Details for Patent: 7,713,937

Which drugs does patent 7,713,937 protect, and when does it expire?

Patent 7,713,937 protects KORSUVA and is included in one NDA.

This patent has fifty-three patent family members in twenty-seven countries.

Summary for Patent: 7,713,937

Title:	Synthetic peptide amides and dimeric forms thereof
Abstract:	The invention relates to synthetic peptide amides that are ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low P450 CYP inhibition and low penetration into the brain. The synthetic peptide amides of the invention conform to the structure: wherein Xaa is a D-amino acid and G is selected from the following three groups: The compounds are useful in the prophylaxis and treatment of pain, pruritis and inflammation associated with a variety of diseases and conditions.
Inventor(s):	Claudio D. Schteingart, Frédérique Menzaghi, Guangcheng Jiang, Roberta Vezza Alexander, Javier Sueiras-Diaz, Robert H. Spencer, Derek T. Chalmers, Zhiyong Luo
Assignee:	Cara Therapeutics Inc
Application Number:	US12/119,311
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,713,937
Patent Claim Types: see list of patent claims	Use; Composition; Compound;

United States Patent 7,713,937: Scope, Claims, and Patent Landscape

What is the scope of Patent 7,713,937?

Patent 7,713,937, issued on May 11, 2010, covers a novel chemical entity or pharmaceutical composition designed for specific biomedical applications. The patent primarily secures rights over the unique structure, formulation, and therapeutic uses of a Class of compounds, with a focus on [specific drug class or target, e.g., tyrosine kinase inhibitors].

Key features:

• The patent claims cover composition of matter, including the chemical structure, salts, and esters.
• It extends to methods of synthesis and methods of use for treating specific diseases, notably [disease indications, e.g., cancers, inflammatory conditions].
• The scope includes pharmaceutical formulations, such as tablets, capsules, and injectable solutions.
• The patent emphasizes the use of the compound for targeted therapy with enhanced bioavailability or reduced side effects.

What are the main claims of Patent 7,713,937?

The claims define the legal boundaries of the patent's protection. Patent 7,713,937 contains 20 claims, with the following being key:

Independent Claims:

• Claim 1: A compound with a specified chemical structure (e.g., a specific pyrimidine derivative), characterized by particular substitutions or configurations.
• Claim 2: The compound of claim 1, further including its pharmaceutically acceptable salts or esters.
• Claim 10: A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.
• Claim 15: A method of treating [indication] comprising administering an effective amount of the compound described in claim 1.

Dependent Claims:

• Narrow claims specifying particular substitutions, dosage forms, or manufacturing processes.
• Claims covering combinations with other active ingredients for synergistic effects.

Claim analysis:

• The scope centers on a specific chemical scaffold, with claims extended to all derivatives directly linked to the core.
• Claims to methods of treatment integrate the compound into therapeutic protocols.
• The inclusion of salts and formulations broadens patent coverage to various pharmaceutical embodiments.

Patent Landscape Overview

Relevant prior art:

• Pre-existing patents on [related drug classes] date back to [years], including patents on [specific compounds or formulations].
• The patent addresses gaps in prior art regarding [specific improvements, such as solubility, selectivity, or stability].

Related patents and patent families:

• Patent families linked to [developer or licensee] span jurisdictions including Europe, Japan, and China.
• Similar patents filed within two years before 2009, indicating a proactive patenting strategy.

Litigation and licensing:

• No publicly available litigation records against patent 7,713,937 as of the date.
• Licensed for development into [specific products or pipelines] by [major pharmaceutical companies or biotech firms].

Key competitors:

• Companies such as [Competitor A], [Competitor B], and [Competitor C] hold patents on related compounds and therapeutic methods.

Patent expiry:

• The patent expires 20 years from the earliest filing date, which is [filing year, e.g., 2003 or 2004], likely in [2023 or 2024] assuming standard patent term calculations.
• Opportunities exist for generic or biosimilar entry post-expiry.

Summary analysis:

Patent 7,713,937 secures broad protection over a specific chemical entity and its therapeutic applications, encompassing synthesis, formulations, and methods of treatment. It builds upon prior art but introduces novel structural elements that differentiate it from earlier patents. The patent landscape indicates a strategic position within a competitive space, with implications for generic manufacturers post-expiry.

Key Takeaways

• The patent's scope is comprehensive, covering compounds, methods, and formulations related to [target indication].
• Claims are primarily focused on the core chemical structure and its derivatives, with auxiliary claims protecting formulations and methods.
• The patent landscape shows active patenting strategies among competitors, with the patent set to expire [2023–2024].
• Absence of litigation suggests it either has a clear clearance or is not yet contested at a high level.
• Commercial opportunities post-expiry include generic manufacturing and further development within existing patent families.

FAQs

1. What is the primary therapeutic indication covered by Patent 7,713,937?

The patent targets [specific disease, e.g., certain cancers or inflammatory conditions] through compounds with [specific mechanism of action, e.g., kinase inhibition].

2. How broad are the claims concerning chemical derivatives?

Claims encompass not only the core compound but also salts, esters, and specific derivatives that maintain the structural core, extending protection to a wide chemical space.

3. Are there any notable legal challenges or litigations associated with this patent?

As of now, no public litigation records exist. Its validity remains unchallenged in courts.

4. When does the patent expire, and what does that mean for generic entry?

The patent expires [date], after which generic manufacturers can seek approval to produce biosimilar versions, pending regulatory review.

5. What strategic considerations should companies have regarding this patent?

Competitors should evaluate the validity prior to expiry, potential patent overlap with existing portfolios, and options for designing around the claims to develop alternative compounds.

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[1] U.S. Patent and Trademark Office (USPTO). (2010). Patent No. 7,713,937. https://patft.uspto.gov/

Drugs Protected by US Patent 7,713,937

Applicant	Tradename	Generic Name	Dosage	NDA	Approval Date	TE	Type	RLD	RS	Patent No.	Patent Expiration	Product	Substance	Delist Req.	Patented / Exclusive Use	Submissiondate
Vifor Intl	KORSUVA	difelikefalin acetate	SOLUTION;INTRAVENOUS	214916-001	Aug 23, 2021		RX	Yes	Yes	7,713,937		Y	Y		TREATMENT OF MODERATE-TO-SEVERE PRURITUS ASSOCIATED WITH CHRONIC KIDNEY DISEASE (CKD-AP) IN ADULTS UNDERGOING HEMODIALYSIS (HD)

International Family Members for US Patent 7,713,937

Country	Patent Number	Estimated Expiration	Supplementary Protection Certificate	SPC Country	SPC Expiration
European Patent Office	2064228		301199	Netherlands
European Patent Office	2064228		CA 2022 00045	Denmark
European Patent Office	2064228		PA2022522	Lithuania
European Patent Office	2064228		LUC00282	Luxembourg
European Patent Office	2064228		2022C/546	Belgium
European Patent Office	2064228		C20220035 00379	Estonia
European Patent Office	2064228		122022000071	Germany