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|Title:||Prediction of QT prolongation based on SNP genotype|
|Abstract:||The present invention relates to the prediction of QT prolongation following administration of a compound capable of increasing an individual's QT interval based on the individual's genotype at one or more single nucleotide polymorphism (SNP) loci and to the treatment of a patient based on such prediction.|
|Inventor(s):||Lavedan; Christian (Potomac, MD), Volpi; Simona (Derwood, MD), Licamele; Louis (Gaithersburg, MD), Mack; Kendra Tomino (Westminster, MD), Heaton; Callie Michelle (Washington, DC)|
|Assignee:||Vanda Pharmaceuticals, Inc. (Washington, DC)|
1. A method of treating a human patient for one or more symptoms of a psychotic disorder, the method comprising: determining, from a biological sample of the patient, the
patient's genotype in both copies of the single nucleotide polymorphism (SNP) locus rs3924426; and treating the patient based upon whether the patient's genotype at the rs3924426 SNP locus is associated with increased QT prolongation, wherein treating
includes: in the case that the patient has a TT genotype at the rs3924426 SNP locus, administering to the patient an effective amount of iloperidone or a pharmaceutically-acceptable salt thereof, the effective amount being less than would be administered
to a patient who does not have a TT genotype at the rs3924426 SNP locus; or in the case that the patient does not have a TT genotype at the rs3924426 SNP locus, administering to the patient an increased amount of iloperidone, the increased amount being
more than would be administered to a patient who has a TT genotype at the rs3924426 SNP locus.
2. The method of claim 1, wherein the effective amount is between about 2 mg/day and about 24 mg/day.
3. The method of claim 2, wherein the effective amount is between about 5 mg/day and about 20 mg/day.
4. The method of claim 3, wherein the effective amount is between about 10 mg/day and about 15 mg/day.
5. The method of claim 1, wherein the increased amount is between about 24 mg/day and about 50 mg/day.
6. The method of claim 5, wherein the increased amount is between about 30 mg/day and about 50 mg/day.
7. The method of claim 6, wherein the increased amount is between about 40 mg/day and about 50 mg/day.
8. The method of claim 1, wherein treating the patient includes monitoring the patient for QT prolongation.
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