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Last Updated: January 16, 2021

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Details for Patent: 8,012,976

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Which drugs does patent 8,012,976 protect, and when does it expire?

Patent 8,012,976 protects TALZENNA and is included in one NDA.

This patent has fifty patent family members in twenty-eight countries.

Summary for Patent: 8,012,976
Title:Dihydropyridophthalazinone inhibitors of poly(ADP-ribose)polymerase (PARP)
Abstract: A compound having the structure set forth in Formula (I) and Formula (II): ##STR00001## wherein the substituents Y, Z, A, B, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. Provided herein are inhibitors of poly(ADP-ribose)polymerase activity. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat diseases, disorders and conditions that are ameliorated by the inhibition of PARP activity.
Inventor(s): Wang; Bing (San Jose, CA), Chu; Daniel (Santa Clara, CA)
Assignee: BioMarin Pharmaceutical Inc. (Novato, CA)
Application Number:12/510,096
Patent Claim Types:
see list of patent claims
Composition; Compound;

Drugs Protected by US Patent 8,012,976

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Pfizer TALZENNA talazoparib tosylate CAPSULE;ORAL 211651-001 Oct 16, 2018 RX Yes No   Start Trial   Start Trial Y Y   Start Trial
Pfizer TALZENNA talazoparib tosylate CAPSULE;ORAL 211651-002 Oct 16, 2018 RX Yes Yes   Start Trial   Start Trial Y Y   Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 8,012,976

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
Argentina 072970   Start Trial
Australia 2009279944   Start Trial
Brazil PI0917119   Start Trial
Canada 2732797   Start Trial
China 102171214   Start Trial
China 103896942   Start Trial
China 104478875   Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

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Serving leading biopharmaceutical companies globally:

Mallinckrodt
Boehringer Ingelheim
Express Scripts
Dow
McKesson
Baxter

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