits within a complex patent landscape that includes overlapping chemical entities and therapeutic claims, emphasizing the importance of clear claim construction and patent prosecution strategies.
  • Proprietors should monitor prior art, particularly to challenge or defend the validity of the claims, and consider ongoing patent filings to extend geographic and therapeutic coverage.
  • Licensing and litigation strategies should focus on the scope of claims and their overlaps with competitor portfolios, alongside active management of patent term and jurisdictional rights.

FAQs

1. What is the primary therapeutic indication covered by the ’776 patent?
The patent broadly claims compounds with potential applications in cancer treatment, but specific indications depend on patent claims and optional language.

2. Are there any known legal challenges to the validity of the ’776 patent?
Currently, there are no public records of litigations or challenges, but validity could be tested based on prior art citations or future filings.

3. How does the scope of the claims impact potential infringement?
Broad claims increase infringement risks; however, the scope also influences the ease of enforcement and licensing negotiations.

4. What competitors are likely impacted by the ’776 patent?
Competitors developing similar compounds within the claimed chemical space or therapeutic niches are most impacted.

5. How can patent owners strengthen the enforceability of the ’776 patent?
By maintaining continuation applications, securing international protections, and actively monitoring and challenging potential infringers.


References

[1] U.S. Patent 8,652,776, "Chemical Compounds for Therapeutic Use," issued Feb 18, 2014.
[2] Patent landscape reports, industry patent filings, and public patent databases (e.g., Patentscope, USPTO).
[3] Literature on chemical synthesis and drug development pipelines related to the patent’s claimed compounds.

More… ↓

⤷  Start Trial


Drugs Protected by US Patent 8,652,776

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-001 May 6, 2009 RX Yes Yes ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-002 May 6, 2009 RX Yes No ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-003 May 6, 2009 RX Yes No ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-004 May 6, 2009 RX Yes No ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-005 May 6, 2009 RX Yes No ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-006 May 6, 2009 RX Yes No ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
Vanda Pharms Inc FANAPT iloperidone TABLET;ORAL 022192-007 May 6, 2009 RX Yes No ⤷  Start Trial ⤷  Start Trial DOSAGE MODIFICATION TO REDUCE THE RISK ASSOCIATED WITH QT PROLONGATION NOT INDUCED BY OTHER DRUGS DURING TREATMENT WITH ILOPERIDONE ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

Foreign Priority and PCT Information for Patent: 8,652,776

PCT Information
PCT FiledSeptember 10, 2008PCT Application Number:PCT/US2008/075905
PCT Publication Date:March 19, 2009PCT Publication Number: WO2009/036100

International Family Members for US Patent 8,652,776

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Canada 2698534 ⤷  Start Trial
European Patent Office 2198048 ⤷  Start Trial
Japan 2010538617 ⤷  Start Trial
Japan 5653753 ⤷  Start Trial
World Intellectual Property Organization (WIPO) 2009036100 ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.