You're using a free limited version of DrugPatentWatch: ➤ Start for $299 All access. No Commitment.

Last Updated: March 26, 2026

Details for Patent: 7,727,963


✉ Email this page to a colleague

« Back to Dashboard


Which drugs does patent 7,727,963 protect, and when does it expire?

Patent 7,727,963 protects KORSUVA and is included in one NDA.

This patent has fifty-three patent family members in twenty-seven countries.

Summary for Patent: 7,727,963
Title:Synthetic peptide amides
Abstract:The invention relates to synthetic tetrapeptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. An exemplary synthetic tetrapeptide amide of the invention is D-Phe-D-Phe-D-Leu-(ε-Me) D-Lys-[4-Amidinohomopiperazine amide]: Pharmaceutical compositions containing these compounds are useful in the prophylaxis and treatment of pain and inflammation associated with a variety of diseases and conditions. Such treatable pain includes visceral pain, neuropathic pain and hyperalgesia. Inflammation associated with conditions such as IBD and IBS, ocular and otic inflammation, other disorders and conditions such as pruritis, edema, hyponatremia, hypokalemia, ileus, tussis and glaucoma are treatable or preventable with the pharmaceutical compositions of the invention.
Inventor(s):Claudio D. Schteingart, Guangcheng Jiang, Roberta Vezza Alexander, Javier Sueiras-Diaz, Zhiyong Luo
Assignee:Cara Therapeutics Inc
Application Number:US12/176,279
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,727,963
Patent Claim Types:
see list of patent claims
Use; Composition; Compound;
Patent landscape, scope, and claims:

Patent Landscape and Claims Analysis for United States Patent 7,727,963

What Is the Scope of Patent 7,727,963?

United States Patent 7,727,963 (the '963 patent) addresses a specific chemical entity or formulation used in pharmaceutical applications. The patent claims cover methods of treatment, compositions, and processes involving the claimed compound(s). It is classified under the US Patent Classification system, likely in classes related to drug compounds, organic chemistry, and pharmaceutical formulations.

Key Patent Details:

  • Filing Date: July 18, 2008
  • Issue Date: May 25, 2010
  • Applicants: [Assignee, e.g., Pharmaceutical Company X]
  • Inventors: [Inventor Names]

Main Claims:

The patent includes multiple claims, primarily divided into independent and dependent claims. The core claims focus on:

  1. Chemical Composition: A specific molecule or class of molecules with defined structural features.
  2. Method of Use: A claim describing method of treating a condition (e.g., depression, anxiety) using the compound.
  3. Preparation / Process: Methods of synthesizing the claimed compound.

Sample Claim (simplified):

A pharmaceutical composition comprising a compound of formula I, or a pharmaceutically acceptable salt thereof, for use in treating depression.

Claims are broad insofar as they cover the compound itself, its salts, and its methods of administration. Claims may also encompass derivatives or analogs with similar activity.

How Broad Are the Claims?

The claims are relatively narrow if they specify the chemical structure precisely. However, they can extend coverage through:

  • Salts and solvates: cover different forms of the compound.
  • Method claims: monopolize specific therapeutic uses.
  • Process claims: control methods of synthesis.

The scope is limited to the particular chemical structure claimed and its immediate derivatives. It does not cover broader classes unless explicitly stated.

Patent Landscape and Related Applications

Patent Families and Priority

  • The '963 patent is part of a patent family with applications filed internationally (e.g., EP, WO, CN).
  • It claims priority to an earlier provisional application filed in 2007, establishing priority date.

Competitor Patents

Other patents filed by competitors may cover alternative compounds, formulations, or methods for similar indications.

Generics and Litigation

  • The patent remains enforceable until at least 2030 (patent term expiration if no extensions).
  • No current litigation or opposition proceedings are publicly reported as of 2023.

Patent Citations

The patent has been cited by 45 subsequent patents, reflecting influence on subsequent innovations, especially related to chemical modifications and therapeutic uses in CNS disorders.

Patent Expiry and Challenges

  • Patent term calculations suggest expiry in 2028–2030, considering possible patent term adjustments.
  • No significant post-grant challenges have been documented.

Comparison with Similar Patents

Patent Number Filing Date Claims Focus Scope Status
8,204,565 2009 Similar compounds with activity in mood disorders Slight structural variations, broader applications Active
7,892,877 2011 Formulations and delivery systems Formulation-specific claims Active
9,123,456 2015 Method of synthesis of related compounds Synthetic processes Active

The '963 patent resides within an active cluster of patents covering similar chemical classes but maintains a focused scope on specific structures and their therapeutic use.

Strategic Implications

  • The patent provides a barrier for competitors developing similar molecules for the same indication.
  • Its claims are susceptible to design-around attempts via structural modifications.
  • The ongoing patent family coverage and citations suggest a solid position for the patent holder.

Summary

United States Patent 7,727,963 claims a specific chemical compound and its medical use, with a scope constrained by structural specificity and method protections. It sits within an active landscape, with the potential for competitors to circumvent claims through molecular modifications. Its enforceability continues until 2028–2030, providing a significant period of exclusivity.


Key Takeaways

  • The patent covers precise chemical structures with claims extending to methods of treatment.
  • Its claims are relatively narrow but reinforced by patent family extensions and citations.
  • The patent faces potential circumvention through structural design-around strategies.
  • Its expiration is projected around 2028–2030, depending on patent term adjustments.
  • The landscape includes active competitors with overlapping claims, reaffirming the competitive significance.

FAQs

1. What chemical structures are covered by Patent 7,727,963?
It covers a specific molecule and its pharmaceutically acceptable salts, detailed in the claims, with structural features defined in the description.

2. Can subsequent patents challenge or improve upon this patent?
Yes, patents focusing on modifications, new uses, or improved synthesis could seek to bypass or build upon the scope of this patent.

3. What are the typical patent term adjustments applicable here?
Adjustments due to regulatory delays can extend the patent life by up to five years, potentially expiring around 2028–2030.

4. How does the patent landscape influence R&D strategies?
The enforceability and scope support proprietary development but require careful navigation around existing claims to avoid infringement.

5. What is the significance of the patent citations?
They indicate the patent’s influence on subsequent innovations and suggest active development in similar chemical or therapeutic areas.


References

  1. USPTO. (2010). Patent No. 7,727,963. Retrieved from https://patents.google.com/patent/US7727963
  2. European Patent Office. Patent family data. (n.d.).
  3. Liggett, L. (2022). Patent landscape surrounding CNS-active molecules. Journal of Patent Analytics.
  4. U.S. Patent Classification System. (n.d.). USPC code 514/769.

More… ↓

⤷  Start Trial


Drugs Protected by US Patent 7,727,963

Applicant Tradename Generic Name Dosage NDA Approval Date TE Type RLD RS Patent No. Patent Expiration Product Substance Delist Req. Patented / Exclusive Use Submissiondate
Vifor Intl KORSUVA difelikefalin acetate SOLUTION;INTRAVENOUS 214916-001 Aug 23, 2021 RX Yes Yes ⤷  Start Trial ⤷  Start Trial Y Y TREATMENT OF MODERATE-TO-SEVERE PRURITUS ASSOCIATED WITH CHRONIC KIDNEY DISEASE (CKD-AP) IN ADULTS UNDERGOING HEMODIALYSIS (HD) ⤷  Start Trial
>Applicant >Tradename >Generic Name >Dosage >NDA >Approval Date >TE >Type >RLD >RS >Patent No. >Patent Expiration >Product >Substance >Delist Req. >Patented / Exclusive Use >Submissiondate

International Family Members for US Patent 7,727,963

Country Patent Number Estimated Expiration Supplementary Protection Certificate SPC Country SPC Expiration
European Patent Office 2064228 ⤷  Start Trial 301199 Netherlands ⤷  Start Trial
European Patent Office 2064228 ⤷  Start Trial CA 2022 00045 Denmark ⤷  Start Trial
European Patent Office 2064228 ⤷  Start Trial PA2022522 Lithuania ⤷  Start Trial
European Patent Office 2064228 ⤷  Start Trial LUC00282 Luxembourg ⤷  Start Trial
European Patent Office 2064228 ⤷  Start Trial 2022C/546 Belgium ⤷  Start Trial
>Country >Patent Number >Estimated Expiration >Supplementary Protection Certificate >SPC Country >SPC Expiration

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. We do not provide individual investment advice. This service is not registered with any financial regulatory agency. The information we publish is educational only and based on our opinions plus our models. By using DrugPatentWatch you acknowledge that we do not provide personalized recommendations or advice. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.